PL2358714T3 - Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu - Google Patents

Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu

Info

Publication number: PL2358714T3
Authority: PL; Poland
Prior art keywords: dihydrotetraazabenzoazulenes; alkylcyclohexylethers
Prior art date: 2008-11-18

Application number

PL09747861T

Other languages

English (en)

Inventor

Patrick Schnider

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-18

Filing date

2009-11-09

Publication date

2012-12-31

2009-11-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2012-12-31 Publication of PL2358714T3 publication Critical patent/PL2358714T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Luminescent Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL09747861T 2008-11-18 2009-11-09 Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu PL2358714T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08169348		2008-11-18
PCT/EP2009/064804 WO2010057795A1 (en)	2008-11-18	2009-11-09	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
EP09747861A EP2358714B1 (en)	2008-11-18	2009-11-09	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes

Publications (1)

Publication Number	Publication Date
PL2358714T3 true PL2358714T3 (pl)	2012-12-31

Family

ID=41398220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09747861T PL2358714T3 (pl)	2008-11-18	2009-11-09	Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu

Country Status (25)

Country	Link
US (1)	US8642590B2 (pl)
EP (1)	EP2358714B1 (pl)
JP (1)	JP5384659B2 (pl)
KR (1)	KR101385433B1 (pl)
CN (1)	CN102216304B (pl)
AR (1)	AR074354A1 (pl)
AU (1)	AU2009317386B2 (pl)
BR (1)	BRPI0921058A2 (pl)
CA (1)	CA2739900C (pl)
CL (1)	CL2011001129A1 (pl)
CY (1)	CY1113692T1 (pl)
DK (1)	DK2358714T3 (pl)
ES (1)	ES2391374T3 (pl)
HR (1)	HRP20120816T1 (pl)
IL (1)	IL212119A (pl)
MX (1)	MX2011005119A (pl)
PE (1)	PE20110590A1 (pl)
PL (1)	PL2358714T3 (pl)
PT (1)	PT2358714E (pl)
RU (1)	RU2510397C2 (pl)
SG (1)	SG171742A1 (pl)
SI (1)	SI2358714T1 (pl)
TW (1)	TWI389911B (pl)
WO (1)	WO2010057795A1 (pl)
ZA (1)	ZA201102604B (pl)

Families Citing this family (14)

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EP2356123B1 (en)	2008-11-13	2012-10-03	F.Hoffmann-La Roche Ag	Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes
JP5384659B2 (ja)	2008-11-18	2014-01-08	エフ．ホフマン−ラロシュアーゲー	ジヒドロテトラアザベンゾアズレンのアルキルシクロヘキシルエーテル
RU2507205C2 (ru) *	2008-11-28	2014-02-20	Ф. Хоффманн-Ля Рош Аг	Арилциклогексилэфиры дигидротетраазабензоазуленов для применения в качестве антагонистов рецептора вазопрессина v1a
US8420633B2 (en) *	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en)	2010-04-13	2013-06-11	Hoffmann-La Roche Inc.	Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en)	2010-04-21	2013-07-23	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en)	2010-04-26	2013-07-09	Hoffmann-La Roche Inc.	Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en)	2010-05-10	2013-08-20	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US8828989B2 (en) *	2011-09-26	2014-09-09	Hoffmann-La Roche Inc.	Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
KR20140082765A (ko) *	2011-10-05	2014-07-02	에프. 호프만-라 로슈 아게	V1a 길항제로서의 사이클로헥실-4H,6H-5-옥사-2,3,10b-트라이아자-벤조[e]아줄렌
WO2015082370A1 (en) *	2013-12-05	2015-06-11	F. Hoffmann-La Roche Ag	Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof
WO2017191117A1 (en)	2016-05-03	2017-11-09	Bayer Pharma Aktiengesellschaft	V1a receptor antagonists for use in the treatment of renal diseases
CN108329051B (zh) *	2017-07-04	2020-09-18	中国科学院金属研究所	一种超高孔隙率和低坯体收缩率Y2SiO5多孔陶瓷的制备方法
IL275144B2 (en) *	2017-12-08	2024-12-01	Hoffmann La Roche	Pharmaceutical formulation

