PL2657350T3 - Reakcja nacinania i amplifikacji z wydłużaniem do wykładniczej amplifikacji kwasów nukleinowych - Google Patents
Reakcja nacinania i amplifikacji z wydłużaniem do wykładniczej amplifikacji kwasów nukleinowychInfo
- Publication number
- PL2657350T3 PL2657350T3 PL12195331T PL12195331T PL2657350T3 PL 2657350 T3 PL2657350 T3 PL 2657350T3 PL 12195331 T PL12195331 T PL 12195331T PL 12195331 T PL12195331 T PL 12195331T PL 2657350 T3 PL2657350 T3 PL 2657350T3
- Authority
- PL
- Poland
- Prior art keywords
- nicking
- nucleic acids
- amplification
- extension
- exponential
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/778,018 US9689031B2 (en) | 2007-07-14 | 2007-07-14 | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| PCT/US2008/070023 WO2009012246A2 (en) | 2007-07-14 | 2008-07-14 | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| EP12195331.9A EP2657350B1 (en) | 2007-07-14 | 2008-07-14 | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| EP08781827.4A EP2181196B1 (en) | 2007-07-14 | 2008-07-14 | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2657350T3 true PL2657350T3 (pl) | 2021-05-31 |
Family
ID=40175258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12195331T PL2657350T3 (pl) | 2007-07-14 | 2008-07-14 | Reakcja nacinania i amplifikacji z wydłużaniem do wykładniczej amplifikacji kwasów nukleinowych |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US9689031B2 (pl) |
| EP (4) | EP2657350B1 (pl) |
| JP (2) | JP5693955B2 (pl) |
| CN (4) | CN106544409A (pl) |
| AU (5) | AU2008276118B2 (pl) |
| BR (1) | BRPI0814527B1 (pl) |
| CA (2) | CA3041145C (pl) |
| DK (3) | DK2660333T4 (pl) |
| ES (3) | ES2816748T3 (pl) |
| FI (1) | FI2660333T4 (pl) |
| PL (1) | PL2657350T3 (pl) |
| PT (1) | PT2657350T (pl) |
| WO (1) | WO2009012246A2 (pl) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| AU2003215391B2 (en) | 2002-02-21 | 2007-05-24 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
| CA2616241C (en) | 2005-07-25 | 2012-02-07 | Asm Scientific, Inc. | Methods for multiplexing recombinase polymerase amplification |
| CA2650993C (en) | 2006-05-04 | 2015-06-16 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US9689031B2 (en) * | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| WO2010120853A2 (en) * | 2009-04-16 | 2010-10-21 | Padma Arunachalam | Methods and compositions to detect and differentiate small rnas in rna maturation pathway |
| WO2010135310A1 (en) | 2009-05-20 | 2010-11-25 | Biosite Incorporated | Dna glycosylase/lyase and ap endonuclease substrates |
| EP2438196B1 (en) | 2009-06-05 | 2016-12-21 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| WO2010147654A2 (en) | 2009-06-15 | 2010-12-23 | Netbio Inc. | Improved methods for forensic dna quantitation |
| US20110003703A1 (en) * | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| EP2287334A1 (de) * | 2009-08-21 | 2011-02-23 | Qiagen GmbH | Verfahren zum Nachweis von Zielnukleinsäuren |
| US20130078676A1 (en) * | 2010-03-30 | 2013-03-28 | Finders University | Method of regulating oligonucleotide functionality |
| EP2567213B1 (en) | 2010-05-05 | 2018-01-24 | The Governing Council of the Universtiy of Toronto | Method of processing dried samples using digital microfluidic device |
| EP2418286A1 (en) | 2010-08-10 | 2012-02-15 | QIAGEN GmbH | Improved method for isothermal amplification of nucleic acids |
| CA2810856C (en) * | 2010-08-13 | 2022-05-17 | Envirologix Inc. | Compositions and methods for quantifying a nucleic acid sequence in a sample |
| EP2420579A1 (en) * | 2010-08-17 | 2012-02-22 | QIAGEN GmbH | Helicase dependent isothermal amplification using nicking enzymes |
| EP2619324B1 (en) | 2010-09-23 | 2018-04-25 | Qiagen GmbH | Method for detecting and/or quantifying human dna |
| WO2012070618A1 (ja) | 2010-11-24 | 2012-05-31 | 株式会社カネカ | 増幅核酸検出方法及び検出デバイス |
| JP6126381B2 (ja) | 2010-12-10 | 2017-05-10 | 国立大学法人東京工業大学 | 標的核酸の検出方法及びキット |
| US9290815B2 (en) | 2011-02-21 | 2016-03-22 | Qiagen Gmbh | Method for quantifying human DNA |
