PL3031825T3 - Immunologiczne oznaczenie aktywności toksyny botulinowej serotypu a - Google Patents
Immunologiczne oznaczenie aktywności toksyny botulinowej serotypu aInfo
- Publication number
- PL3031825T3 PL3031825T3 PL16153819T PL16153819T PL3031825T3 PL 3031825 T3 PL3031825 T3 PL 3031825T3 PL 16153819 T PL16153819 T PL 16153819T PL 16153819 T PL16153819 T PL 16153819T PL 3031825 T3 PL3031825 T3 PL 3031825T3
- Authority
- PL
- Poland
- Prior art keywords
- immuno
- botulinum toxin
- activity assays
- toxin serotype
- based botulinum
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 229940053031 botulinum toxin Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/085—Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus
- C07K14/10—Hepatitis A virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/952—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3672308P | 2008-03-14 | 2008-03-14 | |
| EP20120187775 EP2578601A1 (en) | 2008-03-14 | 2009-03-13 | Immuno-based botulinum toxin serotype A activity assays |
| PCT/US2009/037046 WO2009114748A1 (en) | 2008-03-14 | 2009-03-13 | Immuno-based botulinum toxin serotype a activity assays |
| EP09719709.9A EP2271670B1 (en) | 2008-03-14 | 2009-03-13 | Immuno-based botulinum toxin serotype a activity assays |
| EP16153819.4A EP3031825B1 (en) | 2008-03-14 | 2009-03-13 | Immuno-based botulinum toxin serotype a activity assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3031825T3 true PL3031825T3 (pl) | 2020-02-28 |
Family
ID=40677745
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09719709T PL2271670T3 (pl) | 2008-03-14 | 2009-03-13 | Testy aktywności serotypu A toksyny botulinowej oparte na immunologii |
| PL16153819T PL3031825T3 (pl) | 2008-03-14 | 2009-03-13 | Immunologiczne oznaczenie aktywności toksyny botulinowej serotypu a |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09719709T PL2271670T3 (pl) | 2008-03-14 | 2009-03-13 | Testy aktywności serotypu A toksyny botulinowej oparte na immunologii |
Country Status (26)
| Country | Link |
|---|---|
| US (11) | US8198034B2 (pl) |
| EP (6) | EP3556770A1 (pl) |
| JP (5) | JP5766954B2 (pl) |
| KR (1) | KR101609894B1 (pl) |
| CN (2) | CN102937653B (pl) |
| AU (1) | AU2009223161B2 (pl) |
| BR (2) | BR122012027456A2 (pl) |
| CA (1) | CA2715033C (pl) |
| CO (1) | CO6311001A2 (pl) |
| CY (2) | CY1115771T1 (pl) |
| DK (2) | DK3031825T3 (pl) |
| ES (2) | ES2755505T3 (pl) |
| HR (1) | HRP20191886T1 (pl) |
| HU (1) | HUE046037T2 (pl) |
| IL (2) | IL208097A (pl) |
| LT (1) | LT3031825T (pl) |
| MX (1) | MX2010010137A (pl) |
| MY (2) | MY155049A (pl) |
| NZ (1) | NZ588029A (pl) |
| PL (2) | PL2271670T3 (pl) |
| PT (2) | PT3031825T (pl) |
| RU (2) | RU2491293C2 (pl) |
| SG (1) | SG2014009112A (pl) |
| SI (2) | SI3031825T1 (pl) |
| UA (1) | UA102247C2 (pl) |
| WO (1) | WO2009114748A1 (pl) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563874B2 (en) * | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US8497081B2 (en) | 2004-02-24 | 2013-07-30 | Allergan, Inc. | Botulinum toxin screening assays |
| WO2009008916A2 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of Californina | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| EP2246426A4 (en) * | 2008-01-29 | 2011-08-10 | Inst Antibodies Co Ltd | COMPOSITION FOR THE NEUTRALIZATION OF BOTULINUS TOXIN TYPE-A AND HUMAN ANTIBODIES AGAINST BOTULINUS TOXIN TYPE-A |
