[go: up one dir, main page]

PL3721880T3 - Kompozycja i sposób naprawy i regeneracji mięśni - Google Patents

Kompozycja i sposób naprawy i regeneracji mięśni

Info

Publication number
PL3721880T3
PL3721880T3 PL20171639T PL20171639T PL3721880T3 PL 3721880 T3 PL3721880 T3 PL 3721880T3 PL 20171639 T PL20171639 T PL 20171639T PL 20171639 T PL20171639 T PL 20171639T PL 3721880 T3 PL3721880 T3 PL 3721880T3
Authority
PL
Poland
Prior art keywords
regeneration
composition
muscle repair
muscle
repair
Prior art date
Application number
PL20171639T
Other languages
English (en)
Inventor
Masahiro Iwamoto
Maurizio Pacifici
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45773490&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3721880(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of PL3721880T3 publication Critical patent/PL3721880T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL20171639T 2010-09-01 2011-08-31 Kompozycja i sposób naprawy i regeneracji mięśni PL3721880T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37899610P 2010-09-01 2010-09-01
PCT/US2011/049905 WO2012030919A2 (en) 2010-09-01 2011-08-31 Composition and method for muscle repair and regeneration
EP11822537.4A EP2613776B1 (en) 2010-09-01 2011-08-31 Composition and method for muscle repair and regeneration
EP20171639.6A EP3721880B1 (en) 2010-09-01 2011-08-31 Composition and method for muscle repair and regeneration

Publications (1)

Publication Number Publication Date
PL3721880T3 true PL3721880T3 (pl) 2022-05-23

Family

ID=45773490

Family Applications (2)

Application Number Title Priority Date Filing Date
PL20171639T PL3721880T3 (pl) 2010-09-01 2011-08-31 Kompozycja i sposób naprawy i regeneracji mięśni
PL11822537T PL2613776T3 (pl) 2010-09-01 2011-08-31 Kompozycja oraz sposób naprawy i regeneracji mięśni

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL11822537T PL2613776T3 (pl) 2010-09-01 2011-08-31 Kompozycja oraz sposób naprawy i regeneracji mięśni

Country Status (20)

Country Link
US (6) US9789074B2 (pl)
EP (3) EP4066826B1 (pl)
JP (1) JP5986570B2 (pl)
CN (2) CN111773213B (pl)
AU (1) AU2011296080B2 (pl)
BR (1) BR112013004685B1 (pl)
CA (1) CA2809374C (pl)
CL (1) CL2013000580A1 (pl)
CO (1) CO6680694A2 (pl)
DK (2) DK3721880T3 (pl)
EA (1) EA026251B1 (pl)
ES (3) ES2823234T3 (pl)
HU (2) HUE059024T2 (pl)
IL (1) IL224973B (pl)
MX (2) MX361414B (pl)
NZ (1) NZ607547A (pl)
PL (2) PL3721880T3 (pl)
PT (1) PT2613776T (pl)
WO (1) WO2012030919A2 (pl)
ZA (1) ZA201301536B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3721880T3 (pl) 2010-09-01 2022-05-23 Thomas Jefferson University Kompozycja i sposób naprawy i regeneracji mięśni
US9782417B2 (en) 2011-06-16 2017-10-10 Presidents And Fellows Of Harvard College Methods of increasing satellite cell proliferation with kinase inhibitors
US11963964B2 (en) 2011-06-16 2024-04-23 President And Fellows Of Harvard College Small molecules for mouse satellite cell proliferation
US11026952B2 (en) 2011-06-16 2021-06-08 President And Fellows Of Harvard College Small molecules for mouse satellite cell proliferation
CN105188753B (zh) * 2012-11-08 2018-12-18 国立大学法人山口大学 角结膜病症的治疗剂
US9375439B2 (en) 2013-01-09 2016-06-28 International Stem Cell Corporation Small molecules that promote skin regeneration
JP6407145B2 (ja) * 2013-05-22 2018-10-17 国立大学法人山口大学 網脈絡膜障害の抑制剤
EP3152190B1 (en) 2014-06-04 2024-07-31 Haro Pharmaceutical Inc. 18-20 member bi-polycyclic compounds
US9784665B1 (en) * 2014-12-29 2017-10-10 Flagship Biosciences, Inc. Methods for quantitative assessment of muscle fibers in muscular dystrophy
BR112017023748A2 (pt) * 2015-05-06 2018-07-31 University Of Southern California métodos para tratar hipertensão; reduzir níveis de colesterol elevados e/ou níveis de ldl elevados; reduzir níveis de triglicerídeo elevados e/ou níveis de crp elevados; tratar um indivíduo com níveis de insulina ou glicose elevados; tratar obesidade abdominal; tratar um indivíduo com níveis de igf-1 elevados; tratar ou prevenir inflamação; aumentar regeneração; e reduzir fígado gorduroso
EP3091084A1 (en) * 2015-05-08 2016-11-09 Université Catholique De Louvain Methods for assessing the purity of a mesenchymal stem cells preparation
AU2017213796A1 (en) * 2016-02-01 2018-09-20 President And Fellows Of Harvard College Small molecules for mouse satellite cell proliferation
ES2963348T3 (es) 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
SG10202105186XA (en) 2016-11-16 2021-06-29 Clementia Pharmaceuticals Inc Methods for treating multiple osteochondroma (mo)
CA3019069A1 (en) * 2018-04-02 2019-10-02 Hubit Genomix, Inc. Prophylactic and/or therapeutic drug for diabetic nephropathy
US11135236B2 (en) * 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
GB201907647D0 (en) * 2019-05-30 2019-07-17 King S College London Therapeutic methods
FR3112684B1 (fr) * 2020-07-24 2022-08-12 Univ Grenoble Alpes Composés pour le traitement de l’hémophilie
CN116891497B (zh) * 2022-04-02 2025-12-16 上海旭成医药科技有限公司 视黄酸受体激动剂、其制备方法、中间体、药物组合物和应用
WO2023241715A1 (zh) * 2022-06-16 2023-12-21 中国科学院动物研究所 视黄酸受体激活剂及其组合在哺乳动物再生修复中的应用

