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PL2356227T3 - Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych - Google Patents

Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Info

Publication number
PL2356227T3
PL2356227T3 PL09826863T PL09826863T PL2356227T3 PL 2356227 T3 PL2356227 T3 PL 2356227T3 PL 09826863 T PL09826863 T PL 09826863T PL 09826863 T PL09826863 T PL 09826863T PL 2356227 T3 PL2356227 T3 PL 2356227T3
Authority
PL
Poland
Prior art keywords
capsulation
cells
pancreas
originating
pluripotential stem
Prior art date
Application number
PL09826863T
Other languages
English (en)
Inventor
Laura Martinson
Chad Green
Evert Kroon
Alan Agulnick
Olivia Kelly
Emmanuel E. Baetge
Original Assignee
Viacyte, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viacyte, Inc. filed Critical Viacyte, Inc.
Publication of PL2356227T3 publication Critical patent/PL2356227T3/pl

Links

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10Preservation of living parts
    • A01N1/12Chemical aspects of preservation
    • A01N1/122Preservation or perfusion media
    • A01N1/125Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/022Artificial gland structures using bioreactors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L27/14Macromolecular materials
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
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    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/04General characteristics of the apparatus implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Gastroenterology & Hepatology (AREA)
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PL09826863T 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych PL2356227T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11485708P 2008-11-14 2008-11-14
US12108608P 2008-12-09 2008-12-09
PCT/US2009/064459 WO2010057039A2 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells
EP09826863.4A EP2356227B1 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells

Publications (1)

Publication Number Publication Date
PL2356227T3 true PL2356227T3 (pl) 2018-07-31

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PL09826863T PL2356227T3 (pl) 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Country Status (9)

Country Link
US (9) US8278106B2 (pl)
EP (3) EP3363444B1 (pl)
JP (6) JP2012508584A (pl)
CN (2) CN102282254B (pl)
AU (1) AU2009313870B2 (pl)
CA (2) CA3229301A1 (pl)
ES (2) ES2932850T3 (pl)
PL (1) PL2356227T3 (pl)
WO (1) WO2010057039A2 (pl)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432104B2 (en) * 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CA3114827C (en) 2007-07-31 2023-09-05 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
CA2954431C (en) 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
RU2551772C2 (ru) 2008-02-21 2015-05-27 Сентокор Орто Байотек Инк. Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток
GB2460842B (en) * 2008-06-10 2011-02-16 Cryogenetics As Packaging for biological material
AU2009267137A1 (en) 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
MX2011004565A (es) 2008-10-31 2011-07-28 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
MX2011004563A (es) 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
EP3363444B1 (en) * 2008-11-14 2022-09-14 ViaCyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
EP3260534A1 (en) 2008-11-20 2017-12-27 Janssen Biotech, Inc. Pluripotent stem cell culture on micro-carriers
BRPI0921996A2 (pt) 2008-11-20 2015-08-18 Centocor Ortho Biotech Inc Métodos e composições para cultura e ligação de células em substratos planos.
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
EP2456862A4 (en) * 2009-07-20 2013-02-27 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
AU2010286531B2 (en) 2009-08-28 2014-02-06 Sernova Corporation Methods and devices for cellular transplantation
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
BR112012017761A2 (pt) 2009-12-23 2015-09-15 Centocor Ortho Biotech Inc diferenciação das células-tronco embrionárias humanas
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
US9969981B2 (en) 2010-03-01 2018-05-15 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
RU2663339C1 (ru) 2010-05-12 2018-08-03 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
WO2012020845A1 (ja) 2010-08-09 2012-02-16 武田薬品工業株式会社 膵ホルモン産生細胞の製造法
KR20190027969A (ko) * 2010-08-12 2019-03-15 얀센 바이오테크 인코포레이티드 췌장 내분비 전구 세포를 이용한 당뇨병의 치료
AU2015213422A1 (en) * 2010-08-12 2015-09-10 Janssen Biotech, Inc. Treatment of diabetes with pancreatic endocrine precursor cells
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
JP6133776B2 (ja) 2010-08-31 2017-05-24 ヤンセン バイオテツク,インコーポレーテツド 多能性幹細胞の分化
KR101836850B1 (ko) 2010-08-31 2018-03-09 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
CA2809300A1 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
EP2621403B1 (en) 2010-09-27 2015-03-18 NsGene A/S Implantable cell device with supportive and radial diffusive scaffolding
MX2010013135A (es) * 2010-11-30 2012-05-31 Val De Bio S De R L De C V Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico.