| KR101604515B1 (ko) * | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
| US8198034B2 (en) | 2008-03-14 | 2012-06-12 | Allergan, Inc. | Immuno-based botulinum toxin serotype A activity assays |
| US9000131B2 (en) | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| KR101797045B1 (ko) * | 2009-03-13 | 2017-11-13 | 알러간, 인코포레이티드 | 면역 기반 재표적화된 엔도펩티다제 활성 검정 |
| KR20190104231A (ko) * | 2009-03-13 | 2019-09-06 | 알러간, 인코포레이티드 | 면역 기반 보툴리눔 독소 혈청형 a 활성 검정에 유용한 세포 |
| AU2015203359A1 (en) * | 2009-03-13 | 2015-07-02 | Allergan, Inc. | Cells useful for immuno-based Botulinum toxin serotype A activity assays |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| WO2011022438A2 (en) * | 2009-08-18 | 2011-02-24 | Us Army Medical Research And Materiel Command | Cleavage sensitive antibodies and methods of use thereof |
| CA2780932A1 (en) * | 2009-11-18 | 2011-05-26 | Merz Pharma Gmbh & Co. Kgaa | Assay for quantifying clostridial neurotoxin |
| US9243057B2 (en) | 2010-08-31 | 2016-01-26 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| US10908146B2 (en) | 2011-06-01 | 2021-02-02 | Biomadison, Inc. | Compositions and methods for improving sensitivity in cell based assays |
| US9274121B2 (en) | 2011-06-01 | 2016-03-01 | Biomadison, Inc. | Non-FRET botulinum assay |
| US9303285B2 (en) | 2012-01-04 | 2016-04-05 | Biomadison, Inc. | Methods and compounds for increasing sensitivity of botulinum assays |
| SG11201401007SA (en) | 2011-09-29 | 2014-04-28 | Cellsnap Llc | Compositions and methods for toxigenicity testing |
| CN103974978B (zh) * | 2011-11-25 | 2017-03-08 | 弗劳恩霍夫应用研究促进协会 | 用于检测snap/clip标记物的单克隆抗体 |
| EP3279335B1 (en) | 2011-12-31 | 2021-03-10 | Allergan, Inc. | Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-a |
| LT2800973T (lt) * | 2012-01-04 | 2018-09-10 | Biomadison, Inc. | Būdai ir junginiai, skirti botulino tyrimų jautrumo padidinimui |
| KR102073111B1 (ko) | 2012-10-16 | 2020-02-04 | 메르츠 파마 게엠베하 운트 코. 카가아 | 신경독소 폴리펩티드의 생물학적 활성의 결정을 위한 세포 테스트 시스템 |
| CA3062150C (en) | 2012-11-21 | 2021-12-21 | Ipsen Bioinnovation Limited | Methods for the manufacture of proteolytically processed polypeptides |
| US20140170132A1 (en) | 2012-12-18 | 2014-06-19 | Allergan, Inc. | Prophylatic treatment of herpes recurrence |
| PL3014267T3 (pl) | 2013-06-28 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Środki i sposoby określania aktywności biologicznej polipeptydów neurotoksyny w komórkach |
| KR102246789B1 (ko) | 2013-08-09 | 2021-04-29 | 바이오메디슨, 인코퍼레이티드 | 개선된 민감성을 지닌 보툴리눔 독소 검정 |
| WO2015088477A1 (en) * | 2013-12-09 | 2015-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Peptide substrates recognizable by type e botulinum neurotoxin |
| ES2822942T3 (es) | 2014-04-30 | 2021-05-05 | Allergan Inc | Formulaciones de productos biológicos para instilación intravesical |
| EP2952205B1 (en) | 2014-06-06 | 2017-08-09 | Kleiner-Fisman, Galit | Botulinum toxin for use in the treatment of paratonia |
| EP3166971B1 (en) | 2014-07-07 | 2019-09-11 | Allergan, Inc. | Method of detecting cleaved snap25 in tissue samples |
| SG10201913979VA (en) | 2014-07-07 | 2020-03-30 | Allergan Inc | Method of detecting cleaved snap25 in tissue samples |
| JP6585157B2 (ja) | 2014-07-31 | 2019-10-02 | アラーガン、インコーポレイテッドAllergan,Incorporated | 膀胱内注入用の生物製剤の処方 |
| EP3221699B1 (en) * | 2014-11-21 | 2020-06-17 | Merz Pharma GmbH & Co. KGaA | Methods for the determination of the biological activities of neurotoxin polypeptides |
