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PT1339399E - Combinacoes de drogas (e.g., clorpromazina e pentamidina) para o tratamento de desordens neoplasicas - Google Patents

Combinacoes de drogas (e.g., clorpromazina e pentamidina) para o tratamento de desordens neoplasicas

Info

Publication number
PT1339399E
PT1339399E PT01994213T PT01994213T PT1339399E PT 1339399 E PT1339399 E PT 1339399E PT 01994213 T PT01994213 T PT 01994213T PT 01994213 T PT01994213 T PT 01994213T PT 1339399 E PT1339399 E PT 1339399E
Authority
PT
Portugal
Prior art keywords
clorpromazine
pentamidine
drugs
combinations
treatment
Prior art date
Application number
PT01994213T
Other languages
English (en)
Inventor
Borisy Alexis
Keith Curtis
Michael A Foley
Brent R Stockwell
Original Assignee
Combinatorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc filed Critical Combinatorx Inc
Publication of PT1339399E publication Critical patent/PT1339399E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PT01994213T 2000-11-06 2001-10-30 Combinacoes de drogas (e.g., clorpromazina e pentamidina) para o tratamento de desordens neoplasicas PT1339399E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/706,929 US6569853B1 (en) 2000-11-06 2000-11-06 Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders

Publications (1)

Publication Number Publication Date
PT1339399E true PT1339399E (pt) 2006-07-31

Family

ID=24839666

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01994213T PT1339399E (pt) 2000-11-06 2001-10-30 Combinacoes de drogas (e.g., clorpromazina e pentamidina) para o tratamento de desordens neoplasicas

Country Status (29)