Family Cites Families (23)

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US5521173A (en)	1995-01-17	1996-05-28	American Home Products Corporation	Tricyclic benzazepine vasopressin antagonists
US7138393B2 (en)	1998-07-24	2006-11-21	Wyeth	Biologically active vasopressin agonist metabolites
ES2207333T7 (es)	1999-01-19	2009-06-18	Orto-Mcneil Pharmaceutical, Inc.	Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.
TWI239333B (en) *	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators
US7022699B2 (en)	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
GB0303852D0 (en) *	2003-02-19	2003-03-26	Pfizer Ltd	Triazole compounds useful in therapy
AU2004283196B2 (en)	2003-09-17	2011-08-25	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds
GB0400700D0 (en)	2004-01-13	2004-02-18	Pfizer Ltd	Compounds useful in therapy
JP4085178B2 (ja) *	2004-05-17	2008-05-14	アステラス製薬株式会社	縮合ベンズアゼピン誘導体の新規製造法
CA2568056A1 (en)	2004-05-25	2005-12-08	Pfizer Products Inc.	Tetraazabenzo[e]azulene derivatives and analogs thereof
KR100840852B1 (ko)	2004-05-25	2008-06-23	화이자 프로덕츠 인크.	테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체
EP1632494A1 (en)	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonists
WO2006021882A1 (en) *	2004-08-25	2006-03-02	Pfizer Limited	Triazolobenzodiazepines and their use as vasopressin antagonists
MX2007011156A (es)	2005-03-15	2007-10-23	Hoffmann La Roche	Uso de 2-anilino-3,4-dihidro-quinazolinas como antagonistas del receptor 5ht5a.
CA2605899C (en)	2005-04-26	2011-02-08	Pfizer Limited	Triazole derivatives as vasopressin antagonists
WO2006123242A1 (en)	2005-05-18	2006-11-23	Pfizer Limited	1, 2, 4 -triazole derivatives as vasopressin antagonists
CN101583615B (zh)	2007-01-12	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺哌啶甘氨酰胺衍生物
JP5384659B2 (ja)	2008-11-18	2014-01-08	エフ．ホフマン−ラロシュアーゲー	ジヒドロテトラアザベンゾアズレンのアルキルシクロヘキシルエーテル
US8420633B2 (en)	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en)	2010-04-13	2013-06-11	Hoffmann-La Roche Inc.	Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en)	2010-04-21	2013-07-23	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en)	2010-04-26	2013-07-09	Hoffmann-La Roche Inc.	Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en)	2010-05-10	2013-08-20	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes

2009
- 2009-11-09 JP JP2011535980A patent/JP5384659B2/ja not_active Expired - Fee Related
- 2009-11-09 BR BRPI0921058A patent/BRPI0921058A2/pt not_active IP Right Cessation
- 2009-11-09 PL PL09747861T patent/PL2358714T3/pl unknown
- 2009-11-09 KR KR1020117011201A patent/KR101385433B1/ko not_active Expired - Fee Related
- 2009-11-09 CA CA2739900A patent/CA2739900C/en not_active Expired - Fee Related
- 2009-11-09 PE PE2011000978A patent/PE20110590A1/es not_active Application Discontinuation
- 2009-11-09 MX MX2011005119A patent/MX2011005119A/es active IP Right Grant
- 2009-11-09 HR HRP20120816AT patent/HRP20120816T1/hr unknown
- 2009-11-09 SI SI200930344T patent/SI2358714T1/sl unknown
- 2009-11-09 RU RU2011121438/04A patent/RU2510397C2/ru not_active IP Right Cessation
- 2009-11-09 SG SG2011035474A patent/SG171742A1/en unknown
- 2009-11-09 AU AU2009317386A patent/AU2009317386B2/en not_active Ceased
- 2009-11-09 CN CN200980146033.4A patent/CN102216304B/zh not_active Expired - Fee Related
- 2009-11-09 EP EP09747861A patent/EP2358714B1/en active Active
- 2009-11-09 ES ES09747861T patent/ES2391374T3/es active Active
- 2009-11-09 DK DK09747861.4T patent/DK2358714T3/da active
- 2009-11-09 WO PCT/EP2009/064804 patent/WO2010057795A1/en not_active Ceased
- 2009-11-09 PT PT09747861T patent/PT2358714E/pt unknown
- 2009-11-12 US US12/616,805 patent/US8642590B2/en active Active
- 2009-11-16 AR ARP090104427A patent/AR074354A1/es unknown
- 2009-11-16 TW TW098138877A patent/TWI389911B/zh not_active IP Right Cessation
2011
- 2011-04-04 IL IL212119A patent/IL212119A/en not_active IP Right Cessation
- 2011-04-07 ZA ZA2011/02604A patent/ZA201102604B/en unknown
- 2011-05-15 CL CL2011001129A patent/CL2011001129A1/es unknown
2012
- 2012-10-10 CY CY20121100936T patent/CY1113692T1/el unknown

