PL2812011T3 - Różnicowanie komórek NK z komórek hematopoetycznych CD34<sup>+</sup> ex vivo - Google Patents
Różnicowanie komórek NK z komórek hematopoetycznych CD34<sup>+</sup> ex vivoInfo
- Publication number
- PL2812011T3 PL2812011T3 PL13709575T PL13709575T PL2812011T3 PL 2812011 T3 PL2812011 T3 PL 2812011T3 PL 13709575 T PL13709575 T PL 13709575T PL 13709575 T PL13709575 T PL 13709575T PL 2812011 T3 PL2812011 T3 PL 2812011T3
- Authority
- PL
- Poland
- Prior art keywords
- vivo
- cell differentiation
- hematopoietic cells
- hematopoietic
- cells
- Prior art date
Links
- 230000024245 cell differentiation Effects 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2312—Interleukin-12 (IL-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154554 | 2012-02-08 | ||
| PCT/NL2013/050073 WO2013119118A1 (en) | 2012-02-08 | 2013-02-07 | Ex vivo nk cell differentiation from cd34+ hematopoietic cells |
| EP13709575.8A EP2812011B1 (en) | 2012-02-08 | 2013-02-07 | Ex vivo nk cell differentiation from cd34+ hematopoietic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2812011T3 true PL2812011T3 (pl) | 2020-06-29 |
Family
ID=47884461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13709575T PL2812011T3 (pl) | 2012-02-08 | 2013-02-07 | Różnicowanie komórek NK z komórek hematopoetycznych CD34<sup>+</sup> ex vivo |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20150010583A1 (pl) |
| EP (1) | EP2812011B1 (pl) |
| CA (1) | CA2864283C (pl) |
| DK (1) | DK2812011T3 (pl) |
| ES (1) | ES2771248T3 (pl) |
| PL (1) | PL2812011T3 (pl) |
| WO (1) | WO2013119118A1 (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017014269A2 (pt) * | 2014-12-31 | 2018-03-27 | Anthrogenesis Corp | células exterminadoras naturais e usos das mesmas |
| WO2017042393A1 (en) * | 2015-09-11 | 2017-03-16 | Emercell Sas | Pooled nk cells from umbilical cord blood associated with antibodies and their uses for the treatment of disease |
| WO2017046142A1 (en) * | 2015-09-15 | 2017-03-23 | Stichting Katholieke Universiteit | IMPROVED METHOD FOR EX VIVO EXPANSION CD34+HSPCs INTO NK CELLS USING AN ARYL HYDROCARBON RECEPTOR ANTAGONIST |
| BR112018007538A2 (pt) * | 2015-10-15 | 2018-10-23 | Celularity Inc | células exterminadoras naturais e células ilc3 e usos das mesmas |
| LT3405495T (lt) * | 2016-01-21 | 2021-08-10 | Innate Pharma | Inhibitorių kelių neutralizavimas limfocituose |
| AU2017262581A1 (en) * | 2016-05-07 | 2019-01-03 | Celularity Inc. | Methods of treating acute myeloid leukemia and multiple myeloma using natural killer cells |
| IT201600121081A1 (it) * | 2016-11-29 | 2018-05-29 | Fond Ri Med | Immunoterapia NK-mediata e usi di essa |
| JP6647240B2 (ja) * | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| CN108315299A (zh) * | 2018-02-13 | 2018-07-24 | 南京支云松生物科技有限公司 | 一种即用型异体nk细胞库网络储运应用系统 |
| CA3102055A1 (en) | 2018-05-30 | 2019-12-05 | Glycostem Therapeutics B.V. | Car nk cells |
| KR20210114422A (ko) * | 2018-12-21 | 2021-09-23 | 스템셀 테크놀러지스 캐나다 인크. | 자연살해세포의 분화를 위한 배지 및 방법 |
| JP7213976B2 (ja) | 2019-07-08 | 2023-01-27 | イミュニティーバイオ、インコーポレイテッド | 単核細胞由来のｎｋ細胞 |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| WO2021015615A1 (en) * | 2019-07-22 | 2021-01-28 | Glycostem Therapeutics B.V. | Low density cell culture |
| CN115943214A (zh) * | 2019-11-28 | 2023-04-07 | 格雷克斯迪姆医疗私人有限公司 | 用于获得car-nk细胞的方法 |
| WO2022113056A1 (en) | 2020-11-30 | 2022-06-02 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| CN113416700B (zh) * | 2021-07-09 | 2023-04-11 | 天晴干细胞股份有限公司 | 一种高效的因子分泌型nk细胞扩增方法及其应用 |
| KR102504039B1 (ko) * | 2022-10-25 | 2023-03-02 | 오정훈 | 자연살해세포 증식에 효과적인 배양 방법 및 이의 용도 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090297471A1 (en) * | 2004-05-28 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods For Autologous Stem Cell Transplantation |
| US7915043B2 (en) * | 2005-03-18 | 2011-03-29 | The Ohio State University Research Foundation | CD34(+) cells and their methods of use |
| SI1941027T1 (sl) * | 2005-09-28 | 2014-11-28 | Ipd-Theapeutics B.V. | Postopki in sredstva za proliferacijo zarodnih celic in kasnejšo generacijo in ekspanzijo progenitorskih celic, kot tudi izdelava efektor celic kot kliničnih zdravil |
| DK2142642T3 (en) * | 2007-03-27 | 2017-09-11 | Ipd-Therapeutics B V | METHODS AND AGENTS FOR STEM CELL PROLIFERATION AND SUBSEQUENT GENERATION AND EXPANSION OF PROGENITOR CELLS, AS WELL AS PRODUCTION OF EFFECT CELLS AS CLINICAL THERAPEUTICS |
-
2013
- 2013-02-07 WO PCT/NL2013/050073 patent/WO2013119118A1/en not_active Ceased
- 2013-02-07 DK DK13709575.8T patent/DK2812011T3/da active
- 2013-02-07 EP EP13709575.8A patent/EP2812011B1/en active Active
- 2013-02-07 ES ES13709575T patent/ES2771248T3/es active Active
- 2013-02-07 CA CA2864283A patent/CA2864283C/en active Active
- 2013-02-07 US US14/376,870 patent/US20150010583A1/en not_active Abandoned
- 2013-02-07 PL PL13709575T patent/PL2812011T3/pl unknown
-
2017
- 2017-09-21 US US15/711,141 patent/US10822589B2/en active Active
-
2020
- 2020-10-06 US US17/064,036 patent/US20210054338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150010583A1 (en) | 2015-01-08 |
| US20210054338A1 (en) | 2021-02-25 |
| US20180044636A1 (en) | 2018-02-15 |
| ES2771248T3 (es) | 2020-07-06 |
| EP2812011A1 (en) | 2014-12-17 |
| CA2864283C (en) | 2020-11-03 |
| US10822589B2 (en) | 2020-11-03 |
| CA2864283A1 (en) | 2013-08-15 |
| EP2812011B1 (en) | 2020-01-15 |
| DK2812011T3 (da) | 2020-02-24 |
| WO2013119118A1 (en) | 2013-08-15 |
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