WO2012115619A1 (en) 2011-02-21 2012-08-30 Viacyte, Inc. Loading system for an encapsulation device
ES2902650T3 (es) 2011-06-21 2022-03-29 Novo Nordisk As Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes
CN102550542B (zh) * 2011-08-09 2014-06-25 臻景生物技术(上海)有限公司 用于脂肪干细胞的无血清冻存液及脂肪干细胞库的建立
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
USD726306S1 (en) * 2011-12-12 2015-04-07 Viacyte, Inc. Cell encapsulation device
USD726307S1 (en) * 2011-12-12 2015-04-07 Viacyte Inc. Cell encapsulation device
USD728095S1 (en) * 2011-12-12 2015-04-28 Viacyte, Inc. Cell encapsulation device
AU2012355698B2 (en) 2011-12-22 2018-11-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
RU2018128383A (ru) 2012-03-07 2019-03-14 Янссен Байотек, Инк. Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US10017852B2 (en) 2016-04-14 2018-07-10 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
USD734847S1 (en) * 2012-05-31 2015-07-21 Viacyte, Inc. Cell encapsulation device
RU2018108850A (ru) 2012-06-08 2019-02-26 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки
WO2014008432A1 (en) * 2012-07-06 2014-01-09 The Regents Of The University Of California Cryopreservation of cells inside a macro-encapsulation device
JP6470687B2 (ja) 2012-09-03 2019-02-13 ノヴォ ノルディスク アー/エス 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
EP4039798A1 (en) 2012-12-31 2022-08-10 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells
MX2015008577A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Cultivo de celulas madre embrionarias humanas en la interfase aire-liquido para la diferenciacion en celulas endocrinas pancreaticas.
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
SG10201707811XA (en) 2012-12-31 2017-11-29 Janssen Biotech Inc Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
IL290717B2 (en) * 2013-02-06 2024-10-01 Viacyte Inc Cell compositions derived from dedifferentiated reprogrammed cells
WO2014127219A1 (en) * 2013-02-14 2014-08-21 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
PL2964147T3 (pl) * 2013-03-07 2018-10-31 Viacyte, Inc. Trójwymiarowy zestaw urządzeń o dużej pojemności do kapsułkowania komórek
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
WO2014138671A2 (en) * 2013-03-08 2014-09-12 Viacyte, Inc. Cryopreservation, hibernation and room temperature storage of encapulated pancreatic endoderm cell aggregates
US9592475B2 (en) 2013-03-12 2017-03-14 Lockheed Martin Corporation Method for forming perforated graphene with uniform aperture size
US8859286B2 (en) * 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
EP2988699B1 (en) 2013-04-24 2020-05-27 Société des Produits Nestlé S.A. Encapsulation device
KR102423106B1 (ko) 2013-06-11 2022-07-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
DK3016511T3 (da) 2013-07-02 2020-01-13 Austrianova Singapore Pte Ltd En fremgangsmåde til at frysetørre indkapslede celler, sammensætninger egnet til at fryse indkapslede celler og anvendelse af sådanne sammensætninger
US10231817B2 (en) 2013-09-24 2019-03-19 Giner Life Sciences, Inc. System for gas treatment of a cell implant
KR20160142820A (ko) 2014-01-31 2016-12-13 록히드 마틴 코포레이션 브로드 이온 필드를 사용한 2차원 물질 천공
AU2015210875A1 (en) 2014-01-31 2016-09-15 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
USD718471S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD718470S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD718468S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD718467S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD718466S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-Dimensional large capacity cell encapsulation device
USD718472S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD718469S1 (en) * 2014-03-07 2014-11-25 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
USD714956S1 (en) * 2014-03-07 2014-10-07 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device
MX2016011812A (es) * 2014-03-12 2017-05-09 Lockheed Corp Uso in vivo e in vitro de grafeno.
