PL2346823T3 - Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onu - Google Patents
Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onuInfo
- Publication number
- PL2346823T3 PL2346823T3 PL09792268T PL09792268T PL2346823T3 PL 2346823 T3 PL2346823 T3 PL 2346823T3 PL 09792268 T PL09792268 T PL 09792268T PL 09792268 T PL09792268 T PL 09792268T PL 2346823 T3 PL2346823 T3 PL 2346823T3
- Authority
- PL
- Poland
- Prior art keywords
- phenyl
- decan
- diaza
- spiro
- intermediates
- Prior art date
Links
- FIVSJYGQAIEMOC-UHFFFAOYSA-N 8-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxymethyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one Chemical class C=1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1C(C)OCC(NC1)(C=2C=CC=CC=2)CCC21CCC(=O)N2 FIVSJYGQAIEMOC-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9447408P | 2008-09-05 | 2008-09-05 | |
| EP09792268.6A EP2346823B1 (en) | 2008-09-05 | 2009-09-04 | Intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
| PCT/US2009/056020 WO2010028232A1 (en) | 2008-09-05 | 2009-09-04 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2346823T3 true PL2346823T3 (pl) | 2016-01-29 |
Family
ID=41402490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09792268T PL2346823T3 (pl) | 2008-09-05 | 2009-09-04 | Związki pośrednie w syntezie związków 8-[{1-(3,5-bis-(trifluorometylo)fenylo)etoksy}metylo]-8-fenylo-1,7-diaza-spiro[4.5]dekan-2-onu |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9249144B2 (pl) |
| EP (2) | EP3034493A1 (pl) |
| JP (2) | JP5736313B2 (pl) |
| KR (1) | KR101719004B1 (pl) |
| CN (2) | CN102203062B (pl) |
| AU (1) | AU2009289598B2 (pl) |
| CA (1) | CA2736195C (pl) |
| ES (1) | ES2552322T3 (pl) |
| HU (1) | HUE026148T2 (pl) |
| MX (1) | MX2011002475A (pl) |
| PL (1) | PL2346823T3 (pl) |
| PT (1) | PT2346823E (pl) |
| WO (1) | WO2010028232A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2584838T3 (es) | 2006-04-05 | 2016-09-29 | Opko Health, Inc | Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma |
| ES2553805T3 (es) | 2006-04-05 | 2015-12-11 | Opko Health, Inc. | Formulaciones farmacéuticas que comprenden sales de (5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluorometil)fenil]-etoxi}-metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona y su utilización médica |
| AR066191A1 (es) | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
| AU2009289598B2 (en) | 2008-09-05 | 2014-09-11 | Opko Health, Inc. | Process and intermediates for the synthesis of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl) -ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
| CN105503870A (zh) | 2009-08-14 | 2016-04-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
| CN105017251B (zh) * | 2015-06-30 | 2018-06-29 | 齐鲁制药有限公司 | 一种nk-1受体拮抗剂的制备方法及其中间体 |
| EP3322422A1 (en) * | 2015-07-15 | 2018-05-23 | OPKO Health, Inc. | Heteroaryl carbonitriles for the treatment of disease |
| CN106866669A (zh) * | 2017-04-19 | 2017-06-20 | 成都百特万合医药科技有限公司 | 一种合成罗拉吡坦中间体的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994010165A1 (en) | 1992-10-28 | 1994-05-11 | Merck Sharp & Dohme Limited | 4-arylmethyloxymethyl piperidines as tachykinin antagonists |
| JPH08504435A (ja) | 1992-12-14 | 1996-05-14 | メルク シヤープ エンド ドーム リミテツド | タキキニン受容体拮抗剤としての４−アミノメチル／チオメチル／スルホニルメチル−４−フェニルピペリジン |
| JPH09507500A (ja) | 1994-01-13 | 1997-07-29 | メルク シヤープ エンド ドーム リミテツド | ｇｅｍ二置換アザシクロ系のタキキニン拮抗薬 |
| GB9626746D0 (en) | 1996-12-23 | 1997-02-12 | Knoll Ag | Process |
| JP2001523245A (ja) | 1997-04-24 | 2001-11-20 | メルク シヤープ エンド ドーム リミテツド | 肥満を治療するためのｎｋ−１受容体拮抗薬およびｓｓｒｉの使用 |
| DE19815275B4 (de) | 1998-04-06 | 2009-06-25 | Evonik Degussa Gmbh | Alkylidenkomplexe des Rutheniums mit N-heterozyklischen Carbenliganden und deren Verwendung als hochaktive, selektive Katalysatoren für die Olefin-Metathese |
| US6215019B1 (en) | 1998-09-01 | 2001-04-10 | Tilliechem, Inc. | Synthesis of 5-decenyl acetate and other pheromone components |
| CN1213032C (zh) | 1999-05-24 | 2005-08-03 | 加州理工学院 | 咪唑烷基金属卡宾易位催化剂 |
| EP1237874B1 (en) | 1999-12-17 | 2006-02-22 | Schering Corporation | Selective neurokinin antagonists |
| GB0004699D0 (en) * | 2000-02-28 | 2000-04-19 | Merck Sharp & Dohme | Chemical synthesis |
| CA2419485C (en) | 2000-08-10 | 2007-10-30 | The Trustees Of Boston College | Recyclable metathesis catalysts |
| US7122677B2 (en) * | 2001-11-13 | 2006-10-17 | Scherig Corporation | NK1 antagonists |