| CN107207586B (zh) * | 2014-12-19 | 2021-07-13 | 莫茨药物股份两合公司 | 用于测定BoNT/E在细胞中的生物活性的装置和方法 |
| TWI669129B (zh) | 2014-12-23 | 2019-08-21 | 德商梅茲製藥有限兩合公司 | 預填充式玻璃容器及其套組與使用 |
| RU2761662C2 (ru) * | 2014-12-31 | 2021-12-13 | Девелопмент Сентер Фор Байотекнолоджи | Гуманизированные антитела, специфичные к альфа-энолазе, и способы применения в противоопухолевой терапии |
| US9527922B2 (en) | 2014-12-31 | 2016-12-27 | Development Center For Biotechnology | Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy |
| TWI704156B (zh) * | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| BR112018005322A2 (pt) * | 2015-09-18 | 2018-12-11 | Arch Oncology, Inc. | anticorpo monoclonal ou seu fragmento de ligação a antígenos, composição farmacêutica, anticorpo monoclonal ou seu fragmento de ligação a antígenos para uso, método de tratamento de lesão de isquemia-reperfusão, método de tratamento de câncer em um paciente humano, método de avaliação da expressão de cd47 em células tumorais e/ou imunes usando um anticorpo monoclonal ou seu fragmento de ligação a antígenos |
| WO2017063743A1 (en) | 2015-10-14 | 2017-04-20 | Merz Pharma Gmbh & Co. Kgaa | Improvements to ultrasound-based therapy of photoaged tissue |
| US11969461B2 (en) | 2016-03-02 | 2024-04-30 | Merz Pharma Gmbh & Co. Kgaa | Composition comprising botulinum toxin |
| TWI737742B (zh) | 2016-06-22 | 2021-09-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用 |
| EP3290437A1 (en) | 2016-08-31 | 2018-03-07 | Merz Pharma GmbH & Co. KGaA | Novel recombinant clostridial neurotoxins with decreased duration of effect |
| HRP20191966T4 (hr) | 2016-09-13 | 2022-09-16 | Allergan, Inc. | Stabilizirani neproteinski klostridijalni pripravci toksina |
| EP3312193A1 (en) | 2016-10-19 | 2018-04-25 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with accelerated onset of effect |
| EP3529276A4 (en) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | CD47 THERAPEUTIC ANTIBODIES |
| EP3333179A1 (en) | 2016-12-07 | 2018-06-13 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with accelarated onset of effect |
| EP3335719A1 (en) | 2016-12-14 | 2018-06-20 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with a stabilized light chain |
| KR20240160669A (ko) | 2017-03-24 | 2024-11-11 | 메르츠 파마 게엠베하 운트 코. 카가아 | 타액과다증의 치료에서의 보툴리늄 신경독소의 개선된 용도 |
| US11952601B2 (en) | 2017-06-20 | 2024-04-09 | Merz Pharma Gmbh & Co. Kgaa | Recombinant botulinum toxin with increased duration of effect |
| EP3649143B1 (en) | 2017-07-06 | 2022-08-31 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with increased duration of effect |
| EP3700919A1 (en) | 2017-10-26 | 2020-09-02 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with increased duration of effect |
| EP3713595A1 (en) | 2017-11-22 | 2020-09-30 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with increased duration of effect |
| EP3752128B1 (de) * | 2018-02-16 | 2025-01-15 | preclinics discovery GmbH | Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung |
| JP6544669B1 (ja) | 2018-03-16 | 2019-07-17 | ディヴェロップメント センター フォー バイオテクノロジー | アルファエノラーゼに特異的な抗体及びその使用 |
| WO2020070017A1 (en) | 2018-10-02 | 2020-04-09 | Merz Pharma Gmbh & Co. Kgaa | Novel uses of botulinum neurotoxin for treating lipoedema |
| KR102251096B1 (ko) * | 2018-12-12 | 2021-05-13 | 휴젤(주) | 보툴리눔 독소 활성을 결정하는 세포 기반 방법 |
