PL2356227T3 - Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych - Google Patents
Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystychInfo
- Publication number
- PL2356227T3 PL2356227T3 PL09826863T PL09826863T PL2356227T3 PL 2356227 T3 PL2356227 T3 PL 2356227T3 PL 09826863 T PL09826863 T PL 09826863T PL 09826863 T PL09826863 T PL 09826863T PL 2356227 T3 PL2356227 T3 PL 2356227T3
- Authority
- PL
- Poland
- Prior art keywords
- capsulation
- cells
- pancreas
- originating
- pluripotential stem
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 210000000496 pancreas Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/07—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/19—Growth and differentiation factors [GDF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11485708P | 2008-11-14 | 2008-11-14 | |
| US12108608P | 2008-12-09 | 2008-12-09 | |
| PCT/US2009/064459 WO2010057039A2 (en) | 2008-11-14 | 2009-11-13 | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| EP09826863.4A EP2356227B1 (en) | 2008-11-14 | 2009-11-13 | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2356227T3 true PL2356227T3 (pl) | 2018-07-31 |
Family
ID=42170745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09826863T PL2356227T3 (pl) | 2008-11-14 | 2009-11-13 | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US8278106B2 (pl) |
| EP (3) | EP3363444B1 (pl) |
| JP (6) | JP2012508584A (pl) |
| CN (2) | CN102282254B (pl) |
| AU (1) | AU2009313870B2 (pl) |
| CA (2) | CA3229301A1 (pl) |
| ES (2) | ES2932850T3 (pl) |
| PL (1) | PL2356227T3 (pl) |
| WO (1) | WO2010057039A2 (pl) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432104B2 (en) * | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| RU2551772C2 (ru) | 2008-02-21 | 2015-05-27 | Сентокор Орто Байотек Инк. | Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток |
| GB2460842B (en) * | 2008-06-10 | 2011-02-16 | Cryogenetics As | Packaging for biological material |
| AU2009267137A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| EP3363444B1 (en) * | 2008-11-14 | 2022-09-14 | ViaCyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| EP3260534A1 (en) | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| BRPI0921996A2 (pt) | 2008-11-20 | 2015-08-18 | Centocor Ortho Biotech Inc | Métodos e composições para cultura e ligação de células em substratos planos. |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| EP2456862A4 (en) * | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| AU2010286531B2 (en) | 2009-08-28 | 2014-02-06 | Sernova Corporation | Methods and devices for cellular transplantation |
| US20120321595A1 (en) | 2009-11-09 | 2012-12-20 | The Brigham And Women's Hospital, Inc. | Treatment of heart disease |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| US8455242B2 (en) | 2010-02-22 | 2013-06-04 | Hyclone Laboratories, Inc. | Mixing system with condenser |
| US9969981B2 (en) | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| WO2012020845A1 (ja) | 2010-08-09 | 2012-02-16 | 武田薬品工業株式会社 | 膵ホルモン産生細胞の製造法 |
| KR20190027969A (ko) * | 2010-08-12 | 2019-03-15 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 전구 세포를 이용한 당뇨병의 치료 |
| AU2015213422A1 (en) * | 2010-08-12 | 2015-09-10 | Janssen Biotech, Inc. | Treatment of diabetes with pancreatic endocrine precursor cells |
| US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
| JP6133776B2 (ja) | 2010-08-31 | 2017-05-24 | ヤンセン バイオテツク,インコーポレーテツド | 多能性幹細胞の分化 |
| KR101836850B1 (ko) | 2010-08-31 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| CA2809300A1 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| EP2621403B1 (en) | 2010-09-27 | 2015-03-18 | NsGene A/S | Implantable cell device with supportive and radial diffusive scaffolding |
| MX2010013135A (es) * | 2010-11-30 | 2012-05-31 | Val De Bio S De R L De C V | Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico. |
| WO2012115619A1 (en) | 2011-02-21 | 2012-08-30 | Viacyte, Inc. | Loading system for an encapsulation device |
| ES2902650T3 (es) | 2011-06-21 | 2022-03-29 | Novo Nordisk As | Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes |
| CN102550542B (zh) * | 2011-08-09 | 2014-06-25 | 臻景生物技术(上海)有限公司 | 用于脂肪干细胞的无血清冻存液及脂肪干细胞库的建立 |
| US20140242038A1 (en) * | 2011-10-11 | 2014-08-28 | The Trustees Of Columbia University In The City Of New York | Method for generating beta cells |
| USD726306S1 (en) * | 2011-12-12 | 2015-04-07 | Viacyte, Inc. | Cell encapsulation device |
| USD726307S1 (en) * | 2011-12-12 | 2015-04-07 | Viacyte Inc. | Cell encapsulation device |
| USD728095S1 (en) * | 2011-12-12 | 2015-04-28 | Viacyte, Inc. | Cell encapsulation device |
| AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| RU2018128383A (ru) | 2012-03-07 | 2019-03-14 | Янссен Байотек, Инк. | Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток |
| US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
| US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
| US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
| US10980919B2 (en) | 2016-04-14 | 2021-04-20 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
| US10017852B2 (en) | 2016-04-14 | 2018-07-10 | Lockheed Martin Corporation | Method for treating graphene sheets for large-scale transfer using free-float method |
| US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
| US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
| USD734847S1 (en) * | 2012-05-31 | 2015-07-21 | Viacyte, Inc. | Cell encapsulation device |
| RU2018108850A (ru) | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| WO2014008432A1 (en) * | 2012-07-06 | 2014-01-09 | The Regents Of The University Of California | Cryopreservation of cells inside a macro-encapsulation device |
| JP6470687B2 (ja) | 2012-09-03 | 2019-02-13 | ノヴォ ノルディスク アー/エス | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 |
| AU2013248265B2 (en) | 2012-11-08 | 2018-11-01 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| EP4039798A1 (en) | 2012-12-31 | 2022-08-10 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells |
| MX2015008577A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Cultivo de celulas madre embrionarias humanas en la interfase aire-liquido para la diferenciacion en celulas endocrinas pancreaticas. |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| SG10201707811XA (en) | 2012-12-31 | 2017-11-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| IL290717B2 (en) * | 2013-02-06 | 2024-10-01 | Viacyte Inc | Cell compositions derived from dedifferentiated reprogrammed cells |
| WO2014127219A1 (en) * | 2013-02-14 | 2014-08-21 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| PL2964147T3 (pl) * | 2013-03-07 | 2018-10-31 | Viacyte, Inc. | Trójwymiarowy zestaw urządzeń o dużej pojemności do kapsułkowania komórek |
| USD720469S1 (en) | 2013-03-07 | 2014-12-30 | Viacyte, Inc. | Cell encapsulation device |
| WO2014138671A2 (en) * | 2013-03-08 | 2014-09-12 | Viacyte, Inc. | Cryopreservation, hibernation and room temperature storage of encapulated pancreatic endoderm cell aggregates |
| US9592475B2 (en) | 2013-03-12 | 2017-03-14 | Lockheed Martin Corporation | Method for forming perforated graphene with uniform aperture size |
| US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| EP2988699B1 (en) | 2013-04-24 | 2020-05-27 | Société des Produits Nestlé S.A. | Encapsulation device |
| KR102423106B1 (ko) | 2013-06-11 | 2022-07-21 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
| DK3016511T3 (da) | 2013-07-02 | 2020-01-13 | Austrianova Singapore Pte Ltd | En fremgangsmåde til at frysetørre indkapslede celler, sammensætninger egnet til at fryse indkapslede celler og anvendelse af sådanne sammensætninger |
| US10231817B2 (en) | 2013-09-24 | 2019-03-19 | Giner Life Sciences, Inc. | System for gas treatment of a cell implant |
| KR20160142820A (ko) | 2014-01-31 | 2016-12-13 | 록히드 마틴 코포레이션 | 브로드 이온 필드를 사용한 2차원 물질 천공 |
| AU2015210875A1 (en) | 2014-01-31 | 2016-09-15 | Lockheed Martin Corporation | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
| USD718471S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD718470S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD718468S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD718467S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD718466S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-Dimensional large capacity cell encapsulation device |
| USD718472S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD718469S1 (en) * | 2014-03-07 | 2014-11-25 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| USD714956S1 (en) * | 2014-03-07 | 2014-10-07 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device |
| MX2016011812A (es) * | 2014-03-12 | 2017-05-09 | Lockheed Corp | Uso in vivo e in vitro de grafeno. |
| CN106232205A (zh) | 2014-03-12 | 2016-12-14 | 洛克希德马丁公司 | 由有孔石墨烯形成的分离膜 |
| JP6585616B2 (ja) | 2014-03-21 | 2019-10-02 | ライフ テクノロジーズ コーポレイション | 流体処理システムのためのガスフィルタシステム |
| WO2015142406A1 (en) | 2014-03-21 | 2015-09-24 | Life Technologies Corporation | Condenser systems for fluid processing systems |
| US9950151B2 (en) * | 2014-03-27 | 2018-04-24 | Beta-O2 Technologies Ltd. | Implantable medical devices |
| USD760399S1 (en) * | 2014-04-16 | 2016-06-28 | Viacyte, Inc. | Case for an encapsulation device |
| EP3131497B1 (en) * | 2014-04-16 | 2023-08-16 | ViaCyte, Inc. | Instruments for use with implantable encapsulation devices |
