PL2643313T3 - Azetydyny chinazolino-karboksyamidowe - Google Patents

Azetydyny chinazolino-karboksyamidowe

Info

Publication number: PL2643313T3
Authority: PL; Poland
Prior art keywords: azetidines; quinazoline carboxamide; quinazoline; carboxamide; carboxamide azetidines
Prior art date: 2010-11-24

Application number

PL11785338T

Other languages

English (en)

Inventor

Bayard R. Huck

Reinaldo Jones

Yufang Xiao

Constantin Neagu

Donald Bankston

Andreas Goutopoulos

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-24

Filing date

2011-11-11

Publication date

2017-03-31

2011-11-11 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2017-03-31 Publication of PL2643313T3 publication Critical patent/PL2643313T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL11785338T 2010-11-24 2011-11-11 Azetydyny chinazolino-karboksyamidowe PL2643313T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41713110P	2010-11-24	2010-11-24

Publications (1)

Publication Number	Publication Date
PL2643313T3 true PL2643313T3 (pl)	2017-03-31

Family

ID=45001695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11785338T PL2643313T3 (pl)	2010-11-24	2011-11-11	Azetydyny chinazolino-karboksyamidowe

Country Status (30)

Country	Link
US (1)	US8946247B2 (pl)
EP (1)	EP2643313B9 (pl)
JP (1)	JP5897590B2 (pl)
KR (1)	KR101894116B1 (pl)
CN (1)	CN103228649B (pl)
AR (1)	AR093725A1 (pl)
AU (1)	AU2011334173B2 (pl)
BR (1)	BR112013012488B1 (pl)
CA (1)	CA2818706C (pl)
CL (1)	CL2013001459A1 (pl)
CO (1)	CO6721019A2 (pl)
DK (1)	DK2643313T3 (pl)
EA (1)	EA023821B1 (pl)
ES (1)	ES2594404T3 (pl)
HR (1)	HRP20161183T1 (pl)
HU (1)	HUE028967T2 (pl)
IL (1)	IL226233A (pl)
LT (1)	LT2643313T (pl)
MX (1)	MX355325B (pl)
MY (1)	MY186456A (pl)
NZ (1)	NZ612224A (pl)
PE (1)	PE20140966A1 (pl)
PL (1)	PL2643313T3 (pl)
PT (1)	PT2643313T (pl)
RS (1)	RS55204B1 (pl)
SG (1)	SG190318A1 (pl)
SI (1)	SI2643313T1 (pl)
UA (1)	UA112167C2 (pl)
WO (1)	WO2012069146A1 (pl)
ZA (1)	ZA201304637B (pl)

Families Citing this family (17)

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Publication number	Priority date	Publication date	Assignee	Title
SG10201606301YA (en)	2011-09-12	2016-09-29	Merck Patent Gmbh	Novel imidazole amines as modulators of kinase activity
SI2755958T1 (sl)	2011-09-12	2017-12-29	Merck Patent Gmbh	Aminopirimidinski derivati za uporabo kot modulatorji kinazne aktivnosti
US9580443B2 (en)	2012-11-16	2017-02-28	Merck Patent Gmbh	Heterocyclic derivatives as modulators of kinase activity
ES2807539T3 (es)	2012-11-16	2021-02-23	Merck Patent Gmbh	Derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
ES2821102T3 (es)	2012-11-29	2021-04-23	Merck Patent Gmbh	Derivados de azaquinazolincarboxamida
US9458134B2 (en)	2013-03-11	2016-10-04	Merck Patent Gmbh	Heterocycles as modulators of kinase activity
SG11201608189WA (en)	2014-04-03	2016-10-28	Merck Patent Gmbh	Combinations of cancer therapeutics
CN106999492B (zh) *	2014-12-11	2020-12-11	默克专利股份公司	具有抗癌活性的6-氧代-1,6-二氢-哒嗪衍生物与喹唑啉衍生物的组合
EP3416641A1 (en) *	2016-02-16	2018-12-26	Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts	Modulators of ccr9 for treating tumor resistance to immune responses
US20200164068A1 (en) *	2016-02-16	2020-05-28	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Modulators of tumor immune resistance for the treatment of cancer
EP3762379A1 (en)	2018-03-07	2021-01-13	Bayer Aktiengesellschaft	Identification and use of erk5 inhibitors
WO2021094209A1 (en)	2019-11-12	2021-05-20	Bayer Aktiengesellschaft	Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
AU2021376892A1 (en)	2020-11-16	2023-06-29	Merck Patent Gmbh	Kinase inhibitor combinations for cancer treatment
CN116490187A (zh) *	2020-11-16	2023-07-25	默克专利股份公司	用于癌症治疗的激酶抑制剂组合
US11866421B2 (en) *	2021-05-31	2024-01-09	Epigen Biosciences, Inc.	Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
CA3262155A1 (en)	2022-08-11	2024-02-15	Evexta Bio	COMPOUNDS FOR CANCER TREATMENT
WO2025168601A1 (en)	2024-02-05	2025-08-14	Evexta Bio	Quinazoline carboxamide azetidine compounds for use in treating hormone dependent diseases

