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PL3569238T3 - Mezenchymalne komórki macierzyste z trombiną do leczenia noworodkowej hie - Google Patents

Mezenchymalne komórki macierzyste z trombiną do leczenia noworodkowej hie

Info

Publication number
PL3569238T3
PL3569238T3 PL17892054T PL17892054T PL3569238T3 PL 3569238 T3 PL3569238 T3 PL 3569238T3 PL 17892054 T PL17892054 T PL 17892054T PL 17892054 T PL17892054 T PL 17892054T PL 3569238 T3 PL3569238 T3 PL 3569238T3
Authority
PL
Poland
Prior art keywords
thrombin
stem cells
mesenchymal stem
treating neonatal
neonatal hie
Prior art date
Application number
PL17892054T
Other languages
English (en)
Inventor
Yun Sil Chang
Won Soon Park
So Yoon Ahn
Dong Kyung SUNG
Original Assignee
Medinno Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medinno Inc. filed Critical Medinno Inc.
Publication of PL3569238T3 publication Critical patent/PL3569238T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
PL17892054T 2017-01-16 2017-10-31 Mezenchymalne komórki macierzyste z trombiną do leczenia noworodkowej hie PL3569238T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170007355 2017-01-16
KR1020170142236A KR101973284B1 (ko) 2017-01-16 2017-10-30 신생아 ｈｉｅ 치료용 조성물
EP17892054.2A EP3569238B1 (en) 2017-01-16 2017-10-31 Thrombin-preconditioned mesenchymal stem cells for treating neonatal hie
PCT/KR2017/012119 WO2018131779A1 (ko) 2017-01-16 2017-10-31 신생아 ｈｉｅ 치료용 조성물

Publications (1)

Publication Number Publication Date
PL3569238T3 true PL3569238T3 (pl) 2022-05-23

Family

ID=62840214

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17892054T PL3569238T3 (pl) 2017-01-16 2017-10-31 Mezenchymalne komórki macierzyste z trombiną do leczenia noworodkowej hie

Country Status (8)

Country Link
US (1) US11833176B2 (pl)
EP (1) EP3569238B1 (pl)
JP (1) JP6934207B2 (pl)
KR (1) KR101973284B1 (pl)
CN (1) CN110461344B (pl)
ES (1) ES2910115T3 (pl)
PL (1) PL3569238T3 (pl)
WO (1) WO2018131779A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015179227A1 (en) 2014-05-18 2015-11-26 Children's Medical Center Corporation Methods and compositions relating to exosomes
BR112020020288A2 (pt) * 2018-04-04 2021-01-12 Duke University Métodos para tratar um paciente com paralisia cerebral e um paciente com encefalopatia hipóxico-isquêmica
CA3098514A1 (en) * 2018-04-30 2019-11-14 Children's Medical Center Corporation Mesenchymal stromal cell exosomes and uses thereof
CN110115769A (zh) * 2019-04-08 2019-08-13 浙江大学 一种脑靶向外泌体及其制备方法和应用
CN110772481A (zh) * 2019-10-29 2020-02-11 山东大学 硫化氢修饰的骨髓间充质干细胞外囊泡在缺氧缺血性脑损伤中的应用
CN110772483B (zh) * 2019-11-13 2021-03-26 山东大学 硫化氢修饰的间充质干细胞外囊泡作为miRNA递送载体在缺氧缺血性脑损伤中的应用
KR102479509B1 (ko) 2020-02-03 2022-12-21 성균관대학교산학협력단 Saha를 유효성분으로 포함하는 허혈성 뇌질환 예방 또는 치료용 조성물
JPWO2023200002A1 (pl) * 2022-04-14 2023-10-19

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1803193A (zh) * 2005-01-13 2006-07-19 中山大学 骨髓来源的间质干细胞用于制备治疗缺氧缺血性脑性瘫痪的制剂的用途
US20150125950A1 (en) * 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
JP6343671B2 (ja) * 2013-12-12 2018-06-13 サムスン ライフ パブリック ウェルフェア ファウンデーション トロンビンを利用した幹細胞由来のエキソソームの生成促進方法
US9919011B2 (en) * 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
WO2015164233A1 (en) * 2014-04-21 2015-10-29 Anthrogenesis Corporation Treatment of conditions and complications in infants
WO2015179227A1 (en) * 2014-05-18 2015-11-26 Children's Medical Center Corporation Methods and compositions relating to exosomes
WO2017146468A1 (ko) 2016-02-23 2017-08-31 경희대학교 산학협력단 줄기세포의 효능 개선을 위한 조성물 및 방법
KR101860266B1 (ko) * 2016-07-01 2018-05-24 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물

Also Published As

Publication number Publication date
EP3569238A4 (en) 2020-08-19
WO2018131779A1 (ko) 2018-07-19
KR20180084610A (ko) 2018-07-25
ES2910115T3 (es) 2022-05-11
JP6934207B2 (ja) 2021-09-15
KR101973284B1 (ko) 2019-04-29
US11833176B2 (en) 2023-12-05
CN110461344B (zh) 2024-01-09
EP3569238B1 (en) 2022-03-30
US20190374581A1 (en) 2019-12-12
EP3569238A1 (en) 2019-11-20
JP2020514400A (ja) 2020-05-21
CN110461344A (zh) 2019-11-15

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