| US11051900B2 (en) | 2014-04-16 | 2021-07-06 | Viacyte, Inc. | Tools and instruments for use with implantable encapsulation devices |
| US11083758B2 (en) * | 2014-05-14 | 2021-08-10 | Prime Merger Sub, Llc | Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs |
| KR102162138B1 (ko) | 2014-05-16 | 2020-10-06 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 |
| WO2015178431A1 (ja) * | 2014-05-21 | 2015-11-26 | 国立大学法人京都大学 | 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤 |
| WO2015191547A1 (en) | 2014-06-09 | 2015-12-17 | Cornell University | Implantable therapeutic delivery system and methods thereof |
| CN107073408A (zh) | 2014-09-02 | 2017-08-18 | 洛克希德马丁公司 | 基于二维膜材料的血液透析膜和血液过滤膜及其应用方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| CA3226186A1 (en) | 2015-03-23 | 2016-09-29 | The Regents Of The University Of California | Use of thin film cell encapsulation devices |
| US10494608B2 (en) | 2015-04-24 | 2019-12-03 | University Of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| CA2994549A1 (en) | 2015-08-05 | 2017-02-09 | Lockheed Martin Corporation | Perforatable sheets of graphene-based material |
| CA2994664A1 (en) | 2015-08-06 | 2017-02-09 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
| WO2017049008A1 (en) * | 2015-09-16 | 2017-03-23 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
| EP3167911A1 (en) * | 2015-11-10 | 2017-05-17 | Oniris | Si-hpmc-encapsulated insulin-producing cells for the treatment of type 1 diabetes |
| CN112403668B (zh) * | 2015-12-29 | 2023-06-27 | 生命科技股份有限公司 | 具有部分分割分隔区的柔性生物处理容器 |
| WO2017123759A1 (en) * | 2016-01-12 | 2017-07-20 | Zanella Fabian | Cell medium formulation for cell stabilization |
| US11534466B2 (en) | 2016-03-09 | 2022-12-27 | Aal Scientifics, Inc. | Pancreatic stem cells and uses thereof |
| WO2017165850A1 (en) * | 2016-03-25 | 2017-09-28 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
| MA45479A (fr) * | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| EP3442697A4 (en) | 2016-04-14 | 2020-03-18 | Lockheed Martin Corporation | SELECTIVE INTERFACE REDUCTION OF GRAPH DEFECTS |
| JP2019519756A (ja) | 2016-04-14 | 2019-07-11 | ロッキード・マーチン・コーポレーション | 欠陥形成または欠陥修復をその場で監視して制御する方法 |
| KR20190018410A (ko) | 2016-04-14 | 2019-02-22 | 록히드 마틴 코포레이션 | 흐름 통로들을 갖는 2차원 막 구조들 |
| EP3484997A4 (en) | 2016-07-12 | 2020-07-29 | California Institute of Technology | SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE |
| CA3042712A1 (en) | 2016-11-03 | 2018-08-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and systems for real-time assessment of cells in encapsulation devices pre- and post-transplantation |
| EP3534834A4 (en) | 2016-11-03 | 2020-05-13 | Arizona Board of Regents on behalf of the University of Arizona | Encapsulation device systems with oxygen sensors with or without exogenous oxygen supply |
| CN115429222A (zh) * | 2016-11-03 | 2022-12-06 | 代表亚利桑那大学的亚利桑那董事会 | 用于改进血糖调节的方法、系统和可植入装置 |
| US11446133B2 (en) | 2016-11-03 | 2022-09-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Stacked tissue encapsulation device systems with or without oxygen delivery |
| US11052230B2 (en) | 2016-11-08 | 2021-07-06 | W. L. Gore & Associates, Inc. | Implantable encapsulation devices |
| US10849731B2 (en) * | 2016-11-08 | 2020-12-01 | W. L. Gore & Associates, Inc. | Cell encapsulation devices containing structural spacers |
| USD824042S1 (en) | 2016-11-10 | 2018-07-24 | Viacyte, Inc. | Perforated cell encapsulation device |
| JP7088564B2 (ja) | 2016-11-10 | 2022-06-21 | ヴィアサイト,インコーポレイテッド | 細胞送達装置におけるpdx1膵臓内胚葉細胞及びその方法 |
| RU2019114843A (ru) | 2016-11-15 | 2020-11-16 | Джинер Лайф Сайенс, Инк. | Саморегулируемый электролитический газогенератор и содержащая его имплантационная система |
| US11033666B2 (en) | 2016-11-15 | 2021-06-15 | Giner Life Sciences, Inc. | Percutaneous gas diffusion device suitable for use with a subcutaneous implant |
| CN108148808B (zh) * | 2016-12-05 | 2020-12-11 | 同济大学 | 有助于诱导生成神经前体细胞的诱导培养基 |
| WO2018159805A1 (ja) * | 2017-03-03 | 2018-09-07 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| US12016327B2 (en) | 2017-03-20 | 2024-06-25 | Boston Scientific Medical Device Limited | Cell encapsulation device |
| WO2018204867A1 (en) | 2017-05-04 | 2018-11-08 | Giner, Inc. | Robust, implantable gas delivery device and methods, systems and devices including same |
| EP3409239A1 (en) | 2017-05-29 | 2018-12-05 | University College Dublin, National University of Ireland, Dublin | An implantable active agent encapsulating device |
| CA3066055A1 (en) | 2017-06-14 | 2018-12-20 | Semma Therapeutics, Inc. | Devices and methods for delivering therapeutics |
| JPWO2018230588A1 (ja) * | 2017-06-14 | 2020-04-16 | 武田薬品工業株式会社 | 細胞封入デバイス |
