PT118280A - MACROPHAGE PHENOTYPES FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIA - Google Patents
MACROPHAGE PHENOTYPES FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIAInfo
- Publication number
- PT118280A PT118280A PT118280A PT11828022A PT118280A PT 118280 A PT118280 A PT 118280A PT 118280 A PT118280 A PT 118280A PT 11828022 A PT11828022 A PT 11828022A PT 118280 A PT118280 A PT 118280A
- Authority
- PT
- Portugal
- Prior art keywords
- present
- treatment
- effective
- intervertebral disc
- macrophage phenotype
- Prior art date
Links
- 210000002540 macrophage Anatomy 0.000 title abstract 7
- 206010019909 Hernia Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 230000010287 polarization Effects 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 abstract 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 abstract 1
- 206010028851 Necrosis Diseases 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A PRESENTE INVENÇÃO REFERE-SE A MONÓCITOS E MACRÓFAGOS D PARA UTILIZAÇÃO NO TRATAMENTO DA HÉRNIA DO DISCO INTERVERTEBRAL (IVD). PARA ALÉM DISSO, TAMBÉM É DIVULGADO O FENÓTIPO DE MACRÓFAGOS QUE É MAIS EFICAZ PARA UMA IMUNOTERAPIA BASEADA NA FAGOCITOSE. DESTE MODO, A PRESENTE INVENÇÃO DESCREVE COMPOSIÇÕES DE MONÓCITOS E MACRÓFAGOS, ASSIM COMO A SUA FORMA DE ADMINISTRAÇÃO. A PRESENTE INVENÇÃO DESCREVE AINDA O MÉTODO DE DIFERENCIAÇÃO, POLARIZAÇÃO E PURIFICAÇÃO PARA OBTENÇÃO DO FENÓTIPO DE MACRÓFAGOS MAIS EFICAZ. OUTRO ASPETO DESTA INVENÇÃO REFERE-SE ÀS COMPOSIÇÕES UTILIZADAS NA REFERIDA POLARIZAÇÃO DO FENÓTIPO DE MACRÓFAGO MAIS EFICAZ. AINDA OUTRO ASPETO DA PRESENTE INVENÇÃO REFERE-SE ÀS COMPOSIÇÕES UTILIZADAS NA PURIFICAÇÃO, POR SELEÇÃO NEGATIVA, DO FENÓTIPO DE MACRÓFAGO MAIS EFICAZ. OS USOS, COMPOSIÇÕES E MÉTODOS DA PRESENTE INVENÇÃO PODEM SER UTILIZADOS DE FORMA VANTAJOSA NUMA TERAPIA BASEADA EM CÉLULAS, PRINCIPALMENTE PARA USO NO TRATAMENTO DA HÉRNIA DO DISCO INTERVERTEBRAL (IVD), BEM COMO PARA OUTRAS CONDIÇÕES CLÍNICAS MELHORADAS PELA REGRESSÃO DE TECIDOS REATIVOS ADVERSOS À REGENERAÇÃO, TAIS COMO FERIDAS, TECIDO CICATRICIAL RELACIONADO COM CIRURGIAS, FIBROSE E NECROSE; A REFERIDA CONDIÇÃO CLÍNICA ESTÁ A SER SELECIONADA DA LISTA QUE INCLUÍ ENFARTE DO MIOCÁRDIO, ENDOMETRIOSE, ASMA, CIRROSE HEPÁTICA, LESÃO DA MEDULA ESPINAL E LESÕES DA CARTILAGEM.THE PRESENT INVENTION RELATES TO MONOCYTES AND MACROPHAGES D FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIATION (IVD). IN ADDITION, THE MACROPHAGE PHENOTYPE WHICH IS MOST EFFECTIVE FOR IMMUNOTHERAPY BASED ON PHAGOCYTOSIS IS ALSO DISCLOSED. THUS, THE PRESENT INVENTION DESCRIBES COMPOSITIONS OF MONOCYTES AND MACROPHAGES, AS WELL AS THEIR METHOD OF ADMINISTRATION. THE PRESENT INVENTION FURTHER DESCRIBES THE DIFFERENTIATION, POLARIZATION AND PURIFICATION METHOD FOR OBTAINING THE MOST EFFECTIVE MACROPHAGE PHENOTYPE. ANOTHER ASPECT OF THIS INVENTION REFERS TO THE COMPOSITIONS USED IN SAID POLARIZATION OF THE MOST EFFECTIVE MACROPHAGE PHENOTYPE. YET ANOTHER ASPECT OF THE PRESENT INVENTION REFERS TO COMPOSITIONS USED IN PURIFICATION, BY