| EP3660509B1 (en) | 2018-11-29 | 2022-03-09 | Hugel Inc. | A cell-based method for determining an activity of botulinum toxin |
| KR101983216B1 (ko) * | 2018-11-29 | 2019-05-29 | 주식회사 에이비바이오 | 보툴리눔 독소 활성을 결정하기 위한 항체, 및 이를 이용한 활성 측정방법 |
| JP7646555B2 (ja) | 2019-02-21 | 2025-03-17 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | 振戦治療のためのボツリヌス神経毒素の新規用途 |
| KR102274841B1 (ko) * | 2019-10-16 | 2021-07-12 | 주식회사 하울바이오 | Snare 복합체를 억제하는 항-snap 25 항체 및 이의 용도 |
| CN115666629A (zh) | 2020-06-05 | 2023-01-31 | 莫茨药物股份两合公司 | 面部皱纹的高剂量和低体积肉毒毒素治疗 |
| US20220010355A1 (en) * | 2020-07-10 | 2022-01-13 | Galderma Holding SA | Cell based method for determination of botulinum toxin potency based on western blotting |
| KR102797145B1 (ko) * | 2021-05-24 | 2025-04-22 | 주식회사 에이티지씨 | 렌티바이러스에 의해 특정 유전자가 삽입된 보툴리눔 독소에 민감한 세포 |
| EP4349992A4 (en) * | 2021-05-24 | 2025-09-24 | Atgc Co Ltd | BOTULINUM TOXIN-SENSITIVE CELLS INTO WHICH A SPECIFIC GENE HAS BEEN INSERTED BY A LENTIVIRUS |
| TW202400223A (zh) | 2022-02-15 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 液體製劑及其製備方法與用途 |
| JP2025504249A (ja) | 2022-02-15 | 2025-02-06 | メルツ・ファルマ・ゲーエムベーハー・ウント・コー・カーゲーアーアー | 液体ボツリヌス毒素製剤及びその使用 |
| TW202400122A (zh) | 2022-02-28 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素用於降低皮膚毛孔尺寸及/或皮脂產生之用途、以及降低皮膚毛孔尺寸及/或皮脂產生的方法 |
| WO2023205355A1 (en) * | 2022-04-21 | 2023-10-26 | Biomadison, Inc. | Cell based assays for botulinum neurotoxin |
| EP4615489A1 (en) | 2022-11-07 | 2025-09-17 | Allergan, Inc. | Prevention of post-operative atrial fibrillation with a botulinum toxin |
| AR131172A1 (es) | 2022-11-28 | 2025-02-19 | Merz Pharma Gmbh & Co Kgaa | Inyección de toxina botulínica en el platisma para el rejuvenecimiento del rostro inferior y del cuello |
| CN120379640A (zh) | 2022-11-28 | 2025-07-25 | 莫茨药物股份两合公司 | 用于颈部年轻化的高浓度肉毒杆菌毒素治疗 |
| EP4633596A1 (en) | 2022-12-15 | 2025-10-22 | Merz Pharma GmbH & Co. KGaA | Injectable gel comprising botulinum toxin and uses thereof |
| CH720444A2 (de) | 2023-01-20 | 2024-07-31 | Abbvie Inc | Clostridium botulinum serotyp a neurotoxin (bont/a)- sequenzvarianten |
| CH720447A2 (de) | 2023-01-20 | 2024-07-31 | Abbvie Inc | Zusammensetzungen von clostridium botulinum neurotoxin serotyp a |
| CN120882478A (zh) | 2023-03-15 | 2025-10-31 | 莫茨药物股份两合公司 | 用于处理至少一个流体样品的摇摆式振荡器 |
| WO2024194181A1 (en) | 2023-03-20 | 2024-09-26 | Merz Therapeutics GmbH | Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient |
| WO2024240868A1 (en) | 2023-05-23 | 2024-11-28 | Merz Therapeutics GmbH | Botulinum toxin for treating peripheral neuropathic pain |
| WO2025012403A1 (en) | 2023-07-12 | 2025-01-16 | Merz Pharma Gmbh & Co. Kgaa | Treatment of hyperpigmentation conditions by botulinum toxin |
| WO2025032220A1 (en) | 2023-08-10 | 2025-02-13 | Merz Pharma Gmbh & Co. Kgaa | Liquid botulinum toxin formulation and use thereof |
| DE102025101336A1 (de) | 2024-01-19 | 2025-07-24 | Abbvie Inc. | Zusammensetzungen von clostridium botulinum neurotoxin serotyp a und verbesserte trocknungsprozesse |
| WO2025228877A1 (en) | 2024-04-29 | 2025-11-06 | Merz Therapeutics GmbH | Botulinum toxin for the preventive treatment of migraine |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3672308A (en) | 1970-11-06 | 1972-06-27 | Westinghouse Electric Corp | Roadway switching arrangement for transportation system having center guiderail below track level |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5955584A (en) * | 1986-03-31 | 1999-09-21 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5747641A (en) | 1989-12-21 | 1998-05-05 | Biogen Inc | Tat-derived transport polypeptide conjugates |
