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PL402780A1 - (2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation - Google Patents

(2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation

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Publication number
PL402780A1
PL402780A1 PL402780A PL40278013A PL402780A1 PL 402780 A1 PL402780 A1 PL 402780A1 PL 402780 A PL402780 A PL 402780A PL 40278013 A PL40278013 A PL 40278013A PL 402780 A1 PL402780 A1 PL 402780A1
Authority
PL
Poland
Prior art keywords
hydroxy
acetic acid
butoksyetoksyfosfinylo
preparation
butoxyethoxyphosphinyl
Prior art date
Application number
PL402780A
Other languages
Polish (pl)
Other versions
PL217068B1 (en
Inventor
Paulina Majewska
Original Assignee
Politechnika Wroclawska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Wroclawska filed Critical Politechnika Wroclawska
Priority to PL402780A priority Critical patent/PL217068B1/en
Publication of PL402780A1 publication Critical patent/PL402780A1/en
Publication of PL217068B1 publication Critical patent/PL217068B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Wynalazek dotyczy kwasu (2R,S)-2-hydroksy-2-[((P)R,S)-butoksyetoksyfosfinylo]octowego o wzorze 1, który przeznaczony jest do zastosowania jako chiralny odczynnik przesuniecia chemicznego. Przedmiotem wynalazku jest równiez sposób wytwarzania kwasu (2R,S)-2-hydroksy-2-[((P)R,S)-butoksyetoksyfosfinylo]octowego o wzorze 1, który polega na tym, ze kwas glioksalowy poddaje sie reakcji fosforylacji racemicznym fosforynem butylowo-etylowym, przy czym reakcje prowadzi sie w temperaturze pokojowej w obecnosci trietyloaminy jako katalizatora przez 2 godziny, a nastepnie powstaly produkt oczyszcza sie za pomoca chromatografii jonowymiennej.The invention relates to (2R, S) -2-hydroxy-2 - [((P) R, S) -butoxyethoxyphosphinyl] acetic acid of formula 1, which is intended to be used as a chiral chemical shift reagent. The invention also relates to a method for producing (2R, S) -2-hydroxy-2 - [((P) R, S) -butoxyethoxyphosphinyl] acetic acid, which consists in the fact that glyoxylic acid is subjected to phosphorylation with racemic phosphite butyl ethyl, the reaction being carried out at room temperature in the presence of triethylamine as a catalyst for 2 hours, and then the resulting product is purified by means of ion exchange chromatography.

PL402780A 2013-02-15 2013-02-15 (2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation PL217068B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL402780A PL217068B1 (en) 2013-02-15 2013-02-15 (2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL402780A PL217068B1 (en) 2013-02-15 2013-02-15 (2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation

Publications (2)

Publication Number Publication Date
PL402780A1 true PL402780A1 (en) 2013-09-02
PL217068B1 PL217068B1 (en) 2014-06-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL402780A PL217068B1 (en) 2013-02-15 2013-02-15 (2R,S)-2-hydroxy-2-[((R) R,S)-butoksyetoksyfosfinylo]acetic acid and a process for its preparation

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Also Published As

Publication number Publication date
PL217068B1 (en) 2014-06-30

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