| EP2678443B1 (en) | 2011-02-21 | 2016-11-23 | Qiagen GmbH | Method for quantifying human dna using an internal control |
| SG194745A1 (en) * | 2011-05-20 | 2013-12-30 | Fluidigm Corp | Nucleic acid encoding reactions |
| US9352312B2 (en) | 2011-09-23 | 2016-05-31 | Alere Switzerland Gmbh | System and apparatus for reactions |
| WO2013049463A2 (en) | 2011-09-30 | 2013-04-04 | Stc.Unm | Double gate ion sensitive field effect transistor |
| KR101358416B1 (ko) * | 2012-02-16 | 2014-02-11 | 한국과학기술원 | 리가제 반응과 절단효소 증폭반응을 이용한 표적 유전자 또는 이의 돌연변이 검출방법 |
| BR112014025262A8 (pt) | 2012-04-09 | 2021-06-29 | Envirologix Inc | métodos para quantificar um produto específico em uma reação de amplificação de extensão e corte, para detectar uma pluralidade de produtos de reação distintos produzidos ao longo de uma única reação, para monitorar em tempo real uma reação de amplificação de extensão e corte, para monitorar em tempo real uma molécula-alvo de ácido nucleico em uma reação de amplificação de extensão e corte, para monitorar em tempo real uma molécula-alvo de ácido nucleico em uma amostra de teste, e para amplificar um polinucleotídeo, kit, e, oligonucleotídeo isolado |
| CN114214394A (zh) * | 2012-06-08 | 2022-03-22 | 爱奥尼安技术公司 | 核苷酸扩增反应 |
| CN103667252A (zh) * | 2012-09-10 | 2014-03-26 | 思洛生物技术股份有限公司 | 一种核酸扩增方法 |
| CN103173537B (zh) * | 2012-12-21 | 2014-09-10 | 山东出入境检验检疫局检验检疫技术中心 | 大肠埃希氏菌o157:h7的切刻内切酶核酸恒温扩增快速检测试剂盒 |
| CN105143462A (zh) * | 2013-02-05 | 2015-12-09 | 生物纳米基因有限公司 | 用于单分子分析的方法 |
| US20140255928A1 (en) * | 2013-03-11 | 2014-09-11 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
| US10590474B2 (en) | 2013-03-11 | 2020-03-17 | Elitechgroup B.V. | Methods for true isothermal strand displacement amplification |
| US10196684B2 (en) * | 2013-10-18 | 2019-02-05 | California Institute Of Technology | Enhanced nucleic acid identification and detection |
| WO2015076356A1 (ja) * | 2013-11-22 | 2015-05-28 | 株式会社カネカ | 短鎖rnaの検出方法 |
| CA2936157C (en) | 2014-01-15 | 2021-08-24 | Tokyo Institute Of Technology | Covered sequence conversion dna and detection methods |
| WO2015143385A1 (en) | 2014-03-21 | 2015-09-24 | Life Technologies Corporation | Multi-copy reference assay |
| WO2015164494A1 (en) | 2014-04-22 | 2015-10-29 | Envirologix, Inc. | Compositions and methods for enhancing and/or predicting dna amplification |
| CN106574299A (zh) | 2014-04-30 | 2017-04-19 | 龙公司 | 用来检测黄龙病的组合物和方法 |
| EP3207159B1 (en) | 2014-10-14 | 2019-11-20 | Abbott Laboratories | Sequence conversion and signal amplifier dna having poly dna spacer sequences and detection methods using same |
| US10793922B2 (en) | 2014-10-20 | 2020-10-06 | Envirologix Inc. | Compositions and methods for detecting an RNA virus |
| US10604790B2 (en) | 2014-12-24 | 2020-03-31 | Abbott Laboratories | Sequence conversion and signal amplifier DNA cascade reactions and detection methods using same |
| CN105154556B (zh) * | 2015-01-23 | 2018-10-30 | 中国人民解放军第三军医大学第一附属医院 | 实时荧光恒温指数扩增方法 |
| JP7004570B2 (ja) | 2015-01-30 | 2022-02-10 | エンバイロロジックス インコーポレイテッド | 基質分子 |
| CN114250274A (zh) | 2015-04-24 | 2022-03-29 | 阿提拉生物系统公司 | 利用有限核苷酸组成的引物扩增 |
| CN108026494A (zh) | 2015-06-05 | 2018-05-11 | 米罗库鲁斯公司 | 限制蒸发和表面结垢的空气基质数字微流控装置和方法 |
| CN208562324U (zh) | 2015-06-05 | 2019-03-01 | 米罗库鲁斯公司 | 空气基质数字微流控(dmf)装置 |
| CN104988235B (zh) * | 2015-07-20 | 2019-01-22 | 北京福德安科技有限公司 | 一种切克酶介导等温扩增小分子信标定量检测技术 |
| CN105063190A (zh) * | 2015-07-30 | 2015-11-18 | 中国人民解放军第三军医大学第一附属医院 | 微小rna的固相芯片恒温检测方法 |
| CN105112507A (zh) * | 2015-07-30 | 2015-12-02 | 中国人民解放军第三军医大学第一附属医院 | 微小rna的数字化恒温检测方法 |
| CN105154534A (zh) * | 2015-07-30 | 2015-12-16 | 中国人民解放军第三军医大学第一附属医院 | 微小rna的实时恒温指数扩增方法 |
| EP3256609B1 (en) | 2015-09-15 | 2021-12-22 | Neogen Corporation | Methods of detecting listeria from an environmental sample |
| GB201519565D0 (en) | 2015-11-05 | 2015-12-23 | Alere San Diego Inc | Sample preparation device |
| US10329601B2 (en) * | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| WO2017141067A1 (en) | 2016-02-16 | 2017-08-24 | The University Of Tokyo | Method of eliminating background amplification of nucleic acid targets |