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| ES2180529T3 (es) | 1990-02-26 | 2003-02-16 | Univ Leland Stanford Junior | Identificacion y expresion de secuencias de adn de un receptor de esteroides de insectos. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| ES2227512T3 (es) | 1991-12-02 | 2005-04-01 | Medical Research Council | Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago. |
| US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
| CA2135644C (en) | 1992-05-14 | 2009-01-27 | Elisabetta Vegeto | Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy |
| AU4646393A (en) | 1992-06-23 | 1994-01-24 | Interactive Biologics Associates | Pharmaceutical composition containing botulinum b complex |
| US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| SE9304060D0 (sv) | 1993-12-06 | 1993-12-06 | Bioinvent Int Ab | Sätt att selektera specifika bakteriofager |
| US5962637A (en) | 1994-06-03 | 1999-10-05 | Microbiological Research Authority | Toxin assay |
| GB9411138D0 (en) * | 1994-06-03 | 1994-07-27 | Microbiological Res Authority | Toxin assay |
| US6495518B1 (en) | 1994-06-13 | 2002-12-17 | Vanderbilt University | Method for importing biologically active molecules into cells |
| US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
| GB9500851D0 (en) | 1995-01-17 | 1995-03-08 | Bionvent International Ab | Method of selecting specific bacteriophages |
| JP4423680B2 (ja) * | 1995-06-07 | 2010-03-03 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Cdr−グラフト化抗組織因子抗体及びその使用 |
| FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US6072041A (en) | 1996-06-03 | 2000-06-06 | Case Western Reserve University | Fusion proteins for protein delivery |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| BR9809138A (pt) | 1997-05-21 | 2001-08-28 | Trustees For The Leland Stanfo | Conjugado e método para aumentar o transporte de um composto selecionado atravessando uma membrana biológica |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| SK14812000A3 (sk) * | 1998-04-03 | 2001-08-06 | Chugai Seiyaku Kabushiki Kaisha | Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo |
| US7563874B2 (en) | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| WO2000034308A2 (en) | 1998-12-10 | 2000-06-15 | Washington University | Protein transduction system and methods of use thereof |
| US7034132B2 (en) | 2001-06-04 | 2006-04-25 | Anderson David W | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US7132259B1 (en) | 1999-08-25 | 2006-11-07 | Allergan, Inc. | Activatable recombinant neurotoxins |
| US20030008813A1 (en) | 1999-12-17 | 2003-01-09 | Felgner Philip L. | Intracellular protein delivery compositions and methods of use |
| GB9930519D0 (en) | 1999-12-24 | 2000-02-16 | Phogen Limited | Uses of transport proteins |
| US7034121B2 (en) | 2000-01-27 | 2006-04-25 | Genetics Institue, Llc | Antibodies against CTLA4 |
| US6294553B1 (en) | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| US6325899B1 (en) | 2000-03-10 | 2001-12-04 | Action Caps, Llc | Disposable and recyclable intermediates for use in electrostatic coating processes |
