PL2832740T3 - Sól 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranozylo)cytozyny - Google Patents
Sól 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranozylo)cytozynyInfo
- Publication number
- PL2832740T3 PL2832740T3 PL13770090T PL13770090T PL2832740T3 PL 2832740 T3 PL2832740 T3 PL 2832740T3 PL 13770090 T PL13770090 T PL 13770090T PL 13770090 T PL13770090 T PL 13770090T PL 2832740 T3 PL2832740 T3 PL 2832740T3
- Authority
- PL
- Poland
- Prior art keywords
- arabinofuranosyl
- deoxy
- cytosine
- thio
- fluoro
- Prior art date
Links
- NIDPJRZOVFIBQB-PXBUCIJWSA-N 4-amino-1-[(2r,3s,4s,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)S1 NIDPJRZOVFIBQB-PXBUCIJWSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012074525 | 2012-03-28 | ||
| JP2013050846 | 2013-03-13 | ||
| PCT/JP2013/058896 WO2013146833A1 (ja) | 2012-03-28 | 2013-03-27 | １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩 |
| EP13770090.2A EP2832740B1 (en) | 2012-03-28 | 2013-03-27 | SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL)CYTOSINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2832740T3 true PL2832740T3 (pl) | 2019-09-30 |
Family
ID=49260082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13770090T PL2832740T3 (pl) | 2012-03-28 | 2013-03-27 | Sól 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranozylo)cytozyny |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9896471B2 (pl) |
| EP (1) | EP2832740B1 (pl) |
| JP (1) | JP5833225B2 (pl) |
| KR (2) | KR101770246B1 (pl) |
| CN (1) | CN104203969B (pl) |
| AU (1) | AU2013241341B2 (pl) |
| BR (1) | BR112014020416B1 (pl) |
| CA (2) | CA2943998C (pl) |
| DK (1) | DK2832740T3 (pl) |
| ES (1) | ES2730679T3 (pl) |
| IL (1) | IL234222A (pl) |
| MX (2) | MX352423B (pl) |
| NZ (1) | NZ701245A (pl) |
| PL (1) | PL2832740T3 (pl) |
| RU (1) | RU2600734C2 (pl) |
| SG (2) | SG10201603288XA (pl) |
| TW (1) | TWI637963B (pl) |
| WO (1) | WO2013146833A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102010804B1 (ko) | 2012-08-13 | 2019-08-14 | 후지필름 가부시키가이샤 | 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법 |
| EP3109245B1 (en) | 2014-02-18 | 2018-01-03 | FUJIFILM Corporation | Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| JP6450356B2 (ja) | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
| TWI787201B (zh) * | 2016-08-31 | 2022-12-21 | 日商富士軟片股份有限公司 | 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用套組 |
| CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| WO2019176984A1 (ja) | 2018-03-13 | 2019-09-19 | 富士フイルム株式会社 | 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット |
| CA3110224A1 (en) | 2018-09-25 | 2020-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof |
| KR102106096B1 (ko) | 2019-08-19 | 2020-04-29 | 이명준 | 경추 지압 마사지기 |
| KR20240028451A (ko) | 2021-07-29 | 2024-03-05 | 후지필름 가부시키가이샤 | Bap1 및 pbrm1 중 적어도 하나의 기능 저하를 갖는 종양에 대한 의약 조성물 및 항종양제 |
| KR102454186B1 (ko) | 2022-05-23 | 2022-10-14 | 이명준 | 경추 지압장치 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
| US3243425A (en) | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
| JPS5148682A (ja) * | 1974-10-15 | 1976-04-26 | Asahi Chemical Ind | Nukureochidojudotainoseiho |
| JPS53119810A (en) | 1977-03-25 | 1978-10-19 | Mitsubishi Chem Ind Ltd | Preparation of aldehyde chloride |
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| US4220774A (en) | 1978-10-26 | 1980-09-02 | Omnium Chimique | Vincadifformine synthesis process |
| JPS5692239A (en) | 1979-12-27 | 1981-07-25 | Sagami Chem Res Center | Preparation of 5-oxohexyl compound |
| US4803272A (en) | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
