[go: up one dir, main page]

PL2965749T3 - Zawiesiny nanocząsteczkowe zawierające polimer karboksywinylowy - Google Patents

Zawiesiny nanocząsteczkowe zawierające polimer karboksywinylowy

Info

Publication number
PL2965749T3
PL2965749T3 PL15179323T PL15179323T PL2965749T3 PL 2965749 T3 PL2965749 T3 PL 2965749T3 PL 15179323 T PL15179323 T PL 15179323T PL 15179323 T PL15179323 T PL 15179323T PL 2965749 T3 PL2965749 T3 PL 2965749T3
Authority
PL
Poland
Prior art keywords
carboxyvinyl polymer
containing nanoparticle
nanoparticle suspensions
suspensions
carboxyvinyl
Prior art date
Application number
PL15179323T
Other languages
English (en)
Inventor
Masood A. Chowhan
Malay Ghosh
Wesley Weshin HAN
Bahram Asgharian
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43425837&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2965749(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2965749T3 publication Critical patent/PL2965749T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
PL15179323T 2009-12-03 2010-12-01 Zawiesiny nanocząsteczkowe zawierające polimer karboksywinylowy PL2965749T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26636809P 2009-12-03 2009-12-03
EP10787650.0A EP2506831B1 (en) 2009-12-03 2010-12-01 Carboxyvinyl polymer-containing nanoparticle suspensions
EP13152584.2A EP2586426B1 (en) 2009-12-03 2010-12-01 Carboxyvinyl polymer-containing nanoparticle suspensions
EP15179323.9A EP2965749B1 (en) 2009-12-03 2010-12-01 Carboxyvinyl polymer-containing nanoparticle suspensions

Publications (1)

Publication Number Publication Date
PL2965749T3 true PL2965749T3 (pl) 2018-10-31

Family

ID=43425837

Family Applications (3)

Application Number Title Priority Date Filing Date
PL15179323T PL2965749T3 (pl) 2009-12-03 2010-12-01 Zawiesiny nanocząsteczkowe zawierające polimer karboksywinylowy
PL13152584T PL2586426T3 (pl) 2009-12-03 2010-12-01 Zawiesiny zawierające nanocząsteczkowe polimery karboksywinylowe
PL10787650T PL2506831T3 (pl) 2009-12-03 2010-12-01 Zawiesiny zawierające nanocząsteczkowe polimery karbowinylowe

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL13152584T PL2586426T3 (pl) 2009-12-03 2010-12-01 Zawiesiny zawierające nanocząsteczkowe polimery karboksywinylowe
PL10787650T PL2506831T3 (pl) 2009-12-03 2010-12-01 Zawiesiny zawierające nanocząsteczkowe polimery karbowinylowe

Country Status (27)

Country Link
US (3) US8921337B2 (pl)
EP (3) EP2965749B1 (pl)
JP (3) JP5864433B2 (pl)
KR (2) KR101809484B1 (pl)
CN (1) CN102724965B (pl)
AR (2) AR080572A1 (pl)
AU (1) AU2010326099B2 (pl)
BR (1) BR112012013503B8 (pl)
CA (1) CA2781254C (pl)
CL (1) CL2012001402A1 (pl)
CY (1) CY1120585T1 (pl)
DK (3) DK2506831T3 (pl)
ES (3) ES2550942T3 (pl)
HR (2) HRP20140016T1 (pl)
HU (2) HUE038821T2 (pl)
LT (1) LT2965749T (pl)
MX (1) MX2012006231A (pl)
PH (1) PH12012501111A1 (pl)
PL (3) PL2965749T3 (pl)
PT (3) PT2506831E (pl)
RS (2) RS53085B (pl)
RU (1) RU2571078C2 (pl)
SI (3) SI2586426T1 (pl)
TW (1) TWI486178B (pl)
UY (1) UY33081A (pl)
WO (1) WO2011068872A2 (pl)
ZA (1) ZA201203770B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435631B2 (en) * 2010-04-15 2013-05-07 Ppg Industries Ohio, Inc. Microporous material
KR101956936B1 (ko) * 2010-07-20 2019-03-11 씨-아이피 에스.에이. 붕소 화합물 현탁액
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
KR20150046300A (ko) * 2012-08-31 2015-04-29 보오슈 앤드 롬 인코포레이팃드 오메가-3 지방산을 함유하는 안과용 조성물
EP3013790A1 (en) 2013-06-27 2016-05-04 Mylan Laboratories Ltd. Process for the preparation of nepafenac
US20150191647A1 (en) * 2014-01-07 2015-07-09 Trican Well Service Ltd. Stability of viscous fluids in low salinity environments
PT3721868T (pt) 2015-01-26 2022-08-12 Bausch & Lomb Composição para suspensão oftálmica
EP3310363A4 (en) * 2015-06-18 2019-02-13 Common Pharma, Inc ANTIMICROBIAL FORMULATIONS
US11730699B2 (en) 2018-02-21 2023-08-22 Alcon Inc. Lipid-based ophthalmic emulsion
TW202535338A (zh) * 2018-02-21 2025-09-16 瑞士商愛爾康公司 基於脂質的眼用乳劑
CN115770299A (zh) * 2022-12-15 2023-03-10 佛山市正典生物技术有限公司 改善含瓜尔胶的水悬浮液颜色的组合物及其制备方法和用途