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
WO1984003106A1 (en) 1983-02-04 1984-08-16 Wadley Inst Of Molecular Medic Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins
GB2148299B (en) 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
JPS6253981A (ja) 1985-09-02 1987-03-09 Koichi Shiyudo 新規安息香酸誘導体
AU618590B2 (en) 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
CA2129773C (en) 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
US5408002A (en) 1993-09-09 1995-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
US5498795A (en) 1994-12-29 1996-03-12 Allergan, Inc. Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5807900A (en) 1995-03-31 1998-09-15 Hoffmann-La Roche, Inc. Method for identifying compounds having increased activity for the repair of skin photodamage
US5624957A (en) 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
FR2739557B1 (fr) 1995-10-09 1997-11-14 Cird Galderma Utilisation d'un ligand agoniste specifique rar-gamma
FR2739777B1 (fr) * 1995-10-11 1997-11-14 Cird Galderma Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose
US5726191A (en) 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
FR2747041B1 (fr) 1996-04-05 1998-05-22 Cird Galderma Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US5919970A (en) 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
EP0989855A4 (en) * 1997-05-13 2002-06-12 Osiris Therapeutics Inc REGENERATION OF CARTILAGE IN OSTEOARTHRITIS BY MEANS OF HUMAN MESENCHYMAL STEM CELLS
US7514074B2 (en) * 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
DE69936720T2 (de) 1998-05-29 2008-04-30 Osiris Therapeutics, Inc. Menschliche cd45+ und/oder fibroblasten+ mesenchymale stammzellen
US6331570B1 (en) 1998-09-24 2001-12-18 Bristol-Myers Squibb Company Active enantiomer of RARγ-specific agonist
JO2178B1 (en) 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
US20030114482A1 (en) 1999-12-15 2003-06-19 Maurizio Pacifici Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies
US6313168B1 (en) 1999-12-15 2001-11-06 Allergan Sales, Inc. Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies
JP2003526677A (ja) 2000-03-14 2003-09-09 ザ・ユニバーシテイ・オブ・ウエスタン・オンタリオ 骨形成に影響を与える組成物および方法
EP1285057B1 (en) 2000-04-28 2006-05-31 Children's Medical Center Corporation Isolation of mesenchymal stem cells and use thereof
BRPI0114344B8 (pt) 2000-10-02 2021-05-25 Hoffmann La Roche composto retinóide, seu uso, sua composição farmacêutica e seu processo de preparação
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
WO2003024921A1 (en) 2001-09-18 2003-03-27 F. Hoffmann-La Roche Ag Alkyl urea retinoid agonists i
AU2002340886B2 (en) 2001-09-18 2008-01-31 F. Hoffmann-La Roche Ag Substituted urea retinoid agonists II
AUPR892501A0 (en) * 2001-11-16 2001-12-13 Peter Maccallum Cancer Institute, The Method of enhancing self renewal of stem cells and uses thereof
US7592174B2 (en) 2002-05-31 2009-09-22 The Board Of Trustees Of The Leland Stanford Junior University Isolation of mesenchymal stem cells
RU2004138292A (ru) * 2002-06-04 2005-06-10 Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) Новые лиганды в качестве ингибиторов рецепторов rar, способы их получения и применение в медицине и косметике для человека
DE60326453D1 (de) * 2002-07-03 2009-04-16 Ct Cardiologico Monzino S P A Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung
CA2493871A1 (en) 2002-07-16 2004-01-22 Hadi Aslan Methods of implanting mesenchymal stem cells for tissue repair and formation
