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PL2678432T3 - Rekombinowane mikroorganizmy i ich zastosowania - Google Patents

Rekombinowane mikroorganizmy i ich zastosowania

Info

Publication number
PL2678432T3
PL2678432T3 PL12749472T PL12749472T PL2678432T3 PL 2678432 T3 PL2678432 T3 PL 2678432T3 PL 12749472 T PL12749472 T PL 12749472T PL 12749472 T PL12749472 T PL 12749472T PL 2678432 T3 PL2678432 T3 PL 2678432T3
Authority
PL
Poland
Prior art keywords
recombinant microorganisms
uses therefor
therefor
microorganisms
recombinant
Prior art date
Application number
PL12749472T
Other languages
English (en)
Other versions
PL2678432T4 (pl
Inventor
Sean Dennis Simpson
Michael Koepke
Fungmin Liew
Wendy Yiting Chen
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Publication of PL2678432T3 publication Critical patent/PL2678432T3/pl
Publication of PL2678432T4 publication Critical patent/PL2678432T4/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/13Transferases (2.) transferring sulfur containing groups (2.8)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26Ketones
    • C12P7/28Acetone-containing products
    • C12P7/30Acetone-containing products produced from substrate containing inorganic compounds other than water
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001Alcohol dehydrogenase (1.1.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01004Acetoacetate decarboxylase (4.1.1.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01074Indolepyruvate decarboxylase (4.1.1.74)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency
    • Y02P20/133Renewable energy sources, e.g. sunlight

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PL12749472T 2011-02-25 2012-02-24 Rekombinowane mikroorganizmy i ich zastosowania PL2678432T4 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446832P 2011-02-25 2011-02-25
PCT/NZ2012/000022 WO2012115527A2 (en) 2011-02-25 2012-02-24 Recombinant microorganisms and uses therefor
EP12749472.2A EP2678432B1 (en) 2011-02-25 2012-02-24 Recombinant microorganisms and uses therefor

Publications (2)

Publication Number Publication Date
PL2678432T3 true PL2678432T3 (pl) 2019-05-31
PL2678432T4 PL2678432T4 (pl) 2019-05-31

Family

ID=46721376

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12749472T PL2678432T4 (pl) 2011-02-25 2012-02-24 Rekombinowane mikroorganizmy i ich zastosowania

Country Status (13)

