PL2569314T3 - Skondensowane bicykliczne inhibitory kinazy - Google Patents
Skondensowane bicykliczne inhibitory kinazyInfo
- Publication number
- PL2569314T3 PL2569314T3 PL11721678T PL11721678T PL2569314T3 PL 2569314 T3 PL2569314 T3 PL 2569314T3 PL 11721678 T PL11721678 T PL 11721678T PL 11721678 T PL11721678 T PL 11721678T PL 2569314 T3 PL2569314 T3 PL 2569314T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- condensed bicyclic
- bicyclic kinase
- condensed
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33473410P | 2010-05-14 | 2010-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2569314T3 true PL2569314T3 (pl) | 2017-02-28 |
Family
ID=44211949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11721678T PL2569314T3 (pl) | 2010-05-14 | 2011-05-16 | Skondensowane bicykliczne inhibitory kinazy |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8445510B2 (pl) |
| EP (1) | EP2569314B1 (pl) |
| JP (1) | JP5820472B2 (pl) |
| KR (1) | KR20130118213A (pl) |
| CN (1) | CN102971316A (pl) |
| AR (1) | AR081039A1 (pl) |
| AU (1) | AU2011252784A1 (pl) |
| BR (1) | BR112012028674A2 (pl) |
| CA (1) | CA2790847A1 (pl) |
| EA (1) | EA201291246A1 (pl) |
| ES (1) | ES2604481T3 (pl) |
| MX (1) | MX2012013206A (pl) |
| PH (1) | PH12012502102A1 (pl) |
| PL (1) | PL2569314T3 (pl) |
| PT (1) | PT2569314T (pl) |
| SG (1) | SG184822A1 (pl) |
| TW (1) | TW201141863A (pl) |
| WO (1) | WO2011143645A1 (pl) |
| ZA (1) | ZA201208489B (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| WO2012018668A1 (en) * | 2010-08-05 | 2012-02-09 | Amgen Inc. | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase |
| US20140088114A1 (en) * | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US9353107B2 (en) * | 2012-07-03 | 2016-05-31 | Aurigene Discovery Technologies Limited | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors |
| CN103613591B (zh) * | 2012-09-29 | 2016-04-13 | 上海科州药物研发有限公司 | 作为cMet抑制剂的化合物及其制备方法和用途 |
| BR112015016395A2 (pt) | 2013-01-18 | 2017-07-11 | Hoffmann La Roche | pirazóis 3-substituídos e uso como inibidores de dlk |
| DK2970265T3 (en) * | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| CN104513253A (zh) | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| CN104628555B (zh) * | 2015-01-05 | 2016-11-30 | 烟台蓓丰医药科技有限公司 | 一种药物中间体4-(4-氯苯基)环己基-1-甲酸的合成方法 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| EP3694855A1 (en) | 2017-10-13 | 2020-08-19 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| US20230339937A1 (en) | 2020-06-19 | 2023-10-26 | Sato Pharmaceutical Co., Ltd. | Condensed ring compounds that inhibit h-pgds |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360531A (en) | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
| US6235769B1 (en) | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
| AP2003002929A0 (en) | 2001-06-23 | 2003-12-31 | Aventis Pharma Inc | Pyrrolopyrimidines as protein kinase inhibitors |
| TW200301251A (en) | 2001-12-20 | 2003-07-01 | Wyeth Corp | Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| WO2003082868A1 (en) | 2002-03-28 | 2003-10-09 | Eisai Co., Ltd. | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders |
| JP2006514640A (ja) | 2002-12-10 | 2006-05-11 | ワイス | プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体 |
| WO2004076412A2 (en) | 2003-02-26 | 2004-09-10 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| JP2007516180A (ja) | 2003-07-02 | 2007-06-21 | スゲン，インコーポレイティド | ｃ−Ｍｅｔ阻害薬としてのアリールメチルトリアゾロおよびイミダゾピラジン類 |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| PT1696920E (pt) | 2003-12-19 | 2015-01-14 | Plexxikon Inc | Compostos e métodos para o desenvolvimento de moduladores de ret |
| US20050182060A1 (en) | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