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TW200306819A (en)	2002-01-25	2003-12-01	Vertex Pharma	Indazole compounds useful as protein kinase inhibitors
WO2004014873A1 (ja) *	2002-08-09	2004-02-19	Kyorin Pharmaceutical Co., Ltd.	4-置換キナゾリン-8-カルボン酸アミド誘導体とその薬理上許容される付加塩
US7135575B2 (en) *	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
JP2006522124A (ja)	2003-04-03	2006-09-28	バーテックス　ファーマシューティカルズ　インコーポレイテッド	プロテインキナーゼのインヒビターとして有用な組成物
CN100412066C (zh)	2003-09-30	2008-08-20	Irm责任有限公司	用作蛋白激酶抑制剂的化合物和组合物
EP1678168B1 (en)	2003-10-24	2012-07-11	Exelixis, Inc.	P70s6 kinase modulators and method of use
WO2005054237A1 (en)	2003-11-21	2005-06-16	Novartis Ag	1h-imidazoquinoline derivatives as protein kinase inhibitors
ATE447957T1 (de)	2003-12-09	2009-11-15	Us Gov Health & Human Serv	Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen
US8076338B2 (en)	2004-04-23	2011-12-13	Exelixis, Inc.	Kinase modulators and methods of use
ATE543821T1 (de)	2004-12-28	2012-02-15	Exelixis Inc	Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
GB0501999D0 (en)	2005-02-01	2005-03-09	Sentinel Oncology Ltd	Pharmaceutical compounds
JP2008546751A (ja)	2005-06-22	2008-12-25	アステックス・セラピューティクス・リミテッド	医薬組成物
UA99284C2 (ru)	2007-05-11	2012-08-10	Елі Ліллі Енд Компані	ИНГИБИТОРЫ р70 S6-КИНАЗЫ
DE102007032739A1 (de) *	2007-07-13	2009-01-15	Merck Patent Gmbh	Chinazolinamidderivate
WO2010093419A1 (en)	2009-02-11	2010-08-19	Merck Patent Gmbh	Novel amino azaheterocyclic carboxamides
UA110113C2 (xx) *	2010-07-29	2015-11-25		Біциклічні азагетероциклічні карбоксаміди
ES2729754T3 (es) *	2010-07-29	2019-11-06	Merck Patent Gmbh	Carboxamidas azaheterocíclicas de aminas cíclicas

2011
- 2011-11-11 PL PL11785338T patent/PL2643313T3/pl unknown
- 2011-11-11 LT LTEP11785338.2T patent/LT2643313T/lt unknown
- 2011-11-11 MY MYPI2013700817A patent/MY186456A/en unknown
- 2011-11-11 MX MX2013005751A patent/MX355325B/es active IP Right Grant
- 2011-11-11 CN CN201180056687.5A patent/CN103228649B/zh active Active
- 2011-11-11 SG SG2013038054A patent/SG190318A1/en unknown
- 2011-11-11 US US13/989,199 patent/US8946247B2/en active Active
- 2011-11-11 ES ES11785338.2T patent/ES2594404T3/es active Active
- 2011-11-11 BR BR112013012488-1A patent/BR112013012488B1/pt active IP Right Grant
- 2011-11-11 CA CA2818706A patent/CA2818706C/en active Active
- 2011-11-11 EA EA201300610A patent/EA023821B1/ru not_active IP Right Cessation
- 2011-11-11 HR HRP20161183TT patent/HRP20161183T1/hr unknown
- 2011-11-11 PE PE2013001281A patent/PE20140966A1/es active IP Right Grant
- 2011-11-11 EP EP11785338.2A patent/EP2643313B9/en active Active
- 2011-11-11 UA UAA201307880A patent/UA112167C2/uk unknown
- 2011-11-11 WO PCT/EP2011/005691 patent/WO2012069146A1/en not_active Ceased
- 2011-11-11 KR KR1020137015932A patent/KR101894116B1/ko active Active
- 2011-11-11 HU HUE11785338A patent/HUE028967T2/en unknown
- 2011-11-11 DK DK11785338.2T patent/DK2643313T3/en active
- 2011-11-11 SI SI201130973A patent/SI2643313T1/sl unknown
- 2011-11-11 AU AU2011334173A patent/AU2011334173B2/en active Active
- 2011-11-11 NZ NZ612224A patent/NZ612224A/en unknown
- 2011-11-11 PT PT117853382T patent/PT2643313T/pt unknown
- 2011-11-11 RS RS20160817A patent/RS55204B1/sr unknown
- 2011-11-11 JP JP2013540255A patent/JP5897590B2/ja active Active
- 2011-11-23 AR ARP110104360A patent/AR093725A1/es not_active Application Discontinuation
2013
- 2013-05-08 IL IL226233A patent/IL226233A/en active IP Right Grant
- 2013-05-22 CL CL2013001459A patent/CL2013001459A1/es unknown
- 2013-06-17 CO CO13144136A patent/CO6721019A2/es unknown
- 2013-06-21 ZA ZA2013/04637A patent/ZA201304637B/en unknown

