PL2997035T3 - 11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu x - Google Patents

11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu x

Info

Publication number: PL2997035T3
Authority: PL; Poland
Prior art keywords: farnesoid; hydroxyl; derivatives; substituted; amino acid
Prior art date: 2013-05-14

Application number

PL14723820T

Other languages

English (en)

Inventor

Roberto Pellicciari

Original Assignee

Intercept Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-05-14

Filing date

2014-05-14

Publication date

2018-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50721801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2997035(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-05-14 Application filed by Intercept Pharmaceuticals, Inc. filed Critical Intercept Pharmaceuticals, Inc.

2018-10-31 Publication of PL2997035T3 publication Critical patent/PL2997035T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL14723820T 2013-05-14 2014-05-14 11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu x PL2997035T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361823169P	2013-05-14	2013-05-14
PCT/EP2014/059896 WO2014184271A1 (en)	2013-05-14	2014-05-14	11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
EP14723820.8A EP2997035B8 (en)	2013-05-14	2014-05-14	11-hydroxyl-6-substituted-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

Publications (1)

Publication Number	Publication Date
PL2997035T3 true PL2997035T3 (pl)	2018-10-31

Family

ID=50721801

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL14723820T PL2997035T3 (pl)	2013-05-14	2014-05-14	11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu x
PL18163622T PL3360881T3 (pl)	2013-05-14	2014-05-14	11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidowych X
PL18163623T PL3360882T3 (pl)	2013-05-14	2014-05-14	11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu X

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PL18163622T PL3360881T3 (pl)	2013-05-14	2014-05-14	11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidowych X
PL18163623T PL3360882T3 (pl)	2013-05-14	2014-05-14	11-hydroksy-6-podstawione pochodne kwasów żółciowych i ich koniugaty aminokwasowe jako modulatory receptorów farnezoidu X

Country Status (37)

Country	Link
US (7)	US9611289B2 (pl)
EP (4)	EP3848038B1 (pl)
JP (2)	JP6326131B2 (pl)
KR (1)	KR102229952B1 (pl)
CN (2)	CN105377870B (pl)
AU (1)	AU2014267324B2 (pl)
BR (1)	BR112015028399B1 (pl)
CA (1)	CA2912139C (pl)
CL (2)	CL2015003344A1 (pl)
CR (1)	CR20150643A (pl)
CY (1)	CY1122614T1 (pl)
DK (4)	DK3360881T3 (pl)
EA (1)	EA030152B1 (pl)
ES (4)	ES2671427T3 (pl)
GT (1)	GT201500324A (pl)
HR (1)	HRP20180931T1 (pl)
HU (1)	HUE037996T2 (pl)
IL (2)	IL242555B (pl)
LT (1)	LT2997035T (pl)
MA (1)	MA38647B1 (pl)
ME (1)	ME03082B (pl)
MX (1)	MX352065B (pl)
MY (1)	MY187886A (pl)
NI (1)	NI201500160A (pl)
PE (2)	PE20160665A1 (pl)
PH (1)	PH12015502576B1 (pl)
PL (3)	PL2997035T3 (pl)
PT (3)	PT3360881T (pl)
RS (1)	RS57372B1 (pl)
SA (1)	SA515370140B1 (pl)
SG (1)	SG11201509352XA (pl)
SI (3)	SI3360881T1 (pl)
SM (1)	SMT201800326T1 (pl)
TN (1)	TN2015000497A1 (pl)
TR (1)	TR201809041T4 (pl)
UA (1)	UA118673C2 (pl)
WO (1)	WO2014184271A1 (pl)

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2014
- 2014-05-14 CN CN201480036949.5A patent/CN105377870B/zh active Active
- 2014-05-14 KR KR1020157034951A patent/KR102229952B1/ko active Active
- 2014-05-14 EP EP20211780.0A patent/EP3848038B1/en active Active
- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 SI SI201431742T patent/SI3360881T1/sl unknown
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 SI SI201430701T patent/SI2997035T1/sl unknown
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- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 RS RS20180690A patent/RS57372B1/sr unknown
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- 2014-05-14 EP EP18163622.6A patent/EP3360881B1/en active Active
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- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 TR TR2018/09041T patent/TR201809041T4/tr unknown
- 2014-05-14 HU HUE14723820A patent/HUE037996T2/hu unknown
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
- 2014-05-14 CA CA2912139A patent/CA2912139C/en active Active
- 2014-05-14 HR HRP20180931TT patent/HRP20180931T1/hr unknown
- 2014-05-14 DK DK18163623.4T patent/DK3360882T3/da active
- 2014-05-14 EA EA201592055A patent/EA030152B1/ru unknown
- 2014-05-14 ES ES18163623T patent/ES2843737T3/es active Active
- 2014-05-14 PL PL18163623T patent/PL3360882T3/pl unknown
- 2014-05-14 PE PE2020000355A patent/PE20200844A1/es unknown
- 2014-05-14 SM SM20180326T patent/SMT201800326T1/it unknown
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2016
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2018
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Also Published As