CN106232205A (zh) 2014-03-12 2016-12-14 洛克希德马丁公司 由有孔石墨烯形成的分离膜
JP6585616B2 (ja) 2014-03-21 2019-10-02 ライフ テクノロジーズ コーポレイション 流体処理システムのためのガスフィルタシステム
WO2015142406A1 (en) 2014-03-21 2015-09-24 Life Technologies Corporation Condenser systems for fluid processing systems
US9950151B2 (en) * 2014-03-27 2018-04-24 Beta-O2 Technologies Ltd. Implantable medical devices
USD760399S1 (en) * 2014-04-16 2016-06-28 Viacyte, Inc. Case for an encapsulation device
EP3131497B1 (en) * 2014-04-16 2023-08-16 ViaCyte, Inc. Instruments for use with implantable encapsulation devices
US11051900B2 (en) 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
US11083758B2 (en) * 2014-05-14 2021-08-10 Prime Merger Sub, Llc Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
KR102162138B1 (ko) 2014-05-16 2020-10-06 얀센 바이오테크 인코포레이티드 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도
WO2015178431A1 (ja) * 2014-05-21 2015-11-26 国立大学法人京都大学 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤
WO2015191547A1 (en) 2014-06-09 2015-12-17 Cornell University Implantable therapeutic delivery system and methods thereof
CN107073408A (zh) 2014-09-02 2017-08-18 洛克希德马丁公司 基于二维膜材料的血液透析膜和血液过滤膜及其应用方法
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
WO2016100909A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
CA3226186A1 (en) 2015-03-23 2016-09-29 The Regents Of The University Of California Use of thin film cell encapsulation devices
US10494608B2 (en) 2015-04-24 2019-12-03 University Of Copenhagen Isolation of bona fide pancreatic progenitor cells
CA2994549A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
CA2994664A1 (en) 2015-08-06 2017-02-09 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
WO2017049008A1 (en) * 2015-09-16 2017-03-23 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
EP3167911A1 (en) * 2015-11-10 2017-05-17 Oniris Si-hpmc-encapsulated insulin-producing cells for the treatment of type 1 diabetes
CN112403668B (zh) * 2015-12-29 2023-06-27 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
WO2017123759A1 (en) * 2016-01-12 2017-07-20 Zanella Fabian Cell medium formulation for cell stabilization
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
WO2017165850A1 (en) * 2016-03-25 2017-09-28 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
MA45479A (fr) * 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
EP3442697A4 (en) 2016-04-14 2020-03-18 Lockheed Martin Corporation SELECTIVE INTERFACE REDUCTION OF GRAPH DEFECTS
JP2019519756A (ja) 2016-04-14 2019-07-11 ロッキード・マーチン・コーポレーション 欠陥形成または欠陥修復をその場で監視して制御する方法
KR20190018410A (ko) 2016-04-14 2019-02-22 록히드 마틴 코포레이션 흐름 통로들을 갖는 2차원 막 구조들
EP3484997A4 (en) 2016-07-12 2020-07-29 California Institute of Technology SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
CA3042712A1 (en) 2016-11-03 2018-08-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre- and post-transplantation
EP3534834A4 (en) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Encapsulation device systems with oxygen sensors with or without exogenous oxygen supply
CN115429222A (zh) * 2016-11-03 2022-12-06 代表亚利桑那大学的亚利桑那董事会 用于改进血糖调节的方法、系统和可植入装置
US11446133B2 (en) 2016-11-03 2022-09-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
US10849731B2 (en) * 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
USD824042S1 (en) 2016-11-10 2018-07-24 Viacyte, Inc. Perforated cell encapsulation device
JP7088564B2 (ja) 2016-11-10 2022-06-21 ヴィアサイト,インコーポレイテッド 細胞送達装置におけるpdx1膵臓内胚葉細胞及びその方法
RU2019114843A (ru) 2016-11-15 2020-11-16 Джинер Лайф Сайенс, Инк. Саморегулируемый электролитический газогенератор и содержащая его имплантационная система
US11033666B2 (en) 2016-11-15 2021-06-15 Giner Life Sciences, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
CN108148808B (zh) * 2016-12-05 2020-12-11 同济大学 有助于诱导生成神经前体细胞的诱导培养基
WO2018159805A1 (ja) * 2017-03-03 2018-09-07 国立大学法人京都大学 膵前駆細胞の製造方法
US12016327B2 (en) 2017-03-20 2024-06-25 Boston Scientific Medical Device Limited Cell encapsulation device
WO2018204867A1 (en) 2017-05-04 2018-11-08 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
CA3066055A1 (en) 2017-06-14 2018-12-20 Semma Therapeutics, Inc. Devices and methods for delivering therapeutics
JPWO2018230588A1 (ja) * 2017-06-14 2020-04-16 武田薬品工業株式会社 細胞封入デバイス
KR102001120B1 (ko) 2017-06-29 2019-07-16 서울대학교산학협력단 나노섬유 및 하이드로젤의 복합체 및 이를 포함하는 조직 재생용 스캐폴드
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
EP3677289A4 (en) 2017-08-30 2020-08-26 FUJIFILM Corporation ANGIOGENIC AGENT AND PROCESS FOR THE PRODUCTION OF THE LATTER