Country Link
EP (2) EP3401405A1 (pl)
JP (1) JP6199747B2 (pl)
KR (2) KR102121886B1 (pl)
CN (2) CN108486169B (pl)
AU (1) AU2012221176B2 (pl)
BR (1) BR112013021524A2 (pl)
CA (2) CA2995872C (pl)
DK (1) DK2678432T3 (pl)
ES (1) ES2702621T3 (pl)
MY (2) MY168208A (pl)
PL (1) PL2678432T4 (pl)
TW (1) TWI541348B (pl)
WO (1) WO2012115527A2 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013152236A1 (en) 2012-04-05 2013-10-10 Lanzatech New Zealand Limited Enzyme-altered metabolite activity
US20130316364A1 (en) 2012-05-23 2013-11-28 Lanzatech New Zealand Limited Selection Method and Recombinant Microorganisms and uses Therefor
CA2874832C (en) 2012-05-30 2016-02-02 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
JP6381525B2 (ja) 2012-06-08 2018-08-29 ランザテク・ニュージーランド・リミテッド 組換え微生物およびその使用
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
AU2014274838A1 (en) * 2013-06-05 2015-12-24 Lanzatech New Zealand Limited Recombinant microorganisms exhibiting increased flux through a fermentation pathway
CN112048525B (zh) * 2013-09-22 2024-03-12 朗泽科技新西兰有限公司 发酵工艺
WO2015085015A1 (en) * 2013-12-03 2015-06-11 Lanzatech New Zealand Limited Microorganisms and methods for the production of ketones
KR102320074B1 (ko) 2014-01-28 2021-11-03 란자테크 뉴질랜드 리미티드 재조합 미생물의 생산 방법
EP3210012B1 (en) 2014-10-22 2023-06-07 LanzaTech NZ, Inc. Gas testing unit and method
JP6662868B2 (ja) 2014-10-22 2020-03-11 ランザテク・ニュージーランド・リミテッド 複数ステージバイオリアクタープロセス
HUE052810T2 (hu) 2014-12-08 2021-05-28 Lanzatech New Zealand Ltd Rekombináns mikroorganizmusok, amelyek megnövekedett fluxust mutatnak fermetációs útvonalon keresztül
US10131884B2 (en) 2015-02-23 2018-11-20 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
MY205861A (en) 2015-10-13 2024-11-16 Lanzatech Nz Inc Genetically engineered bacterium comprising energy-generating fermentation pathway
ES2909579T3 (es) 2015-12-03 2022-05-09 Lanzatech Nz Inc Arginina como única fuente de nitrógeno para microorganismos fijadores de C1
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
CN108603201A (zh) 2016-02-01 2018-09-28 朗泽科技新西兰有限公司 整合发酵和电解工艺
SG11201807025SA (en) 2016-02-26 2018-09-27 Lanzatech New Zealand Ltd Crispr/cas systems for c-1 fixing bacteria
KR102514023B1 (ko) 2016-05-14 2023-03-23 란자테크, 인크. 알데히드:페레독신 옥시도리덕타제 활성이 변경된 미생물 및 관련 방법
ES2926336T3 (es) 2017-09-08 2022-10-25 Lanzatech Inc Proceso para la producción de metabolitos utilizando sustratos que contienen C1 ricos en hidrógeno
CN111683731B (zh) 2018-02-12 2022-09-02 朗泽科技有限公司 用于提高碳转化效率的工艺
ES2960999T3 (es) 2018-04-20 2024-03-07 Lanzatech Inc Proceso de fermentación para producir etanol
EP3884060A4 (en) 2018-11-19 2022-08-10 Lanzatech, Inc. FERMENTATION AND GASIFICATION INTEGRATION
KR20240135053A (ko) 2019-02-08 2024-09-10 란자테크, 인크. 유사한 비등점 생성물의 회수 방법
WO2020188033A1 (en) 2019-03-20 2020-09-24 Global Bioenergies Improved means and methods for producing isobutene from acetyl-coa
KR20240158377A (ko) 2019-07-11 2024-11-04 란자테크, 인크. 가스 이용률을 최적화하는 방법
CN111057686B (zh) * 2019-12-23 2021-05-04 浙江大学 一种醇脱氢酶突变体及应用
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
JP2023518045A (ja) 2020-03-18 2023-04-27 ランザテク,インコーポレイテッド ガス基質からの2-フェニルエタノールの発酵産生
KR20230156819A (ko) * 2020-06-06 2023-11-14 란자테크, 인크. 아세토락테이트 탈카복실화효소 유전자위에 녹인이 있는 미생물
JP2023542338A (ja) * 2020-09-25 2023-10-06 ランザテク,インコーポレイテッド 組換え微生物及びそのための使用
US11788092B2 (en) 2021-02-08 2023-10-17 Lanzatech, Inc. Recombinant microorganisms and uses therefor
JP2024513395A (ja) 2021-04-09 2024-03-25 ランザテク,インコーポレイテッド 供給原料を提供するためのプロセス及び装置
CN114561416B (zh) * 2022-04-27 2022-07-15 深圳中科翎碳生物科技有限公司 利用电能固定co2及合成异丙醇的工程菌及构建方法
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
WO2024231219A1 (en) 2023-05-11 2024-11-14 Evonik Operations Gmbh Biotechnological production of acetone
CN117625571B (zh) * 2023-12-05 2025-06-10 迪嘉药业集团股份有限公司 一种改进的酮还原酶及其在依折麦布制备中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
DE60121335T2 (de) 2000-07-25 2007-08-02 Emmaus Foundation, Inc., Fayetteville Verfahren zur steigerung der ethanolproduktion bei der mikrobiellen fermentation
BRPI0619325B8 (pt) * 2005-10-26 2020-11-17 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante e método para produção de isobutanol
NZ546496A (en) * 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
BRPI0817545A2 (pt) * 2007-10-12 2014-11-25 Univ California Microorganismo recombinante, métodos para produzir um microorganismo recombinante e para produzir isopropanol, vetor recombinante, e, célula hospedeira recombinante.
CN102876609A (zh) 2007-11-13 2013-01-16 兰扎泰克新西兰有限公司 新型菌及其使用方法
BRPI0909334B1 (pt) * 2008-03-12 2019-10-29 Lanzatech New Zealand Ltd método para a conversão de ácido em álcool correspondente
KR20110021797A (ko) * 2008-04-25 2011-03-04 자이단호우진 치큐칸쿄 산교기쥬츠 켄큐키코 이소프로판올을 제조할 수 있는 유전자 변형된 코리네형 세균
AU2009327490A1 (en) * 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
DE102009002583A1 (de) * 2009-04-23 2010-10-28 Evonik Degussa Gmbh Zellen und Verfahren zur Herstellung von Aceton
EP2467490A1 (en) * 2009-08-21 2012-06-27 Mascoma Corporation Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii

Also Published As

Publication number Publication date
WO2012115527A3 (en) 2013-01-10
DK2678432T3 (en) 2018-11-26
TWI541348B (zh) 2016-07-11
AU2012221176A1 (en) 2013-05-09
CA2995872A1 (en) 2012-08-30
WO2012115527A2 (en) 2012-08-30
KR102015672B1 (ko) 2019-08-29
CN103502435A (zh) 2014-01-08
EP2678432A4 (en) 2016-06-22
JP2014506478A (ja) 2014-03-17
ES2702621T3 (es) 2019-03-04
KR102121886B1 (ko) 2020-06-15
CA2825267C (en) 2018-04-03
TW201309795A (zh) 2013-03-01
CN103502435B (zh) 2018-05-18
KR20190097292A (ko) 2019-08-20
EP3401405A1 (en) 2018-11-14
CA2825267A1 (en) 2012-08-30
CN108486169A (zh) 2018-09-04
JP6199747B2 (ja) 2017-09-20
CN108486169B (zh) 2022-08-12
NZ614459A (en) 2015-09-25
CA2995872C (en) 2019-09-17
MY168208A (en) 2018-10-15
AU2012221176B2 (en) 2015-03-19
EP2678432B1 (en) 2018-08-01
MY193665A (en) 2022-10-24
PL2678432T4 (pl) 2019-05-31
BR112013021524A2 (pt) 2017-06-13
EP2678432A2 (en) 2014-01-01
KR20140012106A (ko) 2014-01-29

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