PL3368658T3 - Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek - Google Patents

Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek

Info

Publication number: PL3368658T3
Authority: PL; Poland
Prior art keywords: cells; expansion; applications; gamma delta; hematopoietic tissues
Prior art date: 2015-10-30

Application number

PL16788539.1T

Other languages

English (en)

Inventor

Adrian HAYDAY

Oliver Nussbaumer

Richard Woolf

Original Assignee

Cancer Research Technology Limited

King's College London

The Francis Crick Institute Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-30

Filing date

2016-10-31

Publication date

2022-11-28

2015-10-30 Priority claimed from GBGB1519198.4A external-priority patent/GB201519198D0/en

2016-07-22 Priority claimed from GBGB1612731.8A external-priority patent/GB201612731D0/en

2016-10-31 Application filed by Cancer Research Technology Limited, King's College London, The Francis Crick Institute Limited filed Critical Cancer Research Technology Limited

2022-11-28 Publication of PL3368658T3 publication Critical patent/PL3368658T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Food Science & Technology (AREA)
Developmental Biology & Embryology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)

PL16788539.1T 2015-10-30 2016-10-31 Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek PL3368658T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1519198.4A GB201519198D0 (en)	2015-10-30	2015-10-30	Expansion of gamma delta t cells resident in non-haematopoietic tissue and uses of these cells
GBGB1612731.8A GB201612731D0 (en)	2016-07-22	2016-07-22	Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells
PCT/EP2016/076264 WO2017072367A1 (en)	2015-10-30	2016-10-31	EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS

Publications (1)

Publication Number	Publication Date
PL3368658T3 true PL3368658T3 (pl)	2022-11-28

Family

ID=57211532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16788539.1T PL3368658T3 (pl)	2015-10-30	2016-10-31	Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek

Country Status (16)

Country	Link
US (2)	US11618885B2 (pl)
EP (2)	EP3368658B1 (pl)
JP (3)	JP2018533373A (pl)
KR (2)	KR102821381B1 (pl)
CN (1)	CN108473958A (pl)
AU (2)	AU2016344779B2 (pl)
CA (1)	CA3003077A1 (pl)
DK (1)	DK3368658T3 (pl)
ES (1)	ES2925261T3 (pl)
IL (3)	IL315329A (pl)
MX (2)	MX2018005207A (pl)
MY (1)	MY198084A (pl)
PH (1)	PH12018500926A1 (pl)
PL (1)	PL3368658T3 (pl)
PT (1)	PT3368658T (pl)
WO (1)	WO2017072367A1 (pl)

