PL311083A1 - Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin - Google Patents

Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin

Info

Publication number: PL311083A1
Authority: PL; Poland
Prior art keywords: bezodiazepine; gastrin; cck; derivatives; antagonistic activity
Prior art date: 1993-04-15

Application number

PL94311083A

Inventor

Harry Finch

Pritom Shah

Robin Arthur Ellis Carr

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-15

Filing date

1994-04-13

Publication date

1996-02-05

1993-04-15 Priority claimed from GB939307833A external-priority patent/GB9307833D0/en

1994-03-29 Priority claimed from GB9406037A external-priority patent/GB9406037D0/en

1994-04-13 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

1996-02-05 Publication of PL311083A1 publication Critical patent/PL311083A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Crystallography & Structural Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

PL94311083A 1993-04-15 1994-04-13 Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin PL311083A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939307833A GB9307833D0 (en)	1993-04-15	1993-04-15	Modulators of cholecystokinin and gastrin
GB9406037A GB9406037D0 (en)	1994-03-29	1994-03-29	1,5 Benzodiazepine derivatives

Publications (1)

Publication Number	Publication Date
PL311083A1 true PL311083A1 (en)	1996-02-05

Family

ID=26302765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL94311083A PL311083A1 (en)	1993-04-15	1994-04-13	Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin

Country Status (14)

Country	Link
EP (1)	EP0694040A1 (en)
JP (1)	JPH08508743A (en)
CN (1)	CN1120845A (en)
AU (1)	AU688316B2 (en)
CA (1)	CA2158972A1 (en)
CZ (1)	CZ267695A3 (en)
FI (1)	FI954852A7 (en)
HU (1)	HUT74091A (en)
NO (1)	NO954091L (en)
NZ (1)	NZ265271A (en)
OA (1)	OA10236A (en)
PL (1)	PL311083A1 (en)
SK (1)	SK125495A3 (en)
WO (1)	WO1994024151A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69430068T2 (en) *	1993-12-28	2002-08-14	SHIONOGI & CO., LTD.	benzodiazepine derivatives
EP0945445B9 (en) *	1996-12-10	2005-12-28	Zeria Pharmaceutical Co., Ltd.	1,5-benzodiazepine derivatives
US6444849B1 (en)	1997-06-25	2002-09-03	Mitsubishi Chemical Corporation	Amide derivatives
JP2000026434A (en)	1998-06-05	2000-01-25	Zeria Pharmaceut Co Ltd	New 1,5-benzodiazepine derivatives
EP1142868A4 (en) *	1998-12-22	2004-09-29	Mitsubishi Chem Corp	amide derivatives
GB201414116D0 (en)	2014-08-08	2014-09-24	Trio Medicines Ltd	Benzodiazepine derivatives
GB201513979D0 (en)	2015-08-07	2015-09-23	Trio Medicines Ltd	Synthesis of benzodiazepine derivatives
WO2021071837A1 (en)	2019-10-07	2021-04-15	Kallyope, Inc.	Gpr119 agonists
BR112022017039A2 (en)	2020-02-28	2022-11-16	Kallyope Inc	GPR40 AGONISTS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (en) *	1988-12-29	1994-01-21	Roussel Uclaf	NOVEL 2,4-DIOXO 2,3,4,5-TETRAHYDRO 1H-1,5-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2659653B1 (en) *	1990-03-13	1992-05-22	Rhone Poulenc Sante	DERIVATIVES OF UREA, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
US5206234A (en) *	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck
GB9201180D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds

1994
- 1994-04-13 CZ CZ952676A patent/CZ267695A3/en unknown
- 1994-04-13 CA CA002158972A patent/CA2158972A1/en not_active Abandoned
- 1994-04-13 PL PL94311083A patent/PL311083A1/en unknown
- 1994-04-13 JP JP6522733A patent/JPH08508743A/en active Pending
- 1994-04-13 FI FI954852A patent/FI954852A7/en unknown
- 1994-04-13 HU HU9502977A patent/HUT74091A/en unknown
- 1994-04-13 CN CN94191771A patent/CN1120845A/en active Pending
- 1994-04-13 NZ NZ265271A patent/NZ265271A/en unknown
- 1994-04-13 EP EP94913579A patent/EP0694040A1/en not_active Withdrawn
- 1994-04-13 AU AU65675/94A patent/AU688316B2/en not_active Ceased
- 1994-04-13 SK SK1254-95A patent/SK125495A3/en unknown
- 1994-04-13 WO PCT/EP1994/001130 patent/WO1994024151A1/en not_active Ceased
1995
- 1995-10-13 NO NO954091A patent/NO954091L/en unknown
- 1995-10-21 OA OA60721A patent/OA10236A/en unknown