Also Published As

Publication number	Publication date
BR112013012488B1 (pt)	2021-08-31
KR101894116B1 (ko)	2018-08-31
RS55204B1 (sr)	2017-01-31
MY186456A (en)	2021-07-22
KR20130130753A (ko)	2013-12-02
JP5897590B2 (ja)	2016-03-30
EP2643313B1 (en)	2016-06-29
CA2818706A1 (en)	2012-05-31
JP2013544257A (ja)	2013-12-12
EA201300610A1 (ru)	2013-12-30
ES2594404T3 (es)	2016-12-20
AR093725A1 (es)	2015-06-24
CO6721019A2 (es)	2013-07-31
MX2013005751A (es)	2013-08-01
IL226233A (en)	2017-07-31
DK2643313T3 (en)	2016-10-24
AU2011334173B2 (en)	2015-07-16
US8946247B2 (en)	2015-02-03
IL226233A0 (en)	2013-07-31
UA112167C2 (uk)	2016-08-10
HUE028967T2 (en)	2017-01-30
SG190318A1 (en)	2013-06-28
CA2818706C (en)	2019-07-23
HK1188444A1 (zh)	2014-05-02
PT2643313T (pt)	2016-10-11
MX355325B (es)	2018-04-16
CL2013001459A1 (es)	2013-12-27
EP2643313B9 (en)	2017-02-22
BR112013012488A2 (pt)	2016-07-19
EP2643313A1 (en)	2013-10-02
PE20140966A1 (es)	2014-08-06
EA023821B1 (ru)	2016-07-29
AU2011334173A1 (en)	2013-05-02
SI2643313T1 (sl)	2016-11-30
LT2643313T (lt)	2016-10-25
CN103228649B (zh)	2015-11-25
WO2012069146A1 (en)	2012-05-31
ZA201304637B (en)	2014-03-26
HRP20161183T1 (hr)	2016-11-04
NZ612224A (en)	2015-01-30
US20130252942A1 (en)	2013-09-26
CN103228649A (zh)	2013-07-31

Publication	Publication Date	Title
ZA201304637B (en)	2014-03-26	Quinazoline carboxamide azetidines
HUS2100005I1 (hu)	2021-03-29	Metiltioninium-klorid
IL226904A (en)	2015-05-31	Inganol-3-acetylates iii and Inganol-3-carbamates
EP2566328A4 (en)	2013-10-16	indazoles
IL220939A0 (en)	2012-09-24	Compounds and methods
EP2523664A4 (en)	2013-06-26	COMPOUNDS AND METHODS
SI3184136T1 (sl)	2021-11-30	Injektor
GB201213680D0 (en)	2012-09-12	Tent
EP2589693A4 (en)	2014-05-14	NANO FIBER
AP2012006640A0 (en)	2012-12-31	New aminopyrazoloquinazolines
IL220812A0 (en)	2012-08-30	Compounds and methods
ZA201303073B (en)	2014-09-25	Construction block
EP2523560A4 (en)	2013-07-03	CONNECTIONS AND METHODS
GB201013582D0 (en)	2010-09-29	Opening restrictor
TWI372081B (en)	2012-09-11	Showerhead
PL2385261T3 (pl)	2013-09-30	Śruba samogwintująca
PL2577075T3 (pl)	2015-01-30	Zespół mocujący
PL2590966T3 (pl)	2017-05-31	Związki chinazolinowe
GB201004450D0 (en)	2010-05-05	Compounds and methods relating thereto
PL2468952T3 (pl)	2013-11-29	Rafinator
SG10201508549UA (en)	2015-11-27	Modified tamavidin
GB201004491D0 (en)	2010-05-05	Quinazoline analogues
PL2430948T3 (pl)	2014-01-31	Wyciąg szafy
PL119374U1 (pl)	2012-04-10	Anemostat
TWM388579U (en)	2010-09-11	Self-drilling screw