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PL2912162T3 - Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów - Google Patents

Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów

Info

Publication number
PL2912162T3
PL2912162T3 PL13849948T PL13849948T PL2912162T3 PL 2912162 T3 PL2912162 T3 PL 2912162T3 PL 13849948 T PL13849948 T PL 13849948T PL 13849948 T PL13849948 T PL 13849948T PL 2912162 T3 PL2912162 T3 PL 2912162T3
Authority
PL
Poland
Prior art keywords
pichia pastoris
glycan structure
pastoris strains
producing predominantly
predominantly homogeneous
Prior art date
Application number
PL13849948T
Other languages
English (en)
Inventor
Kurt R. Gehlsen
Thomas G. Chappell
Original Assignee
Research Corporation Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corporation Technologies, Inc. filed Critical Research Corporation Technologies, Inc.
Publication of PL2912162T3 publication Critical patent/PL2912162T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477Hemicellulases not provided in a preceding group
    • C12N9/2488Mannanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01232Initiation-specific alpha-1,6-mannosyltransferase (2.4.1.232)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0113Glycoprotein endo-alpha-1,2-mannosidase (3.2.1.130)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
PL13849948T 2012-10-23 2013-10-23 Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów PL2912162T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717423P 2012-10-23 2012-10-23
EP13849948.8A EP2912162B1 (en) 2012-10-23 2013-10-23 Pichia pastoris strains for producing predominantly homogeneous glycan structure
PCT/US2013/066335 WO2014066479A1 (en) 2012-10-23 2013-10-23 Pichia pastoris strains for producing predominantly homogeneous glycan structure

Publications (1)

Publication Number Publication Date
PL2912162T3 true PL2912162T3 (pl) 2018-06-29

Family

ID=50545207

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13849948T PL2912162T3 (pl) 2012-10-23 2013-10-23 Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów

Country Status (14)

Country Link
US (7) US9617550B2 (pl)
EP (1) EP2912162B1 (pl)
JP (1) JP6407872B2 (pl)
KR (1) KR102179986B1 (pl)
CN (2) CN110438023A (pl)
AU (1) AU2013334652B2 (pl)
CA (1) CA2889202C (pl)
DK (1) DK2912162T3 (pl)
ES (1) ES2654664T3 (pl)
IL (1) IL238401B (pl)
NO (1) NO3011258T3 (pl)
PL (1) PL2912162T3 (pl)
PT (1) PT2912162T (pl)
WO (1) WO2014066479A1 (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2912162T3 (pl) 2012-10-23 2018-06-29 Research Corporation Technologies, Inc. Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów
WO2015100058A1 (en) 2013-12-23 2015-07-02 Research Corporation Technologies, Inc. Pichia pastoris surface display system
US11518797B2 (en) 2014-11-11 2022-12-06 Clara Foods Co. Methods and compositions for egg white protein production
GB201421343D0 (en) * 2014-12-02 2015-01-14 VIB VZW and Universiteit Gent Improved production of lipase in yeast
CN106191041B (zh) * 2015-04-30 2020-12-29 杭州菁因康生物科技有限公司 基因打靶方法
JP6912781B2 (ja) * 2016-05-03 2021-08-04 ブイアイビー ブイゼットダブリュVib Vzw 操作された真菌宿主に由来する複合グリカンを産生するための手段および方法
CN109082444A (zh) * 2018-07-30 2018-12-25 惠州卫生职业技术学院 一种毕赤酵母高效基因敲除方法
CN109749949A (zh) * 2019-03-08 2019-05-14 中国人民解放军军事科学院军事医学研究院 一种重组酵母细胞的构建方法及其在制备低糖基化抗体中的应用
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
BR112022000545A2 (pt) 2019-07-11 2022-04-05 Clara Foods Co Composições de proteína e produtos de consumo destas
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
AU2022318574B2 (en) * 2021-07-30 2024-03-21 Helaina, Inc. Methods and compositions for protein synthesis and secretion
WO2024032891A1 (en) * 2022-08-11 2024-02-15 Vib Vzw Glyco-engineered yeast for therapeutic protein production

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7029872B2 (en) 2000-06-28 2006-04-18 Glycofi, Inc Methods for producing modified glycoproteins
ES2316462T3 (es) 2000-06-30 2009-04-16 Vib Vzw Modificacion de glicosilacion de proteina en pichia pastoris.
US7507573B2 (en) * 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
US20110092374A1 (en) 2009-10-16 2011-04-21 Vib, Vzw Methods for producing substantially homogeneous hybrid or complex n-glycans in methylotrophic yeasts
US9187552B2 (en) * 2010-05-27 2015-11-17 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
PL2912162T3 (pl) 2012-10-23 2018-06-29 Research Corporation Technologies, Inc. Szczepy Pichia pastoris do wytwarzania głównie homogennych struktur glikanów

Also Published As

Publication number Publication date
US10329572B2 (en) 2019-06-25
CN110438023A (zh) 2019-11-12
US20250304980A1 (en) 2025-10-02
IL238401A0 (en) 2015-06-30
DK2912162T3 (en) 2018-03-05
EP2912162A1 (en) 2015-09-02
US10612033B2 (en) 2020-04-07
US20200190526A1 (en) 2020-06-18
ES2654664T3 (es) 2018-02-14
US20190256860A1 (en) 2019-08-22
US20150267212A1 (en) 2015-09-24
US20240352472A1 (en) 2024-10-24
CN104797703A (zh) 2015-07-22
KR20150081271A (ko) 2015-07-13
CA2889202C (en) 2023-01-10
EP2912162A4 (en) 2016-06-15
IL238401B (en) 2019-07-31
AU2013334652B2 (en) 2019-02-21
WO2014066479A1 (en) 2014-05-01
CA2889202A1 (en) 2014-05-01
AU2013334652A1 (en) 2015-05-14
US9617550B2 (en) 2017-04-11
JP2016503292A (ja) 2016-02-04
EP2912162B1 (en) 2017-12-13
US20170166910A1 (en) 2017-06-15
JP6407872B2 (ja) 2018-10-17
NO3011258T3 (pl) 2018-07-21
US11220692B2 (en) 2022-01-11
PT2912162T (pt) 2018-02-15
US20220145311A1 (en) 2022-05-12
US12359211B2 (en) 2025-07-15
KR102179986B1 (ko) 2020-11-17
US11866715B2 (en) 2024-01-09

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