PL3324933T3 - Sposób poprawy rozpuszczalności w wodzie leków nierozpuszczalnych lub słabo rozpuszczalnych w wodzie - Google Patents

Sposób poprawy rozpuszczalności w wodzie leków nierozpuszczalnych lub słabo rozpuszczalnych w wodzie

Info

Publication number: PL3324933T3
Authority: PL; Poland
Prior art keywords: water; insoluble; aqueous solubility; soluble drugs; improving aqueous
Prior art date: 2015-07-16

Application number

PL16739477T

Other languages

English (en)

Inventor

Andreas Grassauer

Eva Prieschl-Grassauer

Angelika Bodenteich

Martina Morokutti-Kurz

Sabine Nakowitsch

Cornelia KAINTZ

Original Assignee

Marinomed Biotech Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-16

Filing date

2016-07-15

Publication date

2021-08-02

2016-07-15 Application filed by Marinomed Biotech Ag filed Critical Marinomed Biotech Ag

2021-08-02 Publication of PL3324933T3 publication Critical patent/PL3324933T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0291—Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Birds (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Anesthesiology (AREA)
Tropical Medicine & Parasitology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Transplantation (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Psychiatry (AREA)

PL16739477T 2015-07-16 2016-07-15 Sposób poprawy rozpuszczalności w wodzie leków nierozpuszczalnych lub słabo rozpuszczalnych w wodzie PL3324933T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201514801578A	2015-07-16	2015-07-16
PCT/EP2016/066999 WO2017009480A1 (en)	2015-07-16	2016-07-15	Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs
EP16739477.4A EP3324933B1 (en)	2015-07-16	2016-07-15	Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs

Publications (1)

Publication Number	Publication Date
PL3324933T3 true PL3324933T3 (pl)	2021-08-02

Family

ID=56418519

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16739477T PL3324933T3 (pl)	2015-07-16	2016-07-15	Sposób poprawy rozpuszczalności w wodzie leków nierozpuszczalnych lub słabo rozpuszczalnych w wodzie

Country Status (29)

Country	Link
EP (1)	EP3324933B1 (pl)
JP (1)	JP6836825B2 (pl)
KR (1)	KR102615005B1 (pl)
CN (1)	CN107847440B (pl)
AU (1)	AU2016293125B2 (pl)
CA (1)	CA2992376C (pl)
CL (1)	CL2018000032A1 (pl)
CO (1)	CO2018001460A2 (pl)
CY (1)	CY1124322T1 (pl)
DK (1)	DK3324933T3 (pl)
EA (1)	EA036233B1 (pl)
ES (1)	ES2844581T3 (pl)
HR (1)	HRP20210333T1 (pl)
HU (1)	HUE053116T2 (pl)
IL (1)	IL256882B (pl)
LT (1)	LT3324933T (pl)
MA (1)	MA42472B1 (pl)
MX (1)	MX379341B (pl)
MY (1)	MY196065A (pl)
NZ (1)	NZ738592A (pl)
PH (1)	PH12018500042A1 (pl)
PL (1)	PL3324933T3 (pl)
PT (1)	PT3324933T (pl)
RS (1)	RS61561B1 (pl)
SA (1)	SA518390688B1 (pl)
SI (1)	SI3324933T1 (pl)
UA (1)	UA123312C2 (pl)
WO (1)	WO2017009480A1 (pl)
ZA (1)	ZA201708594B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108143713A (zh) *	2018-01-04	2018-06-12	南方医科大学南方医院	一种增加羟喜树碱溶解度的方法
US12377046B1 (en)	2019-04-24	2025-08-05	Wellomics LLC	Delivery system matrices
CN110074385B (zh) *	2019-05-21	2022-05-31	绥化市蓝源生物工程有限公司	一种生物碱溶解纳他霉素的生物溶剂及其应用
KR20220022829A (ko) *	2020-08-19	2022-02-28	주식회사 모든바이오	글리시리진 및 수용성 약물을 포함하는 나노 입자, 이를 포함하는 약제학적 조성물 및 이들의 제조 방법
CN114588118B (zh) *	2022-01-25	2023-05-23	武汉爱民制药股份有限公司	一种注射用七叶皂苷钠复方制剂
EP4431082A1 (en)	2023-03-13	2024-09-18	Marinomed Biotech AG	Aqueous composition comprising budesonide
EP4516289A1 (en)	2023-08-30	2025-03-05	SPH Sine Pharmaceutical Laboratories Co., Ltd	Antiviral nasal spray comprising favipiravir
CN117562911B (zh) *	2023-12-07	2024-06-04	海南医学院	化合物tigloside在制备治疗和/或预防骨关节炎药物中的用途
WO2025133675A1 (en) *	2023-12-20	2025-06-26	Melikoglu, Ahmet	Method for producing nasal formulation comprising aescin and rutin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1119957A (en)	1979-12-04	1982-03-16	Martin Whitefield	Steroid compositions
US4782047A (en)	1986-05-22	1988-11-01	Syntex Pharmaceuticals International Ltd.	Aqueous steroid formulations for nasal administration
US4868170A (en)	1987-11-13	1989-09-19	E. R. Squibb & Sons, Inc.	Steriod lotion formulation
JPH1025255A (ja) *	1996-07-11	1998-01-27	Taisho Pharmaceut Co Ltd	溶解性の改善された難溶性薬剤
FR2799369B1 (fr)	1999-10-08	2001-12-21	Oreal	Association d'escine et de sulfate de dextran et son utilisation
JP2004522802A (ja) *	2001-02-16	2004-07-29	ラヴィファーム・ラボラトリーズ・インク	水溶性で風味良い複合体
JP4000283B2 (ja) *	2002-08-07	2007-10-31	丸善製薬株式会社	甘草油性抽出物の可溶化組成物、並びに飲料、液状調味料、化粧品及び医薬部外品
US7897587B2 (en)	2004-09-03	2011-03-01	Nycomed Us Inc.	Topical dermatological formulations and use thereof
JP5128801B2 (ja) *	2006-10-16	2013-01-23	フロイント産業株式会社	高水分散性粉末とその製造方法
JP6265624B2 (ja) *	2012-05-11	2018-01-24	ロート製薬株式会社	ルリコナゾール含有外用医薬組成物
WO2014163558A1 (en) *	2013-04-01	2014-10-09	Moreinx Ab	Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
CN103271891B (zh) *	2013-04-28	2016-01-06	福建南方制药股份有限公司	人参皂苷纳米胶束及其制备方法、应用和药物组合物
CN103520081B (zh) *	2013-09-27	2015-10-28	无限极（中国）有限公司	一种调节皮肤免疫力、延缓皮肤老化的外用护肤品

