[go: up one dir, main page]

PL3301447T3 - Odpowiedź przećiwnowotworowa na zmodyfikowane epitopy własne - Google Patents

Odpowiedź przećiwnowotworowa na zmodyfikowane epitopy własne

Info

Publication number
PL3301447T3
PL3301447T3 PL17194252T PL17194252T PL3301447T3 PL 3301447 T3 PL3301447 T3 PL 3301447T3 PL 17194252 T PL17194252 T PL 17194252T PL 17194252 T PL17194252 T PL 17194252T PL 3301447 T3 PL3301447 T3 PL 3301447T3
Authority
PL
Poland
Prior art keywords
epitopes
modified self
tumour response
tumour
response
Prior art date
Application number
PL17194252T
Other languages
English (en)
Inventor
Linda Gillian Durrant
Victoria Anne BRENTVILLE
Rachel Louise METHERINGHAM
Original Assignee
Scancell Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scancell Limited filed Critical Scancell Limited
Publication of PL3301447T3 publication Critical patent/PL3301447T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001162—Kinases, e.g. Raf or Src
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001176—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001188—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
PL17194252T 2012-08-07 2013-08-07 Odpowiedź przećiwnowotworowa na zmodyfikowane epitopy własne PL3301447T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1214007.5A GB201214007D0 (en) 2012-08-07 2012-08-07 Anti-tumour immune responses to modified self-epitopes
EP13750368.6A EP2883054B1 (en) 2012-08-07 2013-08-07 Anti-tumour response to modified self-epitopes
EP17194252.7A EP3301447B1 (en) 2012-08-07 2013-08-07 Anti-tumour response to modified self-epitopes
PCT/GB2013/052109 WO2014023957A2 (en) 2012-08-07 2013-08-07 Anti-tumour response to modified self-epitopes

Publications (1)

Publication Number Publication Date
PL3301447T3 true PL3301447T3 (pl) 2021-09-06

Family

ID=46934958

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17194251T PL3287787T3 (pl) 2012-08-07 2013-08-07 Odpowiedź przeciwnowotworowa na zmodyfikowane epitopy własne
PL17194252T PL3301447T3 (pl) 2012-08-07 2013-08-07 Odpowiedź przećiwnowotworowa na zmodyfikowane epitopy własne

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL17194251T PL3287787T3 (pl) 2012-08-07 2013-08-07 Odpowiedź przeciwnowotworowa na zmodyfikowane epitopy własne

Country Status (16)

