PL3313833T3 - Związki i ich zastosowanie w charakterze inhibitorów transferazy n-mirystoilu - Google Patents
Związki i ich zastosowanie w charakterze inhibitorów transferazy n-mirystoiluInfo
- Publication number
- PL3313833T3 PL3313833T3 PL16736218T PL16736218T PL3313833T3 PL 3313833 T3 PL3313833 T3 PL 3313833T3 PL 16736218 T PL16736218 T PL 16736218T PL 16736218 T PL16736218 T PL 16736218T PL 3313833 T3 PL3313833 T3 PL 3313833T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- compounds
- myristoyl transferase
- myristoyl
- transferase
- Prior art date
Links
- 108010016306 Glycylpeptide N-tetradecanoyltransferase Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1511382.2A GB201511382D0 (en) | 2015-06-29 | 2015-06-29 | Novel compounds and their use in therapy |
| EP16736218.5A EP3313833B1 (en) | 2015-06-29 | 2016-06-29 | Compounds and their use as inhibitors of n-myristoyl transferase |
| PCT/GB2016/000134 WO2017001812A1 (en) | 2015-06-29 | 2016-06-29 | Compounds and their use as inhibitors of n-myristoyl transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3313833T3 true PL3313833T3 (pl) | 2021-06-28 |
Family
ID=53872374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16736218T PL3313833T3 (pl) | 2015-06-29 | 2016-06-29 | Związki i ich zastosowanie w charakterze inhibitorów transferazy n-mirystoilu |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10759804B2 (pl) |
| EP (1) | EP3313833B1 (pl) |
| DK (1) | DK3313833T3 (pl) |
| ES (1) | ES2860629T3 (pl) |
| GB (1) | GB201511382D0 (pl) |
| PL (1) | PL3313833T3 (pl) |
| WO (1) | WO2017001812A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| GB201820659D0 (en) * | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Novel compostions and their use in therapy |
| GB201820660D0 (en) * | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Cancer treatments |
| WO2021008512A1 (zh) * | 2019-07-18 | 2021-01-21 | 石药集团中奇制药技术（石家庄）有限公司 | 作为nmt抑制剂的化合物及其应用 |
| MX2022009528A (es) | 2020-02-04 | 2022-11-14 | Mindset Pharma Inc | Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc. |
| GB202014736D0 (en) | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
| KR20230092962A (ko) * | 2020-10-20 | 2023-06-26 | 페이실렉스 파마슈티컬스 인코포레이티드 | 암, 자가면역 장애, 및 염증성 장애의 치료에서의 n-미리스토일 트랜스퍼라제(nmt) 억제제의 용도 |
| GB202017367D0 (en) | 2020-11-02 | 2020-12-16 | Imperial College Innovations Ltd | Novel use |
| US20250059184A1 (en) * | 2021-12-15 | 2025-02-20 | Delix Therapeutics, Inc. | Imidazopyridine psychoplastogens and uses thereof |
| AU2023336804A1 (en) | 2022-09-09 | 2025-01-16 | Imperial College Innovations Limited | Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy |
| CN119264131A (zh) * | 2023-07-05 | 2025-01-07 | 南京同诺康医药科技有限公司 | Nmt抑制剂及其制备方法和用途 |
| WO2025077671A1 (zh) * | 2023-10-09 | 2025-04-17 | 浙江海正药业股份有限公司 | 多取代芳基类衍生物及其制备方法和用途 |
| WO2025103409A1 (zh) * | 2023-11-16 | 2025-05-22 | 南京同诺康医药科技有限公司 | Nmt抑制剂及其制备方法和用途 |
| GB202403391D0 (en) | 2024-03-08 | 2024-04-24 | Myricx Pharma Ltd | Novel compounds and their use in therapy |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2917511A (en) | 1958-01-30 | 1959-12-15 | Merck & Co Inc | Bicyclic-nitrogen-heterocyclic compounds |
| US3050525A (en) | 1960-12-14 | 1962-08-21 | John B Bicking | Certain derivatives of s-triazolo [4, 3-a]-pyridine |
| US3145215A (en) | 1961-12-19 | 1964-08-18 | Sterling Drug Inc | Indazole derivatives |
| US3457269A (en) | 1967-02-24 | 1969-07-22 | Sterling Drug Inc | N-substituted phenyl and n-substituted phenylalkyl 3 - indazolecarboxamides and preparation thereof |