Publication number	Publication date
ME03082B (me)	2019-01-20
MA38647B1 (fr)	2019-05-31
DK3360881T3 (da)	2021-03-15
IL272718A (en)	2020-04-30
PT3360881T (pt)	2021-02-19
EP2997035B1 (en)	2018-03-28
US20230233581A1 (en)	2023-07-27
US10532061B2 (en)	2020-01-14
EP2997035A1 (en)	2016-03-23
EP3360881A1 (en)	2018-08-15
SI2997035T1 (sl)	2018-10-30
SI3360881T1 (sl)	2021-06-30
CA2912139C (en)	2021-04-20
BR112015028399B1 (pt)	2021-11-16
US20190209586A1 (en)	2019-07-11
IL242555A0 (en)	2016-02-01
EP3360882A1 (en)	2018-08-15
ES2843737T3 (es)	2021-07-20
PT3360882T (pt)	2021-02-12
HUE037996T2 (hu)	2018-09-28
AU2014267324A1 (en)	2015-11-26
PE20200844A1 (es)	2020-08-18
HK1221471A1 (zh)	2017-06-02
US20200297739A1 (en)	2020-09-24
ES2671427T3 (es)	2018-06-06
LT2997035T (lt)	2018-08-10
US9611289B2 (en)	2017-04-04
MX352065B (es)	2017-11-08
PH12015502576B1 (en)	2018-09-12
CA2912139A1 (en)	2014-11-20
CN105377870B (zh)	2018-04-03
EP3848038A1 (en)	2021-07-14
DK3848038T3 (da)	2023-02-06
HK1253326A1 (zh)	2019-06-14
DK2997035T3 (en)	2018-07-02
IL272718B (en)	2020-11-30
PE20160665A1 (es)	2016-08-07
KR102229952B1 (ko)	2021-03-22
CN108245523B (zh)	2021-03-26
TN2015000497A1 (en)	2017-04-06
SA515370140B1 (ar)	2017-04-11
PL3360882T3 (pl)	2021-10-25
CN108245523A (zh)	2018-07-06
UA118673C2 (uk)	2019-02-25
US20170216316A1 (en)	2017-08-03
JP2018127481A (ja)	2018-08-16
NZ714082A (en)	2021-02-26
WO2014184271A1 (en)	2014-11-20
CN105377870A (zh)	2016-03-02
SG11201509352XA (en)	2015-12-30
CL2015003344A1 (es)	2016-07-15
EA030152B1 (ru)	2018-06-29
EP2997035B8 (en)	2018-05-23
CY1122614T1 (el)	2020-07-31
ES2847002T3 (es)	2021-07-30
IL242555B (en)	2020-04-30
EP3360881B1 (en)	2020-12-09
US20140371190A1 (en)	2014-12-18
CR20150643A (es)	2016-06-01
BR112015028399A2 (pt)	2017-07-25
PH12015502576A1 (en)	2016-02-29
AU2014267324B2 (en)	2017-11-02
TR201809041T4 (tr)	2018-07-23
US11000532B2 (en)	2021-05-11
GT201500324A (es)	2017-09-28
PL3360881T3 (pl)	2021-11-15
DK3360882T3 (da)	2021-03-08
CL2016001809A1 (es)	2017-01-27
US20240398834A1 (en)	2024-12-05
EP3360882B1 (en)	2020-12-09
EA201592055A1 (ru)	2016-11-30
KR20160007586A (ko)	2016-01-20
SMT201800326T1 (it)	2018-07-17
JP2016518429A (ja)	2016-06-23
MY187886A (en)	2021-10-26
RS57372B1 (sr)	2018-08-31
US20210228599A1 (en)	2021-07-29
ES2936638T3 (es)	2023-03-21
HRP20180931T1 (hr)	2018-10-05
NI201500160A (es)	2016-01-04
SI3360882T1 (sl)	2021-06-30
PT2997035T (pt)	2018-07-18
JP6326131B2 (ja)	2018-05-16
EP3848038B1 (en)	2022-11-09

Publication	Publication Date	Title
IL272718B (en)	2020-11-30	History of 11-hydroxyl of bile acids and their conjugates with amino acid as paranoid x receptor modulators
SG11201604697TA (en)	2016-07-28	Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
IL240727B (en)	2019-12-31	Peptides and compositions for the treatment of vertebral damage
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IL227890A0 (en)	2014-01-30	Antiaging compounds containing bile acid and fatty acid conjugates
PL2814463T3 (pl)	2016-11-30	Okulistyczne kompozycje farmaceutyczne i sposoby ich wytwarzania i stosowania
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EP2819752A4 (en)	2016-03-09	USE OF MODULATORS OF CPT-1 AND ASSOCIATED COMPOSITIONS
EP3004132A4 (en)	2017-01-18	Bile acid-basic amino acid conjugates and uses thereof
IL240734A0 (en)	2015-10-29	Methods and compositions for preparing nucleic acids
EP2808019A4 (en)	2015-06-10	IMPROVED NITAZOXANIDE COMPOSITION AND PROCESS FOR PREPARING THE SAME
TH1501006859A (th)	2017-07-27	อนุพันธ์ 11-ไฮดรอกซิลและกรดน้ำดีและสารควบคู่กรดอะมิโนของสิ่งนั้นในฐานะ ตัวควบคุมปรับสภาพฟาร์นีซอยด์ x รีเซพเตอร์
GB201202497D0 (en)	2012-03-28	Medicinal applications of substituted hydroxytetronic acids