Country Link
US (4) US6569853B1 (pt)
EP (1) EP1339399B1 (pt)
JP (1) JP2004517915A (pt)
KR (1) KR100720205B1 (pt)
CN (1) CN1484525A (pt)
AR (1) AR035500A1 (pt)
AT (1) ATE318590T1 (pt)
AU (1) AU2002246636B8 (pt)
BG (1) BG107831A (pt)
BR (1) BR0115166A (pt)
CA (1) CA2436799C (pt)
CY (1) CY1105501T1 (pt)
DE (1) DE60117615T2 (pt)
DK (1) DK1339399T3 (pt)
EE (1) EE200300212A (pt)
ES (1) ES2258566T3 (pt)
HR (1) HRP20030460A2 (pt)
HU (1) HUP0400529A3 (pt)
IL (1) IL155795A0 (pt)
IS (1) IS2457B (pt)
MX (1) MXPA03003960A (pt)
NO (1) NO20032036L (pt)
NZ (1) NZ525773A (pt)
PL (1) PL362690A1 (pt)
PT (1) PT1339399E (pt)
RU (1) RU2286769C2 (pt)
SK (1) SK5452003A3 (pt)
TW (1) TWI259077B (pt)
WO (1) WO2002058684A2 (pt)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1231910T3 (da) * 1999-11-16 2009-08-31 Oncozyme Pharma Inc Pentamidin til behandling af cancer
DE10015818A1 (de) * 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
US20030049320A1 (en) * 2000-12-18 2003-03-13 Wockhardt Limited Novel in-situ forming controlled release microcarrier delivery system
US6992082B2 (en) * 2001-01-19 2006-01-31 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
US6693125B2 (en) * 2001-01-24 2004-02-17 Combinatorx Incorporated Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
WO2002069949A2 (en) * 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
CA2451845A1 (en) * 2001-05-31 2002-12-05 The Cleveland Clinic Foundation Ptpase inhibitors and method of using same
FR2825279B1 (fr) * 2001-06-01 2005-04-08 Molecular Engines Lab Medicament utile dans le traitement du cancer
US20040010045A1 (en) * 2001-09-07 2004-01-15 Taolin Yi Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer
EP1572070A4 (en) * 2001-09-07 2009-11-04 Cleveland Clinic Foundation THERAPEUTIC COMPOSITIONS AND METHOD FOR MODULATING PROTEIN TYROSINE PHOSPHATASES
US20050215629A1 (en) * 2001-09-07 2005-09-29 Taolin Yi PTPase inhibitors and methods of using the same
US7544681B2 (en) * 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
AU2004201240B2 (en) * 2001-09-27 2008-08-07 Bar Ilan University Conjugated Psychotropic Drugs and Uses Thereof
US8053477B2 (en) * 2002-03-29 2011-11-08 University Of Maryland, Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
AU2003241346A1 (en) * 2002-05-01 2003-11-17 The Cleveland Clinic Foundation Therapeutic compositions comprised of pentamidine and methods of using same to treat cancer
EP1545544A2 (en) * 2002-07-11 2005-06-29 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
EP1606759B1 (en) * 2003-03-26 2010-05-05 Synergy Biosystems Ltd. Methods to identify biologically active agents and synergistic combinations
EP1651207A4 (en) * 2003-06-12 2008-10-01 Univ Colorado SYSTEMS AND METHODS FOR THE TREATMENT OF HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND INJURIES USING INHIBITORS OF FATTY ACID METABOLISM AND / OR GLYCOLYTIC INHIBITORS
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
MXPA06003066A (es) * 2003-09-18 2006-06-20 Combinatorx Inc Combinaciones de farmacos para el tratamiento de neoplasmas.
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
TW200526777A (en) * 2003-11-12 2005-08-16 Combinatorx Inc Combinations for the treatment of proliferative diseases
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
ATE532517T1 (de) 2003-11-13 2011-11-15 Noa Sic Aps Thioridazin und seine derivate zur umkehr von antimikrobieller arzneimittelresistenz
US7510710B2 (en) 2004-01-08 2009-03-31 The Regents Of The University Of Colorado Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20110008327A1 (en) * 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
EP1737472B1 (en) 2004-03-29 2014-08-13 University Of South Florida Effective treatment of tumors and cancer with triciribine
EP2260870A3 (en) 2004-04-30 2012-12-26 BKG Pharma ApS Treatment of infectious diseases with combinations of a thioxanthene derivative with an anti-infective agent
WO2005117847A2 (en) * 2004-06-02 2005-12-15 Combinatorx, Incorporated Methods and compounds for the treatment of neoplasms
EP1856247B1 (en) * 2005-01-19 2016-05-04 The Trustees of The University of Pennsylvania Regulation of autophagy and cell survival
TW200719903A (en) * 2005-04-19 2007-06-01 Combinatorx Inc Compositions for the treatment of neoplasms
JP2008539238A (ja) * 2005-04-28 2008-11-13 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド 治療用二機能性化合物
JP2008543734A (ja) * 2005-05-02 2008-12-04 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド 脂肪酸代謝および解糖の阻害を提供する化合物の組み合わせ、または二官能性化合物を用いるヒトの炎症性および増殖性疾患を処置するためのシステムおよび方法
US9233094B2 (en) * 2005-05-04 2016-01-12 Medigene Ag Method of administering a cationic liposomal preparation
DE102005024017A1 (de) * 2005-05-25 2006-11-30 Merck Patent Gmbh Chinazolinone
ES2400772T3 (es) * 2005-06-07 2013-04-12 Ramot At Tel Aviv University Ltd. Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
WO2007082052A2 (en) * 2006-01-11 2007-07-19 The Cleveland Clinic Foundation Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases
MX2008011978A (es) 2006-03-22 2009-04-22 Medigene Ag Tratamiento del cancer de seno negativo al triple receptor.
US20080226596A1 (en) * 2006-06-19 2008-09-18 Taolin Yi Therapeutic compositions and methods useful in treating hepatitis
WO2007149381A2 (en) * 2006-06-19 2007-12-27 The Cleveland Clinic Foundation Compositions comprising a ptp-ase inhibitor and use thereof in treating cancer
CN101511388B (zh) * 2006-07-17 2012-10-24 特拉维夫大学拉莫特有限公司 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途
MX2009007235A (es) 2007-01-05 2009-10-16 Bkg Pharma Aps "derivados de tioxanteno utiles para el tratamiento de enfermedades infecciosas.".