| US3705175A (en) | 1969-04-01 | 1972-12-05 | Egyt Gyogyszervegyeszeti Gyar | Indazole-3-carboxylic amides |
| US3678059A (en) | 1969-10-07 | 1972-07-18 | Ciba Geigy Corp | 3-aminoalkylidene-indazoles |
| EP0498466B1 (en) | 1985-04-27 | 2002-07-24 | F. Hoffmann-La Roche Ag | Indazole-3-carboxamide and -3-carboxylic acid derivatives |
| GB8623142D0 (en) | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
| JPS63310891A (ja) | 1987-06-12 | 1988-12-19 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリダジン化合物 |
| DE3827253A1 (de) | 1987-08-20 | 1989-03-02 | Sandoz Ag | Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen |
| US5017573A (en) | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
| EP0410509A1 (en) | 1989-07-25 | 1991-01-30 | Duphar International Research B.V | New substituted 1H-indazole-3-carboxamides |
| JPH03223280A (ja) | 1990-01-26 | 1991-10-02 | Dainippon Pharmaceut Co Ltd | インダゾール―３―カルボキサミド誘導体の新規製造方法 |
| WO1992004025A1 (en) | 1990-08-31 | 1992-03-19 | Warner-Lambert Company | Amino acid analogs as cck antagonists |
| GB9020927D0 (en) | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Pharmaceuticals |
| JPH05230057A (ja) | 1990-11-27 | 1993-09-07 | Dainippon Pharmaceut Co Ltd | 光学活性インダゾール―３―カルボキサミド誘導体及びそれを有効成分とする制吐剤 |
| EP0494774A1 (en) | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazole-substituted fivemembered heteroaromatic compounds |
| JP3026845B2 (ja) | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| EP0517984A1 (en) | 1991-06-11 | 1992-12-16 | Merrell Dow Pharmaceuticals Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| WO1993003725A1 (en) | 1991-08-20 | 1993-03-04 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| FI941649L (fi) | 1991-10-11 | 1994-05-31 | Du Pont Merck Pharma | Retroviirusproteaasi-inhibiittoreina käytettäviä syklisiä ureoita ja analogeja |
| JPH06135960A (ja) | 1991-12-25 | 1994-05-17 | Dainippon Pharmaceut Co Ltd | インダゾール−３−カルボキサミド誘導体 |
| US5190953A (en) | 1992-03-26 | 1993-03-02 | A. H. Robins Company, Incorporated | Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents |
| TW251287B (pl) | 1993-04-30 | 1995-07-11 | Nissei Co Ltd | |
| CA2160420A1 (en) | 1994-10-20 | 1996-04-21 | Haruhiko Kikuchi | 5-ht4 receptor agonists |
| ZA951822B (en) | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
| IL117438A (en) | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
| KR19990022096A (ko) | 1995-05-31 | 1999-03-25 | 쇼다 오사무 | 모노시클릭 아미노기를 갖는 인다졸 유도체 |
| EP0973767A1 (en) | 1997-03-31 | 2000-01-26 | Dupont Pharmaceuticals Company | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US5914405A (en) | 1997-10-07 | 1999-06-22 | Eli Lilly And Company | Process for preparing 3-substituted indazoles |
| US6069152A (en) | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| JPH11279156A (ja) | 1998-03-31 | 1999-10-12 | Dai Ichi Seiyaku Co Ltd | インダゾール誘導体 |
| AU3459999A (en) | 1998-04-27 | 1999-11-16 | Warner-Lambert Company | Substituted diarylalkyl amides as calcium channel antagonists |
| NZ508790A (en) | 1998-05-22 | 2003-10-31 | Scios Inc | Heterocyclic compounds and methods to treat cardiac failure and other disorders |
| US6303625B1 (en) | 1998-07-27 | 2001-10-16 | Ortho-Mcneil Pharmaceutical, Inc. | Triazolopyridines for the treatment of thrombosis disorders |
| DE69916664T2 (de) | 1998-12-18 | 2005-03-31 | Basilea Pharmaceutica Ag | 4-(aminoalkoxy)benzofurane als n-myristoyltransferasehemmer |
| GB2345486A (en) | 1999-01-11 | 2000-07-12 | Glaxo Group Ltd | Heteroaromatic protein tyrosine kinase inhibitors |