Country Link
US (4) US10233220B2 (pl)
EP (3) EP3301447B1 (pl)
JP (2) JP6490581B2 (pl)
KR (1) KR102203096B1 (pl)
CN (2) CN107043414A (pl)
AU (1) AU2013301341B2 (pl)
BR (1) BR112015002574A8 (pl)
DK (3) DK2883054T3 (pl)
ES (3) ES2833962T3 (pl)
GB (1) GB201214007D0 (pl)
IN (1) IN2014DN10629A (pl)
PL (2) PL3287787T3 (pl)
PT (3) PT3301447T (pl)
SG (2) SG11201407804RA (pl)
WO (1) WO2014023957A2 (pl)
ZA (1) ZA201409095B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3061462B1 (en) 2007-07-02 2019-02-27 Etubics Corporation Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
GB201214007D0 (en) 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
WO2014031178A1 (en) 2012-08-24 2014-02-27 Etubics Corporation Replication defective adenovirus vector in vaccination
KR101503341B1 (ko) * 2014-03-12 2015-03-18 국립암센터 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법
CN106459198B (zh) 2014-05-05 2021-07-20 诺维奥Th私人有限公司 类风湿性关节炎的血清学诊断方法
CN104360070B (zh) * 2014-11-28 2017-02-22 山东新创生物科技有限公司 肽基精氨酸脱亚胺酶2在制备肿瘤临床血液诊断试剂中的应用
JP6647315B2 (ja) 2015-01-09 2020-02-14 イーチュービクス コーポレイション 組み合わせ免疫療法のための方法および組成物
EP3286213B1 (en) 2015-04-20 2021-08-04 Etubics Corporation Methods and compositions for combination immunotherapy
CN107847572A (zh) 2015-05-13 2018-03-27 艾吉纳斯公司 用于癌症治疗和预防的疫苗
GB201512703D0 (en) * 2015-07-20 2015-08-26 Scancell Ltd Anti-tumour immune responses to modified self-epitopes
GB201522667D0 (en) * 2015-12-22 2016-02-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
HRP20210698T1 (hr) 2015-12-22 2021-09-17 Immatics Biotechnologies Gmbh Peptidi i kombinacija peptida za uporabu u imunoterapiji protiv karcinoma dojke i drugih karcinoma
WO2018046648A1 (en) * 2016-09-08 2018-03-15 Katholieke Universiteit Leuven Citrullinated peptides for diagnosis or treatment of diabetes
KR102184377B1 (ko) * 2018-02-19 2020-11-30 고려대학교 산학협력단 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
EP3784688A2 (en) 2018-04-26 2021-03-03 Agenus Inc. Heat shock protein-binding peptide compositions and methods of use thereof
GB201815041D0 (en) 2018-09-14 2018-10-31 Scancell Ltd Epitopes
GB202005779D0 (en) * 2020-04-21 2020-06-03 Scancell Ltd Anti-tumour immune responses
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
GB202018395D0 (en) * 2020-11-23 2021-01-06 Scancell Ltd Immunotherapy
CN114404570B (zh) * 2022-01-20 2023-05-30 中国药科大学 一种新型抗肿瘤转移多肽及其应用
KR20230115202A (ko) * 2022-01-26 2023-08-02 서울대학교병원 알데히드 탈수소효소 2 조절을 통한 탈모 또는 백모의 예방, 개선, 또는 치료용 조성물
CN115772526B (zh) * 2022-07-20 2025-01-24 西北农林科技大学 西瓜ClmiR159-3P及其前体基因的应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0831895A1 (en) 1995-06-07 1998-04-01 Akzo Nobel N.V. Tumor associated epitopes
GB9924060D0 (en) 1999-10-11 1999-12-15 Chiron Spa VIP54 protein
JP2002051785A (ja) * 2000-08-09 2002-02-19 Hagiwara Yoshihide 抗癌ヒトモノクローナル抗体ＣＬＮ−ＩｇＧによって認識される抗原エピトープのアミノ酸配列およびそれをコードするＤＮＡヌクレオチド配列
WO2002034287A2 (en) * 2000-10-27 2002-05-02 Pharmexa A/S Therapeutic vaccine formulations containing chitosan
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
GB0102145D0 (en) 2001-01-26 2001-03-14 Scancell Ltd Substances
AU2002327704A1 (en) * 2001-09-21 2003-04-01 Raven Biotechnologies, Inc. Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof
CN1639185A (zh) * 2002-01-03 2005-07-13 斯克里普斯研究学院 癌相关表位
IL164281A0 (en) 2002-04-01 2005-12-18 Euro Celtique Sa Epitope constructs comprising antigen presenting cell targeting mechanisms
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
EP2426139B1 (en) 2002-08-27 2014-10-01 Biokine Therapeutics Ltd. CXCR4 antagonist and use thereof
EP1549673B1 (en) * 2002-10-02 2008-07-30 F. Hoffmann-La Roche Ag Novel mhc ii associated peptides
US7670604B2 (en) 2002-12-13 2010-03-02 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
DE10313819A1 (de) * 2003-03-24 2004-10-07 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
JP2007515924A (ja) * 2003-12-15 2007-06-21 アウレリウム バイオファーマ インク． ビメンチン指向性診断法、および、多剤耐性を示す腫瘍性疾患の治療法
WO2006120474A2 (en) * 2005-05-13 2006-11-16 Oxxon Therapeutics Ltd Compositions for inducing an immune response against tumor antigens
DE102005029845B4 (de) 2005-06-27 2017-03-23 Orgentec Diagnostika Gmbh Verfahren zur Diagnose von rheumatischen Erkrankungen
CN1712964A (zh) * 2005-07-18 2005-12-28 山东省医药生物技术研究中心 类风湿性关节炎特异性抗原性标志物及其应用
US20070122414A1 (en) 2005-11-10 2007-05-31 Aurelium Biopharma Inc. Surface marker-directed cancer therapeutics
US20070248628A1 (en) * 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells
EP1989225A2 (en) * 2006-02-17 2008-11-12 Indiana University Research and Technology Corporation Peptide based inhibition of capcna protein-protein interactions in cancer
WO2007098093A2 (en) * 2006-02-17 2007-08-30 Five Prime Therapeutics, Inc. Compositions and methods of use for modulators of polypeptides and polynucleotides in treating breast cancer and melanoma
CA2651800A1 (en) * 2006-04-24 2007-11-08 Shantha West, Inc. Agrm2 antigen
EP1882697B1 (en) * 2006-07-24 2010-04-21 Institut Pasteur Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins
GB0706070D0 (en) 2007-03-28 2007-05-09 Scancell Ltd Nucleic acids
UA103882C2 (uk) * 2007-07-27 2013-12-10 Імматікс Біотекнолоджіс Гмбх Композиція пухлино-асоційованих пептидів та відповідна протиракова вакцина
JP2011514322A (ja) * 2008-02-08 2011-05-06 ザ スクリプス リサーチ インスティチュート 遺伝的にコードされる非天然アミノ酸による免疫寛容解除
BRPI1013179A2 (pt) * 2009-03-30 2019-09-24 Prometheus Laboratories Inc peptídeo sintético, métodos para detectar um anticorpo de proteína anti-citrulinado em uma amostra biológica, para realizar um ensaio para ajudar no diagnóstico ou prognóstico de artrite reumatóide, para melhorar a sensibilidade de diagnosticar ou prognosticar artrite reumatóide, ensaio para diagnosticar ou prognosticar artrite reumatóide, kit, e, método para identificar um peptídeo que é imunologicamente reativo com um anticorpo de proteína anti-citrulinado
ES3038392T3 (en) * 2010-05-14 2025-10-13 Massachusetts Gen Hospital Neoantigen specific cytotoxic t cells for use in treating cancer
EP2663320A1 (en) 2011-01-10 2013-11-20 Biokine Therapeutics Ltd. Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
WO2012103365A1 (en) 2011-01-28 2012-08-02 Oregon Health & Science University Recombinant t cell ligands and antibodies that bind b cells for the treatment of autoimmune diseases
EP3412680B1 (en) 2011-04-05 2020-11-04 Curara AB Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment
US20120295292A1 (en) * 2011-05-19 2012-11-22 University Of South Carolina Detecting Protein Arginine Deiminase (PAD) Activity in Human Tissues and Sera
KR101968779B1 (ko) 2011-05-27 2019-04-12 노르딕 바이오사이언스 에이/에스 진단용 펩티드의 검출
US20130274125A1 (en) * 2012-04-16 2013-10-17 Bio-Rad Laboratories Inc. Multiplex immunoassay for rheumatoid arthritis and other autoimmune diseases
GB201214007D0 (en) 2012-08-07 2012-09-19 Scancell Ltd Anti-tumour immune responses to modified self-epitopes