2016
- 2016-07-15 HU HUE16739477A patent/HUE053116T2/hu unknown
- 2016-07-15 PL PL16739477T patent/PL3324933T3/pl unknown
- 2016-07-15 KR KR1020187004268A patent/KR102615005B1/ko active Active
- 2016-07-15 SI SI201631114T patent/SI3324933T1/sl unknown
- 2016-07-15 UA UAA201712614A patent/UA123312C2/uk unknown
- 2016-07-15 HR HRP20210333TT patent/HRP20210333T1/hr unknown
- 2016-07-15 WO PCT/EP2016/066999 patent/WO2017009480A1/en not_active Ceased
- 2016-07-15 AU AU2016293125A patent/AU2016293125B2/en active Active
- 2016-07-15 DK DK16739477.4T patent/DK3324933T3/da active
- 2016-07-15 LT LTEP16739477.4T patent/LT3324933T/lt unknown
- 2016-07-15 EP EP16739477.4A patent/EP3324933B1/en active Active
- 2016-07-15 NZ NZ738592A patent/NZ738592A/en unknown
- 2016-07-15 MY MYPI2017704929A patent/MY196065A/en unknown
- 2016-07-15 CA CA2992376A patent/CA2992376C/en active Active
- 2016-07-15 PT PT167394774T patent/PT3324933T/pt unknown
- 2016-07-15 MA MA42472A patent/MA42472B1/fr unknown
- 2016-07-15 ES ES16739477T patent/ES2844581T3/es active Active
- 2016-07-15 CN CN201680039722.5A patent/CN107847440B/zh active Active
- 2016-07-15 JP JP2017566080A patent/JP6836825B2/ja active Active
- 2016-07-15 MX MX2018000286A patent/MX379341B/es unknown
- 2016-07-15 RS RS20210293A patent/RS61561B1/sr unknown
- 2016-07-15 EA EA201890194A patent/EA036233B1/ru unknown
2017
- 2017-12-18 ZA ZA2017/08594A patent/ZA201708594B/en unknown
2018
- 2018-01-03 SA SA518390688A patent/SA518390688B1/ar unknown
- 2018-01-04 PH PH12018500042A patent/PH12018500042A1/en unknown
- 2018-01-05 CL CL2018000032A patent/CL2018000032A1/es unknown
- 2018-01-11 IL IL256882A patent/IL256882B/en unknown
- 2018-02-14 CO CONC2018/0001460A patent/CO2018001460A2/es unknown
2021
- 2021-03-12 CY CY20211100218T patent/CY1124322T1/el unknown

Also Published As

Publication number	Publication date
EP3324933A1 (en)	2018-05-30
CY1124322T1 (el)	2022-07-22
PT3324933T (pt)	2021-01-28
CN107847440A (zh)	2018-03-27
HUE053116T2 (hu)	2021-06-28
AU2016293125A1 (en)	2018-01-18
WO2017009480A1 (en)	2017-01-19
CO2018001460A2 (es)	2018-05-10
KR102615005B1 (ko)	2023-12-18
SI3324933T1 (sl)	2021-04-30
RS61561B1 (sr)	2021-04-29
KR20180054569A (ko)	2018-05-24
IL256882B (en)	2021-12-01
IL256882A (en)	2018-03-29
MA42472A (fr)	2018-05-30
MY196065A (en)	2023-03-13
CA2992376A1 (en)	2017-01-19
UA123312C2 (uk)	2021-03-17
SA518390688B1 (ar)	2022-03-13
MA42472B1 (fr)	2021-02-26
PH12018500042A1 (en)	2018-07-09
CA2992376C (en)	2023-06-20
EA036233B1 (ru)	2020-10-16
CL2018000032A1 (es)	2018-11-16
LT3324933T (lt)	2021-04-26
MX2018000286A (es)	2018-02-19
HRP20210333T1 (hr)	2021-04-16
ES2844581T3 (es)	2021-07-22
NZ738592A (en)	2021-12-24
EP3324933B1 (en)	2020-12-16
JP2019501861A (ja)	2019-01-24
CN107847440B (zh)	2021-06-25
JP6836825B2 (ja)	2021-03-03
MX379341B (es)	2025-03-10
EA201890194A1 (ru)	2018-10-31
HK1253027A1 (zh)	2019-06-06
AU2016293125B2 (en)	2021-05-06
ZA201708594B (en)	2019-06-26
DK3324933T3 (da)	2021-01-18
BR112018000613A2 (pt)	2018-09-18

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