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PL3478712T3 - Przeciwciała przeciwko peptydowi amyloidu beta N3PGLU i ich zastosowania - Google Patents

Przeciwciała przeciwko peptydowi amyloidu beta N3PGLU i ich zastosowania

Info

Publication number
PL3478712T3
PL3478712T3 PL17736841.2T PL17736841T PL3478712T3 PL 3478712 T3 PL3478712 T3 PL 3478712T3 PL 17736841 T PL17736841 T PL 17736841T PL 3478712 T3 PL3478712 T3 PL 3478712T3
Authority
PL
Poland
Prior art keywords
amyloid beta
beta peptide
peptide antibodies
n3pglu amyloid
n3pglu
Prior art date
Application number
PL17736841.2T
Other languages
English (en)
Inventor
Ronald Bradley Demattos
Michael Carl IRIZARRY
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of PL3478712T3 publication Critical patent/PL3478712T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL17736841.2T 2016-07-01 2017-06-23 Przeciwciała przeciwko peptydowi amyloidu beta N3PGLU i ich zastosowania PL3478712T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662357579P 2016-07-01 2016-07-01
PCT/US2017/038999 WO2018005282A1 (en) 2016-07-01 2017-06-23 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number Publication Date
PL3478712T3 true PL3478712T3 (pl) 2023-11-06

Family

ID=59295341

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17736841.2T PL3478712T3 (pl) 2016-07-01 2017-06-23 Przeciwciała przeciwko peptydowi amyloidu beta N3PGLU i ich zastosowania

Country Status (29)

Country Link
US (2) US11312763B2 (pl)
EP (2) EP4272828A3 (pl)
JP (4) JP7165588B2 (pl)
KR (3) KR20230021773A (pl)
CN (3) CN114887054A (pl)
AU (1) AU2017291414B2 (pl)
BR (1) BR112018073843A2 (pl)
CA (1) CA3029550C (pl)
DK (1) DK3478712T5 (pl)
EA (1) EA201892690A1 (pl)
ES (1) ES2958508T3 (pl)
FI (1) FI3478712T3 (pl)
HR (1) HRP20230861T1 (pl)
HU (1) HUE062980T2 (pl)
IL (1) IL263788B2 (pl)
LT (1) LT3478712T (pl)
MA (1) MA45543B1 (pl)
MD (1) MD3478712T2 (pl)
MX (2) MX2018016066A (pl)
NZ (1) NZ772768A (pl)
PL (1) PL3478712T3 (pl)
PT (1) PT3478712T (pl)
RS (1) RS64386B1 (pl)
SG (1) SG11201810371XA (pl)
SI (1) SI3478712T1 (pl)
TW (2) TWI735600B (pl)
UA (2) UA129392C2 (pl)
WO (1) WO2018005282A1 (pl)
ZA (1) ZA201807633B (pl)

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TWI735600B (zh) 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途
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EP3521308B1 (en) * 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
WO2019169448A1 (en) * 2018-03-09 2019-09-12 St Vincent's Institute Of Medical Research Multi-specific antibodies
CN112805031A (zh) * 2018-07-24 2021-05-14 卫材R&D管理有限公司 阿尔茨海默病的治疗及预防方法
CN111184725B (zh) * 2020-02-27 2020-12-01 慈溪市人民医院医疗健康集团(慈溪市人民医院) 一种防治脑梗塞的药物制剂及其制备方法
TWI843040B (zh) * 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
TW202300517A (zh) * 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
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KR102753583B1 (ko) 2021-11-11 2025-01-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물
US20250099434A1 (en) * 2022-01-26 2025-03-27 T3D Therapeutics, Inc. Methods of treating amyloid related brain disorders using novel compounds and antibodies
US20250064417A1 (en) * 2022-02-03 2025-02-27 Eli Lilly And Company Regional tau imaging for diagnosing and treating alzheimer's disease
WO2025106313A1 (en) 2023-11-14 2025-05-22 Eli Lilly And Company Fc RECEPTOR BASED ASSAYS FOR ANALYZING IgG ANTIBODIES

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TWI599358B (zh) * 2014-09-16 2017-09-21 美國禮來大藥廠 組合療法
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JOP20170004B1 (ar) 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TWI735600B (zh) 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途

Also Published As

Publication number Publication date
HUE062980T2 (hu) 2023-12-28
KR20190012208A (ko) 2019-02-08
CN114887054A (zh) 2022-08-12
KR102221402B1 (ko) 2021-03-02
KR20210024213A (ko) 2021-03-04
LT3478712T (lt) 2023-08-25
IL263788A (en) 2019-01-31
MA45543B1 (fr) 2023-08-31
MD3478712T2 (ro) 2024-01-31
JP2019518783A (ja) 2019-07-04
MX2018016066A (es) 2019-04-24
JP7241058B2 (ja) 2023-03-16
BR112018073843A2 (pt) 2019-02-26
DK3478712T3 (da) 2023-09-04
TW202140544A (zh) 2021-11-01
KR20230021773A (ko) 2023-02-14
UA129392C2 (uk) 2025-04-09
RS64386B1 (sr) 2023-08-31
EP4272828A3 (en) 2024-01-10
MA45543A (fr) 2019-05-08
JP7165588B2 (ja) 2022-11-04
AU2017291414A1 (en) 2018-12-13
UA127101C2 (uk) 2023-04-19
CA3029550A1 (en) 2018-01-04
AU2017291414B2 (en) 2019-11-21
EP3478712A1 (en) 2019-05-08
US11312763B2 (en) 2022-04-26
CN109415433A (zh) 2019-03-01
SG11201810371XA (en) 2018-12-28
MX2023001299A (es) 2023-02-22
NZ772768A (en) 2024-11-29
US20220235122A1 (en) 2022-07-28
TW201811363A (zh) 2018-04-01
DK3478712T5 (da) 2024-09-09
TWI735600B (zh) 2021-08-11
JP2023123503A (ja) 2023-09-05
IL263788B2 (en) 2024-10-01
JP2021059547A (ja) 2021-04-15
PT3478712T (pt) 2023-08-21
EA201892690A1 (ru) 2019-05-31
ES2958508T3 (es) 2024-02-09
HRP20230861T1 (hr) 2023-11-10
SI3478712T1 (sl) 2023-10-30
EP3478712B1 (en) 2023-07-19
NZ748496A (en) 2021-02-26
IL263788B1 (en) 2024-06-01
EP4272828A2 (en) 2023-11-08
TWI798751B (zh) 2023-04-11
CN114917338A (zh) 2022-08-19
CA3029550C (en) 2023-08-22
FI3478712T3 (fi) 2023-10-02
US20190382471A1 (en) 2019-12-19
ZA201807633B (en) 2021-05-26
JP2021059546A (ja) 2021-04-15
WO2018005282A1 (en) 2018-01-04

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