PT1468692E - Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma - Google Patents

Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma

Info

Publication number: PT1468692E
Authority: PT; Portugal
Prior art keywords: xantoma; silyphenols; dialquil; treatment; group
Prior art date: 1993-12-10

Application number

PT04016883T

Other languages

English (en)

Inventor

Mao Simon Jen Tan

Yates Mark Thirston

Roger Alan Parker

Original Assignee

Aventis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-11-03

Publication date

2006-09-29

1994-11-03 Application filed by Aventis Inc filed Critical Aventis Inc

2006-09-29 Publication of PT1468692E publication Critical patent/PT1468692E/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

PT04016883T 1993-12-10 1994-11-03 Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma PT1468692E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16528193A	1993-12-10	1993-12-10

Publications (1)

Publication Number	Publication Date
PT1468692E true PT1468692E (pt)	2006-09-29

Family

ID=22598245

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT95901141T PT732928E (pt)	1993-12-10	1994-11-03	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois
PT04016883T PT1468692E (pt)	1993-12-10	1994-11-03	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT95901141T PT732928E (pt)	1993-12-10	1994-11-03	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois

Country Status (16)

Country	Link
EP (3)	EP1468692B1 (pt)
JP (1)	JPH09511222A (pt)
CN (1)	CN1092517C (pt)
AT (2)	ATE324113T1 (pt)
AU (1)	AU681731B2 (pt)
CA (1)	CA2177968C (pt)
DE (2)	DE69434198T2 (pt)
DK (2)	DK1468692T3 (pt)
ES (2)	ES2233937T3 (pt)
HU (1)	HU220761B1 (pt)
IL (1)	IL111905A (pt)
NO (1)	NO311868B1 (pt)
NZ (1)	NZ276285A (pt)
PT (2)	PT732928E (pt)
WO (1)	WO1995015760A1 (pt)
ZA (1)	ZA949663B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1275596C (zh)	1997-05-14	2006-09-20	阿特罗吉尼克斯公司	普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
ES2190592T3 (es) *	1997-06-24	2003-08-01	Aventis Pharma Inc	Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes.
US6133467A (en) *	1997-06-25	2000-10-17	Hoechst Marion Roussel, Inc.	2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
WO1998058937A1 (en) *	1997-06-25	1998-12-30	Hoechst Marion Roussel, Inc.	2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL
JP2002511878A (ja)	1997-07-01	2002-04-16	アセロジエニクス・インコーポレイテツド	抗酸化剤による過増殖状態の治療の増強
US6887712B1 (en)	1998-11-09	2005-05-03	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
EP1137948B1 (en) *	1998-11-09	2006-05-10	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en)	1999-01-20	2004-11-23	The Board Of Regents For Oklahoma State University	Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
BR0115474A (pt)	2000-11-17	2006-01-31	Idenix Cayman Ltd	Composição e método para inibição da transmissão de hiv que usam 6-benzil-4-oxopirimidinas substituìdas aplicada por via tópica
JP2005516941A (ja)	2001-12-19	2005-06-09	アセロジエニクス・インコーポレイテツド	カルコン誘導体及び疾患を治療するためのそれらの使用
US6960683B2 (en)	2002-07-12	2005-11-01	Atherogenics, Inc.	Salt forms of poorly soluble probucol esters and ethers
US7173129B2 (en)	2003-06-06	2007-02-06	Athero Genics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) *	2003-10-17	2005-05-06	Amylin Pharmaceuticals, Inc.	Silyl phenols for promoting vascular health
WO2005112914A2 (en)	2004-04-20	2005-12-01	Atherogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
BRPI0809423A2 (pt)	2007-03-26	2014-09-09	Salutria Pharmaceuticals Llc	Usos e composições de derivados de probucol para o tratamento de diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE349046B (pt) *	1966-12-23	1972-09-18	C Guevne
FR2230376A1 (en) *	1973-05-24	1974-12-20	Gueyne Jean	Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) *	1975-04-21	1976-11-19	Cortial	Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) *	1982-07-12	1987-06-02	American Cyanamid Company	Antiatherosclerotic silanes
US4900757A (en) *	1988-12-08	1990-02-13	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) *	1990-07-05	1994-03-25	Merrell Dow Pharma	Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) *	1990-07-05	1992-10-13	Merrell Dow Pharmaceuticals Inc.	2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