| FR2792318B1 (fr) | 1999-04-16 | 2001-06-15 | Synthelabo | Derives d'indazole, leur preparation et leur application en therapeutique |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| GB0002666D0 (en) | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
| US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| OA12552A (en) | 2001-03-09 | 2006-06-06 | Pfizer Prod Inc | Triazolopyridines as anti-inflammatory agents. |
| US7094909B2 (en) | 2001-06-11 | 2006-08-22 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
| HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
| EP1403255A4 (en) | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | RHO KINASE INHIBITORS |
| WO2003004488A1 (en) | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| US7101884B2 (en) | 2001-09-14 | 2006-09-05 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CA2460680A1 (en) | 2001-09-19 | 2003-05-01 | Pharmacia Corporation | Substituted indazole compounds for the treatment of inflammation |
| US7671054B1 (en) | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| FR2836914B1 (fr) | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| US20040014764A1 (en) | 2002-03-29 | 2004-01-22 | Smith Charles D. | N-myristoyltransferase inhibitor compositions and methods of use |
| GB0218625D0 (en) | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
| US7005523B2 (en) | 2002-08-30 | 2006-02-28 | Pfizer Inc. | Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines |
| PA8579601A1 (es) | 2002-08-30 | 2004-05-07 | Pfizer Prod Inc | Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas |
| MY139563A (en) | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| FR2845382A1 (fr) | 2002-10-02 | 2004-04-09 | Sanofi Synthelabo | Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique |
| WO2004072072A1 (en) | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines as anti-inflammatory compounds |
| DE10309255B4 (de) | 2003-02-25 | 2007-09-13 | 4TECH Gesellschaft für Technologie- und Know-how-Transfer mbH | Verfahren und Schaltungen zur Erkennung unidirektionaler Fehler |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| CN100390149C (zh) | 2003-07-30 | 2008-05-28 | 协和发酵工业株式会社 | 吲唑衍生物 |
| AU2004260759B2 (en) | 2003-07-30 | 2010-04-22 | Kyowa Hakko Kirin Co., Ltd. | Protein kinase inhibitors |
| US7008953B2 (en) | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| WO2005014554A1 (en) | 2003-08-08 | 2005-02-17 | Astex Therapeutics Limited | 1h-indazole-3-carboxamide compounds as mapkap kinase modulators |
| EP2468729B1 (en) | 2003-10-15 | 2013-12-25 | Ube Industries, Ltd. | Novel indazole derivative |
| EP1593671A1 (en) | 2004-03-05 | 2005-11-09 | Graffinity Pharmaceuticals AG | DPP-IV inhibitors |
| HRP20080608T3 (hr) | 2004-08-12 | 2008-12-31 | Pfizer Inc. | Triazolopiridinilsulfanilni derivati kao inhibitori p38 map kinaze |
| EP1781655A2 (en) | 2004-08-18 | 2007-05-09 | Pharmacia & Upjohn Company LLC | Triazolopyridine compounds useful for the treatment of inflammation |
| BRPI0514327A (pt) | 2004-08-18 | 2008-06-10 | Pharmacia & Upjohn Co Llc | compostos triazolopiridina |
| MX2007007818A (es) | 2004-12-22 | 2007-09-11 | Theravance Inc | Compuestos de indazol-carboxamida. |
| EP1674464A1 (en) | 2004-12-23 | 2006-06-28 | Santhera Pharmaceuticals (Schweiz) GmbH | Novel thrombin inhibitors |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| GB0602178D0 (en) | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
| JP2009530337A (ja) | 2006-03-23 | 2009-08-27 | エフ．ホフマン−ラ ロシュ アーゲー | 置換インダゾール誘導体、その製造方法、及びその薬剤としての利用法 |
