[go: up one dir, main page]

PL3265126T3 - Preparaty połączenia tesofensyny i metoprololu - Google Patents

Preparaty połączenia tesofensyny i metoprololu

Info

Publication number
PL3265126T3
PL3265126T3 PL16711521T PL16711521T PL3265126T3 PL 3265126 T3 PL3265126 T3 PL 3265126T3 PL 16711521 T PL16711521 T PL 16711521T PL 16711521 T PL16711521 T PL 16711521T PL 3265126 T3 PL3265126 T3 PL 3265126T3
Authority
PL
Poland
Prior art keywords
tesofensine
metoprolol
combination formulation
formulation
combination
Prior art date
Application number
PL16711521T
Other languages
English (en)
Inventor
Peter G. Nielsen
Mikael S. THOMSEN
Bent HØJGAARD
Original Assignee
Saniona A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saniona A/S filed Critical Saniona A/S
Publication of PL3265126T3 publication Critical patent/PL3265126T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL16711521T 2015-03-03 2016-03-02 Preparaty połączenia tesofensyny i metoprololu PL3265126T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201570117 2015-03-03
DKPA201570644 2015-10-09
PCT/DK2016/050058 WO2016138908A1 (en) 2015-03-03 2016-03-02 Tesofensine, beta blocker combination formulation
EP16711521.1A EP3265126B1 (en) 2015-03-03 2016-03-02 Tesofensine and metoprolol combination formulation

Publications (1)

Publication Number Publication Date
PL3265126T3 true PL3265126T3 (pl) 2021-12-06

Family

ID=55589632

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16711521T PL3265126T3 (pl) 2015-03-03 2016-03-02 Preparaty połączenia tesofensyny i metoprololu

Country Status (32)

Country Link
US (6) US10231951B2 (pl)
EP (1) EP3265126B1 (pl)
JP (1) JP6772430B2 (pl)
KR (1) KR101999463B1 (pl)
CN (1) CN107666913B (pl)
AU (1) AU2016228002B2 (pl)
CA (1) CA2977415A1 (pl)
CL (1) CL2017002214A1 (pl)
CO (1) CO2017009930A2 (pl)
CR (1) CR20170447A (pl)
DK (1) DK3265126T3 (pl)
DO (1) DOP2017000219A (pl)
EA (1) EA033298B1 (pl)
EC (1) ECSP17059323A (pl)
ES (1) ES2885437T3 (pl)
GT (1) GT201700194A (pl)
HR (1) HRP20211361T1 (pl)
HU (1) HUE055974T2 (pl)
IL (1) IL254179B (pl)
LT (1) LT3265126T (pl)
MA (1) MA41634B1 (pl)
MX (1) MX377172B (pl)
PE (1) PE20180187A1 (pl)
PH (1) PH12017501509A1 (pl)
PL (1) PL3265126T3 (pl)
PT (1) PT3265126T (pl)
RS (1) RS62275B1 (pl)
SA (1) SA517382209B1 (pl)
SG (1) SG11201706899VA (pl)
SI (1) SI3265126T1 (pl)
UA (1) UA122224C2 (pl)
WO (1) WO2016138908A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2814473T3 (pl) * 2012-02-16 2019-06-28 Saniona A/S Kompozycje farmaceutyczne do terapii skojarzonej
RS62275B1 (sr) 2015-03-03 2021-09-30 Saniona As Kombinovana formulacija tesofensina i metoprolola
EP3402473A1 (en) * 2016-01-15 2018-11-21 Saniona A/S Tesofensine and metoprolol for treatment of hypertension
KR20180117696A (ko) * 2016-03-07 2018-10-29 아트로기 에이비 과혈당증의 치료를 위한 화합물
WO2020026471A1 (ja) * 2018-07-31 2020-02-06 株式会社親広産業 グルコース消費促進剤および解糖系促進剤
JP6612004B1 (ja) * 2018-07-31 2019-11-27 株式会社親広産業 グルコース消費促進剤および解糖系促進剤
MX2021008208A (es) * 2019-01-07 2021-11-17 Saniona As Tesofensina para la reduccion del peso corporal para pacientes con sindrome de prader-willi.
EP4138830A1 (en) * 2020-04-22 2023-03-01 Saniona A/S Treatment of hypothalamic obesity
CN117045610B (zh) * 2023-08-24 2024-04-30 杭州沐源生物医药科技有限公司 一种溶出高稳定性的盐酸拉贝洛尔组合物及其制备方法
WO2025219590A1 (en) * 2024-04-19 2025-10-23 Actimed Therapeutics Ltd Beta-blockers for preserving muscle mass, bone density, and cardiac function in weight loss treatments