EP3677287B1 (en) 2017-08-30 2024-05-29 FUJIFILM Corporation Cell transplantation device and method for manufacturing same
CN111108190B (zh) * 2017-09-11 2024-06-21 诺和诺德股份有限公司 在体外从干细胞衍生的nkx6.1和c-肽共表达细胞的富集
CN111491617B (zh) 2017-09-29 2024-12-31 沃泰克斯药物股份有限公司 细胞容纳装置
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
AU2018370029B2 (en) * 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
JP2019097442A (ja) 2017-11-30 2019-06-24 株式会社日立製作所 免疫隔離デバイス
JP6417023B2 (ja) * 2017-12-20 2018-10-31 ネステク ソシエテ アノニム カプセル化デバイス
CN108543116B (zh) * 2018-05-02 2021-04-27 深圳市华异生物科技有限责任公司 海藻酸钠与明胶复合水凝胶3d胰岛支架及其制备方法
CA3100192C (en) 2018-05-17 2023-03-14 Giner Life Sciences, Inc. Electrolytic gas generator with combined lead and gas port terminals
CN112912490B (zh) * 2018-08-03 2023-12-26 千纸鹤治疗公司 细胞制造方法
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
EP3840693A1 (en) * 2018-08-22 2021-06-30 Boston Scientific Scimed Inc. Cell encapsulation device including a porous tube
US12408661B2 (en) * 2018-08-30 2025-09-09 The Curators Of The University Of Missouri Efficient cryopreservation device preventing the direct contact between samples and extracellular ice
US10724052B2 (en) 2018-09-07 2020-07-28 Crispr Therapeutics Ag Universal donor cells
US20210401564A1 (en) * 2018-09-24 2021-12-30 Arizona Board Regents On Behalf Of The University Of Arizona Methods and systems for implantable medical devices and vascularization membranes
US12303374B2 (en) * 2018-09-26 2025-05-20 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled cell bed thickness
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
AU2019360857A1 (en) * 2018-10-15 2021-06-03 Evia Life Sciences Inc. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN109289090A (zh) * 2018-10-31 2019-02-01 陈津 一种胰岛移植微环境及其构建方法
WO2020138028A1 (ja) * 2018-12-25 2020-07-02 富士フイルム株式会社 細胞移植キット、袋状構造物の製造方法、および糖尿病治療剤
JP7267377B2 (ja) * 2019-02-25 2023-05-01 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
JP6970245B2 (ja) * 2019-02-25 2021-11-24 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
CN119345037A (zh) * 2019-04-03 2025-01-24 沃泰克斯药物股份有限公司 大胶囊装置
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
AU2020283056B2 (en) * 2019-05-31 2023-06-08 Viacyte, Inc. A biocompatible membrane composite
EP3976237A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. Cell encapsulation devices with controlled oxygen diffusion distances
CA3139591C (en) 2019-05-31 2024-01-16 Timothy M. BRUHN A biocompatible membrane composite
AU2020340622A1 (en) 2019-09-05 2022-03-03 Crispr Therapeutics Ag Universal donor cells
US11118195B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
AU2020352623A1 (en) * 2019-09-27 2022-05-12 Isla Technologies, Inc. Bioartificial pancreas
WO2022047543A1 (en) * 2020-09-04 2022-03-10 Captix Biomedical Pty Ltd "bone implant"
CA3196876A1 (en) 2020-10-30 2022-05-05 Klearchos Papas Methods and systems for encapsulation devices for housing cells and agents
CN112544613B (zh) * 2020-12-25 2022-08-16 武汉睿健医药科技有限公司 一种多能干细胞冻存液、其应用及冻存方法
AU2021414405A1 (en) 2020-12-31 2023-08-10 Crispr Therapeutics Ag Universal donor cells
JP2024530690A (ja) * 2021-08-10 2024-08-23 ユニフェルシテイト マーストリヒト 開放型移植可能細胞送達デバイス
US20250152324A1 (en) 2022-02-25 2025-05-15 Viacyte, Inc. Multilayer implantable cell encapsulation devices and methods thereof
WO2023203208A1 (en) 2022-04-21 2023-10-26 Evotec International Gmbh New cell populations and means and methods for their differentiation and preservation
WO2024039773A1 (en) 2022-08-19 2024-02-22 Dimension Inx Corp Biointegrative implantable cell encapsulation device and system
EP4593994A1 (en) 2022-09-30 2025-08-06 W. L. Gore & Associates, Inc. Implantable membrane construct and encapsulaton devices incorporating the same
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
EP4602155A1 (en) 2022-10-11 2025-08-20 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
WO2025088022A1 (en) 2023-10-24 2025-05-01 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Method for generating homogenous, size-defined pseudo-islets of porcine origin by rho/rock pathway inhibition
JP7451818B1 (ja) 2023-11-10 2024-03-18 洋之 高尾 Diffusion Chamber型人工膵島器
WO2025226588A1 (en) * 2024-04-22 2025-10-30 Wake Forest University Health Sciences Artificial implants that promote neovascularization

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500388A (en) 1948-07-21 1950-03-14 Minnesota Mining & Mfg Fluorocarbon ethers