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GB201707048D0 (en) *	2017-05-03	2017-06-14	King S College London	Expansion of gamma delta cells, compositions, and methods of use thereof
WO2018229163A1 (en)	2017-06-14	2018-12-20	King's College London	Methods of activating v delta 2 negative gamma delta t cells
EP4467146A3 (en)	2017-09-15	2025-05-07	King's College London	Compositions and methods for enhancing gamma delta t cells in the gut
CN109777778B (zh) *	2017-11-14	2023-07-18	中国科学院广州生物医药与健康研究院	一种基因改造的γδT细胞
GB201804701D0 (en)	2018-03-23	2018-05-09	Gammadelta Therapeutics Ltd	Lymphocytes expressing heterologous targeting constructs
EP3831937A4 (en) *	2018-07-31	2022-05-04	Mie University	METHODS OF GENE TRANSFER INTO A ??-TYPE T-CELL
GB201818243D0 (en) *	2018-11-08	2018-12-26	Gammadelta Therapeutics Ltd	Methods for isolating and expanding cells
MX2021005481A (es) *	2018-11-08	2021-11-04	Gammadelta Therapeutics Ltd	Metodos para aislar y expandir celulas.
AU2020205965A1 (en)	2019-01-07	2021-07-01	Shattuck Labs. Inc.	Heterodimeric proteins for modulating gamma delta T cells
US11098093B2 (en)	2019-01-07	2021-08-24	Shattuck Labs, Inc.	Heterodimeric proteins for modulating gamma delta T cells
CN112029719B (zh) *	2019-06-04	2024-05-03	北京医明佳和生物科技有限公司	纯化的双阴性t细胞及其制备和应用
WO2021016652A1 (en) *	2019-07-29	2021-02-04	The University Of Melbourne	METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS
CA3145523A1 (en)	2019-08-16	2021-02-25	GammaDelta Therapeutics Limited	Therapeutic uses of anti-tcr delta variable 1 antibodies
WO2021032961A1 (en)	2019-08-16	2021-02-25	GammaDelta Therapeutics Limited	Ex vivo gamma delta t cell populations
IL292213A (en)	2019-10-31	2022-06-01	Morphosys Ag	Combination anti-tumor therapy including anti-cd19 antibody and gamma delta t cells
EP4114415A1 (en)	2020-03-06	2023-01-11	Sorrento Therapeutics, Inc.	Innate immunity killer cells targeting psma positive tumor cells
JP2023527502A (ja)	2020-03-20	2023-06-29	ガンマデルタセラピューティクスリミティッド	骨髄性悪性病変の治療のためのｖデルタ１＋ｔ細胞
GB202006989D0 (en) *	2020-05-12	2020-06-24	Gammadelta Therapeutics Ltd	Methods for isolating gamma delta t cells
ES2943063T3 (es)	2020-08-14	2023-06-08	Gammadelta Therapeutics Ltd	Anticuerpos multiespecíficos anti-TCR delta variable 1
GB202013962D0 (en)	2020-09-04	2020-10-21	Gammadelta Therapeutics Ltd	Immunotherapy composition
IL305024A (en)	2021-02-17	2023-10-01	Gammadelta Therapeutics Ltd	Antibodies against variable TCR delta 1
GB202105113D0 (en)	2021-04-09	2021-05-26	Gammadelta Therapeutics Ltd	Novel method
CA3228168A1 (en)	2021-08-03	2023-02-09	Gammadelta Therapeutics Ltd	Engineering of gamma delta t cells and compositions thereof
JP7758307B2 (ja) *	2021-09-29	2025-10-22	アイピース，インコーポレイテッド	幹細胞の製造方法
CA3208653A1 (en)	2022-02-17	2022-08-25	Mihriban Tuna	Multispecific anti-tcr delta variable 1 antibodies
WO2023176896A1 (ja) *	2022-03-18	2023-09-21	国立大学法人長崎大学	糸状菌感染症の治療薬及び糸状菌感染症の治療方法
EP4504247A1 (en)	2022-04-04	2025-02-12	Gammadelta Therapeutics Ltd	Novel gene armoring
WO2024209429A1 (en)	2023-04-07	2024-10-10	Takeda Pharmaceutical Company Limited	T cells for use in treating relapsed or refractory acute myeloid leukemia
WO2025017531A1 (en)	2023-07-20	2025-01-23	Takeda Pharmaceutical Company Limited	Grid-free methods for making gamma delta t cells
CN118165933B (zh) *	2024-05-14	2024-07-16	成都美杰赛尔生物科技有限公司	组合物、提高cd39-cd69-t细胞比例的方法
CN118853566B (zh) *	2024-09-26	2025-05-09	青岛华赛伯曼医学细胞生物有限公司	一种肿瘤浸润淋巴细胞的培养方法及培养基