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
KR101151477B1 (ko) 2003-12-10 2012-06-22 메다렉스, 인코포레이티드 인터페론 알파 항체 및 그의 용도
JP2005206544A (ja) 2004-01-23 2005-08-04 Yasuyoshi Uchida 筋肉再生剤
AU2005240078A1 (en) * 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
WO2005115304A2 (en) 2004-05-24 2005-12-08 Ab Science Use of c-kit inhibitors for treating fibrodysplasia
US7345931B2 (en) 2005-08-01 2008-03-18 Infineon Technologies Ag Maintaining internal voltages of an integrated circuit in response to a clocked standby mode
FR2894960B1 (fr) 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteurs rar-gamma
FR2894959B1 (fr) 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteur rar-gamma
EP1999626A4 (en) 2006-01-26 2009-11-25 Combinatorx Inc METHODS, COMPOSITIONS AND NEEDS FOR TREATING MUSCULOSKELETAL DISORDERS AND SYMPTOMS ASSOCIATED THEREWITH
EP2404596A1 (en) * 2006-03-23 2012-01-11 TMRC Co., Ltd. Kit for Cancer Treatment and Pharmaceutical Composition for Cancer Treatment
CA2647275A1 (en) 2006-03-31 2007-10-11 F. Hoffmann-La Roche Ag Process for preparing retinoid compounds
TR201819157T4 (tr) 2006-05-16 2019-01-21 Io Therapeutics Llc Kemoterapi Ve Veya Radyasyon Terapisinin Yan Etkilerinin Tedavisinde Kullanıma Yönelik Rar Antagonisti Veya Ters Agonisti
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8507501B2 (en) 2008-03-13 2013-08-13 The Brigham And Women's Hospital, Inc. Inhibitors of the BMP signaling pathway
US8969350B2 (en) 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
EP2393915A4 (en) * 2009-02-05 2012-12-26 Regenertech Pty Ltd PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS
WO2011011513A1 (en) 2009-07-21 2011-01-27 University Of Washington Through Its Center For Commercialization Inhibition of pathological bone formation
UA50725U (ru) * 2009-12-01 2010-06-25 Институт Нейрохирургии Им. Акад. А.П. Ромоданова Амн Украины Способ лечения больных с прогрессирующей мышечной дистрофией трансплантацией миобластов эмбриона человека
PL3721880T3 (pl) 2010-09-01 2022-05-23 Thomas Jefferson University Kompozycja i sposób naprawy i regeneracji mięśni
CN103702967A (zh) 2011-03-14 2014-04-02 貝丝以色列女执事医疗中心 用于治疗增殖性病症的方法和组合物
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
WO2013006372A1 (en) 2011-07-01 2013-01-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of treating pathologic heterotopic ossification
EP2817292B1 (en) 2012-02-22 2019-12-18 Sanford-Burnham Medical Research Institute Sulfonamide compounds and uses as tnap inhibitors
CA2886187C (en) 2012-09-28 2020-04-14 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
JP2016510745A (ja) 2013-03-04 2016-04-11 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｂｍｐ阻害剤およびその使用方法
US9682983B2 (en) 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
JP6407145B2 (ja) 2013-05-22 2018-10-17 国立大学法人山口大学 網脈絡膜障害の抑制剤
EP3201187A4 (en) 2014-10-01 2018-04-11 The Brigham and Women's Hospital, Inc. Compositions and methods for inhibiting bmp
US20180311356A1 (en) 2015-10-19 2018-11-01 The Children's Medical Center Corporation Method to inhibit endothelial-to-mesenchymal transition
US10278982B2 (en) 2015-12-24 2019-05-07 The Regents Of The University Of Michigan Method of treating heterotopic ossification
ES2963348T3 (es) 2016-06-08 2024-03-26 Clementia Pharmaceuticals Inc Métodos para tratar la osificación heterotópica
JP6630255B2 (ja) 2016-09-30 2020-01-15 株式会社沖データ 画像形成装置及び通信システム