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE141049T1 (de) 1991-03-18 1996-08-15 Sepracor Inc Zubereitung und verfahren enthaltend optisch reines s-metoprolol
ZA971525B (en) 1996-02-22 1997-10-21 Neurosearch As Tropane derivatives, their preparation and use.
US5885616A (en) * 1997-08-18 1999-03-23 Impax Pharmaceuticals, Inc. Sustained release drug delivery system suitable for oral administration
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
SE0100200D0 (sv) 2001-01-24 2001-01-24 Astrazeneca Ab New film coating
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
HUP0200849A2 (hu) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
AU2003282375A1 (en) 2003-02-05 2004-08-30 Ipca Laboratories Limited Pharmaceutical compositions and process of production thereof
DK1620437T3 (da) 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
WO2005070427A1 (en) 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
DE102005034351A1 (de) 2005-07-22 2007-01-25 Sension, Biologische Detektions- Und Schnelltestsysteme Gmbh Farb-Umschlag-Indikator zur Statusanzeige von RFID-Tickets und -Etiketten
US20070053983A1 (en) 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
US20070092573A1 (en) 2005-10-24 2007-04-26 Laxminarayan Joshi Stabilized extended release pharmaceutical compositions comprising a beta-adrenoreceptor antagonist
CA2635313C (en) 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
US20090068260A1 (en) * 2006-02-24 2009-03-12 Tomer Gold Beta-1-selective adrenoceptor blocking agent compositions and methods for their preparation
US20070202172A1 (en) 2006-02-24 2007-08-30 Tomer Gold Metoprolol succinate E.R. tablets and methods for their preparation
WO2007110753A2 (en) 2006-03-28 2007-10-04 Wockhardt Ltd Extended release dosage forms of metoprolol
DE102006020604A1 (de) 2006-05-02 2007-11-08 Bayer Healthcare Ag Flüssige Arzneimittelformulierung
NZ574427A (en) 2006-07-28 2011-11-25 Zaklady Farmaceutyczne Polpharma S A Extended release pharmaceutical formulation of metoprolol and process for its preparation
US20110118304A1 (en) 2007-11-20 2011-05-19 Neurosearch A/S Method for treating over-eating disorders
CA2709861A1 (en) 2007-12-20 2009-07-02 Neurosearch A/S Pharmaceutical compositions
WO2009080693A2 (en) 2007-12-20 2009-07-02 Neurosearch A/S Pharmaceutical composition comprising tesofensine or its analogue and a beta blocker
CA2710665A1 (en) 2007-12-27 2009-07-09 Bayer Animal Health Gmbh Treatment of heart disease using .beta.-blockers
US9408837B2 (en) 2008-05-28 2016-08-09 Kitov Pharmaceutical Ltd. Ameliorating drug-induced elevations in blood pressure by adjunctive use of antihypertensive drugs
AU2010222589B2 (en) 2009-03-11 2012-08-16 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
JP2012528847A (ja) 2009-06-05 2012-11-15 ファイザー・インク Ｇｐｒ１１９調節因子としてのｌ−（ピペリジン−４−イル）−ピラゾール誘導体
CN102548544B (zh) * 2009-10-09 2015-01-21 永进药品工业株式会社 同时具有速效特性和长效特性的药物组合物
PL2496583T3 (pl) 2009-11-02 2015-04-30 Pfizer Pochodne dioksabicyklo[3.2.1]oktano-2,3,4-triolowe
US10485770B2 (en) 2009-12-21 2019-11-26 Aptapharma, Inc. Functionally-coated multilayer tablets
CN102145000A (zh) * 2010-02-06 2011-08-10 赤峰维康生化制药有限公司 一种坎地沙坦酯和美托洛尔复方制剂
CN102198112A (zh) * 2010-03-26 2011-09-28 北京天衡药物研究院 一种渗透泵型控释片及其制备方法
US8235632B2 (en) 2010-05-14 2012-08-07 Illinois Tool Works Inc. Cargo bag valve deflector
CN102762198A (zh) * 2010-05-15 2012-10-31 欢腾生命科学有限公司 多单元组合物
WO2012052834A2 (en) 2010-10-21 2012-04-26 Inventia Healthcare Private Limited Multiple unit particulate system comprising metoprolol succinate
CN102085195A (zh) * 2011-01-10 2011-06-08 中国药科大学 琥珀酸美托洛尔缓释片及其制备方法
BR112013028668A2 (pt) 2011-05-06 2017-01-24 Glaxosmithkline Llc formulações de paracetamol de liberação sustentada
CA2840765A1 (en) * 2011-06-29 2013-01-03 Ranbaxy Laboratories Limited Multilayered dosage form
KR101708538B1 (ko) 2011-08-26 2017-02-20 욱크하르트 리미티드 심혈관 질환의 치료 방법
RU2014127884A (ru) 2011-12-09 2016-02-10 Вокхардт Лимитед Способы лечения сердечно-сосудистого нарушения
PL2814473T3 (pl) 2012-02-16 2019-06-28 Saniona A/S Kompozycje farmaceutyczne do terapii skojarzonej
IN2012DE00826A (pl) * 2012-03-21 2015-08-21 Ranbaxy Lab Ltd
CN102626396B (zh) * 2012-04-28 2014-05-07 海南华益泰康药业有限公司 一种美托洛尔缓释片剂及其制备方法
WO2015004617A1 (en) 2013-07-09 2015-01-15 Ranbaxy Laboratories Limited Extended-release pharmaceutical compositions of metoprolol
RS62275B1 (sr) 2015-03-03 2021-09-30 Saniona As Kombinovana formulacija tesofensina i metoprolola

