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PT1183015E - Pastilha em multicamadas para administracao de uma combinacao fixa de tramadol e diclofenac - Google Patents

Pastilha em multicamadas para administracao de uma combinacao fixa de tramadol e diclofenac

Info

Publication number
PT1183015E
PT1183015E PT00945739T PT00945739T PT1183015E PT 1183015 E PT1183015 E PT 1183015E PT 00945739 T PT00945739 T PT 00945739T PT 00945739 T PT00945739 T PT 00945739T PT 1183015 E PT1183015 E PT 1183015E
Authority
PT
Portugal
Prior art keywords
diclofenac
tramadol
multilayer
pillet
administration
Prior art date
Application number
PT00945739T
Other languages
English (en)
Inventor
Iris Ziegler
Bartholomaeus Johannes
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7911585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1183015(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of PT1183015E publication Critical patent/PT1183015E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT00945739T 1999-06-17 2000-06-13 Pastilha em multicamadas para administracao de uma combinacao fixa de tramadol e diclofenac PT1183015E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19927688A DE19927688A1 (de) 1999-06-17 1999-06-17 Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac

Publications (1)

Publication Number Publication Date
PT1183015E true PT1183015E (pt) 2005-02-28

Family

ID=7911585

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00945739T PT1183015E (pt) 1999-06-17 2000-06-13 Pastilha em multicamadas para administracao de uma combinacao fixa de tramadol e diclofenac

Country Status (12)

Country Link
US (1) US6558701B2 (pt)
EP (1) EP1183015B1 (pt)
JP (1) JP4945041B2 (pt)
AT (1) ATE279915T1 (pt)
AU (1) AU770777B2 (pt)
CA (1) CA2377167C (pt)
DE (2) DE19927688A1 (pt)
ES (1) ES2231221T3 (pt)
HU (1) HUP0201686A3 (pt)
MX (1) MXPA01013047A (pt)
PT (1) PT1183015E (pt)
WO (1) WO2000078289A1 (pt)