US2594272A (en) 1948-09-10 1952-04-29 Minnesota Mining & Mfg Cyclic fluoroalkylene oxide compounds
US2519983A (en) 1948-11-29 1950-08-22 Minnesota Mining & Mfg Electrochemical process of making fluorine-containing carbon compounds
US2616927A (en) 1950-05-12 1952-11-04 Minnesota Mining & Mfg Fluorocarbon tertiary amines
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4723953A (en) * 1985-01-07 1988-02-09 Rocky Mountain Medical Corporation Absorbent pad
US4788339A (en) 1985-09-06 1988-11-29 Minnesota Mining And Manufacturing Company Perfluoroaminoethers
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US5418154A (en) 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5182111A (en) 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5219361A (en) 1988-09-16 1993-06-15 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011494A (en) 1988-09-16 1991-04-30 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
CA1335181C (en) 1988-10-11 1995-04-11 R. Alan Hardwick System for selective cell separation from cell concentrate
ATE114507T1 (de) 1988-12-28 1994-12-15 Stefan Miltenyi Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.
US5116493A (en) 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5002661A (en) 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5100392A (en) 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
US5171846A (en) 1990-05-21 1992-12-15 Coulter Corporation Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use
US5272257A (en) 1990-05-21 1993-12-21 Coulter Corporation Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use
US5240640A (en) 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5314471A (en) 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
US5713888A (en) 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5344454A (en) 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5466609A (en) 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5733336A (en) 1990-10-31 1998-03-31 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5639620A (en) 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
JP3508023B2 (ja) 1990-10-31 2004-03-22 バクスター、インターナショナル、インコーポレイテッド 密接血管化埋め込み材料
ATE243747T1 (de) 1991-07-15 2003-07-15 Wellcome Found Herstellung von antikörpern
US5453278A (en) 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
JPH06502577A (ja) 1991-07-30 1994-03-24 バクスター、インターナショナル、インコーポレイテッド 有孔埋め込み物
JPH0613739Y2 (ja) * 1991-09-26 1994-04-13 富士システムズ株式会社 人工臓器用カプセル及び人工臓器
US5248772A (en) 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
WO1993021902A1 (en) 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5262055A (en) 1992-10-19 1993-11-16 The University Of Utah Implantable and refillable biohybrid artificial pancreas
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
CA2164646A1 (en) 1993-06-11 1994-12-22 Wade E. Bolton Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation
EP0708670A4 (en) * 1993-06-23 1998-07-01 Cytotherapeutics Inc METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES
JPH08503715A (ja) 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド 埋め込み装置の血管化を促進するための方法
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US5421923A (en) 1993-12-03 1995-06-06 Baxter International, Inc. Ultrasonic welding horn with sonics dampening insert
US5549675A (en) 1994-01-11 1996-08-27 Baxter International, Inc. Method for implanting tissue in a host
US6156305A (en) 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US5989833A (en) 1994-09-20 1999-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for detection of molecules with affinity for MPL polypeptides
US5807406A (en) * 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
WO1996032076A1 (en) * 1995-04-11 1996-10-17 Baxter Internatonal Inc. Tissue implant systems
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
EP0773753B1 (en) 1995-06-07 2003-10-08 Gore Hybrid Technologies, Inc. An implantable containment apparatus for a therapeutical device
AU6854696A (en) * 1995-09-22 1997-04-09 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
JP2001517927A (ja) 1996-02-28 2001-10-09 バンダービルト ユニバーシティ 胚幹細胞を作製する組成物および方法
US5964261A (en) 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
EP0986635A4 (en) 1997-01-10 2001-11-07 Life Technologies Inc SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
ES2279580T3 (es) 1997-09-15 2007-08-16 Genetic Immunity, Llc Composiciones para administrar genes a celulas de la piel que presentan antigenos.