Also Published As

Publication number	Publication date
WO1994024151A1 (en)	1994-10-27
JPH08508743A (en)	1996-09-17
SK125495A3 (en)	1996-06-05
NZ265271A (en)	1997-06-24
CN1120845A (en)	1996-04-17
EP0694040A1 (en)	1996-01-31
CA2158972A1 (en)	1994-10-27
FI954852A0 (en)	1995-10-12
NO954091D0 (en)	1995-10-13
NO954091L (en)	1995-12-13
CZ267695A3 (en)	1996-04-17
HUT74091A (en)	1996-11-28
FI954852L (en)	1995-10-12
HU9502977D0 (en)	1995-12-28
AU688316B2 (en)	1998-03-12
AU6567594A (en)	1994-11-08
FI954852A7 (en)	1995-10-12
OA10236A (en)	1997-10-07

Publication	Publication Date	Title
PL311084A1 (en)	1996-02-05	Derivatives of 1,5-bezodiazepine exhibiting antagonistic or agonistic activity of cck
HU9600932D0 (en)	1996-06-28	In-alkyl-n-arylpyrimidinamines and derivatives thereof
AP9300478A0 (en)	1993-01-31	1,5 benzodiazepine derivatives
GR3023258T3 (en)	1997-07-30	3-Aryl-4-hydroxy-delta3-dihydrofuranone and 3-aryl-4-hydroxy-delta3-dihydrothiophenone derivatives
NZ248178A (en)	1995-09-26	Substituted 4-benzoylisoxazole derivatives and herbicidal compositions thereof
ZA921279B (en)	1993-08-23	Substituted alpha-aminoaldehydes and derivatives
EP0482649A3 (en)	1992-11-19	Cm-chitin derivatives and use thereof
AP9400657A0 (en)	1994-07-31	1,5 benzodiazepine derivatives
AU7978794A (en)	1995-05-04	3,17-dihydroxy-3,7,16 and/or 17-methyl-androst-5-ene compounds, derivatives thereof, and their use
ZA941926B (en)	1995-09-18	Heterocyclic compounds their preparation and use
PL311083A1 (en)	1996-02-05	Derivatives of 1,5-bezodiazepine exhibiting antagonistic activity of cck and/or gastrin
ZA93582B (en)	1994-07-27	Substituted hexahyhdroazephinones and tetrahydrobenzazepinones
ZA949293B (en)	1995-08-17	Hydrazine derivatives and uses thereof
AU3748293A (en)	1993-12-13	N-{n'-(5-amino-4-hydroxy-acyloyl)-alpha-aminoacyloyl} substituted heterocycles and their use as antiviral agents
GB9403775D0 (en)	1994-04-20	Hinge arrangements, their construction and use
HU9500177D0 (en)	1995-03-28	3-aryluracil derivatives and their use as herbicides
ZA932458B (en)	1994-10-05	Naphtoquinones and their use.
HU9502057D0 (en)	1995-09-28	Novel substituted thiosemicarbazone derivatives
GB9308077D0 (en)	1993-06-02	Assay of 2,4-dinitrophenylhydrazones and related compounds
GB9325420D0 (en)	1994-02-16	4'-o-sulfonyl-anthracycline derivatives
PL301984A1 (en)	1995-07-24	Derivatives of 3-phenyl-5-methylisoxzaole and 4,5-dihydroisoxasole
ZA93143B (en)	1994-07-08	Piperazinyl derivatives
GB9425776D0 (en)	1995-02-22	1,3,5-triazine derivatives,their preparations and uses
ZA947921B (en)	1996-04-11	In-alkyl-n-arylpyrimidinamines and derivatives thereof
GB2451221B (en)	2009-07-22	Azidoalkylformals, their prepararion and use