| IE74701B1 (en) | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| SE9003151D0 (sv) | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| FI105556B (fi) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
| JP3138834B2 (ja) | 1991-12-26 | 2001-02-26 | 生化学工業株式会社 | フコピラノース類縁体の製造方法およびその合成中間化合物 |
| GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
| GB9515279D0 (en) * | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
| WO1996001834A1 (en) | 1994-07-12 | 1996-01-25 | Yamasa Corporation | 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside |
| JPH0853490A (ja) | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド |
| ES2182061T3 (es) * | 1996-04-09 | 2003-03-01 | Yamasa Corp | 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. |
| JP4202327B2 (ja) | 1996-04-09 | 2008-12-24 | ヤマサ醤油株式会社 | １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン |
| EP0839813A1 (en) | 1996-04-09 | 1998-05-06 | Yamasa Corporation | 9-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)purine derivatives |
| US7875733B2 (en) | 2003-09-18 | 2011-01-25 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
| HUP9601756A3 (en) | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
| JP4087471B2 (ja) | 1997-03-31 | 2008-05-21 | 大日本印刷株式会社 | 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法 |
| HUP9702348A3 (en) | 1997-12-04 | 2000-12-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them |
| WO1999043690A1 (en) | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | L-4'-arabinofuranonucleoside compound and medicine composition comprising the same |
| ES2402799T3 (es) | 1998-07-23 | 2013-05-09 | Southern Research Institute | Prepreparación de compuestos de tioarabinofuranosilo y utilización de los mismos |
| WO2001066118A1 (en) | 2000-03-08 | 2001-09-13 | Southern Research Institute | 4'-thio-l-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof |
| KR100426030B1 (ko) | 2000-07-22 | 2004-04-03 | (주) 한켐 | 락톤계 당화합물에서의 키랄성 전환방법 |
| TWI247609B (en) | 2001-01-23 | 2006-01-21 | Nihon Mediphysics Co Ltd | Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease |
| JP2005503358A (ja) | 2001-06-22 | 2005-02-03 | フアーマセツト・リミテツド | β−２’−または３’−ハロヌクレオシド |
| JP2003172990A (ja) | 2001-08-03 | 2003-06-20 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤及びハロゲン化銀写真感光材料 |
| RU2322449C2 (ru) | 2002-08-09 | 2008-04-20 | Тайсо Фармасьютикал Ко., Лтд. | ПРОИЗВОДНЫЕ АРИЛ 5-ТИО-β-D-ГЛЮКОПИРАНОЗИДА И ТЕРАПЕВТИЧЕСКИЕ СРЕДСТВА ПРИ ДИАБЕТЕ, СОДЕРЖАЩИЕ ИХ |
| AU2003200960B2 (en) | 2002-09-18 | 2005-01-06 | Mackinnon, Sebastian Mr | System for Ordering, Tracking and Payment of Goods and Services |
| CA2525099A1 (en) | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
| JPWO2004106280A1 (ja) | 2003-05-28 | 2006-07-20 | 日本たばこ産業株式会社 | ＣａＳＲアンタゴニスト |
| JPWO2004106352A1 (ja) | 2003-05-29 | 2006-07-20 | 大正製薬株式会社 | アルドヘキソピラノース中間体の製造法 |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
| US7858788B2 (en) | 2005-02-21 | 2010-12-28 | Shionogi & Co., Ltd. | Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
| JP2006335737A (ja) | 2005-06-03 | 2006-12-14 | Ihara Nikkei Kagaku Kogyo Kk | ベンゾ［ｃ］ヘテロ５員環化合物の製造方法 |
| US20090069263A1 (en) | 2005-12-16 | 2009-03-12 | Damha Masad J | 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof |
| CN100513395C (zh) | 2006-04-17 | 2009-07-15 | 中国科学院化学研究所 | 一种制备多羟基环状硝酮的方法 |
| ES2600792T3 (es) | 2006-05-03 | 2017-02-10 | Chimerix, Inc. | Alcoxialquilésteres metabólicamente estables de fosfonatos, fosfonatos nucleosídicos y fosfatos nucleosídicos antivirales o antiproliferativos |
| CN101200463B (zh) | 2007-12-11 | 2011-06-22 | 复旦大学 | 全酰化-4-硫代-d-核糖及其制备方法 |
| US8859589B2 (en) | 2008-03-12 | 2014-10-14 | Southern Research Institute | Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents |
| CN101880287B (zh) | 2009-05-05 | 2012-07-25 | 上海医药工业研究院 | 一类四氢噻吩核苷类似物的中间体化合物及其制备方法 |
| FI2431376T4 (fi) * | 2009-05-15 | 2024-03-13 | Delta Fly Pharma Inc | 1-(2'-syano-2'-deoksi-beeta-D-arabinofuranosyyli)sytosiinimonohydrokloridin uusi vakaa kide |
| MY156954A (en) | 2009-12-18 | 2016-04-15 | Libramedicina Inc | PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES |
| DE102010042013A1 (de) | 2010-10-06 | 2012-04-12 | Robert Bosch Gmbh | Verfahren zur Einstellung einer Temperatur eines Sensorelements |
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| JP5776564B2 (ja) | 2012-01-20 | 2015-09-09 | 日本精工株式会社 | ワーク処理装置、及びワーク処理方法 |
| US20140029864A1 (en) | 2012-07-30 | 2014-01-30 | Dror Reif | Compression encoding and decoding method and apparatus |
| KR102010804B1 (ko) | 2012-08-13 | 2019-08-14 | 후지필름 가부시키가이샤 | 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법 |
| EP3109245B1 (en) | 2014-02-18 | 2018-01-03 | FUJIFILM Corporation | Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
| JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
| US10662214B2 (en) | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
-
2013
- 2013-03-27 PL PL13770090T patent/PL2832740T3/pl unknown
- 2013-03-27 ES ES13770090T patent/ES2730679T3/es active Active
- 2013-03-27 NZ NZ701245A patent/NZ701245A/en unknown
- 2013-03-27 KR KR1020147030209A patent/KR101770246B1/ko active Active
- 2013-03-27 MX MX2014011182A patent/MX352423B/es active IP Right Grant
- 2013-03-27 MX MX2017008865A patent/MX370733B/es unknown
- 2013-03-27 KR KR1020177018337A patent/KR20170082650A/ko not_active Ceased
- 2013-03-27 TW TW102110915A patent/TWI637963B/zh active
- 2013-03-27 CN CN201380016308.9A patent/CN104203969B/zh active Active
- 2013-03-27 BR BR112014020416-0A patent/BR112014020416B1/pt active IP Right Grant
- 2013-03-27 EP EP13770090.2A patent/EP2832740B1/en active Active
- 2013-03-27 SG SG10201603288XA patent/SG10201603288XA/en unknown
- 2013-03-27 RU RU2014143277/04A patent/RU2600734C2/ru active
- 2013-03-27 AU AU2013241341A patent/AU2013241341B2/en active Active
- 2013-03-27 CA CA2943998A patent/CA2943998C/en active Active
- 2013-03-27 SG SG11201406080VA patent/SG11201406080VA/en unknown
- 2013-03-27 JP JP2014507938A patent/JP5833225B2/ja active Active
- 2013-03-27 CA CA2865742A patent/CA2865742C/en active Active
- 2013-03-27 WO PCT/JP2013/058896 patent/WO2013146833A1/ja not_active Ceased
- 2013-03-27 DK DK13770090.2T patent/DK2832740T3/da active
-
2014
- 2014-08-21 IL IL234222A patent/IL234222A/en active IP Right Grant
- 2014-09-26 US US14/498,334 patent/US9896471B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL273276A (en) | salt crystals | |
| SG10201603288XA (en) | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine | |
| GB201507921D0 (en) | Mapping cytosine modifications | |
| ZA201606590B (en) | Heterocyclic glutaminase inhibitors | |
| ZA201406225B (en) | Thiadiazolidinediones as gsk-3 inhibitors | |
| ZA201406082B (en) | Use of ccr3-inhibitors | |
| IL238391A (en) | Rock inhibitors | |
| EP2866893A4 (en) | HETEROCYCLIC GUANIDINE F1FO ATPASE INHIBITORS | |
| IL235919A0 (en) | inhibitors of fbxo3 | |
| EP2885291A4 (en) | INHIBITORS OF VEGFR3 | |
| EP2885292A4 (en) | VEGFR3 INHIBITORS | |
| PL2888228T3 (pl) | Inhibitory oddziaływania CD40-TRAF6 | |
| IL239281A0 (en) | Dihydrochloride salt of cubicistat | |
| IL235935A0 (en) | Transmutable kinase inhibitor picolinamides | |
| GB2523919B (en) | Mapping cytosine modifications | |
| GB201201857D0 (en) | Pseudonymisation/de-pseudonymisation of data | |
| GB201217666D0 (en) | Construction of surfaces | |
| IL229411A0 (en) | Using a dinitromethane salt |