Also Published As

Publication number Publication date
HUE051664T2 (hu) 2021-03-29
JP2013536855A (ja) 2013-09-26
EP2613776A4 (en) 2014-03-12
BR112013004685A2 (pt) 2019-04-24
CN111773213B (zh) 2023-02-24
NZ607547A (en) 2015-06-26
CN111773213A (zh) 2020-10-16
AU2011296080B2 (en) 2014-12-04
EP4066826C0 (en) 2024-03-06
PT2613776T (pt) 2020-10-21
EP2613776A2 (en) 2013-07-17
HUE059024T2 (hu) 2022-10-28
US20180000762A1 (en) 2018-01-04
CA2809374C (en) 2021-02-23
ES2912593T3 (es) 2022-05-26
ES2975123T3 (es) 2024-07-03
IL224973B (en) 2018-06-28
CO6680694A2 (es) 2013-05-31
US20140363402A1 (en) 2014-12-11
AU2011296080A1 (en) 2013-03-14
MX2013002275A (es) 2013-05-22
BR112013004685B1 (pt) 2021-09-21
US9789074B2 (en) 2017-10-17
PL2613776T3 (pl) 2021-01-11
EP4066826B1 (en) 2024-03-06
US20200069620A1 (en) 2020-03-05
DK3721880T3 (da) 2022-05-09
EA026251B1 (ru) 2017-03-31
EP4066826A1 (en) 2022-10-05
WO2012030919A2 (en) 2012-03-08
EA201370051A1 (ru) 2014-03-31
EP3721880B1 (en) 2022-02-02
US9314439B2 (en) 2016-04-19
MX361414B (es) 2018-12-05
CA2809374A1 (en) 2012-03-08
US11433039B2 (en) 2022-09-06
CN103200937A (zh) 2013-07-10
US12023312B2 (en) 2024-07-02
DK2613776T3 (da) 2020-10-19
ES2823234T3 (es) 2021-05-06
US20140303223A1 (en) 2014-10-09
EP3721880A1 (en) 2020-10-14
CN103200937B (zh) 2020-07-03
EP2613776B1 (en) 2020-07-29
JP5986570B2 (ja) 2016-09-06
US20250108022A1 (en) 2025-04-03
ZA201301536B (en) 2015-06-24
MX2018015032A (es) 2021-12-08
US20230201146A1 (en) 2023-06-29
US10292954B2 (en) 2019-05-21
CL2013000580A1 (es) 2013-07-12
WO2012030919A3 (en) 2012-07-05

Similar Documents

Publication Publication Date Title
PL3721880T3 (pl) Kompozycja i sposób naprawy i regeneracji mięśni
EP2787985A4 (en) BIOCIDAL COMPOSITION AND METHODS OF USE
ME03766B (me) Određeni amino-pirimidini, njihove kompozicije, i metode njihove upotrebe
EP2736974A4 (en) POLYMER COMPOSITIONS AND METHODS
EP2579816A4 (en) Implant components and methods
BR112013010725A2 (pt) método, e, composição
BR112014010450A2 (pt) composição e método
EP3797746C0 (en) COMPOSITE STRUCTURE AND METHOD FOR ITS MANUFACTURE
PL2734049T3 (pl) Kompozycje probiotyczne i sposoby
BR112012027159A2 (pt) estrutura e método
PL2523678T3 (pl) Antagoniści Wnt i sposoby leczenia
BR112015002365A2 (pt) composição de borracha natural e método de produção de uma composição de borracha natural
EP2744519A4 (en) COMPOSITIONS AND METHODS FOR DERMAL REJUVENATION
BR112014008471A2 (pt) método de cimentação e composição de escória
BR112013007298A2 (pt) método para produzir composição de borracha
DK2661274T3 (da) Sammensætninger og fremgangsmåder med aloepolysaccharider
PL2632550T3 (pl) Sposoby i kompozycja do leczenia biegunki związanej z HIV
BR112013022306A2 (pt) método, e, composição
DE112011102437B8 (de) Klemmenverbindungsstruktur und Verfahren zum Herstellen derselben
FI20105423L (fi) Pinnoitusmenetelmä ja -laitteisto
BR112012029669A2 (pt) composição e método
EP2589489A4 (en) SHRINKABLE FILM AND METHOD FOR MANUFACTURING THE SAME
BR112013019224A2 (pt) composição, e metodo
BR112014010860A2 (pt) composição e método
BR112014007779A2 (pt) método e composição