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PL3145508T3 - Nanocząstki klewidypiny i ich kompozycje farmaceutyczne - Google Patents

Nanocząstki klewidypiny i ich kompozycje farmaceutyczne

Info

Publication number
PL3145508T3
PL3145508T3 PL15795707.7T PL15795707T PL3145508T3 PL 3145508 T3 PL3145508 T3 PL 3145508T3 PL 15795707 T PL15795707 T PL 15795707T PL 3145508 T3 PL3145508 T3 PL 3145508T3
Authority
PL
Poland
Prior art keywords
clevidipine
nanoparticles
pharmaceutical compositions
pharmaceutical
compositions
Prior art date
Application number
PL15795707.7T
Other languages
English (en)
Inventor
Rajeshwar Motheram
Sr. David C. HANLEY
Akif Emre TÜRELI
Monika KANTER
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of PL3145508T3 publication Critical patent/PL3145508T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
PL15795707.7T 2014-05-19 2015-05-19 Nanocząstki klewidypiny i ich kompozycje farmaceutyczne PL3145508T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462000119P 2014-05-19 2014-05-19
PCT/US2015/031470 WO2015179334A1 (en) 2014-05-19 2015-05-19 Clevidipine nanoparticles and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
PL3145508T3 true PL3145508T3 (pl) 2023-10-23

Family

ID=54554604

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15795707.7T PL3145508T3 (pl) 2014-05-19 2015-05-19 Nanocząstki klewidypiny i ich kompozycje farmaceutyczne

Country Status (10)

Country Link
US (2) US11737989B2 (pl)
EP (1) EP3145508B1 (pl)
KR (1) KR102380701B1 (pl)
CN (2) CN106456617A (pl)
CA (1) CA2947486C (pl)
ES (1) ES2950154T3 (pl)
MX (1) MX385243B (pl)
PL (1) PL3145508T3 (pl)
RU (1) RU2759673C2 (pl)
WO (1) WO2015179334A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105796490B (zh) * 2016-04-01 2019-12-10 广东药科大学 一种含氨基酸的尼莫地平注射液组合物及其制备方法
CN105796494B (zh) * 2016-04-01 2019-10-11 广东药科大学 一种含氨基酸的尼莫地平亚微乳注射液及其制备方法
CN107281104B (zh) * 2017-05-27 2021-02-02 济南康和医药科技有限公司 一种丁酸氯维地平磷脂复合物脂质体及其制备方法
EP3804703A1 (de) * 2019-10-10 2021-04-14 Bayer AG Verfahren zur herstellung eines nanopartikulären wirkstoffs
EP3884930A1 (en) 2020-03-23 2021-09-29 Bayer AG Nano-dry-melting
WO2024246613A1 (en) * 2023-05-28 2024-12-05 Precise Biopharma Pvt Ltd A room temperature stable aqueous solution for injection of clevidipine

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453523A (en) * 1993-06-16 1995-09-26 Emulsion Technology, Inc. Process for obtaining highly purified phosphatidylcholine
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
SE9303744D0 (sv) 1993-11-12 1993-11-12 Astra Ab Pharmaceutical emulsion
SE9804002D0 (sv) 1998-11-23 1998-11-23 Astra Ab New manufacturing process
US20090181076A1 (en) * 2006-05-04 2009-07-16 University Of South Australia Drug Release From Nanoparticle-Coated Capsules
NZ591205A (en) 2008-08-01 2012-11-30 Medicines Co Pharmaceutical compositions comprising clevidipine and methods for producing low impurity concentrations of the same
US8679344B2 (en) * 2008-12-17 2014-03-25 Cerion Technology, Inc. Process for solvent shifting a nanoparticle dispersion
DE102009008478A1 (de) 2009-02-11 2010-08-19 PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren
EA025562B1 (ru) * 2010-03-22 2017-01-30 Инстилло Гмбх Способ для получения микрочастиц или наночастиц и устройство для его осуществления
GB201015079D0 (en) 2010-09-10 2010-10-27 Helperby Therapeutics Ltd Novel use
BR112013008601B1 (pt) * 2010-10-12 2020-03-31 Chiesi Farmaceutici S.P.A. Formulações de emulsão de clevidipina contendo agentes antimicrobianos
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
EP2526926A1 (de) 2011-05-25 2012-11-28 Justus-Liebig-Universität Gießen Biokompatible Nanopolymerpartikel mit Wirkstoffen für die pulmonale Applikation
MX2014002163A (es) 2011-08-26 2014-09-25 Wockhardt Ltd Métodos para el tratamiento de desórdenes cardiovasculares.
US20150246137A1 (en) 2012-09-27 2015-09-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
UA117571C2 (uk) 2012-10-26 2018-08-27 Чіесі Фармацеутічі С.П.А. Способи контролювання кров'яного тиску та зниження диспное при серцевій недостатності
CN103479577A (zh) * 2013-09-30 2014-01-01 山东大学 含有丁酸氯维地平的脂质纳米混悬剂及其冻干制剂

Also Published As

Publication number Publication date
KR102380701B1 (ko) 2022-03-31
RU2759673C2 (ru) 2021-11-16
US11737989B2 (en) 2023-08-29
US12383507B2 (en) 2025-08-12
EP3145508B1 (en) 2023-07-05
CA2947486A1 (en) 2015-11-26
RU2016149538A3 (pl) 2019-01-17
KR20170032886A (ko) 2017-03-23
RU2016149538A (ru) 2018-06-20
CA2947486C (en) 2023-09-26
CN114668740A (zh) 2022-06-28
CN106456617A (zh) 2017-02-22
ES2950154T3 (es) 2023-10-05
WO2015179334A1 (en) 2015-11-26
MX385243B (es) 2025-03-14
BR112016027104A2 (pt) 2018-07-10
EP3145508A4 (en) 2018-01-24
MX2016015208A (es) 2017-03-23
US20230145206A1 (en) 2023-05-11
EP3145508C0 (en) 2023-07-05
US20170087093A1 (en) 2017-03-30
EP3145508A1 (en) 2017-03-29

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