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NZ517559A (en) * 1999-08-31 2004-08-27 Gruenenthal Chemie Sustained release pharmaceutical composition containing tramadol saccharinate
US7045550B2 (en) 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
WO2003066572A1 (en) 2002-02-07 2003-08-14 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
PA8578501A1 (es) 2002-07-25 2005-02-04 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
DE602004012403T2 (de) 2003-04-29 2009-03-19 Orexigen Therapeutics, Inc., La Jolla Zusammensetzungen zur beeinflussung des gewichtsverlusts
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
WO2005014524A2 (en) 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
PT1667664T (pt) * 2003-09-24 2016-11-21 Novartis Consumer Health Sa Comprimidos revestidos de diclofenac
US8157788B2 (en) * 2003-11-06 2012-04-17 Paolo L. Manfredi Multi-site drug delivery platform
US7329418B2 (en) * 2004-05-21 2008-02-12 Accu Break Technologies, Inc. Pharmaceutical tablets having height greater than width
JP5395355B2 (ja) * 2004-05-21 2014-01-22 アキュ−ブレイク テクノロジーズ インコーポレーテッド ２個またはそれ以上の単位セグメントを含む医薬錠剤
US7838031B2 (en) 2004-05-21 2010-11-23 Lawrence Solomon Method of administering a partial dose using a segmented pharmaceutical tablet
US7780985B2 (en) * 2005-07-12 2010-08-24 Accu-Break Technologies, Inc. Tablets having a printed separation mark to guide breaking
US7713547B2 (en) 2004-05-21 2010-05-11 Accu-Break Pharmaceuticals, Inc. Method of administering a partial dose of a segmented pharmaceutical tablet
US7622137B2 (en) * 2004-05-21 2009-11-24 Accu-Break Technologies, Inc. Dosage forms contained within a capsule or sachet
US20060003000A1 (en) * 2004-07-01 2006-01-05 Lawrence Solomon Adhesively bonded dosage form
US7318935B2 (en) * 2004-05-21 2008-01-15 Accu-Break Technologies, Inc. Pharmaceutical tablets with active and inactive segments
SG164375A1 (en) * 2004-08-13 2010-09-29 Boehringer Ingelheim Int Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
DE602005024570D1 (de) 2004-08-13 2010-12-16 Boehringer Ingelheim Pharma Tablettenformulierung mit verlängerter freisetzung mit pramipexol oder einem pharmazeutisch zulässigen salz davon, herstellungsverfahren und verwendung dafür
AR051950A1 (es) * 2004-11-10 2007-02-21 Osmotica Pharmaceutical Argent Comprimido multicapa con capas que se separan
KR100714616B1 (ko) * 2005-06-23 2007-05-07 삼성전기주식회사 지수 함수 발생기 및 이를 이용한 가변 이득 증폭기
AU2006269225B2 (en) * 2005-07-07 2011-10-06 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
DK1931346T3 (da) * 2005-09-09 2012-10-22 Angelini Labopharm Llc Trazodonsammensætning til indgivelse en gang om dagen
CN101242856A (zh) * 2005-09-09 2008-08-13 莱博法姆公司 持续药物释放的组合物
JP5259413B2 (ja) * 2005-11-18 2013-08-07 エーシーシーユー−ブレイク テクノロジーズ，インク． セグメント化した薬の剤形
US8691272B2 (en) * 2005-12-30 2014-04-08 Intelgenx Corp. Multilayer tablet
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
US20070237815A1 (en) * 2006-04-06 2007-10-11 Lawrence Solomon Dosage forms and methods comprising amlodipine and chlorthalidone
US20090280171A1 (en) * 2006-04-13 2009-11-12 Accu-Break Technologies, Inc. Method of treatment with predictably breakable pharmaceutical tablets
BRPI0602179A (pt) * 2006-06-08 2008-01-22 Biolab Sanus Farmaceutica Ltda composição farmacêutica compreendendo ciclobenzaprina e aceclofenaco em combinação
WO2007149860A1 (en) * 2006-06-19 2007-12-27 Accu-Break Technologies, Inc. Segmented pharmaceutical dosage forms
JP2010500374A (ja) * 2006-08-08 2010-01-07 エーシーシーユー−ブレイク テクノロジーズ，インク． 複数の活性セグメントを含む薬剤の錠剤
EP2089005B1 (en) * 2006-11-09 2010-03-17 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations comprising an intermediate rapidly dissolving layer
US20100068271A1 (en) * 2006-11-30 2010-03-18 Accu-Break Technologies, Inc Divisible Osmotic Dosage Forms and Methods of Use
RS51313B (sr) * 2007-11-09 2010-12-31 Acino Pharma Ag.51311 Retard tablete sa hidromorfonom
US20110144145A1 (en) 2008-05-30 2011-06-16 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
EP2266948A1 (en) * 2009-06-16 2010-12-29 Laboratorios Del. Dr. Esteve, S.A. Salts of tramadol and diflunisal and their crystal form in the treatment of pain
EP2281558A1 (en) 2009-08-06 2011-02-09 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors
EP2311446A1 (en) 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) * 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
JP6196041B2 (ja) 2010-01-11 2017-09-13 オレキシジェン・セラピューティクス・インコーポレーテッド 大うつ病を有する患者において減量療法を提供する方法
EP2353594A1 (en) 2010-02-09 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising tramadol and the co-crystal of celecoxib and L-proline in the treatment of pain
EP2593096A4 (en) * 2010-07-12 2014-02-26 Yung Shin Pharm Ind Co Ltd DICLOFENAC SALT OF TRAMADOL
US20120015031A1 (en) 2010-07-14 2012-01-19 Grunenthal Gmbh Novel gastro-retentive dosage forms
US20120040008A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
CA2875056C (en) 2012-06-06 2024-03-26 Orexigen Therapeutics, Inc. Methods of treating overweight and obesity
SG11202001855QA (en) 2017-09-15 2020-04-29 Crystalgenomics Inc Pharmaceutical composition for treating acute and chronic pain, containing polmacoxib and tramadol
KR102631399B1 (ko) 2018-03-30 2024-02-01 씨지인바이츠 주식회사 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물
US20210317086A1 (en) * 2018-08-20 2021-10-14 Mylan Laboratories Limited Tramadol HBR-Celecoxib Co-Crystal

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GB8521350D0 (en) * 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
IT1282576B1 (it) * 1996-02-06 1998-03-31 Jagotec Ag Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili
JP3049483B2 (ja) * 1996-05-02 2000-06-05 和夫 小笠原 ストレッチ器具
DE19710008A1 (de) * 1997-03-12 1998-09-17 Basf Ag Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
US6284273B1 (en) * 1998-02-24 2001-09-04 Vincent Lenaerts Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds

Also Published As

Publication number Publication date
US6558701B2 (en) 2003-05-06
CA2377167C (en) 2009-06-09
JP2003502358A (ja) 2003-01-21
JP4945041B2 (ja) 2012-06-06
WO2000078289A1 (de) 2000-12-28
HUP0201686A2 (en) 2002-09-28
ES2231221T3 (es) 2005-05-16
US20020132850A1 (en) 2002-09-19
EP1183015A1 (de) 2002-03-06
AU5972200A (en) 2001-01-09
MXPA01013047A (es) 2002-06-04
AU770777B2 (en) 2004-03-04
EP1183015B1 (de) 2004-10-20
DE19927688A1 (de) 2000-12-21
CA2377167A1 (en) 2000-12-28
ATE279915T1 (de) 2004-11-15
HUP0201686A3 (en) 2005-07-28
DE50008336D1 (de) 2004-11-25

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