PL2614838T3 - Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka - Google Patents

Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka

Info

Publication number: PL2614838T3
Authority: PL; Poland
Prior art keywords: diquafosol; salts; treatment; hyaluronic acid; dry eye
Prior art date: 2010-09-10

Application number

PL11823663.7T

Other languages

English (en)

Inventor

Yuko Shichijo

Atsuyoshi Dota

Takashi Nagano

Masatsugu Nakamura

Asuka Sakamoto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-10

Filing date

2011-09-09

Publication date

2016-10-31

2011-09-09 Application filed filed Critical

2016-10-31 Publication of PL2614838T3 publication Critical patent/PL2614838T3/pl

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
208000003556 Dry Eye Syndromes Diseases 0.000 title 1
206010013774 Dry eye Diseases 0.000 title 1
NMLMACJWHPHKGR-NCOIDOBVSA-N P(1),P(4)-bis(uridin-5'-yl) tetraphosphate Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O NMLMACJWHPHKGR-NCOIDOBVSA-N 0.000 title 1
229950003529 diquafosol Drugs 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Non-Alcoholic Beverages (AREA)

PL11823663.7T 2010-09-10 2011-09-09 Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka PL2614838T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2010203198		2010-09-10

Publications (1)

Publication Number	Publication Date
PL2614838T3 true PL2614838T3 (pl)	2016-10-31

Family

ID=45810785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11823663.7T PL2614838T3 (pl)	2010-09-10	2011-09-09	Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka

Country Status (19)

Country	Link
US (1)	US9006208B2 (pl)
EP (1)	EP2614838B1 (pl)
JP (1)	JP5956735B2 (pl)
KR (2)	KR20170018462A (pl)
CN (2)	CN103096929A (pl)
AU (2)	AU2011299851A1 (pl)
BR (1)	BR112013005438B1 (pl)
CA (1)	CA2810481C (pl)
DK (1)	DK2614838T3 (pl)
EA (1)	EA026680B1 (pl)
ES (1)	ES2569246T3 (pl)
MX (1)	MX336944B (pl)
MY (1)	MY170198A (pl)
NZ (1)	NZ608202A (pl)
PH (1)	PH12013500424B1 (pl)
PL (1)	PL2614838T3 (pl)
SG (1)	SG188482A1 (pl)
TW (1)	TWI519301B (pl)
WO (1)	WO2012033189A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2012149057A (ja) *	2010-12-28	2012-08-09	Santen Pharmaceut Co Ltd	ジクアホソル含有点眼液およびその製造方法、不溶性析出物発生の抑制方法
SG10201607872PA (en)	2012-03-26	2016-11-29	Santen Pharmaceutical Co Ltd	Ophthalmic solution comprising diquafosol
US9492474B2 (en)	2013-07-10	2016-11-15	Matrix Biology Institute	Compositions of hyaluronan with high elasticity and uses thereof
US9289494B2 (en)	2013-11-20	2016-03-22	RestorTears, LLC	Method of treating ocular disorders with compounds found in Harderian gland secretions
JP6267003B2 (ja) *	2014-02-27	2018-01-24	参天製薬株式会社	ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤
JP6608620B2 (ja) *	2015-05-26	2019-11-20	ロート製薬株式会社	皮膚外用剤
CN107635565A (zh)	2015-06-05	2018-01-26	参天制药株式会社	以向佩戴有软性隐形眼镜的干眼症患者的眼中滴入的方式使用为特征的干眼症治疗剂
JP2017052723A (ja) *	2015-09-10	2017-03-16	株式会社Ｌｔｔバイオファーマ	ドライアイ改善剤
PT3842047T (pt)	2015-09-24	2024-09-19	Matrix Biology Inst	Composições de hialuronano de elevada elasticidade e processos para o seu uso
KR20190068575A (ko) *	2016-10-14	2019-06-18	이콤 메디칼 게엠베하	안구 표면 항상성의 확립, 회복 및 보존 방법
CN109843288A (zh)	2016-10-21	2019-06-04	狮王株式会社	眼科用制剂和眼科用药
CN107096016B (zh) *	2017-06-26	2021-04-06	蒋广伟	一种缓解视力疲劳的滴液
RU2652581C1 (ru) *	2017-07-03	2018-04-26	федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации	Способ лечения роговично-конъюнктивального ксероза
KR102108552B1 (ko) *	2018-05-15	2020-05-08	한국세라믹기술원	히알루론산 마이크로비드의 제조 방법 및 상기 히알루론산 마이크로비드의 용도
CN109260146A (zh) *	2018-10-12	2019-01-25	广州大光制药有限公司	地夸磷索钠眼用即用型凝胶滴眼液及制备方法
TWI833913B (zh)	2019-02-27	2024-03-01	日商參天製藥股份有限公司	含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物
KR20240049646A (ko) *	2019-08-27	2024-04-16	산텐 세이야꾸 가부시키가이샤	디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01115902A (ja)	1987-10-30	1989-05-09	Showa Sangyo Co Ltd	ヒアルロン酸の製造法
US5900407A (en) *	1997-02-06	1999-05-04	Inspire Pharmaceuticals, Inc.	Method of treating dry eye disease with uridine triphosphates and related compounds
ES2264197T3 (es) *	1997-02-06	2006-12-16	Inspire Pharmaceuticals, Inc.	Dinucleotidos y sus usos.
US7223744B2 (en) *	1997-02-10	2007-05-29	Inspire Pharmaceuticals, Inc.	Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
KR20010013797A (ko)	1997-07-25	2001-02-26	인스파이어 파마슈티컬스 인코퍼레이티드	디(우리딘 5'-테트라포스페이트) 염 및 그의 제조방법과용도
JP2003160491A (ja)	2001-09-11	2003-06-03	Santen Pharmaceut Co Ltd	ジウリジンリン酸含有点眼液