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864183A (en) * 1972-11-21 1975-02-04 Tokyo Hat Method for producing pen core from filament tows
US4313949A (en) 1979-09-26 1982-02-02 A. H. Robins Company, Inc. Method of producing an inhibitory effect on blood platelet aggregation
IL80298A (en) 1986-10-14 1993-01-31 Res & Dev Co Ltd Eye drops
US5188826A (en) 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5461081A (en) 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5429824A (en) 1992-12-15 1995-07-04 Eastman Kodak Company Use of tyloxapole as a nanoparticle stabilizer and dispersant
US5475034A (en) 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
FR2761959B1 (fr) * 1997-04-15 1999-05-21 Oreal Ensemble de conditionnement et d'application d'un produit fluide
CN100408100C (zh) * 1997-07-29 2008-08-06 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
IT1306123B1 (it) 1999-04-02 2001-05-30 Technopharma Sa Soluzione oftalmica viscosizzata con azione detergente sulle lenti acontatto.
ITMI991453A1 (it) 1999-07-01 2001-01-01 Farmila Farma Milano Composizioni oftalmiche in forma di gel acquosi
CZ20022047A3 (cs) 1999-12-23 2003-09-17 Pfizer Products Inc. Farmaceutické kompozice poskytující zvýšenou koncentraci léčiva
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
HUP0400264A2 (hu) 2001-06-22 2004-08-30 Pfizer Products Inc. Alacsony oldékonyságú és/vagy savra érzékeny hatóanyagokat és semlegesített savas polimereket tartalmazó gyógyszerkészítmények és eljárás az előállításukra
WO2003035080A2 (en) 2001-08-28 2003-05-01 Ranbaxy Laboratories Limited A process for the preparation of pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors
US7045121B2 (en) 2001-12-14 2006-05-16 Allergan, Inc. Ophthalmic compositions for lubricating eyes and methods for making and using same
CA2477044A1 (en) * 2002-02-22 2003-09-04 Pharmacia Corporation Ophthalmic formulation with gum system
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
US7947295B2 (en) 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US8512717B2 (en) 2003-08-07 2013-08-20 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using same
FR2865648B1 (fr) 2004-02-03 2006-06-30 Philippe Perovitch Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
US20080145430A1 (en) 2004-12-08 2008-06-19 Santipharp Panmai Ophthalmic Nanoparticulate Formulation Of A Cyclooxygenase-2 Selective Inhibitor
TWI393567B (zh) 2005-03-31 2013-04-21 Bausch & Lomb 治療乾眼之組合物及相關之製造方法及使用方法
JP4257860B2 (ja) * 2005-04-19 2009-04-22 中得工業株式会社 化粧材の塗布具
WO2006121964A2 (en) * 2005-05-10 2006-11-16 Alcon, Inc. Ophthalmic suspension comprising an ophthalmic drug, a poloxamine and a glycol tonicity-adjusting agent, use of said composition for the manufacture of a medicament for treating ophthalmic disorders
PT1885336E (pt) 2005-05-10 2009-05-07 Alcon Inc Formulações de suspensão compreendendo um princípio activo, um tensoactivo poloxâmero ou meroxapol e um glicol, sua utilização no fabrico de um medicamento para tratamento de distúrbios oftálmicos
AU2006254825A1 (en) 2005-06-08 2006-12-14 Targegen, Inc. Methods and compositions for the treatment of ocular disorders
JP5112669B2 (ja) * 2005-09-30 2013-01-09 富山化学工業株式会社 難溶性薬物のナノ微粒子を含有する水性懸濁液剤
US20070110812A1 (en) 2005-11-14 2007-05-17 Bausch & Lomb Incorporated Ophthalmic composition for dry eye therapy
CA2636646A1 (en) 2006-01-25 2007-08-02 Aciex, Inc. Formulations and methods for treating dry eye
US20070297981A1 (en) 2006-01-25 2007-12-27 Ousler George W Iii Formulations and methods for treating dry eye
US20080039398A1 (en) 2006-01-25 2008-02-14 Ousler George W Iii Formulations and methods for treating dry eye
US20070299124A1 (en) 2006-01-25 2007-12-27 Ousler George W Iii Formulations and methods for treating dry eye
US20090010850A1 (en) 2007-05-24 2009-01-08 Ousler Iii George W Formulations and methods for treating dry eye
US20080181957A1 (en) 2006-06-23 2008-07-31 Min Wei Increased amorphous stability of poorly water soluble drugs by nanosizing
US20080260837A1 (en) 2007-04-20 2008-10-23 Qpharma, L.L.C. Physically stable aqueous suspensions of active pharmaceuticals
MX2010011736A (es) * 2008-04-26 2011-01-21 Alcon Res Ltd Sistema polimérico de lágrimas artificiales.
JP4395189B1 (ja) * 2008-08-29 2010-01-06 株式会社ソリトン 塗布具
KR20110113199A (ko) 2009-02-05 2011-10-14 알콘 리서치, 리미티드 구아의 정제 방법
JP5716960B2 (ja) * 2011-05-23 2015-05-13 オーベクス株式会社 塗布体用素材の製造方法及び塗布体用素材並びに塗布体及び塗布具