NEGATIVE SELECTION, OF THE MOST EFFECTIVE MACROPHAGE PHENOTYPE. THE USES, COMPOSITIONS AND METHODS OF THE PRESENT INVENTION MAY BE ADVANTAGEOUSLY USED IN CELL-BASED THERAPY, PRIMARY FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC (IVD) HERNIATION, AS WELL AS FOR OTHER CLINICAL CONDITIONS IMPROVED BY REACTIVE TISSUE REGRESSION ADVERSE TO REGENERATION , SUCH AS WOUNDS, SCAR TISSUE RELATED TO SURGERY, FIBROSIS AND NECROSIS; SAID CLINICAL CONDITION IS BEING SELECTED FROM THE LIST WHICH INCLUDES MYOCARDIAL INFARCTION, ENDOMETRIOSIS, ASTHMA, LIVER CIRRHOSIS, SPINAL CORD INJURY AND CARTILAGE INJURY.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT118280A PT118280A (en) | 2022-10-24 | 2022-10-24 | MACROPHAGE PHENOTYPES FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIA |
| PCT/PT2022/050028 WO2023075623A1 (en) | 2021-10-26 | 2022-10-26 | Macrophage phenoypes for use in the treatment of intravertebral discs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT118280A PT118280A (en) | 2022-10-24 | 2022-10-24 | MACROPHAGE PHENOTYPES FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT118280A true PT118280A (en) | 2024-04-24 |
Family
ID=90922285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT118280A PT118280A (en) | 2021-10-26 | 2022-10-24 | MACROPHAGE PHENOTYPES FOR USE IN THE TREATMENT OF INTERVERTEBRAL DISC HERNIA |
Country Status (1)
| Country | Link |
|---|---|
| PT (1) | PT118280A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150010630A1 (en) * | 2011-12-29 | 2015-01-08 | Trustees Of Tufts College | Functionalization of biomaterials to control regeneration and inflammation responses |
| WO2020232148A1 (en) * | 2019-05-13 | 2020-11-19 | The Johns Hopkins University | Macrophage diversity in regenerative, fibrotic biomaterial environments |
| US20210228771A1 (en) * | 2020-01-27 | 2021-07-29 | Case Western Reserve University | Biologic material comprising a crosslinked structural protein and macrophages seeded on the crosslinked structural protein |
| US20220395609A1 (en) * | 2021-06-15 | 2022-12-15 | Nanofiber Solutions, Llc | Electrospun structures for m1/m2 macrophage modulation and methods of making and using the same |
-
2022
- 2022-10-24 PT PT118280A patent/PT118280A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150010630A1 (en) * | 2011-12-29 | 2015-01-08 | Trustees Of Tufts College | Functionalization of biomaterials to control regeneration and inflammation responses |
| WO2020232148A1 (en) * | 2019-05-13 | 2020-11-19 | The Johns Hopkins University | Macrophage diversity in regenerative, fibrotic biomaterial environments |
| US20210228771A1 (en) * | 2020-01-27 | 2021-07-29 | Case Western Reserve University | Biologic material comprising a crosslinked structural protein and macrophages seeded on the crosslinked structural protein |
| US20220395609A1 (en) * | 2021-06-15 | 2022-12-15 | Nanofiber Solutions, Llc | Electrospun structures for m1/m2 macrophage modulation and methods of making and using the same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 20230104 |