| KR102001120B1 (ko) | 2017-06-29 | 2019-07-16 | 서울대학교산학협력단 | 나노섬유 및 하이드로젤의 복합체 및 이를 포함하는 조직 재생용 스캐폴드 |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| EP3677289A4 (en) | 2017-08-30 | 2020-08-26 | FUJIFILM Corporation | ANGIOGENIC AGENT AND PROCESS FOR THE PRODUCTION OF THE LATTER |
| EP3677287B1 (en) | 2017-08-30 | 2024-05-29 | FUJIFILM Corporation | Cell transplantation device and method for manufacturing same |
| CN111108190B (zh) * | 2017-09-11 | 2024-06-21 | 诺和诺德股份有限公司 | 在体外从干细胞衍生的nkx6.1和c-肽共表达细胞的富集 |
| CN111491617B (zh) | 2017-09-29 | 2024-12-31 | 沃泰克斯药物股份有限公司 | 细胞容纳装置 |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| AU2018370029B2 (en) * | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| JP2019097442A (ja) | 2017-11-30 | 2019-06-24 | 株式会社日立製作所 | 免疫隔離デバイス |
| JP6417023B2 (ja) * | 2017-12-20 | 2018-10-31 | ネステク ソシエテ アノニム | カプセル化デバイス |
| CN108543116B (zh) * | 2018-05-02 | 2021-04-27 | 深圳市华异生物科技有限责任公司 | 海藻酸钠与明胶复合水凝胶3d胰岛支架及其制备方法 |
| CA3100192C (en) | 2018-05-17 | 2023-03-14 | Giner Life Sciences, Inc. | Electrolytic gas generator with combined lead and gas port terminals |
| CN112912490B (zh) * | 2018-08-03 | 2023-12-26 | 千纸鹤治疗公司 | 细胞制造方法 |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| EP3840693A1 (en) * | 2018-08-22 | 2021-06-30 | Boston Scientific Scimed Inc. | Cell encapsulation device including a porous tube |
| US12408661B2 (en) * | 2018-08-30 | 2025-09-09 | The Curators Of The University Of Missouri | Efficient cryopreservation device preventing the direct contact between samples and extracellular ice |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| US20210401564A1 (en) * | 2018-09-24 | 2021-12-30 | Arizona Board Regents On Behalf Of The University Of Arizona | Methods and systems for implantable medical devices and vascularization membranes |
| US12303374B2 (en) * | 2018-09-26 | 2025-05-20 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled cell bed thickness |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| AU2019360857A1 (en) * | 2018-10-15 | 2021-06-03 | Evia Life Sciences Inc. | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| CN109289090A (zh) * | 2018-10-31 | 2019-02-01 | 陈津 | 一种胰岛移植微环境及其构建方法 |
| WO2020138028A1 (ja) * | 2018-12-25 | 2020-07-02 | 富士フイルム株式会社 | 細胞移植キット、袋状構造物の製造方法、および糖尿病治療剤 |
| JP7267377B2 (ja) * | 2019-02-25 | 2023-05-01 | ヴィアサイト インコーポレイテッド | 埋め込み可能な封入デバイスと共に使用するツールおよび器具 |
| JP6970245B2 (ja) * | 2019-02-25 | 2021-11-24 | ヴィアサイト インコーポレイテッド | 埋め込み可能な封入デバイスと共に使用するツールおよび器具 |
| CN119345037A (zh) * | 2019-04-03 | 2025-01-24 | 沃泰克斯药物股份有限公司 | 大胶囊装置 |
| EP3975926A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | A biocompatible membrane composite |
| AU2020283056B2 (en) * | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| CA3139591C (en) | 2019-05-31 | 2024-01-16 | Timothy M. BRUHN | A biocompatible membrane composite |
| AU2020340622A1 (en) | 2019-09-05 | 2022-03-03 | Crispr Therapeutics Ag | Universal donor cells |
| US11118195B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| AU2020352623A1 (en) * | 2019-09-27 | 2022-05-12 | Isla Technologies, Inc. | Bioartificial pancreas |
| WO2022047543A1 (en) * | 2020-09-04 | 2022-03-10 | Captix Biomedical Pty Ltd | "bone implant" |
| CA3196876A1 (en) | 2020-10-30 | 2022-05-05 | Klearchos Papas | Methods and systems for encapsulation devices for housing cells and agents |
| CN112544613B (zh) * | 2020-12-25 | 2022-08-16 | 武汉睿健医药科技有限公司 | 一种多能干细胞冻存液、其应用及冻存方法 |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
| JP2024530690A (ja) * | 2021-08-10 | 2024-08-23 | ユニフェルシテイト マーストリヒト | 開放型移植可能細胞送達デバイス |
| US20250152324A1 (en) | 2022-02-25 | 2025-05-15 | Viacyte, Inc. | Multilayer implantable cell encapsulation devices and methods thereof |
| WO2023203208A1 (en) | 2022-04-21 | 2023-10-26 | Evotec International Gmbh | New cell populations and means and methods for their differentiation and preservation |
| WO2024039773A1 (en) | 2022-08-19 | 2024-02-22 | Dimension Inx Corp | Biointegrative implantable cell encapsulation device and system |
| EP4593994A1 (en) | 2022-09-30 | 2025-08-06 | W. L. Gore & Associates, Inc. | Implantable membrane construct and encapsulaton devices incorporating the same |
| WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
| EP4602155A1 (en) | 2022-10-11 | 2025-08-20 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
| WO2025088022A1 (en) | 2023-10-24 | 2025-05-01 | Technische Universität Dresden, Körperschaft des öffentlichen Rechts | Method for generating homogenous, size-defined pseudo-islets of porcine origin by rho/rock pathway inhibition |
| JP7451818B1 (ja) | 2023-11-10 | 2024-03-18 | 洋之 高尾 | Diffusion Chamber型人工膵島器 |
| WO2025226588A1 (en) * | 2024-04-22 | 2025-10-30 | Wake Forest University Health Sciences | Artificial implants that promote neovascularization |