Also Published As

Publication number Publication date
SI2586426T1 (sl) 2015-11-30
EP2506831B1 (en) 2013-11-20
EP2586426B1 (en) 2015-09-23
HRP20140016T1 (hr) 2014-01-31
US9662398B2 (en) 2017-05-30
DK2506831T3 (da) 2013-12-16
KR20120099269A (ko) 2012-09-07
KR101543613B1 (ko) 2015-08-11
UY33081A (es) 2011-04-29
JP2013512912A (ja) 2013-04-18
RU2012127675A (ru) 2014-01-20
WO2011068872A3 (en) 2012-01-12
RS53085B (sr) 2014-06-30
HUE038821T2 (hu) 2018-11-28
CL2012001402A1 (es) 2014-03-28
LT2965749T (lt) 2018-08-10
PT2506831E (pt) 2014-01-08
US20110135743A1 (en) 2011-06-09
ZA201203770B (en) 2013-08-28
BR112012013503A2 (pt) 2016-06-07
CN102724965A (zh) 2012-10-10
ES2684752T3 (es) 2018-10-04
WO2011068872A8 (en) 2013-04-04
AR080572A1 (es) 2012-04-18
HK1170164A1 (en) 2013-02-22
JP2016106155A (ja) 2016-06-16
HK1217091A1 (en) 2016-12-23
HRP20181337T1 (hr) 2018-10-19
EP2965749B1 (en) 2018-05-23
PL2586426T3 (pl) 2016-01-29
PH12012501111A1 (en) 2016-09-09
EP2506831A2 (en) 2012-10-10
PT2586426E (pt) 2015-11-17
PL2506831T3 (pl) 2014-05-30
US20150072011A1 (en) 2015-03-12
US8921337B2 (en) 2014-12-30
AU2010326099A1 (en) 2012-07-19
CN102724965B (zh) 2015-08-05
AU2010326099B2 (en) 2013-03-07
TWI486178B (zh) 2015-06-01
KR101809484B1 (ko) 2017-12-15
CY1120585T1 (el) 2019-07-10
EP2965749A1 (en) 2016-01-13
JP2015061886A (ja) 2015-04-02
DK2586426T3 (en) 2015-11-23
BR112012013503B1 (pt) 2021-04-20
HK1178802A1 (en) 2013-09-19
CA2781254A1 (en) 2011-06-09
PT2965749T (pt) 2018-10-09
RS57465B1 (sr) 2018-09-28
CA2781254C (en) 2016-06-28
RU2571078C2 (ru) 2015-12-20
ES2550942T3 (es) 2015-11-13
AR122463A2 (es) 2022-09-14
JP6055849B2 (ja) 2016-12-27
MX2012006231A (es) 2012-07-03
TW201129395A (en) 2011-09-01
SI2965749T1 (sl) 2018-09-28
US20170020818A1 (en) 2017-01-26
HUE025838T2 (en) 2016-04-28
DK2965749T3 (en) 2018-08-27
JP5864433B2 (ja) 2016-02-17
BR112012013503B8 (pt) 2021-05-25
WO2011068872A2 (en) 2011-06-09
KR20150063587A (ko) 2015-06-09
SI2506831T1 (sl) 2014-01-31
EP2586426A1 (en) 2013-05-01
ES2441420T3 (es) 2014-02-04

Similar Documents

Publication Publication Date Title
HRP20181337T1 (hr) Suspenzije nanočestica koje sadrže karboksivinilni polimer
GB201005601D0 (en) Ecapsulated nanoparticles
ZA201107131B (en) Polymer particles
GB0714865D0 (en) Nanoparticles
EP2423009A4 (en) SUSPENSION DEVICE
IL216066A0 (en) Suspension device
EP2323947A4 (en) DISPERSABLE NANOPARTICLES IN WATER
ZA201106237B (en) Polymer particles
ZA201106673B (en) Hindered-settling fluid classifier
GB0906367D0 (en) Security document
EP2464786A4 (en) HIGH-TIGHT PAPER
GB0913297D0 (en) Security document
GB0811170D0 (en) Nanoparticles
GB201018120D0 (en) Security document
GB201016568D0 (en) Security arrangement
GB0905232D0 (en) Nanoparticles
GB0815308D0 (en) Nanoparticles
GB0907587D0 (en) Kode-kit securities
GB0914906D0 (en) Suspension arrangement
HU0900007V0 (en) Cheque
SI2311646T1 (sl) Vrednostni dokument
AU2009904603A0 (en) Improved Shackle
GB0921004D0 (en) Suspension biasing
GB0813878D0 (en) Biocapsulate suspensions
TWM370595U (en) Suspension device