1994
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 EP EP04016883A patent/EP1468692B1/en not_active Expired - Lifetime
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en not_active Ceased
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 EP EP04016884A patent/EP1468693A3/en not_active Withdrawn
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 EP EP95901141A patent/EP0732928B1/en not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2177968A1 (en)	1995-06-15
ATE285238T1 (de)	2005-01-15
AU681731B2 (en)	1997-09-04
ZA949663B (en)	1995-08-15
HUT74015A (en)	1996-10-28
ES2233937T3 (es)	2005-06-16
NO962415D0 (no)	1996-06-07
JPH09511222A (ja)	1997-11-11
CA2177968C (en)	2000-03-28
DE69434720T2 (de)	2007-05-16
AU1049995A (en)	1995-06-27
DE69434198D1 (de)	2005-01-27
WO1995015760A1 (en)	1995-06-15
PT732928E (pt)	2005-03-31
ES2263094T3 (es)	2006-12-01
EP1468692A3 (en)	2004-11-03
CN1092517C (zh)	2002-10-16
EP0732928A1 (en)	1996-09-25
EP1468692B1 (en)	2006-04-26
ATE324113T1 (de)	2006-05-15
DE69434198T2 (de)	2005-12-29
EP1468693A3 (en)	2004-11-03
EP1468692A2 (en)	2004-10-20
DE69434720D1 (de)	2006-06-01
EP0732928B1 (en)	2004-12-22
EP1468693A2 (en)	2004-10-20
NO311868B1 (no)	2002-02-11
NZ276285A (en)	2004-11-26
DK1468692T3 (da)	2006-08-28
HU220761B1 (hu)	2002-05-28
IL111905A0 (en)	1995-03-15
CN1140995A (zh)	1997-01-22
DK0732928T3 (da)	2005-04-18
NO962415L (no)	1996-06-07
HU9601590D0 (en)	1996-08-28
IL111905A (en)	2001-04-30

Publication	Publication Date	Title
PT1468692E (pt)	2006-09-29	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
DE3781716D1 (de)	1992-10-22	Mittel zur ortsspezifischen alkylierung.
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
EP0632031A4 (pt)	1995-02-08
BG97221A (bg)	1993-12-24	Ортозаместени бифениламидини и бифенилизанидини и съдържащите ги антидиабетични или хипогликемични средства
FI864618A0 (fi)	1986-11-13	Nya 3-oxadiazol- och 3-karboksylsyra- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
FI882477A0 (fi)	1988-05-26	>nya alkansulfonanilidderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
FI902632A0 (fi)	1990-05-25	Menetelmä terapeuttisesti käyttökelpoisten 5-substitoitujen 5,11-dihydrodibentso/b,e//1,4/tiatsepiinijohdannaisten valmistamiseksi sekä menetelmässä käyttökelpoisia välituotteita
EP0712398A1 (en)	1996-05-22	BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
DK0410305T3 (da)	1995-04-03	Anvendelse af bis(4-hydroxyphenylthio)methanderivater til behandling af diabetes mellitus
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus
ATE148462T1 (de)	1997-02-15	Isoxazole derivate als lichtschutzmittel
EA200200462A1 (ru)	2002-10-31	Производные 2-арилхинолина, их получение и терапевтическое применение
SE8000138L (sv)	1980-07-18	Nya 3-cyklopentan-1,2'(1'h)-naftalen-derivat, framstellning derav och lekemedel innehallande desamma
FI935399L (fi)	1995-06-03	N-substituerade azabicykloheptanderivat samt deras framstaellning och anvaendning
ATE44741T1 (de)	1989-08-15	2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.