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PL3292133T3 - Sposób wytwarzania monochlorowodorku L-alanylo-L-alaninianu 2-{4-[2-({[2-(4-chlorofenylo)-1,3-tiazol-4-ilo]-metylo}-sulfanylo)-3,5-dicyjano-6-(pirolidyn-1-ylo)-pirydyn-4-ylo]-fenoksy}-etylu - Google Patents

Sposób wytwarzania monochlorowodorku L-alanylo-L-alaninianu 2-{4-[2-({[2-(4-chlorofenylo)-1,3-tiazol-4-ilo]-metylo}-sulfanylo)-3,5-dicyjano-6-(pirolidyn-1-ylo)-pirydyn-4-ylo]-fenoksy}-etylu

Info

Publication number
PL3292133T3
PL3292133T3 PL16722584T PL16722584T PL3292133T3 PL 3292133 T3 PL3292133 T3 PL 3292133T3 PL 16722584 T PL16722584 T PL 16722584T PL 16722584 T PL16722584 T PL 16722584T PL 3292133 T3 PL3292133 T3 PL 3292133T3
Authority
PL
Poland
Prior art keywords
dicyan
sulfanyl
alanyl
thiazol
pyrrolidin
Prior art date
Application number
PL16722584T
Other languages
English (en)
Inventor
Franz-Josef Mais
Werner Heilmann
Britta Olenik
Birgit Keil
Guido Becker
Daniel Meibom
Thomas Kuhlmann
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of PL3292133T3 publication Critical patent/PL3292133T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL16722584T 2015-05-06 2016-05-02 Sposób wytwarzania monochlorowodorku L-alanylo-L-alaninianu 2-{4-[2-({[2-(4-chlorofenylo)-1,3-tiazol-4-ilo]-metylo}-sulfanylo)-3,5-dicyjano-6-(pirolidyn-1-ylo)-pirydyn-4-ylo]-fenoksy}-etylu PL3292133T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15166606 2015-05-06
EP15192030 2015-10-29
PCT/EP2016/059779 WO2016188711A1 (de) 2015-05-06 2016-05-02 Verfahren zur herstellung von 2-{4-[2-({[2-(4-chlorphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyan-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-l-alanyl-l-alaninat-monohydrochlorid
EP16722584.6A EP3292133B1 (de) 2015-05-06 2016-05-02 Verfahren zur herstellung von 2-{4-[2-({[2-(4-chlorphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyan-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-l-alanyl-l-alaninat-monohydrochlorid

Publications (1)

Publication Number Publication Date
PL3292133T3 true PL3292133T3 (pl) 2019-12-31

Family

ID=55969107

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16722584T PL3292133T3 (pl) 2015-05-06 2016-05-02 Sposób wytwarzania monochlorowodorku L-alanylo-L-alaninianu 2-{4-[2-({[2-(4-chlorofenylo)-1,3-tiazol-4-ilo]-metylo}-sulfanylo)-3,5-dicyjano-6-(pirolidyn-1-ylo)-pirydyn-4-ylo]-fenoksy}-etylu

Country Status (32)

Country Link
US (1) US20180155336A1 (pl)
EP (1) EP3292133B1 (pl)
JP (1) JP2018516882A (pl)
KR (1) KR20180002698A (pl)
CN (1) CN107531688A (pl)
AU (1) AU2016268920A1 (pl)
BR (1) BR112017023852A2 (pl)
CA (1) CA2984984A1 (pl)
CL (1) CL2017002764A1 (pl)
CO (1) CO2017011294A2 (pl)
CU (1) CU20170136A7 (pl)
DK (1) DK3292133T3 (pl)
EA (1) EA201792422A1 (pl)
EC (1) ECSP17072780A (pl)
ES (1) ES2744227T3 (pl)
HK (1) HK1246290A1 (pl)
HR (1) HRP20191596T1 (pl)
HU (1) HUE044787T2 (pl)
IL (1) IL255208A0 (pl)
LT (1) LT3292133T (pl)
MA (1) MA42039A (pl)
MX (1) MX2017014134A (pl)
PE (1) PE20180204A1 (pl)
PH (1) PH12017502010A1 (pl)
PL (1) PL3292133T3 (pl)
PT (1) PT3292133T (pl)
SG (1) SG11201708747PA (pl)
SI (1) SI3292133T1 (pl)
TN (1) TN2017000466A1 (pl)
TW (1) TW201713651A (pl)
UY (1) UY36664A (pl)
WO (1) WO2016188711A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018108884A1 (de) 2016-12-16 2018-06-21 Bayer Pharma Aktiengesellschaft Pharmazeutische tablettenformulierung
WO2019180072A1 (en) 2018-03-22 2019-09-26 Bayer Pharma Aktiengesellschaft Parenteral pharmaceutical composition comprising neladenoson bialanate
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
TWI721449B (zh) * 2019-06-11 2021-03-11 行政院原子能委員會核能研究所 2-[[2-[[[3-(4-氯苯基)-8-甲基-8-氮雜雙環[3.2.1]-辛-2-基]-甲基](2-巰基乙基)胺基]乙基]胺基]乙硫醇-[1r(外向-外向)]三鹽酸化物之純化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10238113A1 (de) * 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
US20120058983A1 (en) * 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension

Also Published As

Publication number Publication date
CA2984984A1 (en) 2016-12-01
KR20180002698A (ko) 2018-01-08
HK1246290A1 (zh) 2018-09-07
TN2017000466A1 (en) 2019-04-12
IL255208A0 (en) 2017-12-31
MA42039A (fr) 2018-03-14
SI3292133T1 (sl) 2019-08-30
PE20180204A1 (es) 2018-01-31
PH12017502010A1 (en) 2018-03-26
CO2017011294A2 (es) 2018-01-16
TW201713651A (zh) 2017-04-16
HRP20191596T1 (hr) 2019-11-29
CN107531688A (zh) 2018-01-02
PT3292133T (pt) 2019-09-18
WO2016188711A1 (de) 2016-12-01
JP2018516882A (ja) 2018-06-28
UY36664A (es) 2016-11-30
ECSP17072780A (es) 2017-12-01
CL2017002764A1 (es) 2018-05-25
EP3292133B1 (de) 2019-06-26
US20180155336A1 (en) 2018-06-07
SG11201708747PA (en) 2017-11-29
ES2744227T3 (es) 2020-02-24
DK3292133T3 (da) 2019-09-23
EA201792422A1 (ru) 2018-02-28
LT3292133T (lt) 2019-08-26
BR112017023852A2 (pt) 2018-07-17
HUE044787T2 (hu) 2019-11-28
AU2016268920A1 (en) 2017-11-09
EP3292133A1 (de) 2018-03-14
CU20170136A7 (es) 2018-02-08
MX2017014134A (es) 2018-03-15

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