| US7361764B2 (en) | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| AU2005269387A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7626021B2 (en) | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7709645B2 (en) | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| MX2007001986A (es) | 2004-08-26 | 2007-05-10 | Pfizer | Compuestos de aminoheteroarilo como inhibidores de proteina quinasa. |
| ATE492544T1 (de) | 2004-08-26 | 2011-01-15 | Pfizer | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer |
| BRPI0513915A (pt) | 2004-08-26 | 2008-05-20 | Pfizer | compostos aminoeteroarila enantiomericamente puros como inibidores de proteìna quinase |
| KR20080027775A (ko) | 2005-05-17 | 2008-03-28 | 플렉시콘, 인코퍼레이티드 | 피롤(２,３-ｂ)피리딘 유도체 단백질 키나제 억제제 |
| BRPI0611620A2 (pt) | 2005-06-10 | 2009-01-13 | Boehringer Ingelheim Int | mimÉticos de glicocorticàide, mÉtodos de fazÊ-los, composiÇÕes farmacÊuticas e usos dos mesmos |
| PL1893612T3 (pl) | 2005-06-22 | 2012-01-31 | Plexxikon Inc | Pochodne pirolo-[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| EP1957488B1 (en) | 2005-11-30 | 2009-09-09 | F.Hoffmann-La Roche Ag | 3-amino-2-arylpropyl azaindoles and uses thereof |
| NZ568666A (en) | 2005-11-30 | 2011-09-30 | Vertex Pharma | [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole derivative as inhibitors of c-Met |
| SI1963302T1 (sl) | 2005-12-05 | 2013-04-30 | Pfizer Products Inc. | Polimorfne oblike inhibitorja c-met/hgfr |
| JP2009531274A (ja) | 2005-12-07 | 2009-09-03 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | キナーゼ阻害性ピロロピリジン化合物 |
| ME02736B (me) | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| EP2032578A2 (en) | 2006-05-30 | 2009-03-11 | Pfizer Products Incorporated | Triazolopyridazine derivatives |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| CN101501002B (zh) | 2006-08-16 | 2012-06-27 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
| DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| US8639558B2 (en) | 2006-09-25 | 2014-01-28 | International Business Machines Corporation | Providing markdown item pricing and promotion calendar |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| NZ575336A (en) | 2006-10-23 | 2012-04-27 | Sgx Pharmaceuticals Inc | Bicyclic triazoles as protein kinase modulators |
| ES2393132T3 (es) | 2006-10-23 | 2012-12-18 | Sgx Pharmaceuticals, Inc. | Moduoladores de proteína quinasa de triazolopiridazina |
| GB0621607D0 (en) | 2006-10-31 | 2006-12-06 | Chroma Therapeutics Ltd | Inhibitors of c-Met |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| PE20121126A1 (es) | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| JP2010514695A (ja) | 2006-12-21 | 2010-05-06 | プレキシコン，インコーポレーテッド | キナーゼ調節のための化合物および方法およびそのための適応症 |
| ES2531002T3 (es) | 2007-01-19 | 2015-03-09 | Xcovery Inc | Compuestos inhibidores de quinasa |
| TW200908968A (en) | 2007-05-29 | 2009-03-01 | Sgx Pharmaceuticals Inc | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators |
| BRPI0821349A2 (pt) | 2007-12-21 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| EA020885B1 (ru) | 2008-01-22 | 2015-02-27 | Мерк Патент Гмбх | Ингибиторы протеинкиназы и их применение |
| AU2009246263B2 (en) | 2008-05-14 | 2014-08-21 | Amgen Inc. | Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-Met) inhibitors for the treatment of cancer |
| CA2738583A1 (en) | 2008-10-01 | 2010-04-08 | Ludwig Institute For Cancer Research | Methods for the treatment of cancer |
| US8592448B2 (en) * | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
| WO2010104945A1 (en) | 2009-03-11 | 2010-09-16 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| JP2013526570A (ja) * | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 縮合二環式キナーゼ阻害剤 |
-
2011