US5945293A (en) 1997-10-09 1999-08-31 Coulter International Corp. Protein-colloidal metal-aminodextran coated particle and methods of preparation and use
US6074884A (en) 1997-10-09 2000-06-13 Coulter International Corp. Stable protein-nickel particles and methods of production and use thereof
EP1025204A4 (en) 1997-10-23 2001-02-28 Geron Corp Methods and materials for the growth of primate-derived primordial stem cells
IL138502A0 (en) 1998-04-09 2001-10-31 Bresagen Ltd Cell differentiation/ proliferation and maintenaince factor and uses thereof
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
PL191994B1 (pl) * 1998-12-15 2006-08-31 Univ Mexico Nacional Autonoma Sposób i urządzenie do wspomagania implantowania materiału biologicznego
EP1175487A2 (en) * 1999-02-10 2002-01-30 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6617151B1 (en) 2000-02-29 2003-09-09 Gore Enterprise Holdings, Inc. Method of closing a cell containment device with a wet seal
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
AU8617301A (en) 2000-08-01 2002-02-13 Yissum Res Dev Co Directed differentiation of embryonic cells
WO2002034880A2 (en) 2000-10-23 2002-05-02 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
JP2005501573A (ja) * 2000-12-01 2005-01-20 ネフロス セラピューティクス, インコーポレイテッド 血管内薬物送達デバイスおよびその使用
US6616912B2 (en) 2001-01-05 2003-09-09 Spectrum Laboratories, Inc. Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
EP1366148A2 (en) 2001-01-24 2003-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Differentiation of stem cells to pancreatic endocrine cells
WO2002101385A1 (en) 2001-06-13 2002-12-19 Massachusetts Institute Of Technology In vivo bioreactors
US6702857B2 (en) * 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US7432104B2 (en) 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
PT1420716E (pt) * 2001-08-29 2012-11-21 Ricardo A P De Carvalho Um sistema implantável e selável destinado à administração unidireccional de agentes terapêuticos em tecidos-alvo
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
US7157278B2 (en) 2001-12-04 2007-01-02 Organogenesis, Inc. Cultured cells from pancreatic islets
EP1461440B1 (en) * 2001-12-04 2011-11-09 Organogenesis Inc. Cultured cells from pancreatic islets
GB2399823B (en) 2001-12-07 2006-02-15 Geron Corp Islet cells from primate pluripotent stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US7101546B2 (en) * 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004098490A2 (en) 2002-05-17 2004-11-18 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
CN1668324A (zh) 2002-05-28 2005-09-14 诺沃塞尔公司 用于胰岛素产生细胞的方法、组合物及生长与分化因子
CN1662643A (zh) 2002-05-28 2005-08-31 贝克顿·迪金森公司 人腺泡细胞的扩增和转分化
NZ539713A (en) * 2002-10-11 2008-07-31 Novocell Inc Implantation of encapsulated biological materials for treating diseases
US20060040385A1 (en) 2002-12-05 2006-02-23 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
CA2515108A1 (en) 2003-02-07 2004-08-26 Wisconsin Alumni Research Foundation Directed genetic modifications of human stem cells
WO2005045001A2 (en) 2003-02-14 2005-05-19 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
WO2004104184A1 (ja) 2003-05-20 2004-12-02 Riken 内胚葉系幹細胞の調製
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
AU2004269395A1 (en) 2003-08-27 2005-03-10 Stemcells California, Inc. Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations
WO2005033294A2 (en) 2003-09-30 2005-04-14 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
WO2005059095A2 (en) * 2003-12-10 2005-06-30 The General Hospital Corporation Expansion and differentiation of islet progenitor cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