Also Published As

Publication number	Publication date
KR20110074594A (ko)	2011-06-30
TWI389911B (zh)	2013-03-21
PT2358714E (pt)	2012-10-09
CY1113692T1 (el)	2016-06-22
SG171742A1 (en)	2011-07-28
AU2009317386B2 (en)	2013-07-25
ES2391374T3 (es)	2012-11-23
JP5384659B2 (ja)	2014-01-08
MX2011005119A (es)	2011-05-30
CL2011001129A1 (es)	2011-10-07
CN102216304A (zh)	2011-10-12
BRPI0921058A2 (pt)	2018-10-16
DK2358714T3 (da)	2012-08-20
CN102216304B (zh)	2014-07-09
IL212119A (en)	2014-12-31
JP2012508269A (ja)	2012-04-05
WO2010057795A1 (en)	2010-05-27
CA2739900A1 (en)	2010-05-27
ZA201102604B (en)	2012-09-26
HRP20120816T1 (hr)	2012-11-30
EP2358714A1 (en)	2011-08-24
RU2510397C2 (ru)	2014-03-27
CA2739900C (en)	2016-11-08
US20100125066A1 (en)	2010-05-20
RU2011121438A (ru)	2012-12-27
AR074354A1 (es)	2011-01-12
EP2358714B1 (en)	2012-08-01
US8642590B2 (en)	2014-02-04
TW201031666A (en)	2010-09-01
AU2009317386A1 (en)	2010-05-27
PE20110590A1 (es)	2011-08-31
IL212119A0 (en)	2011-06-30
KR101385433B1 (ko)	2014-04-14
SI2358714T1 (sl)	2012-11-30

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GB2459968B (en)	2011-03-02	Efficiency-based determination of operational characteristics
EP2280616A4 (en)	2012-11-21	BODY FOR BABY
ZA201102604B (en)	2012-09-26	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
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PL2133419T3 (pl)	2019-02-28	Zastosowania beta-dipeptydów cyjanoficyny
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EP2313147A4 (en)	2013-05-22	crimping
EP2233305A4 (en)	2010-11-17	GRAPHIC PRINTER
ZA201004979B (en)	2011-03-30	Extracts of sclerocarya birrea
GB0800389D0 (en)	2008-02-20	Gileo hang-it
GB201114396D0 (en)	2011-10-05	Location of basesation
EP2331490A4 (en)	2012-09-26	PREPARATION OF DIBUTOXYMETHANE
GB0800161D0 (en)	2008-02-13	Rota-board
GB0810084D0 (en)	2008-07-09	Eqne trainign aid
AU3972P (en)	2010-03-02	Tobruk xTriticosecale
AU4098P (en)	2010-09-29	NPW2 Dianella tasmanica
AU3977P (en)	2010-03-09	PARV01 Myoporum parvifolium
AU3935P (en)	2009-12-24	DPV308 Dianella prunina
GB0821710D0 (en)	2008-12-31	Derivatives of dihydroindolone
HU0800656D0 (en)	2008-12-29	Effective use of tea-composition
PL386302A1 (pl)	2010-04-26	Nowa pochodna izotiazolopirydyny
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GB0818211D0 (en)	2008-11-12	Windee pops-baby aid
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