PL3228619T3 - Sposób wytwarzania apiksabanu - Google Patents
Sposób wytwarzania apiksabanuInfo
- Publication number
- PL3228619T3 PL3228619T3 PL16460019T PL16460019T PL3228619T3 PL 3228619 T3 PL3228619 T3 PL 3228619T3 PL 16460019 T PL16460019 T PL 16460019T PL 16460019 T PL16460019 T PL 16460019T PL 3228619 T3 PL3228619 T3 PL 3228619T3
- Authority
- PL
- Poland
- Prior art keywords
- apixaban
- preparation
- Prior art date
Links
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 title 1
- 229960003886 apixaban Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16460019.9A EP3228619B1 (en) | 2016-04-04 | 2016-04-04 | Process for the preparation of apixaban |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3228619T3 true PL3228619T3 (pl) | 2020-12-28 |
Family
ID=55808540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16460019T PL3228619T3 (pl) | 2016-04-04 | 2016-04-04 | Sposób wytwarzania apiksabanu |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3228619B1 (pl) |
| ES (1) | ES2827459T3 (pl) |
| PL (1) | PL3228619T3 (pl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102188341B1 (ko) | 2018-10-24 | 2020-12-08 | 하나제약 주식회사 | 아픽사반의 제조방법 |
| CN109400606B (zh) * | 2018-12-26 | 2020-01-17 | 山东鲁抗医药股份有限公司 | 一种从阿哌沙班粗品中精制阿哌沙班的方法 |
| CN110467614A (zh) * | 2019-09-12 | 2019-11-19 | 江西国药有限责任公司 | 一种阿哌沙班酸杂质的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
| TW200303201A (en) * | 2001-12-10 | 2003-09-01 | Bristol Myers Squibb Co | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
| WO2014072884A1 (en) | 2012-11-12 | 2014-05-15 | Alembic Pharmaceuticals Limited | Process for the synthesis of apixaban |
| CN104045637B (zh) * | 2014-04-18 | 2016-04-06 | 河北科技大学 | 一种阿哌沙班的制备方法 |
| CN103992314A (zh) * | 2014-04-25 | 2014-08-20 | 济南大学 | 一种抗凝血药阿哌沙班的合成方法改进 |
| HU231122B1 (hu) * | 2014-08-06 | 2020-11-30 | Egis Gyógyszergyár Zrt | Eljárás apixaban előállítására |
-
2016
- 2016-04-04 PL PL16460019T patent/PL3228619T3/pl unknown
- 2016-04-04 EP EP16460019.9A patent/EP3228619B1/en active Active
- 2016-04-04 ES ES16460019T patent/ES2827459T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3228619B1 (en) | 2020-07-29 |
| EP3228619A1 (en) | 2017-10-11 |
| ES2827459T3 (es) | 2021-05-21 |
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