2011
- 2011-09-09 CN CN2011800435775A patent/CN103096929A/zh active Pending
- 2011-09-09 WO PCT/JP2011/070578 patent/WO2012033189A1/ja not_active Ceased
- 2011-09-09 MY MYPI2013000810A patent/MY170198A/en unknown
- 2011-09-09 NZ NZ60820211A patent/NZ608202A/en not_active IP Right Cessation
- 2011-09-09 KR KR1020177003213A patent/KR20170018462A/ko not_active Ceased
- 2011-09-09 TW TW100132506A patent/TWI519301B/zh not_active IP Right Cessation
- 2011-09-09 EA EA201390364A patent/EA026680B1/ru not_active IP Right Cessation
- 2011-09-09 PH PH1/2013/500424A patent/PH12013500424B1/en unknown
- 2011-09-09 ES ES11823663.7T patent/ES2569246T3/es active Active
- 2011-09-09 MX MX2013002677A patent/MX336944B/es active IP Right Grant
- 2011-09-09 PL PL11823663.7T patent/PL2614838T3/pl unknown
- 2011-09-09 SG SG2013017652A patent/SG188482A1/en unknown
- 2011-09-09 AU AU2011299851A patent/AU2011299851A1/en not_active Abandoned
- 2011-09-09 BR BR112013005438-7A patent/BR112013005438B1/pt not_active IP Right Cessation
- 2011-09-09 CN CN201611152170.7A patent/CN106729718A/zh active Pending
- 2011-09-09 EP EP11823663.7A patent/EP2614838B1/en not_active Not-in-force
- 2011-09-09 US US13/821,717 patent/US9006208B2/en not_active Expired - Fee Related
- 2011-09-09 JP JP2011197020A patent/JP5956735B2/ja active Active
- 2011-09-09 CA CA2810481A patent/CA2810481C/en not_active Expired - Fee Related
- 2011-09-09 DK DK11823663.7T patent/DK2614838T3/en active
- 2011-09-09 KR KR1020137008451A patent/KR101707269B1/ko active Active
2017
- 2017-02-07 AU AU2017200821A patent/AU2017200821B2/en not_active Ceased