| EP4556571A3 (en) | 2016-02-26 | 2025-09-03 | Abbott Diagnostics Scarborough, Inc. | Redox labeled oligonucleotide probes and their use |
| AU2017228401B2 (en) | 2016-03-04 | 2023-07-27 | Abbott Diagnostics Scarborough, Inc. | Automated nested recombinase polymerase amplification |
| US11299777B2 (en) | 2016-04-04 | 2022-04-12 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| US9617587B1 (en) | 2016-04-04 | 2017-04-11 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| WO2017201315A1 (en) | 2016-05-18 | 2017-11-23 | Roche Sequencing Solutions, Inc. | Quantitative real time pcr amplification using an electrowetting-based device |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| KR101820440B1 (ko) * | 2016-06-28 | 2018-01-22 | 한국과학기술원 | 표적핵산의 검출방법 |
| GB201611469D0 (en) * | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| WO2018039281A1 (en) | 2016-08-22 | 2018-03-01 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
| EP3885448B1 (en) * | 2016-09-02 | 2023-03-22 | New England Biolabs, Inc. | Analysis of chromatin using a nicking enzyme |
| AU2017325833B2 (en) | 2016-09-15 | 2022-06-16 | Abbott Laboratories | Devices and methods for sample analysis |
| US11078527B2 (en) | 2016-09-16 | 2021-08-03 | Qiagen Gmbh | Method for quantifying and/or detecting human male DNA |
| WO2018050844A1 (en) | 2016-09-16 | 2018-03-22 | Qiagen Gmbh | Method for determining nucleic acid degradation in a sample in which at least two overlapping amplicons are produced and two probes are used in the method |
| CN110023494A (zh) | 2016-09-30 | 2019-07-16 | 加利福尼亚大学董事会 | Rna指导的核酸修饰酶及其使用方法 |
| JP7306696B2 (ja) | 2016-09-30 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Rna誘導型核酸修飾酵素及びその使用方法 |
| EP3563151A4 (en) | 2016-12-28 | 2020-08-19 | Miroculus Inc. | DIGITAL MICROFLUIDIC DEVICES AND METHODS |
| GB201701262D0 (en) | 2017-01-25 | 2017-03-08 | Sense Biodetection Ltd | Nucleic acid detection method |
| AU2018227436A1 (en) | 2017-02-28 | 2019-09-12 | Abbott Diagnostics Scarborough, Inc. | Microfluidic devices and related methods |
| US20200017862A1 (en) * | 2017-03-07 | 2020-01-16 | University Of North Carolina Charlotte | Systems and methods for single-strand break signaling and repair in a cell-free system |
| WO2018187476A1 (en) | 2017-04-04 | 2018-10-11 | Miroculus Inc. | Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets |
| CA3058202A1 (en) * | 2017-04-17 | 2018-10-25 | Montana State University | Switch-like isothermal dna amplification demonstrating a non-linear amplification rate |
| WO2019023133A1 (en) | 2017-07-24 | 2019-01-31 | Miroculus Inc. | DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE |
| RU2020100221A (ru) * | 2017-08-31 | 2021-09-30 | Иониан Текнолоджис, Ллс | Реакция амплификации с разрывом и удлинением (near) разновидностей респираторно-синцитиального вируса |
| WO2019046860A1 (en) | 2017-09-01 | 2019-03-07 | Miroculus Inc. | DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE |
| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| BR112020008654A2 (pt) | 2017-11-01 | 2020-11-10 | The Regents Of The University Of California | composições casz e métodos de uso |
| WO2019089808A1 (en) * | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Class 2 crispr/cas compositions and methods of use |
| GB2569965A (en) | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| GB201804585D0 (en) * | 2018-03-22 | 2018-05-09 | Dnae Diagnostics Ltd | Methods for amplication of nucleic acids with Endonuclease-Mediated shifting equilibrium amplification (EM-SEq) |
| CN112469504B (zh) | 2018-05-23 | 2024-08-16 | 米罗库鲁斯公司 | 对数字微流控中的蒸发的控制 |
| SG11202012785VA (en) * | 2018-06-26 | 2021-01-28 | Broad Inst Inc | Crispr double nickase based amplification compositions, systems, and methods |
| CN109055524B (zh) * | 2018-07-24 | 2022-03-15 | 中山大学 | 一种基于DNA组装的恒温条件下同时检测多种microRNA的探针和方法 |
| GB201812149D0 (en) | 2018-07-25 | 2018-09-05 | Sense Biodetection Ltd | Nucleic acid detection method |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| CN109136353B (zh) * | 2018-08-21 | 2021-11-16 | 中山大学 | 一种低序列依赖高阶恒温指数扩增检测microRNA的方法 |