| ES2617692T3 (es) | 2000-07-21 | 2017-06-19 | Revance Therapeutics, Inc. | Sistemas de transporte de agentes biológicos de múltiples componentes |
| US20030219462A1 (en) | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
| US7491799B2 (en) | 2000-07-21 | 2009-02-17 | Allergan, Inc. | Modified botulinum neurotoxins |
| US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| AU2001280767A1 (en) | 2000-07-31 | 2002-02-13 | Active Motif | Peptide-mediated delivery of molecules into cells |
| US6678651B2 (en) * | 2000-09-15 | 2004-01-13 | Mindspeed Technologies, Inc. | Short-term enhancement in CELP speech coding |
| CA2428270C (en) * | 2000-11-06 | 2013-07-02 | Leonard A. Smith | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
| US7223577B2 (en) | 2000-11-17 | 2007-05-29 | Allergan, Inc. | Post-translational modifications and Clostridial neurotoxins |
| US7208285B2 (en) | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
| US8022172B2 (en) | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
| US20080064054A1 (en) * | 2001-08-28 | 2008-03-13 | Ester Fernandez-Salas | Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity |
| US7332567B2 (en) | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
| US7374896B2 (en) | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
| WO2003040347A2 (en) * | 2001-11-09 | 2003-05-15 | The Ohio State University Research Foundation | Baalc expression as a diagnostic marker for acute leukemia |
| AU2003216389A1 (en) | 2002-02-21 | 2003-09-09 | Essentia Biosystems, Inc. | Induction of hair growth with vascular endothelial growth factor |
| AU2003210060B2 (en) | 2002-03-22 | 2010-02-25 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US20040057958A1 (en) | 2002-05-17 | 2004-03-25 | Waggoner David W. | Immunogenicity-enhancing carriers and compositions thereof and methods of using the same |
| RU2230325C2 (ru) * | 2002-08-15 | 2004-06-10 | Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации | Способ приготовления очищенного препарата ботулинического токсина типа а |
| US7183066B2 (en) | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| US7341843B2 (en) * | 2003-04-11 | 2008-03-11 | Allergan, Inc. | Botulinum toxin A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy |
| WO2005076785A2 (en) * | 2003-12-19 | 2005-08-25 | Wisconsin Alumni Research Foundation | Method and compositions for detecting botulinum neurotoxin |
| WO2005082096A2 (en) * | 2004-02-24 | 2005-09-09 | Allergan, Inc. | Botulinum toxin screening assays |
| US8497081B2 (en) * | 2004-02-24 | 2013-07-30 | Allergan, Inc. | Botulinum toxin screening assays |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| AU2011253597B2 (en) | 2004-03-03 | 2014-12-04 | Revance Therapeutics, Inc. | Multi-component biological transport systems |
| SI2985039T1 (sl) | 2004-03-03 | 2018-12-31 | Revance Therapeutics, Inc. | Topična aplikacija in transdermalna dostava toksinov botulina |
| EP1734984A4 (en) | 2004-03-03 | 2009-07-29 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL DIAGNOSIS AND THERAPEUTIC TRANSPORT |
| WO2005118582A1 (ja) | 2004-06-03 | 2005-12-15 | Senju Pharmaceutical Co., Ltd. | アミド化合物を含有する角膜知覚回復剤 |
| US7906276B2 (en) * | 2004-06-30 | 2011-03-15 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
| US7514088B2 (en) | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| US7399607B2 (en) | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