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EP1627231A2 (en) *	2003-05-23	2006-02-22	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Improvements to gamma delta t cell-mediated therapy
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2016
- 2016-10-31 WO PCT/EP2016/076264 patent/WO2017072367A1/en not_active Ceased
- 2016-10-31 US US15/771,875 patent/US11618885B2/en active Active
- 2016-10-31 AU AU2016344779A patent/AU2016344779B2/en active Active
- 2016-10-31 EP EP16788539.1A patent/EP3368658B1/en active Active
- 2016-10-31 PL PL16788539.1T patent/PL3368658T3/pl unknown
- 2016-10-31 CN CN201680074800.5A patent/CN108473958A/zh active Pending
- 2016-10-31 EP EP22182997.1A patent/EP4148124A1/en active Pending
- 2016-10-31 KR KR1020187015244A patent/KR102821381B1/ko active Active
- 2016-10-31 CA CA3003077A patent/CA3003077A1/en active Pending
- 2016-10-31 KR KR1020257019399A patent/KR20250093576A/ko active Pending
- 2016-10-31 MY MYPI2018000604A patent/MY198084A/en unknown
- 2016-10-31 DK DK16788539.1T patent/DK3368658T3/da active
- 2016-10-31 JP JP2018541524A patent/JP2018533373A/ja active Pending
- 2016-10-31 IL IL315329A patent/IL315329A/en unknown
- 2016-10-31 ES ES16788539T patent/ES2925261T3/es active Active
- 2016-10-31 IL IL295838A patent/IL295838B2/en unknown
- 2016-10-31 PT PT167885391T patent/PT3368658T/pt unknown
- 2016-10-31 MX MX2018005207A patent/MX2018005207A/es unknown
2018
- 2018-04-26 IL IL258985A patent/IL258985B2/en unknown
- 2018-04-26 MX MX2022011003A patent/MX2022011003A/es unknown
- 2018-04-30 PH PH12018500926A patent/PH12018500926A1/en unknown
2021
- 2021-09-10 JP JP2021147372A patent/JP7451468B2/ja active Active
2022
- 2022-09-29 US US17/936,811 patent/US20230099491A1/en active Pending
- 2022-12-09 AU AU2022283768A patent/AU2022283768A1/en active Pending
2024
- 2024-03-06 JP JP2024033438A patent/JP2024069306A/ja active Pending

Also Published As

Publication number	Publication date
JP2022002517A (ja)	2022-01-11
AU2022283768A1 (en)	2023-02-02
DK3368658T3 (da)	2022-08-01
IL258985B2 (en)	2023-02-01
PH12018500926A1 (en)	2018-11-05
IL295838B2 (en)	2025-02-01
KR20180098235A (ko)	2018-09-03
ES2925261T3 (es)	2022-10-14
EP3368658B1 (en)	2022-07-06
IL295838A (en)	2022-10-01
CA3003077A1 (en)	2017-05-04
MX2022011003A (es)	2022-10-07
MY198084A (en)	2023-07-31
KR102821381B1 (ko)	2025-06-13
IL295838B1 (en)	2024-10-01
US11618885B2 (en)	2023-04-04
MX2018005207A (es)	2018-09-19
RU2018119684A3 (pl)	2020-03-17
AU2016344779B2 (en)	2023-01-05
BR112018008293A2 (en)	2018-10-30
EP3368658A1 (en)	2018-09-05
CN108473958A (zh)	2018-08-31
US20180312808A1 (en)	2018-11-01
IL258985B (en)	2022-10-01
KR20250093576A (ko)	2025-06-24
US20230099491A1 (en)	2023-03-30
PT3368658T (pt)	2022-08-17
RU2018119684A (ru)	2019-12-02
WO2017072367A1 (en)	2017-05-04
IL315329A (en)	2024-10-01
JP2018533373A (ja)	2018-11-15
AU2016344779A1 (en)	2018-06-14
IL258985A (en)	2018-06-28
EP4148124A1 (en)	2023-03-15
JP2024069306A (ja)	2024-05-21
JP7451468B2 (ja)	2024-03-18
HK1253954A1 (en)	2019-07-05

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PL3368658T3 (pl)	2022-11-28	Namnażanie komórek T gamma delta rezydujących w tkankach nie-krwiotwórczych i zastosowania tych komórek
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EP3707248A4 (en)	2021-08-18	MODIFIED IMMUNE CELLS AND THEIR USES
EP3544618A4 (en)	2020-02-12	MODIFIED CELL EXPANSION AND USES THEREOF
IL269334A (en)	2019-11-28	Improved t cell compositions and methods
PL2978419T3 (pl)	2020-10-19	Kompozycje do zwiększania żywotności komórek i metody ich stosowania
IL254734A0 (en)	2017-11-30	Modified t cells and methods for their preparation and use
IL259586B (en)	2022-10-01	Genetically modified stem cells and uses thereof
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