| JP7734964B2 (ja) * | 2018-09-26 | 2025-09-08 | ランプロジェン, インコーポレイテッド | タンパク質検出のためのデジタル増幅 |
| CN109321669B (zh) * | 2018-10-29 | 2022-03-15 | 江南大学 | 一种基于嵌合体序列设计和分子信标的荧光检测金黄色葡萄球菌的方法 |
| CN109593863A (zh) * | 2018-11-28 | 2019-04-09 | 江南大学 | 一种链置换型dna聚合酶诱导等温循环扩增反应检测肉类来源的方法 |
| WO2020142754A2 (en) | 2019-01-04 | 2020-07-09 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| CN113543883A (zh) | 2019-01-31 | 2021-10-22 | 米罗库鲁斯公司 | 非结垢组合物以及用于操控和处理包封的微滴的方法 |
| EP3953041A4 (en) | 2019-04-08 | 2023-01-25 | Miroculus Inc. | MULTI-CARTRIDGE DIGITAL MICROFLUID DEVICES AND METHODS OF USE |
| GB201915346D0 (en) | 2019-06-21 | 2019-12-04 | Lumiradx Tech Ltd | Improvements in or relating to nicking enzymes |
| KR102531590B1 (ko) * | 2019-07-16 | 2023-05-11 | 고려대학교 산학협력단 | 절단효소 인식부위의 미러링 결합에 의한 표적핵산의 검출 방법 및 핵산 검출용 조성물 |
| JP2021019581A (ja) * | 2019-07-25 | 2021-02-18 | 株式会社リコー | 標準核酸試料調製用鋳型核酸分子 |
| WO2021016614A1 (en) | 2019-07-25 | 2021-01-28 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| CN115003828A (zh) | 2020-01-25 | 2022-09-02 | 圣斯生物检测有限公司 | 病毒检测 |
| US20230086471A1 (en) * | 2020-02-15 | 2023-03-23 | Agency For Science, Technology And Research | A method to amplify a nucleic acid |
| CN111979303A (zh) * | 2020-08-11 | 2020-11-24 | 上海奕谱生物科技有限公司 | 一种核酸检测试剂盒、方法及其应用 |
| AU2021365149A1 (en) | 2020-10-22 | 2023-06-08 | Neogen Corporation | Methods of detecting listeria from an environmental sample |
| CN112899349B (zh) * | 2020-12-03 | 2022-12-27 | 青岛大学附属医院 | 同时检测一种或多种靶标核酸的可视化核酸检测方法及其应用 |
| CN112646862B (zh) * | 2020-12-28 | 2022-07-15 | 天津市疾病预防控制中心 | 一种新型的自我链置换原理及其多重链置换反应的应用 |
| CN112760362B (zh) * | 2021-02-04 | 2023-07-07 | 中国人民解放军陆军特色医学中心 | 一种用于寡核苷酸扩增的环形信号扩增模板及其应用 |
| US20240210431A1 (en) | 2021-04-29 | 2024-06-27 | Abbott Laboratories | Systems and methods for pooling samples for high-throughput analysis |
| EP4347868A1 (en) | 2021-05-27 | 2024-04-10 | Lumiradx Uk Ltd | Improvements in or relating to digestion of reaction products |
| US20240376531A1 (en) * | 2021-06-09 | 2024-11-14 | New England Biolabs, Inc. | Target Initiation and Amplification of Long DNA with Nuclease and Replisome Enzymes |
| CN113481283A (zh) * | 2021-06-30 | 2021-10-08 | 上海伯杰医疗科技有限公司北京分公司 | 等温扩增核酸靶序列的方法 |
| ES3037735T3 (en) | 2021-08-03 | 2025-10-06 | Univ Wageningen | Argonaute-based nucleic acid detection system |
| US11772093B2 (en) | 2022-01-12 | 2023-10-03 | Miroculus Inc. | Methods of mechanical microfluidic manipulation |
| EP4565720A1 (en) | 2022-08-04 | 2025-06-11 | Abbott Laboratories | Assays for detecting monkeypox virus |
| WO2024040020A1 (en) | 2022-08-15 | 2024-02-22 | Absci Corporation | Quantitative affinity activity specific cell enrichment |
| WO2025030178A1 (en) | 2023-08-03 | 2025-02-06 | Abbott Laboratories | Isothermal amplification of nucleic acids |
| WO2025049451A1 (en) | 2023-08-28 | 2025-03-06 | Abbott Molecular, Inc. | Assays for detecting cytomegalovirus (cmv) or epstein-bar virus (ebv) |
| WO2025049450A1 (en) | 2023-08-28 | 2025-03-06 | Abbott Molecular, Inc. | Assays for detecting bk virus (bkv) |
| WO2025050131A1 (en) | 2023-09-01 | 2025-03-06 | Abbott Laboratories | Methods of detecting variant nucleic acids |
| WO2025111147A1 (en) | 2023-11-21 | 2025-05-30 | Abbott Laboratories | Two-dimensional matrix droplet array |
| WO2025129195A1 (en) | 2023-12-15 | 2025-06-19 | New England Biolabs, Inc. | Dna polymerases and related methods |
| WO2025137528A1 (en) | 2023-12-20 | 2025-06-26 | Abbott Laboratories | Reducing agent compositions for isothermal amplification of nucleic acids |
| WO2025144700A1 (en) | 2023-12-27 | 2025-07-03 | Absci Corporation | Nanobody library screening using bacterial surface display |
| WO2025171104A1 (en) * | 2024-02-08 | 2025-08-14 | Alere San Diego, Inc. | Universal hairpin probes |
| WO2025240630A1 (en) | 2024-05-14 | 2025-11-20 | Abbott Laboratories | Reagent compositions for isothermal amplification of nucleic acids |