Family Cites Families (163)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2500388A (en) | 1948-07-21 | 1950-03-14 | Minnesota Mining & Mfg | Fluorocarbon ethers |
| US2594272A (en) | 1948-09-10 | 1952-04-29 | Minnesota Mining & Mfg | Cyclic fluoroalkylene oxide compounds |
| US2519983A (en) | 1948-11-29 | 1950-08-22 | Minnesota Mining & Mfg | Electrochemical process of making fluorine-containing carbon compounds |
| US2616927A (en) | 1950-05-12 | 1952-11-04 | Minnesota Mining & Mfg | Fluorocarbon tertiary amines |
| US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
| US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| US4723953A (en) * | 1985-01-07 | 1988-02-09 | Rocky Mountain Medical Corporation | Absorbent pad |
| US4788339A (en) | 1985-09-06 | 1988-11-29 | Minnesota Mining And Manufacturing Company | Perfluoroaminoethers |
| US5026365A (en) * | 1987-04-29 | 1991-06-25 | The University Of Massachusetts | Method and apparatus for therapeutically treating immunological disorders and disease states |
| US5418154A (en) | 1987-11-17 | 1995-05-23 | Brown University Research Foundation | Method of preparing elongated seamless capsules containing biological material |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5182111A (en) | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5219361A (en) | 1988-09-16 | 1993-06-15 | Clemson University | Soft tissue implant with micron-scale surface texture to optimize anchorage |
| US5011494A (en) | 1988-09-16 | 1991-04-30 | Clemson University | Soft tissue implant with micron-scale surface texture to optimize anchorage |
| CA1335181C (en) | 1988-10-11 | 1995-04-11 | R. Alan Hardwick | System for selective cell separation from cell concentrate |
| ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| US5116493A (en) | 1989-08-25 | 1992-05-26 | W. R. Grace & Co.-Conn. | Artificial pancreatic perfusion device with reseedable matrix |
| US5002661A (en) | 1989-08-25 | 1991-03-26 | W. R. Grace & Co.-Conn. | Artificial pancreatic perfusion device |
| US5100392A (en) | 1989-12-08 | 1992-03-31 | Biosynthesis, Inc. | Implantable device for administration of drugs or other liquid solutions |
| US5171846A (en) | 1990-05-21 | 1992-12-15 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use |
| US5272257A (en) | 1990-05-21 | 1993-12-21 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use |
| US5240640A (en) | 1990-06-04 | 1993-08-31 | Coulter Corporation | In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5314471A (en) | 1991-07-24 | 1994-05-24 | Baxter International Inc. | Tissue inplant systems and methods for sustaining viable high cell densities within a host |
| US5713888A (en) | 1990-10-31 | 1998-02-03 | Baxter International, Inc. | Tissue implant systems |
| US5344454A (en) | 1991-07-24 | 1994-09-06 | Baxter International Inc. | Closed porous chambers for implanting tissue in a host |
| US5466609A (en) | 1990-10-31 | 1995-11-14 | Coulter Corporation | Biodegradable gelatin-aminodextran particle coatings of and processes for making same |
| US5733336A (en) | 1990-10-31 | 1998-03-31 | Baxter International, Inc. | Ported tissue implant systems and methods of using same |
| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| JP3508023B2 (ja) | 1990-10-31 | 2004-03-22 | バクスター、インターナショナル、インコーポレイテッド | 密接血管化埋め込み材料 |
| ATE243747T1 (de) | 1991-07-15 | 2003-07-15 | Wellcome Found | Herstellung von antikörpern |
| US5453278A (en) | 1991-07-24 | 1995-09-26 | Baxter International Inc. | Laminated barriers for tissue implants |
| US6773458B1 (en) | 1991-07-24 | 2004-08-10 | Baxter International Inc. | Angiogenic tissue implant systems and methods |
| JPH06502577A (ja) | 1991-07-30 | 1994-03-24 | バクスター、インターナショナル、インコーポレイテッド | 有孔埋め込み物 |
| JPH0613739Y2 (ja) * | 1991-09-26 | 1994-04-13 | 富士システムズ株式会社 | 人工臓器用カプセル及び人工臓器 |
| US5248772A (en) | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| US6165993A (en) | 1992-03-23 | 2000-12-26 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| WO1993021902A1 (en) | 1992-04-24 | 1993-11-11 | Somatix Therapy Corporation | Biocompatible, therapeutic, implantable device |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US7153684B1 (en) | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5262055A (en) | 1992-10-19 | 1993-11-16 | The University Of Utah | Implantable and refillable biohybrid artificial pancreas |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| CA2164646A1 (en) | 1993-06-11 | 1994-12-22 | Wade E. Bolton | Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation |
| EP0708670A4 (en) * | 1993-06-23 | 1998-07-01 | Cytotherapeutics Inc | METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES |
| JPH08503715A (ja) | 1993-09-24 | 1996-04-23 | バクスター、インターナショナル、インコーポレイテッド | 埋め込み装置の血管化を促進するための方法 |
| US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5421923A (en) | 1993-12-03 | 1995-06-06 | Baxter International, Inc. | Ultrasonic welding horn with sonics dampening insert |
| US5549675A (en) | 1994-01-11 | 1996-08-27 | Baxter International, Inc. | Method for implanting tissue in a host |
| US6156305A (en) | 1994-07-08 | 2000-12-05 | Baxter International Inc. | Implanted tumor cells for the prevention and treatment of cancer |
| US5989833A (en) | 1994-09-20 | 1999-11-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for detection of molecules with affinity for MPL polypeptides |
| US5807406A (en) * | 1994-10-07 | 1998-09-15 | Baxter International Inc. | Porous microfabricated polymer membrane structures |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5705059A (en) | 1995-02-27 | 1998-01-06 | Miltenyi; Stefan | Magnetic separation apparatus |
| WO1996032076A1 (en) * | 1995-04-11 | 1996-10-17 | Baxter Internatonal Inc. | Tissue implant systems |
| US6060640A (en) | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
| EP0773753B1 (en) | 1995-06-07 | 2003-10-08 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device |
| AU6854696A (en) * | 1995-09-22 | 1997-04-09 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
| JP2001517927A (ja) | 1996-02-28 | 2001-10-09 | バンダービルト ユニバーシティ | 胚幹細胞を作製する組成物および方法 |
| US5964261A (en) | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| ES2279580T3 (es) | 1997-09-15 | 2007-08-16 | Genetic Immunity, Llc | Composiciones para administrar genes a celulas de la piel que presentan antigenos. |
| US5945293A (en) | 1997-10-09 | 1999-08-31 | Coulter International Corp. | Protein-colloidal metal-aminodextran coated particle and methods of preparation and use |
| US6074884A (en) | 1997-10-09 | 2000-06-13 | Coulter International Corp. | Stable protein-nickel particles and methods of production and use thereof |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| IL138502A0 (en) | 1998-04-09 | 2001-10-31 | Bresagen Ltd | Cell differentiation/ proliferation and maintenaince factor and uses thereof |
| US6921811B2 (en) | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE19852800C1 (de) | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
| PL191994B1 (pl) * | 1998-12-15 | 2006-08-31 | Univ Mexico Nacional Autonoma | Sposób i urządzenie do wspomagania implantowania materiału biologicznego |
| EP1175487A2 (en) * | 1999-02-10 | 2002-01-30 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| US6365385B1 (en) * | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
| US6872389B1 (en) | 1999-07-08 | 2005-03-29 | Rhode Island Hospital | Liver stem cell |
| US6520997B1 (en) | 1999-12-08 | 2003-02-18 | Baxter International Inc. | Porous three dimensional structure |
| US6617151B1 (en) | 2000-02-29 | 2003-09-09 | Gore Enterprise Holdings, Inc. | Method of closing a cell containment device with a wet seal |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US7256042B2 (en) | 2000-04-27 | 2007-08-14 | Geron Corporation | Process for making hepatocytes from pluripotent stem cells |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| AU8617301A (en) | 2000-08-01 | 2002-02-13 | Yissum Res Dev Co | Directed differentiation of embryonic cells |
| WO2002034880A2 (en) | 2000-10-23 | 2002-05-02 | University Of Kansas | Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion |
| JP2005501573A (ja) * | 2000-12-01 | 2005-01-20 | ネフロス セラピューティクス, インコーポレイテッド | 血管内薬物送達デバイスおよびその使用 |
| US6616912B2 (en) | 2001-01-05 | 2003-09-09 | Spectrum Laboratories, Inc. | Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells |
| EP1366148A2 (en) | 2001-01-24 | 2003-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Differentiation of stem cells to pancreatic endocrine cells |
| WO2002101385A1 (en) | 2001-06-13 | 2002-12-19 | Massachusetts Institute Of Technology | In vivo bioreactors |
| US6702857B2 (en) * | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US7432104B2 (en) | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| PT1420716E (pt) * | 2001-08-29 | 2012-11-21 | Ricardo A P De Carvalho | Um sistema implantável e selável destinado à administração unidireccional de agentes terapêuticos em tecidos-alvo |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| US7157278B2 (en) | 2001-12-04 | 2007-01-02 | Organogenesis, Inc. | Cultured cells from pancreatic islets |
| EP1461440B1 (en) * | 2001-12-04 | 2011-11-09 | Organogenesis Inc. | Cultured cells from pancreatic islets |
| GB2399823B (en) | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| US20030138949A1 (en) | 2001-12-12 | 2003-07-24 | Anil Bhushan | Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells |
| US7101546B2 (en) * | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2004098490A2 (en) | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| CN1668324A (zh) | 2002-05-28 | 2005-09-14 | 诺沃塞尔公司 | 用于胰岛素产生细胞的方法、组合物及生长与分化因子 |
| CN1662643A (zh) | 2002-05-28 | 2005-08-31 | 贝克顿·迪金森公司 | 人腺泡细胞的扩增和转分化 |
| NZ539713A (en) * | 2002-10-11 | 2008-07-31 | Novocell Inc | Implantation of encapsulated biological materials for treating diseases |
| US20060040385A1 (en) | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| CA2515108A1 (en) | 2003-02-07 | 2004-08-26 | Wisconsin Alumni Research Foundation | Directed genetic modifications of human stem cells |
| WO2005045001A2 (en) | 2003-02-14 | 2005-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20030224411A1 (en) | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| WO2004104184A1 (ja) | 2003-05-20 | 2004-12-02 | Riken | 内胚葉系幹細胞の調製 |
| WO2005017131A2 (en) | 2003-08-14 | 2005-02-24 | THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES | Methods for the differentiation of human stem cells |
| AU2004269395A1 (en) | 2003-08-27 | 2005-03-10 | Stemcells California, Inc. | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations |
| WO2005033294A2 (en) | 2003-09-30 | 2005-04-14 | Regents Of The University Of California | Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage |
| WO2005059095A2 (en) * | 2003-12-10 | 2005-06-30 | The General Hospital Corporation | Expansion and differentiation of islet progenitor cells |
| US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| WO2007059007A2 (en) | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| KR101221302B1 (ko) | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US20050191282A1 (en) * | 2004-03-01 | 2005-09-01 | Opara Emmanuel C. | Method of cryopreserving pancreatic islet cells |
| WO2005086860A2 (en) | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| CA2555571C (en) | 2004-04-01 | 2012-10-16 | Wisconsin Alumni Research Foundation | Differentiation of stem cells to endoderm and pancreatic lineage |
| ES2751095T3 (es) | 2004-04-27 | 2020-03-30 | Viacyte Inc | Endodermo que expresa pdx1 |
| CN100457900C (zh) * | 2004-06-29 | 2009-02-04 | 天津大学 | 细胞和组织移植用金属微囊 |
| AU2005272078B2 (en) | 2004-07-09 | 2011-04-14 | Viacyte, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| ES2754038T3 (es) | 2004-07-09 | 2020-04-15 | Viacyte Inc | Células mesendodérmicas y células de línea pre-primitiva |
| EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| US20060063141A1 (en) | 2004-09-17 | 2006-03-23 | Mcgann Locksley E | Method of cryopreserving cells |
| WO2006034873A1 (en) | 2004-09-29 | 2006-04-06 | Cellartis Ab | METHODS FOR THE GENERATION OF HEPATOCYTE-LIKE CELLS FROM HUMAN BLASTOCYST-DERIVED STEM (hBs) |
| JP2008538276A (ja) * | 2005-01-28 | 2008-10-23 | ノヴァセラ・リミテッド | 胚幹細胞培養のための方法 |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| US20060182722A1 (en) | 2005-02-11 | 2006-08-17 | Hering Bernhard J | Methods and materials for isolating isogenic islet cells |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2007002210A2 (en) | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| EP3584311A1 (en) | 2005-10-27 | 2019-12-25 | Viacyte, Inc. | Pdx-1 expressing dorsal and ventral foregut endoderm |
| GB0522564D0 (en) * | 2005-11-04 | 2005-12-14 | Reneuron Ltd | Cells |
| GB0602063D0 (en) | 2006-02-02 | 2006-03-15 | Univ Manchester | Cell Culture |
| ES2614510T3 (es) | 2006-02-07 | 2017-05-31 | Spinalcyte, Llc | Método y composiciones para la reparación del cartílago usando un biorreactor in vivo |
| EP1994141B1 (en) | 2006-02-23 | 2017-11-15 | ViaCyte, Inc. | Compositions and methods useful for culturing differentiable cells |
| CA2644468C (en) | 2006-03-02 | 2022-02-01 | Cythera, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| AP2949A (en) * | 2006-03-07 | 2014-07-31 | Shroff Geeta | Compositions comprising human embryonic stem cellsand their derivatives, methods of use, and method s of preparation |
| US20070237749A1 (en) * | 2006-04-07 | 2007-10-11 | Wang Taylor G | Multi-membrane immunoisolation system for cellular transplant |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| US20090274712A1 (en) * | 2006-10-24 | 2009-11-05 | Dennis James E | Compositions for coating cell membranes and methods of use thereof |
| US20080241250A1 (en) | 2006-11-08 | 2008-10-02 | Emans Pieter J | In vivo bioreactors and methods of making and using same |
| US20080176318A1 (en) * | 2006-12-07 | 2008-07-24 | Wilson John R | Highly efficient devices and methods for culturing cells |