KR101221302B1 (ko) 2003-12-23 2013-01-11 비아싸이트, 인크. 완전 내배엽
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US20050191282A1 (en) * 2004-03-01 2005-09-01 Opara Emmanuel C. Method of cryopreserving pancreatic islet cells
WO2005086860A2 (en) 2004-03-09 2005-09-22 Gang Xu Methods for generating insulin-producing cells
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
CA2555571C (en) 2004-04-01 2012-10-16 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
ES2751095T3 (es) 2004-04-27 2020-03-30 Viacyte Inc Endodermo que expresa pdx1
CN100457900C (zh) * 2004-06-29 2009-02-04 天津大学 细胞和组织移植用金属微囊
AU2005272078B2 (en) 2004-07-09 2011-04-14 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
ES2754038T3 (es) 2004-07-09 2020-04-15 Viacyte Inc Células mesendodérmicas y células de línea pre-primitiva
EP1791952A4 (en) 2004-08-13 2008-06-11 Univ Georgia Res Found COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS
US20060063141A1 (en) 2004-09-17 2006-03-23 Mcgann Locksley E Method of cryopreserving cells
WO2006034873A1 (en) 2004-09-29 2006-04-06 Cellartis Ab METHODS FOR THE GENERATION OF HEPATOCYTE-LIKE CELLS FROM HUMAN BLASTOCYST-DERIVED STEM (hBs)
JP2008538276A (ja) * 2005-01-28 2008-10-23 ノヴァセラ・リミテッド 胚幹細胞培養のための方法
JP2008528038A (ja) 2005-01-31 2008-07-31 エス セル インターナショナル ピーティーイー リミテッド 胚性幹細胞の指示された分化及びその利用
US20060182722A1 (en) 2005-02-11 2006-08-17 Hering Bernhard J Methods and materials for isolating isogenic islet cells
CN100425694C (zh) 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
EP3584311A1 (en) 2005-10-27 2019-12-25 Viacyte, Inc. Pdx-1 expressing dorsal and ventral foregut endoderm
GB0522564D0 (en) * 2005-11-04 2005-12-14 Reneuron Ltd Cells
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
ES2614510T3 (es) 2006-02-07 2017-05-31 Spinalcyte, Llc Método y composiciones para la reparación del cartílago usando un biorreactor in vivo
EP1994141B1 (en) 2006-02-23 2017-11-15 ViaCyte, Inc. Compositions and methods useful for culturing differentiable cells
CA2644468C (en) 2006-03-02 2022-02-01 Cythera, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
AP2949A (en) * 2006-03-07 2014-07-31 Shroff Geeta Compositions comprising human embryonic stem cellsand their derivatives, methods of use, and method s of preparation
US20070237749A1 (en) * 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
US20090274712A1 (en) * 2006-10-24 2009-11-05 Dennis James E Compositions for coating cell membranes and methods of use thereof
US20080241250A1 (en) 2006-11-08 2008-10-02 Emans Pieter J In vivo bioreactors and methods of making and using same
US20080176318A1 (en) * 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
US20080279833A1 (en) 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US20100292543A1 (en) 2007-10-30 2010-11-18 Tufts University Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
EP3363444B1 (en) * 2008-11-14 2022-09-14 ViaCyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
AU2010286531B2 (en) 2009-08-28 2014-02-06 Sernova Corporation Methods and devices for cellular transplantation
BR112012017761A2 (pt) 2009-12-23 2015-09-15 Centocor Ortho Biotech Inc diferenciação das células-tronco embrionárias humanas
RU2663339C1 (ru) 2010-05-12 2018-08-03 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
US10702008B2 (en) 2018-02-26 2020-07-07 Hbn Shoe, Llc Device and method of constructing shoes
US11586805B2 (en) 2021-07-26 2023-02-21 Atlassian Pty Ltd. Machine-learning-based natural language processing techniques for low-latency document summarization

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