Family Cites Families (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040166A (en) | 1985-03-28 | 2000-03-21 | Roche Molecular Systems, Inc. | Kits for amplifying and detecting nucleic acid sequences, including a probe |
| US5273879A (en) | 1987-07-23 | 1993-12-28 | Syntex (U.S.A.) Inc. | Amplification method for polynucleotide assays |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5556751A (en) | 1991-04-25 | 1996-09-17 | Amoco Corporation | Selective amplification system using Q-β replicase |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| FR2683827B1 (fr) | 1991-11-15 | 1994-03-04 | Institut Nal Sante Recherc Medic | Procede de determination de la quantite d'un fragment d'adn d'interet par une methode d'amplification enzymatique. |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5614389A (en) | 1992-08-04 | 1997-03-25 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| US5733733A (en) | 1992-08-04 | 1998-03-31 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| US5834202A (en) | 1992-08-04 | 1998-11-10 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| WO1994003635A1 (en) | 1992-08-04 | 1994-02-17 | Institute Of Molecular Biology & Biotechnology | Rapid amplification and detection of nucleic acids |
| US5457027A (en) | 1993-05-05 | 1995-10-10 | Becton, Dickinson And Company | Internal controls for isothermal nucleic acid amplification reactions |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5470723A (en) | 1993-05-05 | 1995-11-28 | Becton, Dickinson And Company | Detection of mycobacteria by multiplex nucleic acid amplification |
| JPH09510351A (ja) | 1994-03-16 | 1997-10-21 | ジェン−プローブ・インコーポレイテッド | 等温鎖置換核酸増幅法 |
| US5648211A (en) * | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| US5547861A (en) | 1994-04-18 | 1996-08-20 | Becton, Dickinson And Company | Detection of nucleic acid amplification |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| EP1260593A3 (en) | 1994-12-23 | 2003-12-03 | Dade Behring Inc. | Detection of nucleic acids by nuclease-catalyzed product formation |
| US5556771A (en) | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
| AUPN245295A0 (en) | 1995-04-13 | 1995-05-11 | Johnson & Johnson Research Pty. Limited | Assay for genetic abnormalities |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| US5681705A (en) | 1995-08-28 | 1997-10-28 | Schram; James L. | Amplification and detection of mycobacterium avium complex species |
| US5916779A (en) | 1995-09-21 | 1999-06-29 | Becton, Dickinson And Company | Strand displacement amplification of RNA targets |
| US5747255A (en) | 1995-09-29 | 1998-05-05 | Lynx Therapeutics, Inc. | Polynucleotide detection by isothermal amplification using cleavable oligonucleotides |
| US7432048B2 (en) | 1996-11-29 | 2008-10-07 | Third Wave Technologies, Inc. | Reactions on a solid surface |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| JP2000505312A (ja) * | 1996-03-18 | 2000-05-09 | モレキュラー バイオロジー リソーシーズ,インコーポレイテッド | 標的核酸配列増幅 |
| EP0912767B1 (en) | 1996-07-16 | 2006-09-13 | Gen-Probe Incorporated | Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific tm |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5853990A (en) | 1996-07-26 | 1998-12-29 | Edward E. Winger | Real time homogeneous nucleotide assay |
| WO1998008975A1 (en) | 1996-08-29 | 1998-03-05 | Daikin Industries, Ltd. | Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using reca-like recombinase |
| US6482590B1 (en) | 1996-12-20 | 2002-11-19 | Aventis Behring Gmbh | Method for polynucleotide amplification |
| US6117634A (en) | 1997-03-05 | 2000-09-12 | The Reagents Of The University Of Michigan | Nucleic acid sequencing and mapping |
| US6197557B1 (en) | 1997-03-05 | 2001-03-06 | The Regents Of The University Of Michigan | Compositions and methods for analysis of nucleic acids |
| WO1998044161A1 (en) | 1997-04-03 | 1998-10-08 | Life Technologies, Inc. | Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr) |
| WO1998045474A1 (en) | 1997-04-04 | 1998-10-15 | Innogenetics N.V. | Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions |
| US5928869A (en) | 1997-05-30 | 1999-07-27 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
| TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| GB9717061D0 (en) | 1997-08-13 | 1997-10-15 | Tepnel Medical Ltd | Amplification of nucleic acids |
| US6077669A (en) | 1997-11-04 | 2000-06-20 | Becton Dickinson And Company | Kit and method for fluorescence based detection assay |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| JP4317953B2 (ja) | 1998-01-22 | 2009-08-19 | 独立行政法人理化学研究所 | Dnaの塩基配列決定方法 |
| US6686150B1 (en) | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| US6287825B1 (en) | 1998-09-18 | 2001-09-11 | Molecular Staging Inc. | Methods for reducing the complexity of DNA sequences |
| AU1908100A (en) | 1998-11-06 | 2000-05-29 | Molecular Biology Resources, Inc. | Isothermal nucleic acid amplification methods |
| WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6316200B1 (en) | 2000-06-08 | 2001-11-13 | Becton, Dickinson And Company | Probes and methods for detection of nucleic acids |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6893819B1 (en) | 2000-11-21 | 2005-05-17 | Stratagene California | Methods for detection of a nucleic acid by sequential amplification |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| US6783934B1 (en) | 2000-05-01 | 2004-08-31 | Cepheid, Inc. | Methods for quantitative analysis of nucleic acid amplification reaction |
| US6191267B1 (en) * | 2000-06-02 | 2001-02-20 | New England Biolabs, Inc. | Cloning and producing the N.BstNBI nicking endonuclease |
| DE10028837A1 (de) | 2000-06-15 | 2001-12-20 | Roche Diagnostics Gmbh | Verfahren zum Nachweis von Influenza A/B-Viren |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| AU2002232393A1 (en) | 2000-10-27 | 2002-05-06 | Molecular Staging, Inc. | Methods for identifying genes associated with diseases or specific phenotypes |
| WO2002061133A2 (en) | 2000-11-09 | 2002-08-08 | Yale University | Nucleic acid detection using structured probes |
| US7309573B2 (en) | 2000-11-21 | 2007-12-18 | Stratagene California | Methods for detection of a nucleic acid by sequential amplification |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| US6660475B2 (en) | 2000-12-15 | 2003-12-09 | New England Biolabs, Inc. | Use of site-specific nicking endonucleases to create single-stranded regions and applications thereof |
| US6958217B2 (en) | 2001-01-24 | 2005-10-25 | Genomic Expression Aps | Single-stranded polynucleotide tags |
| DE60226856D1 (de) | 2001-04-20 | 2008-07-10 | Penn State Res Found | Verfahren zur manipulation von nukleinsäuren |
| WO2004022701A2 (en) | 2001-07-15 | 2004-03-18 | Keck Graduate Institute | Exponential amplification of nucleic acids using nicking agents |
| US7112423B2 (en) | 2001-07-15 | 2006-09-26 | Keck Graduate Institute | Nucleic acid amplification using nicking agents |
| JP2004535815A (ja) | 2001-07-15 | 2004-12-02 | ケック グラデュエイト インスティテュート | ニック形成剤を用いた核酸フラグメントの増幅 |
| US6632611B2 (en) | 2001-07-20 | 2003-10-14 | Affymetrix, Inc. | Method of target enrichment and amplification |
| WO2003012066A2 (en) | 2001-08-02 | 2003-02-13 | Barnes Wayne M | Magnesium precipitate hot start method for molecular manipulation of nucleic acids |
| US6403341B1 (en) | 2001-08-02 | 2002-06-11 | Wayne M. Barnes | Magnesium precipitate hot start method for PCR |
| US20040058349A1 (en) | 2001-10-01 | 2004-03-25 | Jeffrey Van Ness | Methods for identifying nucleotides at defined positions in target nucleic acids |
| US20040038256A1 (en) | 2001-10-01 | 2004-02-26 | Keck Graduate Institute | Methods for identifying nucleotides at defined positions in target nucleic acids using fluorescence polarization |
| US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| AU2003215391B2 (en) | 2002-02-21 | 2007-05-24 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
| GB0207063D0 (en) | 2002-03-26 | 2002-05-08 | Amersham Biosciences Uk Ltd | Immobilised probes |
| AU2003272438B2 (en) | 2002-09-20 | 2009-04-02 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| US20060160759A1 (en) | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| WO2004067764A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Nucleic acid sequencing using nicking agents |