JP5201744B2 (ja) * 2007-01-09 2013-06-05 フォヴェア ファルマシューティカル 眼内注射装置
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
WO2008138123A1 (en) * 2007-05-09 2008-11-20 Thomas David Y Screening assay to identify correctors of protein trafficking defects
CN101138558B (zh) * 2007-09-13 2010-08-25 汕头大学医学院 喷他脒及死亡结构域受体配体联合应用
EP2194981B1 (en) * 2007-10-05 2011-11-23 Université de Mons-Hainaut Bisbenzimidazoles as antimalarial agents
EP2252578B1 (en) * 2008-02-11 2012-08-01 Ramot at Tel Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
US8835506B2 (en) 2008-06-05 2014-09-16 Stc.Unm Methods and related compositions for the treatment of cancer
US20100035858A1 (en) * 2008-07-18 2010-02-11 Immune Control, Inc. Novel Compositions and Methods for Binding and Inhibiting 5-HT4 Receptor
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US9034389B2 (en) 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
JP2012525371A (ja) * 2009-05-01 2012-10-22 オンコザイム・ファーマ・インコーポレイテッド 癌を治療するためのペンタミジンの組み合わせ
CN102439453A (zh) 2009-05-20 2012-05-02 日内瓦大学 癌症起始细胞的线粒体活性抑制剂及其用途
US20120277193A1 (en) * 2009-09-21 2012-11-01 President And Fellows Of Harvard College Synergistic Combination Therapy
AU2010329440A1 (en) * 2009-12-09 2012-08-09 Bar-Ilan University Methods of improving cognitive functions
US20130165417A1 (en) * 2010-04-23 2013-06-27 University Of Florida Research Foundation Methods and compositions for treating ace2-related disorders
US8916610B2 (en) 2010-09-22 2014-12-23 Ramot At Tel-Aviv University Ltd. Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same
PT2550963T (pt) * 2011-07-25 2017-01-19 Dritte Patentportfolio Beteili Ésteres de ácido carboxílico de amidoxima de pentamidina como pró-drogas, e a utilização dos mesmos como fármaco
CN103781481B (zh) * 2011-08-02 2018-12-14 亥姆霍兹慕尼黑中心-德国环境健康研究中心 (Gmbh) 吩噻嗪衍生物对malt1蛋白酶的选择性抑制
WO2014086478A1 (en) * 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
CA2894466A1 (en) 2012-12-21 2014-06-26 Patrick Colin Uses and methods for the treatment of liver diseases or conditions
RU2530651C1 (ru) * 2013-11-06 2014-10-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук Средство, обладающее противовоспалительным и антифибротическим действием в легочной ткани при цитостатическом воздействии
KR101538264B1 (ko) * 2014-01-24 2015-07-20 계명대학교 산학협력단 티오리다진과 트레일을 유효성분으로 함유하는 암 예방 또는 치료용 약학조성물
CN106794184A (zh) * 2014-06-02 2017-05-31 黄奇英 抗药性癌症的治疗方法
CN105255887B (zh) * 2015-07-17 2018-05-18 四川大学 一种重组慢病毒及其在制备治疗可卡因成瘾的药物中的用途
WO2020082037A1 (en) * 2018-10-19 2020-04-23 Auransa Inc. Methods for treating a subtype of small cell lung cancer
EA202191741A1 (ru) 2018-12-20 2021-10-25 Ауранса Инк. Аналоги пентамидина и их применение
CN109793727A (zh) * 2019-03-13 2019-05-24 湖北科技学院 一种有效抗恶性肿瘤的药物组合物及其应用
KR102562739B1 (ko) * 2020-09-11 2023-08-03 연세대학교 산학협력단 암의 기원 세포의 사멸용 약학적 조성물
CN114588163A (zh) * 2020-12-04 2022-06-07 中国福利会国际和平妇幼保健院 盐酸氯丙嗪在治疗子宫内膜癌中的应用
KR102315103B1 (ko) * 2021-01-21 2021-10-20 주식회사 뉴캔서큐어바이오 티오리다진 및 퍼헥실린을 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645640A (en) * 1953-07-14 Phenthiazine derivatives
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
GB1288376A (pt) 1968-10-29 1972-09-06
DE3827974A1 (de) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen
US5104858A (en) 1988-09-29 1992-04-14 Yale University Sensitizing multidrug resistant cells to antitumor agents
CH681780A5 (en) * 1991-02-25 1993-05-28 Patrinove Anticancer compsns. - consists of a cytotoxic agent with a agent to prevent multi:drug resistance, e.g. in liposome(s)
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase
US5602172A (en) * 1994-05-06 1997-02-11 The University Of North Carolina At Chapel Hill Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
US5521189A (en) * 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
US5770585A (en) 1995-05-08 1998-06-23 Kaufman; Robert J. Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
WO1998000018A1 (en) * 1996-07-03 1998-01-08 Prm Pharmaceuticals, Inc. Berberine alkaloids as a treatment for chronic, protozoally-induced diarrhea
US6008247A (en) * 1998-02-27 1999-12-28 The University Of North Carolina At Chapel Hill 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents
KR20010041811A (ko) 1998-03-12 2001-05-25 온토젠 코포레이션 단백질 티로신 포스파타제의 조절제
WO2000010990A2 (en) * 1998-08-20 2000-03-02 University Of North Carolina At Chapel Hill Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
EP1143959B1 (en) * 1998-09-17 2006-11-02 University Of North Carolina At Chapel Hill Antifungal activity of dicationic molecules
JP3679943B2 (ja) * 1999-03-02 2005-08-03 大日本印刷株式会社 パターン形成体の製造方法
DK1231910T3 (da) 1999-11-16 2009-08-31 Oncozyme Pharma Inc Pentamidin til behandling af cancer
US6777433B2 (en) * 1999-12-22 2004-08-17 Merck Frosst Canada & Co. Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates
US6911468B2 (en) * 2000-05-22 2005-06-28 Takeda Chemical Industries, Ltd. Tyrosine phosphatase inhibitors
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
US6642221B1 (en) * 2000-11-15 2003-11-04 Parker Hughes Institute Vanadium compounds as anti-proliferative agents
US6693125B2 (en) * 2001-01-24 2004-02-17 Combinatorx Incorporated Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
US20030161893A1 (en) * 2001-09-07 2003-08-28 Taolin Yi PTPase inhibitors and methods of using the same
EP1545544A2 (en) * 2002-07-11 2005-06-29 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
MXPA06003066A (es) * 2003-09-18 2006-06-20 Combinatorx Inc Combinaciones de farmacos para el tratamiento de neoplasmas.
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases

Also Published As

Publication number Publication date
US20070099906A1 (en) 2007-05-03
ATE318590T1 (de) 2006-03-15
RU2286769C2 (ru) 2006-11-10
CN1484525A (zh) 2004-03-24
AR035500A1 (es) 2004-06-02
NO20032036D0 (no) 2003-05-06
IS6806A (is) 2003-05-05
US6846816B2 (en) 2005-01-25
AU2002246636B2 (en) 2005-12-01
WO2002058684A2 (en) 2002-08-01
DE60117615D1 (de) 2006-04-27
HRP20030460A2 (en) 2005-04-30
HUP0400529A3 (en) 2006-02-28
EP1339399A2 (en) 2003-09-03
JP2004517915A (ja) 2004-06-17
KR20030048460A (ko) 2003-06-19
US6569853B1 (en) 2003-05-27
US7148216B2 (en) 2006-12-12
NO20032036L (no) 2003-07-04
WO2002058684A3 (en) 2003-04-17
IS2457B (is) 2008-11-15
HUP0400529A2 (hu) 2004-06-28
PL362690A1 (en) 2004-11-02
DE60117615T2 (de) 2006-11-09
CY1105501T1 (el) 2010-04-28
BR0115166A (pt) 2003-12-30
DK1339399T3 (da) 2006-06-19
CA2436799A1 (en) 2002-08-01
TWI259077B (en) 2006-08-01
US20050192274A1 (en) 2005-09-01
BG107831A (bg) 2004-02-27
CA2436799C (en) 2007-12-18
US20030166642A1 (en) 2003-09-04
EE200300212A (et) 2003-08-15
AU2002246636B8 (en) 2006-01-19
MXPA03003960A (es) 2004-09-10
KR100720205B1 (ko) 2007-05-21
NZ525773A (en) 2005-04-29
EP1339399B1 (en) 2006-03-01
IL155795A0 (en) 2003-12-23
SK5452003A3 (en) 2004-07-07
ES2258566T3 (es) 2006-09-01

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