Also Published As

Publication number Publication date
EP3287787B1 (en) 2020-09-23
SG11201407804RA (en) 2015-02-27
PT3287787T (pt) 2020-11-26
EP3287787A1 (en) 2018-02-28
US20150232525A1 (en) 2015-08-20
IN2014DN10629A (pl) 2015-09-11
CN107043414A (zh) 2017-08-15
CN104823054A (zh) 2015-08-05
SG10201701001VA (en) 2017-05-30
EP3301447A1 (en) 2018-04-04
ES2681973T3 (es) 2018-09-17
EP2883054B1 (en) 2018-06-13
PL3287787T3 (pl) 2021-06-14
EP3301447B1 (en) 2020-12-02
US20230192790A1 (en) 2023-06-22
WO2014023957A2 (en) 2014-02-13
US20180346537A1 (en) 2018-12-06
BR112015002574A2 (pt) 2017-11-07
ZA201409095B (en) 2016-09-28
HK1206427A1 (en) 2016-01-08
JP2018197236A (ja) 2018-12-13
AU2013301341A1 (en) 2014-12-18
KR20150040314A (ko) 2015-04-14
CN104823054B (zh) 2019-03-26
WO2014023957A3 (en) 2014-05-15
PT2883054T (pt) 2018-10-15
BR112015002574A8 (pt) 2018-01-23
JP6490581B2 (ja) 2019-03-27
CA2874515A1 (en) 2014-02-13
ES2833962T3 (es) 2021-06-16
AU2013301341B2 (en) 2018-09-20
US12258377B2 (en) 2025-03-25
US20210198334A1 (en) 2021-07-01
DK2883054T3 (en) 2018-09-17
GB201214007D0 (en) 2012-09-19
PT3301447T (pt) 2021-02-18
KR102203096B1 (ko) 2021-01-14
DK3301447T3 (da) 2021-03-08
US10233220B2 (en) 2019-03-19
DK3287787T3 (da) 2020-12-21
ES2843777T3 (es) 2021-07-20
EP2883054A2 (en) 2015-06-17
JP2015525569A (ja) 2015-09-07

Similar Documents

Publication Publication Date Title
SG10201701001VA (en) Anti-tumour response to modified self-epitopes
ZA201503358B (en) Structure
IL233649A0 (en) Preparations derived from chitosan
GB2511197B (en) Compositions
GB201319035D0 (en) Spolier structure
GB201210800D0 (en) Compositions
GB201209244D0 (en) Compositions
GB201201287D0 (en) Compositions
HUP1300640A2 (en) Belt-mounting structure
EP2871919A4 (en) STRUCTURE
AP2015008378A0 (en) Improvements relating to buoyancy-supported risers
GB201220068D0 (en) Compositions
GB2507762B (en) Improvements to dartboards
GB201318407D0 (en) Compositions
GB201219973D0 (en) Compositions
GB201219980D0 (en) Compositions
GB201219962D0 (en) Compositions
GB201222774D0 (en) Improvements relating to aution mechanisms
GB201201142D0 (en) Sdd
TWM433525U (en) Structure of calorifier
GB201216226D0 (en) Improvements to sandbags
EP2926813A4 (en) METFORMIN-Orlistat COMPOSITIONS
GB201219497D0 (en) Improvements to gaming systems
GB201223148D0 (en) Compositions
GB201222702D0 (en) Compositions