| WO2004067726A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Isothermal reactions for the amplification of oligonucleotides |
| EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
| CN101410530B (zh) | 2003-04-18 | 2013-03-27 | 贝克顿·迪金森公司 | 免疫-扩增 |
| EP1618214A4 (en) | 2003-04-25 | 2008-02-13 | Becton Dickinson Co | DETECTION OF TYPES 1 AND 2 OF HERPES SIMPLEX VIRUS BY AMPLIFICATION OF NUCLEIC ACID |
| US20050266417A1 (en) | 2003-09-12 | 2005-12-01 | Francis Barany | Methods for identifying target nucleic acid molecules |
| US20050069938A1 (en) | 2003-09-26 | 2005-03-31 | Youxiang Wang | Amplification of polynucleotides by rolling circle amplification |
| US7314714B2 (en) | 2003-12-19 | 2008-01-01 | Affymetrix, Inc. | Method of oligonucleotide synthesis |
| EP1725682B1 (en) | 2004-03-08 | 2015-09-09 | Rubicon Genomics, Inc. | Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation |
| US20050233332A1 (en) | 2004-04-14 | 2005-10-20 | Collis Matthew P | Multiple fluorophore detector system |
| JP5026958B2 (ja) | 2004-06-01 | 2012-09-19 | アリーア サン ディエゴ, インコーポレイテッド | リコンビナーゼポリメラーゼ増幅 |
| GB2416352B (en) | 2004-07-21 | 2009-01-28 | Bioline Ltd | A method for performing the hot start of enzymatic reactions |
| JP2008515393A (ja) * | 2004-09-20 | 2008-05-15 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 複数モードの多重化反応消去方法 |
| AU2006244460B2 (en) | 2005-05-06 | 2010-04-08 | Gen-Probe Incorporated | Compositions and assays to detect influenza virus A and B nucleic acids |
| US20070020639A1 (en) | 2005-07-20 | 2007-01-25 | Affymetrix, Inc. | Isothermal locus specific amplification |
| CA2616241C (en) | 2005-07-25 | 2012-02-07 | Asm Scientific, Inc. | Methods for multiplexing recombinase polymerase amplification |
| EP1924704B1 (en) | 2005-08-02 | 2011-05-25 | Rubicon Genomics, Inc. | Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| US7939645B2 (en) | 2006-01-06 | 2011-05-10 | Agilent Technologies, Inc | Reaction buffer composition for nucleic acid replication with packed DNA polymerases |
| SG10201604720SA (en) | 2006-02-13 | 2016-07-28 | Us Gov Health & Human Serv | Primers and probes for detection and discrimination of types and subtypes of influenza viruses |
| CN103172700B (zh) | 2006-02-27 | 2014-12-17 | 霍夫曼-拉罗奇有限公司 | 经由镁螯合的pcr热启动 |
| CN100489112C (zh) | 2006-03-10 | 2009-05-20 | 杭州优思达生物技术有限公司 | 切口酶扩增靶核酸序列的方法及用于扩增靶核酸序列的试剂盒及其应用 |
| US20090092967A1 (en) * | 2006-06-26 | 2009-04-09 | Epoch Biosciences, Inc. | Method for generating target nucleic acid sequences |
| US20080096257A1 (en) | 2006-08-15 | 2008-04-24 | Zuxu Yao | Methods for Rapid, Single-Step Strand Displacement Amplification of Nucleic Acids |
| US8481506B2 (en) | 2006-12-05 | 2013-07-09 | Rosetta Genomics, Ltd. | Nucleic acids involved in viral infection |
| US8202972B2 (en) * | 2007-01-10 | 2012-06-19 | General Electric Company | Isothermal DNA amplification |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| AU2011204313A1 (en) | 2010-01-08 | 2012-07-26 | Qiagen Gaithersburg, Inc. | Materials and methods for isothermal nucleic acid amplification |
| KR101870311B1 (ko) | 2012-03-09 | 2018-06-25 | (주)바이오니아 | 핫스타트 역전사반응 또는 핫스타트 역전사 중합효소 연쇄반응용 조성물 |
| EP3099810B1 (en) | 2014-01-31 | 2019-05-01 | Qiagen GmbH | Cation chelator hot start |
| WO2016004333A2 (en) | 2014-07-02 | 2016-01-07 | Promega Corporation | Reversible metal ion chelators |
| US10329601B2 (en) * | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| RU2020100221A (ru) * | 2017-08-31 | 2021-09-30 | Иониан Текнолоджис, Ллс | Реакция амплификации с разрывом и удлинением (near) разновидностей респираторно-синцитиального вируса |
-
2007
- 2007-07-14 US US11/778,018 patent/US9689031B2/en active Active
-
2008
- 2008-07-14 JP JP2010517111A patent/JP5693955B2/ja active Active
- 2008-07-14 PT PT121953319T patent/PT2657350T/pt unknown
- 2008-07-14 DK DK12195333.5T patent/DK2660333T4/da active
- 2008-07-14 ES ES12195331T patent/ES2816748T3/es active Active