Also Published As

Publication number Publication date
IL254179A0 (en) 2017-10-31
US20160279067A1 (en) 2016-09-29
JP6772430B2 (ja) 2020-10-21
GT201700194A (es) 2019-06-12
US20180071250A1 (en) 2018-03-15
PH12017501509B1 (en) 2018-02-05
CA2977415A1 (en) 2016-09-09
SG11201706899VA (en) 2017-09-28
DK3265126T3 (da) 2021-09-13
DOP2017000219A (es) 2018-02-15
US10537551B2 (en) 2020-01-21
KR101999463B1 (ko) 2019-10-01
US20200129478A1 (en) 2020-04-30
WO2016138908A1 (en) 2016-09-09
CL2017002214A1 (es) 2018-04-13
US20230092397A1 (en) 2023-03-23
US10231951B2 (en) 2019-03-19
CN107666913B (zh) 2021-11-26
HRP20211361T1 (hr) 2021-11-26
MX377172B (es) 2025-03-07
AU2016228002A1 (en) 2017-09-14
EA033298B1 (ru) 2019-09-30
HUE055974T2 (hu) 2022-01-28
EP3265126A1 (en) 2018-01-10
HK1247127A1 (zh) 2018-09-21
US11426383B2 (en) 2022-08-30
ES2885437T3 (es) 2021-12-13
SA517382209B1 (ar) 2021-04-19
AU2016228002B2 (en) 2020-10-01
CN107666913A (zh) 2018-02-06
UA122224C2 (uk) 2020-10-12
US20210023050A1 (en) 2021-01-28
SI3265126T1 (sl) 2021-11-30
MA41634B1 (fr) 2021-09-30
US20180360804A1 (en) 2018-12-20
ECSP17059323A (es) 2018-06-30
US12016840B2 (en) 2024-06-25
PT3265126T (pt) 2021-08-30
EP3265126B1 (en) 2021-06-02
LT3265126T (lt) 2021-09-10
CO2017009930A2 (es) 2018-01-05
BR112017018871A2 (pt) 2018-04-17
EA201791875A1 (ru) 2017-12-29
KR20170134393A (ko) 2017-12-06
PE20180187A1 (es) 2018-01-23
RS62275B1 (sr) 2021-09-30
MX2017011257A (es) 2018-04-10
IL254179B (en) 2020-11-30
US10828278B2 (en) 2020-11-10
MA41634A (fr) 2018-01-09
CR20170447A (es) 2018-03-13
JP2018507875A (ja) 2018-03-22
US9579288B2 (en) 2017-02-28
PH12017501509A1 (en) 2018-02-05

Similar Documents

Publication Publication Date Title
SG11201708044RA (en) Beauty device
GB201411197D0 (en) Composition and use thereof
HUE060941T2 (hu) Halogénolefin-bázisú készítmény és alkalmazása
SI3265126T1 (sl) Formulacija kombinacije tezofenzina in metoprolola
GB201401617D0 (en) Novel combination and use
IL297057B2 (en) Conjunctions and their uses
SI3233105T1 (sl) Nove kombinacije in uporaba
GB201502002D0 (en) Uses and compositions
GB201504763D0 (en) Compounds and uses
GB201411196D0 (en) Composition and use thereof
IL251335A0 (en) Piperidinylpyrazolopyrimidinones and their use
GB201522309D0 (en) Use
GB201522311D0 (en) Use
GB201521190D0 (en) Application in german
GB201502268D0 (en) Dental composition and use
IL254241A0 (en) Etv2 and its uses
GB201502026D0 (en) Uses and compositions
GB201501991D0 (en) Uses and compositions
GB201603591D0 (en) Improved promotors and compositions
GB201521085D0 (en) Use
PL3307080T3 (pl) Środek słodzący oraz jego zastosowanie
GB201518466D0 (en) Use
GB201511886D0 (en) Uses and compositions
GB201510077D0 (en) Use
ZA201608775B (en) Hair treatment composition