PL3573948T3 - Sposoby otrzymywania cytotoksycznych pochodnych benzodiazepiny - Google Patents
Sposoby otrzymywania cytotoksycznych pochodnych benzodiazepinyInfo
- Publication number
- PL3573948T3 PL3573948T3 PL18704352.6T PL18704352T PL3573948T3 PL 3573948 T3 PL3573948 T3 PL 3573948T3 PL 18704352 T PL18704352 T PL 18704352T PL 3573948 T3 PL3573948 T3 PL 3573948T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- benzodiazepine derivatives
- cytotoxic benzodiazepine
- preparing cytotoxic
- preparing
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450270P | 2017-01-25 | 2017-01-25 | |
| PCT/US2018/014956 WO2018140435A1 (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3573948T3 true PL3573948T3 (pl) | 2023-01-30 |
Family
ID=61189535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18704352.6T PL3573948T3 (pl) | 2017-01-25 | 2018-01-24 | Sposoby otrzymywania cytotoksycznych pochodnych benzodiazepiny |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US10385071B2 (pl) |
| EP (2) | EP4148044A1 (pl) |
| JP (3) | JP7066725B2 (pl) |
| KR (2) | KR20230005410A (pl) |
| CN (3) | CN116102615A (pl) |
| AU (3) | AU2018213202B2 (pl) |
| CA (1) | CA3050262A1 (pl) |
| DK (1) | DK3573948T3 (pl) |
| ES (1) | ES2935346T3 (pl) |
| FI (1) | FI3573948T3 (pl) |
| HR (1) | HRP20230002T1 (pl) |
| HU (1) | HUE060746T2 (pl) |
| IL (3) | IL287405B (pl) |
| LT (1) | LT3573948T (pl) |
| PL (1) | PL3573948T3 (pl) |
| PT (1) | PT3573948T (pl) |
| RS (1) | RS63871B1 (pl) |
| RU (2) | RU2021138005A (pl) |
| SG (1) | SG11201906666QA (pl) |
| SI (1) | SI3573948T1 (pl) |
| SM (1) | SMT202300001T1 (pl) |
| TW (3) | TWI805325B (pl) |
| WO (1) | WO2018140435A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018213202B2 (en) | 2017-01-25 | 2022-03-24 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CA3119358A1 (en) | 2018-11-12 | 2020-05-22 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| SG11202104423XA (en) * | 2018-11-12 | 2021-05-28 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| US20230094471A1 (en) * | 2019-03-29 | 2023-03-30 | Immunogen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| JPWO2024005123A1 (pl) | 2022-06-30 | 2024-01-04 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| KR101839365B1 (ko) | 2010-12-21 | 2018-03-16 | 얀센 파마슈티카 엔.브이. | 바이사이클릭 벤젠 유도체로 치환된 신규 항진균성 5,6-디하이드로-4H-피롤로[1,2-a][1,4]벤조디아제핀 및 6H-피롤로[1,2-a][1,4]벤조디아제핀 |
| RS58620B1 (sr) * | 2011-02-15 | 2019-05-31 | Immunogen Inc | Metodi pripremanja konjugata |
| CN107428780B (zh) | 2015-01-14 | 2020-09-04 | 百时美施贵宝公司 | 苯并二氮杂*二聚体、其缀合物及制备和使用方法 |
| CN120248124A (zh) | 2015-06-29 | 2025-07-04 | 伊缪诺金公司 | 抗cd123抗体以及其缀合物和衍生物 |
| RS60840B1 (sr) * | 2015-07-21 | 2020-10-30 | Immunogen Inc | Postupci pripreme citotoksičnih derivata benzodiazepina |
| AU2018213202B2 (en) | 2017-01-25 | 2022-03-24 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
-
2018
- 2018-01-24 AU AU2018213202A patent/AU2018213202B2/en not_active Ceased
- 2018-01-24 TW TW111114178A patent/TWI805325B/zh active
- 2018-01-24 IL IL287405A patent/IL287405B/en unknown
- 2018-01-24 IL IL293645A patent/IL293645A/en unknown
- 2018-01-24 CN CN202310124604.6A patent/CN116102615A/zh active Pending
- 2018-01-24 SG SG11201906666QA patent/SG11201906666QA/en unknown
- 2018-01-24 PL PL18704352.6T patent/PL3573948T3/pl unknown
- 2018-01-24 WO PCT/US2018/014956 patent/WO2018140435A1/en not_active Ceased
- 2018-01-24 CA CA3050262A patent/CA3050262A1/en active Pending
- 2018-01-24 RS RS20221193A patent/RS63871B1/sr unknown
- 2018-01-24 TW TW107102506A patent/TWI763771B/zh active
- 2018-01-24 TW TW112117953A patent/TW202400551A/zh unknown
- 2018-01-24 HU HUE18704352A patent/HUE060746T2/hu unknown
- 2018-01-24 FI FIEP18704352.6T patent/FI3573948T3/fi active
- 2018-01-24 CN CN201880008141.4A patent/CN110225904B/zh active Active
- 2018-01-24 DK DK18704352.6T patent/DK3573948T3/da active
- 2018-01-24 HR HRP20230002TT patent/HRP20230002T1/hr unknown
- 2018-01-24 ES ES18704352T patent/ES2935346T3/es active Active
- 2018-01-24 US US15/878,991 patent/US10385071B2/en active Active
- 2018-01-24 RU RU2021138005A patent/RU2021138005A/ru unknown
- 2018-01-24 SM SM20230001T patent/SMT202300001T1/it unknown
- 2018-01-24 EP EP22199432.0A patent/EP4148044A1/en not_active Withdrawn
- 2018-01-24 LT LTEPPCT/US2018/014956T patent/LT3573948T/lt unknown
- 2018-01-24 JP JP2019540404A patent/JP7066725B2/ja active Active
- 2018-01-24 RU RU2019125133A patent/RU2762891C2/ru active
- 2018-01-24 CN CN202310124650.6A patent/CN116554262A/zh active Pending
- 2018-01-24 EP EP18704352.6A patent/EP3573948B1/en active Active
- 2018-01-24 PT PT187043526T patent/PT3573948T/pt unknown
- 2018-01-24 KR KR1020227044421A patent/KR20230005410A/ko not_active Abandoned
- 2018-01-24 SI SI201830832T patent/SI3573948T1/sl unknown
- 2018-01-24 KR KR1020197024738A patent/KR102480594B1/ko active Active
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2019
- 2019-06-17 US US16/442,718 patent/US10844078B2/en active Active
- 2019-07-22 IL IL268213A patent/IL268213B/en unknown
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2020
- 2020-10-22 US US17/077,688 patent/US11390633B2/en active Active
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2022
- 2022-03-07 AU AU2022201572A patent/AU2022201572B2/en not_active Ceased
- 2022-04-27 JP JP2022072946A patent/JP7400005B2/ja active Active
- 2022-06-15 US US17/841,026 patent/US11981687B2/en active Active
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2023
- 2023-12-06 JP JP2023205788A patent/JP2024028860A/ja not_active Withdrawn
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2024
- 2024-02-21 AU AU2024201119A patent/AU2024201119A1/en not_active Abandoned
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