- 2008-07-14 US US12/173,020 patent/US9617586B2/en active Active
- 2008-07-14 CA CA3041145A patent/CA3041145C/en active Active
- 2008-07-14 AU AU2008276118A patent/AU2008276118B2/en active Active
- 2008-07-14 FI FIEP12195333.5T patent/FI2660333T4/fi active
- 2008-07-14 WO PCT/US2008/070023 patent/WO2009012246A2/en not_active Ceased
- 2008-07-14 PL PL12195331T patent/PL2657350T3/pl unknown
- 2008-07-14 CN CN201610524989.5A patent/CN106544409A/zh active Pending
- 2008-07-14 EP EP12195331.9A patent/EP2657350B1/en active Active
- 2008-07-14 BR BRPI0814527A patent/BRPI0814527B1/pt active IP Right Grant
- 2008-07-14 ES ES08781827T patent/ES2434220T3/es active Active
- 2008-07-14 CN CN201410465144.4A patent/CN104357546B/zh active Active
- 2008-07-14 EP EP08781827.4A patent/EP2181196B1/en not_active Revoked
- 2008-07-14 CN CN2008801054247A patent/CN101952459A/zh active Pending
- 2008-07-14 DK DK12195331.9T patent/DK2657350T3/da active
- 2008-07-14 CA CA2693805A patent/CA2693805C/en active Active
- 2008-07-14 ES ES12195333T patent/ES2759872T5/es active Active
- 2008-07-14 EP EP12195333.5A patent/EP2660333B2/en active Active
- 2008-07-14 DK DK08781827.4T patent/DK2181196T3/da active
- 2008-07-14 CN CN201410466581.8A patent/CN104372076B/zh active Active
- 2008-07-14 EP EP20174530.4A patent/EP3754029A1/en active Pending
-
2013
- 2013-10-30 US US14/067,623 patent/US9562264B2/en active Active
- 2013-10-30 US US14/067,620 patent/US9562263B2/en active Active
-
2014
- 2014-01-22 JP JP2014009503A patent/JP2014073137A/ja active Pending
-
2015
- 2015-05-06 AU AU2015202439A patent/AU2015202439C1/en active Active
-
2017
- 2017-03-23 US US15/467,893 patent/US20180023130A1/en not_active Abandoned
- 2017-05-22 US US15/600,951 patent/US10851406B2/en active Active
- 2017-11-29 AU AU2017268587A patent/AU2017268587A1/en not_active Abandoned
-
2019
- 2019-01-09 US US16/243,829 patent/US20190323072A1/en not_active Abandoned
-
2020
- 2020-01-16 AU AU2020200321A patent/AU2020200321B2/en active Active
-
2021
- 2021-08-11 US US17/399,482 patent/US20210388425A1/en not_active Abandoned
-
2022
- 2022-08-26 AU AU2022221561A patent/AU2022221561A1/en not_active Abandoned
-
2024
- 2024-07-30 US US18/788,585 patent/US20240409987A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2657350T3 (pl) | Reakcja nacinania i amplifikacji z wydłużaniem do wykładniczej amplifikacji kwasów nukleinowych | |
| GB2470672B (en) | Methods of RNA amplification in the presence of DNA | |
| ZA201008749B (en) | Isothermal nucleic acid amplification | |
| GB0910302D0 (en) | Nucleic acid amplification | |
| IL204892A0 (en) | Assembly of large nucleic acids | |
| GB0706243D0 (en) | Modified nucleic acids | |
| EP2224017A4 (en) | PROCESS FOR INCREASING THE NUCLEIC ACID TARGET SEQUENCE AND PROBE USED THEREFOR | |
| IL202649A0 (en) | Specific amplification of tumor specific dna sequences | |
| EP2193207A4 (en) | STABILIZATION OF NUCLEIC ACIDS ON SOLID SUPPORTS | |
| GB0701253D0 (en) | Nucleic acid amplification and testing | |
| EP2058396A4 (en) | nucleic acid amplification | |
| EP2222850A4 (en) | DISPOSAL OF CONTAMINANTS RELATED TO NUCLEIC ACID AMPLIFICATION | |
| GB0812862D0 (en) | Nucleic acid amplification | |
| EP2054530A4 (en) | PRIMER WITH DOUBLE FUNCTION FOR DNA REINFORCEMENT AND USE METHOD THEREFOR | |
| GB2463170B (en) | Method for increasing the speed of nucleic acid amplification reactions | |
| EP2318508A4 (en) | DETERMINATION OF RNA INTEGRITY | |
| EP2350039A4 (en) | INHIBITORS OF VIRAL POLYMERASE | |
| EP2195453A4 (en) | METHOD FOR AMPLIFYING NUCLEIC ACID | |
| EP2167524A4 (en) | METHOD FOR DIRECTLY AMPLIFYING NUCLEIC ACIDS FROM NON-CLEANED SAMPLES | |
| GB0807321D0 (en) | Analysis of nucleic acids | |
| ZA201102807B (en) | Primer and amplification method for forming single stranded dna amplicons | |
| GB0711714D0 (en) | Multi-primer isothermal nucleic acid amplification | |
| GB0620656D0 (en) | Isothermal nucleic acid amplification | |
| AU2007905445A0 (en) | Nucleic acid amplification | |
| GB0721978D0 (en) | Multi-primer isothermal nucleic acid amplification method |