PL356802A1 - Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors - Google Patents

Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors

Info

Publication number: PL356802A1
Authority: PL; Poland
Prior art keywords: pyrido; pyrimidine; diamine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

PL01356802A

Other languages

Polish (pl)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Nagendra Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2004-07-12

2001-01-23 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2004-07-12 Publication of PL356802A1 publication Critical patent/PL356802A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

PL01356802A 2000-01-25 2001-01-23 Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors PL356802A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
PL356802A1 true PL356802A1 (en)	2004-07-12

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01356802A PL356802A1 (en)	2000-01-25	2001-01-23	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (en)
JP (1)	JP4047010B2 (en)
KR (1)	KR20020065939A (en)
CN (1)	CN1395578A (en)
AP (1)	AP2002002586A0 (en)
AR (1)	AR030044A1 (en)
AU (1)	AU2542501A (en)
BG (1)	BG106850A (en)
BR (1)	BR0107751A (en)
CA (1)	CA2397961C (en)
CO (1)	CO5261549A1 (en)
CR (1)	CR6706A (en)
CZ (1)	CZ20022475A3 (en)
DZ (1)	DZ3266A1 (en)
EA (1)	EA200200643A1 (en)
EE (1)	EE200200405A (en)
GT (1)	GT200100016A (en)
HN (1)	HN2001000013A (en)
HU (1)	HUP0204141A3 (en)
IL (1)	IL150545A0 (en)
IS (1)	IS6443A (en)
MA (1)	MA26868A1 (en)
MX (1)	MXPA02007221A (en)
NO (1)	NO20023527L (en)
OA (1)	OA12161A (en)
PA (1)	PA8510701A1 (en)
PE (1)	PE20011066A1 (en)
PL (1)	PL356802A1 (en)
SK (1)	SK10632002A3 (en)
SV (1)	SV2002000294A (en)
TN (1)	TNSN01014A1 (en)
WO (1)	WO2001055147A1 (en)
YU (1)	YU50402A (en)
ZA (1)	ZA200205879B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
KR100850812B1 (en)	2000-10-23	2008-08-06	스미스클라인 비참 코포레이션	Novel Compounds
PE20030008A1 (en) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	DUAL INHIBITORS OF PDE 7 AND PDE 4
WO2003088972A1 (en)	2002-04-19	2003-10-30	Smithkline Beecham Corporation	Novel compounds
BR0316680A (en) *	2002-11-28	2005-10-18	Schering Ag	Chk, pdk and akt inhibitor pyrimidines, their production and use as pharmaceutical agents
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en) *	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (en)	2004-07-15	2007-11-23	Sanofi Synthelabo	PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
US7550589B2 (en) *	2004-09-21	2009-06-23	Hoffman-La Roche Inc.	6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors
UY29439A1 (en)	2005-03-25	2006-10-02	Glaxo Group Ltd	NEW COMPOUNDS
AU2006229995A1 (en)	2005-03-25	2006-10-05	Glaxo Group Limited	Process for preparing pyrido(2,3-d)pyrimidin-7-one and 3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one derivatives
WO2006110298A2 (en)	2005-03-25	2006-10-19	Glaxo Group Limited	8-alkyl/aryl-4-aryl-2-n- (alkylamino)-n'-substituted-n'-cyanoguanidino-8h-pyrido[2,3-d]pyrimidin-7-one compounds and use thereof
PE20061351A1 (en)	2005-03-25	2007-01-14	Glaxo Group Ltd	8H-PYRID [2,3-d] PYRIMIDIN-7-ONA 2,4,8-TRISUSTITUTED COMPOUNDS AS CSBP / RK / p38 KINASE INHIBITORS
FR2887882B1 (en) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
ATE449097T1 (en) *	2005-07-21	2009-12-15	Hoffmann La Roche	PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS
ES2351939T3 (en) *	2005-08-09	2011-02-14	Irm Llc	COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN KINASES.
FR2896246B1 (en)	2006-01-13	2008-08-15	Sanofi Aventis Sa	PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (en)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	MAPK/ERK Kinase Inhibitors
FR2910813B1 (en) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
JP5697601B2 (en) *	2008-12-01	2015-04-08	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	2,5-Diamino-substituted pyrido [4,3-D] pyrimidines as autotaxin inhibitors against cancer
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
EP2968331B1 (en) *	2013-03-14	2020-07-01	Icahn School of Medicine at Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (en) *	2014-09-02	2016-11-02	한국원자력의학원	Pyrimidine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof
CN107286180B (en) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	Heteropyridopyrimidinone derivatives as CDK inhibitors and their applications
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2146782T3 (en) *	1994-11-14	2000-08-16	Warner Lambert Co	6-ARYL-PIRIDO (2,3-D) PIRIMIDINAS AND NAFTIRIDINAS FOR THE INHIBITION OF THE CELL PROLIFERATION INDUCED BY THE PROTEIN TIROSINA QUINASA.
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EE200000706A (en) *	1998-05-26	2002-06-17	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cell proliferation

