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PL3763718T3 - Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same - Google Patents

Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same

Info

Publication number
PL3763718T3
PL3763718T3 PL20781429.4T PL20781429T PL3763718T3 PL 3763718 T3 PL3763718 T3 PL 3763718T3 PL 20781429 T PL20781429 T PL 20781429T PL 3763718 T3 PL3763718 T3 PL 3763718T3
Authority
PL
Poland
Prior art keywords
oxazino
pyrido
dione
tetrahydro
triazine
Prior art date
Application number
PL20781429.4T
Other languages
Polish (pl)
Inventor
Oleg Dmitrievich Mitkin
Alexandre Vasilievich IVACHTCHENKO
Andrey Alexandrovich Ivashchenko
Original Assignee
Viriom, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viriom, Inc. filed Critical Viriom, Inc.
Publication of PL3763718T3 publication Critical patent/PL3763718T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL20781429.4T 2019-05-07 2020-03-27 Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same PL3763718T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2019113751A RU2720305C1 (en) 2019-05-07 2019-05-07 Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, methods for production and use thereof
PCT/RU2020/000163 WO2020226532A1 (en) 2019-05-07 2020-03-27 Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same

Publications (1)

Publication Number Publication Date
PL3763718T3 true PL3763718T3 (en) 2025-05-26

Family

ID=70553085

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20781429.4T PL3763718T3 (en) 2019-05-07 2020-03-27 Substituted 3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same

Country Status (19)

Country Link
US (3) US12091423B2 (en)
EP (1) EP3763718B8 (en)
JP (1) JP7625527B2 (en)
CN (1) CN112204035A (en)
AU (1) AU2020269125A1 (en)
CA (1) CA3106620A1 (en)
DK (1) DK3763718T3 (en)
EA (1) EA202190324A1 (en)
ES (1) ES3018631T3 (en)
FI (1) FI3763718T3 (en)
HR (1) HRP20250317T1 (en)
HU (1) HUE071356T2 (en)
LT (1) LT3763718T (en)
PL (1) PL3763718T3 (en)
PT (1) PT3763718T (en)
RS (1) RS66803B1 (en)
RU (1) RU2720305C1 (en)
SI (1) SI3763718T1 (en)
WO (1) WO2020226532A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2745985C1 (en) * 2020-05-07 2021-04-05 Андрей Александрович Иващенко Anticoronavirus therapeutic agent - substituted 7-hydroxy-3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione for the prevention and treatment of covid-19
CN116284046B (en) * 2023-02-22 2025-11-11 山东新华制药股份有限公司 Ballon Sha Wei derivative and preparation method and application thereof
CN119841849B (en) * 2024-09-26 2025-08-15 浙江大学 Pyridone compound, synthesis method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5553393B2 (en) * 2010-09-24 2014-07-16 塩野義製薬株式会社 Prodrugs of substituted polycyclic carbamoylpyridone derivatives
WO2016005330A1 (en) * 2014-07-07 2016-01-14 F. Hoffmann-La Roche Ag Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases
CR20170530A (en) * 2015-04-28 2018-01-25 Shionogi & Co DERIVATIVES OF REPLACED POLICYCLIC PIRIDONA AND PROFÁRMACO OF THE SAME.
CN113004304B (en) * 2015-04-28 2022-03-18 盐野义制药株式会社 Substituted polycyclic pyridone derivatives and prodrugs thereof
JP6806413B2 (en) * 2016-02-03 2021-01-06 塩野義製薬株式会社 Polycyclic pyridone derivatives and their prodrugs
US10759814B2 (en) * 2016-08-10 2020-09-01 Shionogi & Co., Ltd. Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
TWI785116B (en) * 2017-09-18 2022-12-01 大陸商廣東東陽光藥業有限公司 Inhibitors of influenza virus replication and uses thereof
CN109503625A (en) * 2018-01-19 2019-03-22 赵蕾 A kind of polycyclic pyridines ketone compound and its pharmaceutical composition and purposes
CN112778330A (en) * 2019-11-05 2021-05-11 上海翰森生物医药科技有限公司 Pyridone-containing polycyclic derivative inhibitor, and preparation method and application thereof

Also Published As

Publication number Publication date
EP3763718A4 (en) 2021-11-17
JP7625527B2 (en) 2025-02-03
FI3763718T3 (en) 2025-04-01
WO2020226532A1 (en) 2020-11-12
AU2020269125A1 (en) 2021-02-11
US20240383918A1 (en) 2024-11-21
CA3106620A1 (en) 2020-11-12
LT3763718T (en) 2025-05-12
RS66803B1 (en) 2025-06-30
CN112204035A (en) 2021-01-08
DK3763718T3 (en) 2025-03-24
ES3018631T3 (en) 2025-05-16
EA202190324A1 (en) 2021-05-18
SI3763718T1 (en) 2025-06-30
EP3763718B1 (en) 2025-02-26
HUE071356T2 (en) 2025-08-28
PT3763718T (en) 2025-03-14
US20240383919A1 (en) 2024-11-21
US12091423B2 (en) 2024-09-17
JP2022539939A (en) 2022-09-14
EP3763718A1 (en) 2021-01-13
EP3763718B8 (en) 2025-04-09
US20220048925A1 (en) 2022-02-17
HRP20250317T1 (en) 2025-05-09
RU2720305C1 (en) 2020-04-28

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