| WO2006042149A2 (en) * | 2004-10-06 | 2006-04-20 | Allergan, Inc. | Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin a peptides |
| GB0426394D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| WO2006094263A2 (en) | 2005-03-03 | 2006-09-08 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| EP1861419B1 (en) | 2005-03-15 | 2011-06-29 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
| ATE470857T1 (de) | 2005-04-05 | 2010-06-15 | Allergan Inc | Lipophile, farbstoffbasierte fret-assays für die clostridientoxinaktivität |
| US8067231B2 (en) | 2005-04-05 | 2011-11-29 | Allergan, Inc. | Clostridial toxin activity assays |
| ATE555387T1 (de) | 2005-10-12 | 2012-05-15 | Allergan Inc | Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret) |
| US8568740B2 (en) | 2005-11-17 | 2013-10-29 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
| GB2437311A (en) * | 2006-04-07 | 2007-10-24 | Mologic Ltd | A protease detection product |
| US8796429B2 (en) | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| DK2027156T3 (da) * | 2006-06-02 | 2011-04-26 | Aveo Pharmaceuticals Inc | Hepatocytvækstfaktor (HGF)bindingsprotein |
| AU2007272515B2 (en) | 2006-07-11 | 2013-09-26 | Allergan, Inc. | Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells |
| MY142256A (en) | 2006-09-14 | 2010-11-15 | Revance Therapeutics Inc | Compositions and methods for topical diagnostic and therapeutic transport |
| CN100577149C (zh) * | 2006-12-21 | 2010-01-06 | 北京民海生物科技有限公司 | 一种治疗用a型肉毒毒素冻干粉针剂新型冻干保护剂配方 |
| WO2008082889A2 (en) | 2006-12-29 | 2008-07-10 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat |
| EP2109363A4 (en) | 2006-12-29 | 2014-07-09 | Revance Therapeutics Inc | TRANSPORTING MOLECULES WITH REVERSE SEQUENCE HIV TAT POLYPEPTIDES |
| US8753831B2 (en) * | 2007-06-05 | 2014-06-17 | City Of Hope | Methods for detection of botulinum neurotoxin |
| JP5401457B2 (ja) | 2007-07-26 | 2014-01-29 | ルバンス セラピュティックス インク. | 抗菌ペプチド、組成物及びその使用方法 |
| US20100227868A1 (en) | 2007-09-20 | 2010-09-09 | Johnson Brent A | Treatment methods with brimonidine |
| KR101604515B1 (ko) | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
| US8198034B2 (en) | 2008-03-14 | 2012-06-12 | Allergan, Inc. | Immuno-based botulinum toxin serotype A activity assays |
| ES2669020T3 (es) | 2008-12-31 | 2018-05-23 | Revance Therapeutics, Inc. | Formulaciones inyectables de toxina botulínica |
| KR101797045B1 (ko) | 2009-03-13 | 2017-11-13 | 알러간, 인코포레이티드 | 면역 기반 재표적화된 엔도펩티다제 활성 검정 |
| KR20190104231A (ko) * | 2009-03-13 | 2019-09-06 | 알러간, 인코포레이티드 | 면역 기반 보툴리눔 독소 혈청형 a 활성 검정에 유용한 세포 |
| LT5982B (lt) * | 2012-04-24 | 2013-12-27 | Uab Friday Lab | Su planšetiniu kompiuteriu arba išmaniuoju telefonu suderintas žuvų ieškiklis |
| KR102073111B1 (ko) * | 2012-10-16 | 2020-02-04 | 메르츠 파마 게엠베하 운트 코. 카가아 | 신경독소 폴리펩티드의 생물학적 활성의 결정을 위한 세포 테스트 시스템 |
| SG11201502375QA (en) * | 2012-11-21 | 2015-05-28 | Merz Pharma Gmbh & Co Kgaa | Means and methods for determination of botulinum neurotoxin biological activity |
| EP3166971B1 (en) * | 2014-07-07 | 2019-09-11 | Allergan, Inc. | Method of detecting cleaved snap25 in tissue samples |
| CN107207586B (zh) * | 2014-12-19 | 2021-07-13 | 莫茨药物股份两合公司 | 用于测定BoNT/E在细胞中的生物活性的装置和方法 |
| TWI704156B (zh) * | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
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