- 2011-05-12 AR ARP110101643A patent/AR081039A1/es not_active Application Discontinuation
- 2011-05-13 TW TW100116943A patent/TW201141863A/zh unknown
- 2011-05-16 CA CA2790847A patent/CA2790847A1/en not_active Abandoned
- 2011-05-16 MX MX2012013206A patent/MX2012013206A/es active IP Right Grant
- 2011-05-16 BR BR112012028674A patent/BR112012028674A2/pt not_active IP Right Cessation
- 2011-05-16 KR KR1020127032736A patent/KR20130118213A/ko not_active Withdrawn
- 2011-05-16 PT PT117216788T patent/PT2569314T/pt unknown
- 2011-05-16 CN CN2011800236682A patent/CN102971316A/zh active Pending
- 2011-05-16 US US13/108,024 patent/US8445510B2/en active Active
- 2011-05-16 PL PL11721678T patent/PL2569314T3/pl unknown
- 2011-05-16 EA EA201291246A patent/EA201291246A1/ru unknown
- 2011-05-16 PH PH1/2012/502102A patent/PH12012502102A1/en unknown
- 2011-05-16 SG SG2012075495A patent/SG184822A1/en unknown
- 2011-05-16 ES ES11721678.8T patent/ES2604481T3/es active Active
- 2011-05-16 EP EP11721678.8A patent/EP2569314B1/en active Active
- 2011-05-16 JP JP2013511247A patent/JP5820472B2/ja active Active
- 2011-05-16 WO PCT/US2011/036572 patent/WO2011143645A1/en not_active Ceased
- 2011-05-16 AU AU2011252784A patent/AU2011252784A1/en not_active Abandoned
-
2012
- 2012-11-12 ZA ZA2012/08489A patent/ZA201208489B/en unknown
-
2013
- 2013-04-30 US US13/873,353 patent/US20130253197A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011252784A1 (en) | 2012-09-13 |
| EP2569314A1 (en) | 2013-03-20 |
| EP2569314B1 (en) | 2016-09-07 |
| ES2604481T3 (es) | 2017-03-07 |
| US8445510B2 (en) | 2013-05-21 |
| JP2013526569A (ja) | 2013-06-24 |
| TW201141863A (en) | 2011-12-01 |
| ZA201208489B (en) | 2013-09-25 |
| MX2012013206A (es) | 2012-12-17 |
| PT2569314T (pt) | 2016-10-25 |
| SG184822A1 (en) | 2012-12-28 |
| US20130253197A1 (en) | 2013-09-26 |
| CN102971316A (zh) | 2013-03-13 |
| PH12012502102A1 (en) | 2013-02-11 |
| CA2790847A1 (en) | 2011-11-17 |
| BR112012028674A2 (pt) | 2016-08-16 |
| AR081039A1 (es) | 2012-05-30 |
| WO2011143645A1 (en) | 2011-11-17 |
| JP5820472B2 (ja) | 2015-11-24 |
| EA201291246A1 (ru) | 2013-04-30 |
| KR20130118213A (ko) | 2013-10-29 |
| US20110281888A1 (en) | 2011-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR25C1006I1 (fr) | Inhibiteurs de pyrazolyl-quinoxaline kinase | |
| PL2569314T3 (pl) | Skondensowane bicykliczne inhibitory kinazy | |
| IL265007B (en) | Pyrazolopyrimidine compounds as kinase inhibitors | |
| PL3459942T3 (pl) | Inhibitory DNA-PK | |
| EP2710007A4 (en) | Kinase inhibitors | |
| CO6970602A2 (es) | Inhibidores de quinasa | |
| SMT201600311B (it) | Inibitori di cdk | |
| CO6950481A2 (es) | Inhibidores de proteínas quinasas | |
| EP2632898A4 (en) | HETEROCYCLIC TYROSINE KINASE HEMMER | |
| BR112014003214A2 (pt) | polimorfos inibidores de cinase | |
| BR112014000653A2 (pt) | inibidores de tirosina quinase de bruton | |
| SMT201500271B (it) | Inibitori di neprilisina | |
| BR112013029620A2 (pt) | inibidores de tirosina quinase de bruton | |
| EP2822935A4 (en) | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) | |
| HRP20150878T1 (xx) | Kondenzirani heteroaromatski pirolidinoni kao inhibitori syk | |
| IL230561A0 (en) | Inhibitors of bruton's tyrosine kinsae | |
| PL3673906T3 (pl) | Inhibitory syntazy glukozyloceramidu | |
| DK2371923T3 (da) | Aflejringshæmmer | |
| EP2734205A4 (en) | HETEROCYCLIC PROTEIN KINASE HEMMER | |
| CO6880068A2 (es) | Aminoquinazolinas como inhibidores de quinasa | |
| EP2917210A4 (en) | KINASE INHIBITORS | |
| BR112013025761A2 (pt) | inibidores de hsp90 | |
| EP2863748A4 (en) | 1,2,4-triazine-6-CARBOXAMIDKINASEINHIBITOREN | |
| IL228311A0 (en) | Protein kinase inhibitors | |
| BR112015005361A2 (pt) | inibidores de tirosina quinase de bruton |