2001
- 2001-01-23 AR ARP010100285A patent/AR030044A1/en not_active Application Discontinuation
- 2001-01-23 PL PL01356802A patent/PL356802A1/en not_active Application Discontinuation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/en not_active IP Right Cessation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/en unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/en unknown
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 EE EEP200200405A patent/EE200200405A/en unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 YU YU50402A patent/YU50402A/en unknown
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/en active
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/en not_active Application Discontinuation
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/en not_active Application Discontinuation
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/en not_active Expired - Fee Related
- 2001-01-23 CN CN01804048A patent/CN1395578A/en active Pending
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/en not_active Ceased
- 2001-01-23 EA EA200200643A patent/EA200200643A1/en unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/en unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Ceased
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/en not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/en unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/en unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/en not_active Application Discontinuation
- 2001-01-24 CO CO01005268A patent/CO5261549A1/en not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/en unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/en unknown
- 2002-06-25 IS IS6443A patent/IS6443A/en unknown
- 2002-07-17 CR CR6706A patent/CR6706A/en not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/en unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0204141A2 (en)	2003-04-28
CA2397961A1 (en)	2001-08-02
CR6706A (en)	2005-04-04
SV2002000294A (en)	2002-07-16
AU2542501A (en)	2001-08-07
IL150545A0 (en)	2003-02-12
SK10632002A3 (en)	2003-06-03
HN2001000013A (en)	2001-06-18
EE200200405A (en)	2003-12-15
DZ3266A1 (en)	2001-08-02
IS6443A (en)	2002-06-25
AP2002002586A0 (en)	2002-09-30
PA8510701A1 (en)	2002-12-11
MA26868A1 (en)	2004-12-20
NO20023527L (en)	2002-09-10
CO5261549A1 (en)	2003-03-31
HUP0204141A3 (en)	2005-03-29
JP2003523357A (en)	2003-08-05
JP4047010B2 (en)	2008-02-13
OA12161A (en)	2006-05-08
EA200200643A1 (en)	2002-12-26
NO20023527D0 (en)	2002-07-24
CZ20022475A3 (en)	2003-03-12
AR030044A1 (en)	2003-08-13
BG106850A (en)	2003-02-28
KR20020065939A (en)	2002-08-14
PE20011066A1 (en)	2001-10-22
CA2397961C (en)	2008-08-26
MXPA02007221A (en)	2002-11-29
TNSN01014A1 (en)	2005-11-10
WO2001055147A1 (en)	2001-08-02
CN1395578A (en)	2003-02-05
ZA200205879B (en)	2003-09-29
GT200100016A (en)	2001-10-19
EP1254137A1 (en)	2002-11-06
BR0107751A (en)	2002-11-12
YU50402A (en)	2005-11-28

Publication	Publication Date	Title
IL150545A0 (en)	2003-02-12	PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
HRP20020798A2 (en)	2004-02-29	5-ALKYLPYRIDO[2,3-d]PYRIMIDINES TYROZINE KINASE INHIBITORS
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
PL357536A1 (en)	2004-07-26	Pyrazolo `4,3-d! pyrimidine derivatives
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
IL153754A0 (en)	2003-07-06	Pyrimidine derivatives
IL158697A0 (en)	2004-05-12	4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives
HUP0202713A3 (en)	2005-02-28	Pteridinones as kinase inhibitors
AU1041802A (en)	2002-01-30	Tetrahydro-heterocycloazepinyl pyrimidine derivatives
DE50001191D1 (en)	2003-03-06	PYRAZOLO [4, 3-D] PYRIMIDINE
PL358551A1 (en)	2004-08-09	5-aminoalkyl-pyrazolo[4,3-d]pyrimidines
AU2792102A (en)	2002-06-03	Pyrimidine derivatives
PL363077A1 (en)	2004-11-15	Use of pyrazolo[4,3-d]pyrimidines
PL361890A1 (en)	2004-10-04	Use of pyrazolo[4,3-d]pyrimidines
AU8578501A (en)	2002-01-08	2-aminoalkyl-thieno(2,3-d)pyrimidines
IL155380A0 (en)	2003-11-23	SUBSTITUTED 3,4-DIHYDRO-PYRIDO[1,2-a] PYRIMIDINES
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
SI1303496T1 (en)	2007-12-31	Pyrimidine derivatives

Legal Events

Date	Code	Title	Description
2008-09-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)