| US20080279833A1 (en) | 2007-05-10 | 2008-11-13 | Matheny Robert G | Laminate sheet articles for tissue regeneration |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| US8623650B2 (en) | 2007-10-19 | 2014-01-07 | Viacyte, Inc. | Methods and compositions for feeder-free pluripotent stem cell media containing human serum |
| US20100292543A1 (en) | 2007-10-30 | 2010-11-18 | Tufts University | Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| EP3363444B1 (en) * | 2008-11-14 | 2022-09-14 | ViaCyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| AU2010286531B2 (en) | 2009-08-28 | 2014-02-06 | Sernova Corporation | Methods and devices for cellular transplantation |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| US10702008B2 (en) | 2018-02-26 | 2020-07-07 | Hbn Shoe, Llc | Device and method of constructing shoes |
| US11586805B2 (en) | 2021-07-26 | 2023-02-21 | Atlassian Pty Ltd. | Machine-learning-based natural language processing techniques for low-latency document summarization |
-
2009
- 2009-11-13 EP EP18163933.7A patent/EP3363444B1/en active Active
- 2009-11-13 WO PCT/US2009/064459 patent/WO2010057039A2/en not_active Ceased
- 2009-11-13 US US12/618,659 patent/US8278106B2/en active Active
- 2009-11-13 CN CN200980154622.7A patent/CN102282254B/zh active Active
- 2009-11-13 AU AU2009313870A patent/AU2009313870B2/en active Active
- 2009-11-13 CA CA3229301A patent/CA3229301A1/en active Pending
- 2009-11-13 PL PL09826863T patent/PL2356227T3/pl unknown
- 2009-11-13 JP JP2011536536A patent/JP2012508584A/ja active Pending
- 2009-11-13 ES ES18163933T patent/ES2932850T3/es active Active
- 2009-11-13 CN CN201510760059.5A patent/CN105349517B/zh active Active
- 2009-11-13 ES ES09826863.4T patent/ES2667493T3/es active Active
- 2009-11-13 EP EP22195181.7A patent/EP4176888A1/en active Pending
- 2009-11-13 EP EP09826863.4A patent/EP2356227B1/en active Active
- 2009-11-13 CA CA2743641A patent/CA2743641C/en active Active
-
2011
- 2011-07-22 US US13/188,706 patent/US8425928B2/en active Active
-
2013
- 2013-03-26 US US13/850,978 patent/US20130209425A1/en not_active Abandoned
- 2013-05-24 US US13/902,774 patent/US9132226B2/en active Active
-
2014
- 2014-05-28 JP JP2014110151A patent/JP2014159477A/ja active Pending
-
2015
- 2015-08-07 US US14/820,807 patent/US9764062B2/en active Active
- 2015-11-13 US US14/941,052 patent/US9913930B2/en active Active
-
2017
- 2017-07-28 JP JP2017146480A patent/JP2017197578A/ja active Pending
- 2017-08-16 US US15/679,002 patent/US10272179B2/en active Active
-
2018
- 2018-09-10 JP JP2018168902A patent/JP2018188484A/ja not_active Withdrawn
-
2019
- 2019-03-11 US US16/299,022 patent/US11660377B2/en active Active
-
2020
- 2020-10-09 JP JP2020170889A patent/JP2021004258A/ja active Pending
-
2022
- 2022-07-05 JP JP2022108223A patent/JP2022125204A/ja active Pending
-
2023
- 2023-04-25 US US18/138,904 patent/US20230256137A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2356227T3 (pl) | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych | |
| BR112012001564A2 (pt) | Diferenciação de células tronco embrionárias humanas. | |
| BR112012001557A2 (pt) | diferenciação de células-tronco embrionárias humanas. | |
| EP3680323C0 (en) | PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE | |
| EP2346734A4 (en) | ACTIVE WINGLET | |
| SE0950586L (sv) | Förbättrad odling av stamceller | |
| BRPI0814894A2 (pt) | Diferenciação de células-tronco embrionárias de ser humano. | |
| DK3130923T3 (da) | Terapeutiske fremgangsmåder i forbindelse med cancerstamceller | |
| SMT201600040B (it) | Rilascio non covalente peptide-mediato di agenti attivi attraverso la barriera emato-encefalica | |
| BRPI0814425A2 (pt) | Diferenciação de células-tronco embrionárias humanas | |
| BR112012001480A2 (pt) | Diferenciação de células-tronco embriônicas humanas | |
| FR2947716B1 (fr) | Implant prothetique ameliore | |
| EP2556145A4 (en) | ANGIOGENESIS USING PLAZENTA STEM CELLS | |
| EP2467097A4 (en) | POROUS IMPLANT STRUCTURES | |
| EP2315829A4 (en) | INDUCED PLURIPOTENTIAL STEM CELLS | |
| PL2611909T3 (pl) | Zróżnicowanie ludzkich embrionalnych komórek macierzystych | |
| PL3050571T3 (pl) | Preparat enzymu trawiennego do leczenia rzucawki | |
| BRPI0822221A2 (pt) | Composições aquosas e estáveis de ciclosporina | |
| BRPI0913925A2 (pt) | Diferenciação de células-tronco pluripotentes | |
| DOP2011000397A (es) | Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10a | |
| IT1396692B1 (it) | Struttura di protesi per amputati agli arti inferiori. | |
| DK3591046T3 (da) | Amylasepolypeptide | |
| SMT201600332B (it) | Composizioni e metodi per l’aumento dell’attivitàtelomerasica | |
| BR112012003258A2 (pt) | Composição ativa de aroma | |
| BR112012001916A2 (pt) | soluções estabilizadas de halogênio ativo |