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PL3010940T3 - Nowe sposoby wytwarzania chemicznie zmodyfikowanych heparyn - Google Patents

Nowe sposoby wytwarzania chemicznie zmodyfikowanych heparyn

Info

Publication number
PL3010940T3
PL3010940T3 PL14739914T PL14739914T PL3010940T3 PL 3010940 T3 PL3010940 T3 PL 3010940T3 PL 14739914 T PL14739914 T PL 14739914T PL 14739914 T PL14739914 T PL 14739914T PL 3010940 T3 PL3010940 T3 PL 3010940T3
Authority
PL
Poland
Prior art keywords
chemically
production
new processes
modified heparins
heparins
Prior art date
Application number
PL14739914T
Other languages
English (en)
Inventor
Per-Olov Eriksson
Erik Yngve Holmer
Original Assignee
Dilafor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dilafor Ab filed Critical Dilafor Ab
Publication of PL3010940T3 publication Critical patent/PL3010940T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
PL14739914T 2013-06-19 2014-06-19 Nowe sposoby wytwarzania chemicznie zmodyfikowanych heparyn PL3010940T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1310928.5A GB2515315A (en) 2013-06-19 2013-06-19 New Processes
EP14739914.1A EP3010940B1 (en) 2013-06-19 2014-06-19 New processes for the production of chemically-modified heparins
PCT/GB2014/051878 WO2014202982A1 (en) 2013-06-19 2014-06-19 New processes for the production of chemically-modified heparins

Publications (1)

Publication Number Publication Date
PL3010940T3 true PL3010940T3 (pl) 2018-01-31

Family

ID=48914809

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14739914T PL3010940T3 (pl) 2013-06-19 2014-06-19 Nowe sposoby wytwarzania chemicznie zmodyfikowanych heparyn

Country Status (15)

Country Link
US (1) US10023659B2 (pl)
EP (1) EP3010940B1 (pl)
JP (1) JP6378328B2 (pl)
CN (1) CN105324398B (pl)
CA (1) CA2914256C (pl)
DK (1) DK3010940T3 (pl)
ES (1) ES2646337T3 (pl)
GB (1) GB2515315A (pl)
HU (1) HUE037037T2 (pl)
IL (1) IL242888B (pl)
LT (1) LT3010940T (pl)
PL (1) PL3010940T3 (pl)
PT (1) PT3010940T (pl)
TW (1) TWI672146B (pl)
WO (1) WO2014202982A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
CN115103679A (zh) 2020-02-17 2022-09-23 迪乐方有限责任公司 用于治疗先兆子痫的他福昔肝素
EP4272749A1 (en) 2022-05-03 2023-11-08 Dilafor AB New medical use of tafoxiparin
JP2025514038A (ja) 2022-05-03 2025-05-02 ディラフォール アクチエボラグ タフォキシパリンの新規な医学的使用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
SE9101155D0 (sv) 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB2299998B (en) * 1995-03-31 1997-03-26 Hamilton Civic Hospitals Res Compositions for inhibiting thrombogenesis
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
EP1033375A4 (en) 1997-11-20 2002-04-24 Ikuo Yamashina MODIFICATION OF LOW MOLECULAR MASS HEPARIN AND REMEDY FOR SKIN Ulcer
DE69931038T2 (de) 1998-02-26 2006-11-23 Seikagaku Corp. Neue polysaccharidderivate, verfahren zu ihrer herstellung und medizinische zusammensetzungen die diese als aktives bestandteil enthalten
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
US20060040896A1 (en) 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
US20070021378A1 (en) 2005-07-22 2007-01-25 The Regents Of The University Of California Heparin compositions and selectin inhibition
JP2008120441A (ja) * 2006-11-15 2008-05-29 Maruichi Valve Co Ltd エアゾール容器用噴射装置
CN100467493C (zh) * 2007-02-01 2009-03-11 高树华 一种低分子量肝素钙生产工艺
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
CA2703848C (en) 2007-11-02 2016-10-11 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
BR112014014454B1 (pt) * 2011-12-19 2021-03-09 Dilafor Ab glicosaminoglicanos não anti-coagulativos compreendendo unidade de dissacarìdo repetida e seus usos médicos
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
JP2018034714A (ja) * 2016-09-01 2018-03-08 日立金属株式会社 車両用ホイール

Also Published As

Publication number Publication date
PT3010940T (pt) 2017-11-14
CA2914256A1 (en) 2014-12-24
HK1220475A1 (en) 2017-05-05
IL242888B (en) 2018-08-30
HUE037037T2 (hu) 2018-08-28
CA2914256C (en) 2021-03-02
US10023659B2 (en) 2018-07-17
ES2646337T3 (es) 2017-12-13
CN105324398B (zh) 2018-06-01
GB201310928D0 (en) 2013-07-31
EP3010940B1 (en) 2017-08-09
GB2515315A (en) 2014-12-24
WO2014202982A1 (en) 2014-12-24
EP3010940A1 (en) 2016-04-27
JP2016522302A (ja) 2016-07-28
CN105324398A (zh) 2016-02-10
DK3010940T3 (en) 2017-10-30
LT3010940T (lt) 2017-09-25
JP6378328B2 (ja) 2018-08-22
TWI672146B (zh) 2019-09-21
US20160137754A1 (en) 2016-05-19
TW201534309A (zh) 2015-09-16

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