| US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| JP2010500365A (ja) | 2006-08-07 | 2010-01-07 | インサイト・コーポレイション | キナーゼ阻害剤としてのトリアゾロトリアジン |
| WO2008054605A2 (en) | 2006-10-06 | 2008-05-08 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| WO2008040974A1 (en) | 2006-10-07 | 2008-04-10 | Peakdale Molecular Limited | Indoles for use as dpp-iv inhibitors |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| BRPI0812450A2 (pt) | 2007-06-05 | 2019-09-24 | Schering Corp | derivados de indazol policíclicos e seu uso como inibidores de erk para o tratamento de câncer |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| CA2690567A1 (en) | 2007-06-12 | 2008-12-18 | Boehringer Ingelheim International Gmbh | 3-hetrocyclylidene-indolinone derivatives as inhibitors of specific cell cycle kinases |
| US8188083B2 (en) | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
| UY31832A (es) | 2008-05-20 | 2010-01-05 | Astrazeneca Ab | Derivados de indazol sustituidos con fenilo y benzodioxinilo |
| MX2011000460A (es) | 2008-07-18 | 2011-03-15 | Takeda Pharmaceutical | Derivados de benzazepina y su uso como antagonistas de histamina h3. |
| GB0815947D0 (en) | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
| WO2010113834A1 (ja) | 2009-03-30 | 2010-10-07 | アステラス製薬株式会社 | ピリミジン化合物 |
| WO2011019738A1 (en) * | 2009-08-10 | 2011-02-17 | Galenea Corporation | Compounds and methods of use thereof |
| WO2012065297A1 (en) | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| US9090593B2 (en) | 2010-12-09 | 2015-07-28 | Amgen Inc. | Bicyclic compounds as Pim inhibitors |
| WO2012095781A1 (en) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
| EP2734199B1 (en) | 2011-07-22 | 2022-11-16 | Pacylex Pharmaceuticals Inc. | Synthetic lethality and the treatment of cancer |
| EP2742046A1 (en) | 2011-08-12 | 2014-06-18 | F.Hoffmann-La Roche Ag | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE |
| AU2012308570B2 (en) | 2011-09-14 | 2016-11-10 | Samumed, Llc | Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors |
| GB201120993D0 (en) * | 2011-12-06 | 2012-01-18 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| US20140378474A1 (en) | 2012-01-27 | 2014-12-25 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| KR101869534B1 (ko) | 2012-03-05 | 2018-06-20 | 한국화학연구원 | 신규한 트리아졸로 피리다진 유도체 및 그의 용도 |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
-
2015
- 2015-06-29 GB GBGB1511382.2A patent/GB201511382D0/en not_active Ceased
-
2016
- 2016-06-29 ES ES16736218T patent/ES2860629T3/es active Active
- 2016-06-29 US US15/739,166 patent/US10759804B2/en active Active
- 2016-06-29 WO PCT/GB2016/000134 patent/WO2017001812A1/en not_active Ceased
- 2016-06-29 EP EP16736218.5A patent/EP3313833B1/en active Active
- 2016-06-29 DK DK16736218.5T patent/DK3313833T3/da active
- 2016-06-29 PL PL16736218T patent/PL3313833T3/pl unknown
-
2020
- 2020-07-08 US US16/923,133 patent/US11466011B2/en active Active
-
2022
- 2022-07-27 US US17/874,324 patent/US20220411431A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017001812A1 (en) | 2017-01-05 |
| ES2860629T3 (es) | 2021-10-05 |
| US11466011B2 (en) | 2022-10-11 |
| GB201511382D0 (en) | 2015-08-12 |
| US20200339586A1 (en) | 2020-10-29 |
| EP3313833B1 (en) | 2021-01-06 |
| US10759804B2 (en) | 2020-09-01 |
| US20220411431A1 (en) | 2022-12-29 |
| US20180370974A1 (en) | 2018-12-27 |
| DK3313833T3 (da) | 2021-02-15 |
| EP3313833A1 (en) | 2018-05-02 |
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