Also Published As

Publication number	Publication date
NZ608202A (en)	2014-08-29
EP2614838B1 (en)	2016-04-20
EA201390364A1 (ru)	2013-08-30
WO2012033189A1 (ja)	2012-03-15
AU2017200821A1 (en)	2017-03-02
EP2614838A1 (en)	2013-07-17
EA026680B1 (ru)	2017-05-31
EP2614838A4 (en)	2014-02-26
ES2569246T3 (es)	2016-05-09
CA2810481C (en)	2018-06-19
BR112013005438A2 (pt)	2016-05-17
MX2013002677A (es)	2013-06-13
KR20130109130A (ko)	2013-10-07
SG188482A1 (en)	2013-04-30
HK1184686A1 (en)	2014-01-30
MY170198A (en)	2019-07-09
JP2012077080A (ja)	2012-04-19
PH12013500424B1 (en)	2018-07-11
AU2017200821B2 (en)	2018-08-30
CA2810481A1 (en)	2012-03-15
PH12013500424A1 (en)	2013-04-15
KR20170018462A (ko)	2017-02-17
DK2614838T3 (en)	2016-05-02
CN106729718A (zh)	2017-05-31
TW201216971A (en)	2012-05-01
BR112013005438B1 (pt)	2021-09-21
JP5956735B2 (ja)	2016-07-27
MX336944B (es)	2016-02-03
AU2011299851A1 (en)	2013-04-04
US9006208B2 (en)	2015-04-14
KR101707269B1 (ko)	2017-02-15
US20130172287A1 (en)	2013-07-04
TWI519301B (zh)	2016-02-01
CN103096929A (zh)	2013-05-08

Publication	Publication Date	Title
PL2614838T3 (pl)	2016-10-31	Dikwafozol i kwas hialuronowy lub ich sole do zastosowania w leczeniu zespołu suchego oka
IL261768B (en)	2021-05-31	Devices and methods for tissue treatment
AP3482A (en)	2015-12-31	Branched 3-phenylpropionic acid derivatives and the use thereof
ZA201404121B (en)	2016-07-27	Compositions for the treatment of dry eye
HUE051612T2 (hu)	2021-03-01	Eljárások és készítmények lizoszomális tárolási betegségek kezelésére
AP2014007533A0 (en)	2014-03-31	Substituted benzylindazoles for use as BUB1 kinaseinhibitors in the treatment of hyperproliferative diseases
PT2558133T (pt)	2020-04-23	Revestimentos para o fabrico e aplicação de dispositivos médicos de polihidroxialcanqato
IL237848A0 (en)	2015-05-31	Sterile aqueous injectable formulation based on cross-linked lauronic acid and hydroxyapatite for esthetic use
EP2645938A4 (en)	2014-04-23	SURGICAL STABILIZER AND CLOSURE SYSTEM
PL2521562T3 (pl)	2020-04-30	Ev576 do zastosowania w leczeniu zakażeń wirusowych dróg oddechowych
PT2810599T (pt)	2016-09-01	Sistema de estimulação elétrica para o tratamento da apneia do sono
IL225793A0 (en)	2013-09-30	Methods and preparations for curing insulin-related medical conditions
PL2576782T3 (pl)	2019-09-30	SiRNA i ich zastosowanie w sposobach i kompozycjach do leczenia i/lub zapobiegania schorzeniom oczu
SG11201500669SA (en)	2015-02-27	Alpha-1-microglobulin for use in the treatment of mitochondria-related diseases
GB201001412D0 (en)	2010-03-17	Propolis and process for the treatment thereof
ZA201503171B (en)	2016-11-30	Modified hyaluronic acid derivatives and use thereof
SG11201501386TA (en)	2015-03-30	Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions
ZA201307058B (en)	2015-08-26	Use of polyaminoisoprenyl derrivatives in antobiotic or antisertic treatment
EP2934501A4 (en)	2016-06-01	USES AND METHOD FOR THE TREATMENT OF LIVER DISEASES OR DRESSES
SG11201501385UA (en)	2015-03-30	Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions
PT2456445E (pt)	2014-07-17	Agente para o tratamento de condições da pele
ZA201005770B (en)	2012-07-25	The treatment of damaged skin
ZA201505093B (en)	2016-04-28	Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium or a pharmaceutically acceptable salt thereof in the treatment of atherosclerosis
GB0911581D0 (en)	2009-08-12	Compositions for use in the treatment of dry eye
AU2012900286A0 (en)	2012-02-16	"Methods of treatment or prophylaxis"