| GB0129525D0 (en) | 2001-12-10 | 2002-01-30 | Floor Image Internat Ltd | Improvements to floor posters |
| PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
| PL199412B1 (pl) | 2002-10-15 | 2008-09-30 | Boehringer Ingelheim Int | Nowe kompleksy rutenu jako (pre)katalizatory reakcji metatezy, pochodne 2-alkoksy-5-nitrostyrenu jako związki pośrednie i sposób ich wytwarzania |
| AR048526A1 (es) * | 2004-04-07 | 2006-05-03 | Schering Corp | Antagonistas de nk1 de anillo de piperidina o pirrolidina fusionado, composiciones farmaceuticas que los comprenden y su uso en el tratamiento de enfermedades relacionadas con los receptores de neuroquinina nk1 |
| EP2522664B1 (en) | 2004-07-01 | 2017-04-12 | OPKO Health, Inc. | Piperidine derivatives as NK1 antagonists |
| JP4444745B2 (ja) | 2004-07-08 | 2010-03-31 | キヤノン株式会社 | 偏光分離素子および画像投射装置 |
| US7354922B2 (en) * | 2004-12-14 | 2008-04-08 | Schering Corporation | Bridged ring NK1 antagonists |
| TW200630380A (en) | 2005-02-18 | 2006-09-01 | Nat Univ Chung Hsing | N-acylamino acid racemase of Deinococcus radiodurans and producing method thereof, and L-amino acid production method therefrom |
| EP2886549A1 (en) | 2005-07-04 | 2015-06-24 | Zannan Scitech Co., Ltd. | Ruthenium complex ligand, ruthenium complex and the use of the complex as a catalyst in olefin metathesis reactions |
| ES2584838T3 (es) | 2006-04-05 | 2016-09-29 | Opko Health, Inc | Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma |
| WO2007114922A2 (en) * | 2006-04-05 | 2007-10-11 | Schering Corporation | Salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor |
| ES2553805T3 (es) | 2006-04-05 | 2015-12-11 | Opko Health, Inc. | Formulaciones farmacéuticas que comprenden sales de (5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluorometil)fenil]-etoxi}-metil]-8-fenil-1,7-diazaespiro[4.5]decan-2-ona y su utilización médica |
| AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
| PE20081891A1 (es) | 2007-03-22 | 2008-12-27 | Opko Health Inc | Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas |
| AU2009289598B2 (en) | 2008-09-05 | 2014-09-11 | Opko Health, Inc. | Process and intermediates for the synthesis of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl) -ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
| CN105503870A (zh) | 2009-08-14 | 2016-04-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
-
2009
- 2009-09-04 AU AU2009289598A patent/AU2009289598B2/en not_active Ceased
- 2009-09-04 JP JP2011526223A patent/JP5736313B2/ja not_active Expired - Fee Related
- 2009-09-04 PT PT97922686T patent/PT2346823E/pt unknown
- 2009-09-04 HU HUE09792268A patent/HUE026148T2/en unknown
- 2009-09-04 CA CA2736195A patent/CA2736195C/en active Active
- 2009-09-04 CN CN200980144713.2A patent/CN102203062B/zh not_active Expired - Fee Related
- 2009-09-04 KR KR1020117007788A patent/KR101719004B1/ko not_active Expired - Fee Related
- 2009-09-04 MX MX2011002475A patent/MX2011002475A/es active IP Right Grant
- 2009-09-04 CN CN201410652644.9A patent/CN104496988B/zh not_active Expired - Fee Related
- 2009-09-04 WO PCT/US2009/056020 patent/WO2010028232A1/en not_active Ceased
- 2009-09-04 EP EP15181326.8A patent/EP3034493A1/en not_active Withdrawn
- 2009-09-04 ES ES09792268.6T patent/ES2552322T3/es active Active
- 2009-09-04 EP EP09792268.6A patent/EP2346823B1/en not_active Not-in-force
- 2009-09-04 PL PL09792268T patent/PL2346823T3/pl unknown
-
2013
- 2013-10-01 US US14/043,210 patent/US9249144B2/en active Active
-
2015
- 2015-04-20 JP JP2015085814A patent/JP2015143265A/ja active Pending
-
2016
- 2016-02-01 US US15/012,422 patent/US9822116B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2736195A1 (en) | 2010-03-11 |
| JP2015143265A (ja) | 2015-08-06 |
| PT2346823E (pt) | 2015-11-26 |
| CN104496988A (zh) | 2015-04-08 |
| CN102203062B (zh) | 2014-12-17 |
| HUE026148T2 (en) | 2016-05-30 |
| AU2009289598A1 (en) | 2010-03-11 |
| MX2011002475A (es) | 2011-08-03 |
| KR101719004B1 (ko) | 2017-03-22 |
| CA2736195C (en) | 2017-05-16 |
| ES2552322T3 (es) | 2015-11-27 |
| CN102203062A (zh) | 2011-09-28 |
| AU2009289598B2 (en) | 2014-09-11 |
| US9249144B2 (en) | 2016-02-02 |
| US20160145256A1 (en) | 2016-05-26 |
| JP2012502053A (ja) | 2012-01-26 |
| US9822116B2 (en) | 2017-11-21 |
| WO2010028232A1 (en) | 2010-03-11 |
| HK1158623A1 (en) | 2012-07-20 |
| EP2346823A1 (en) | 2011-07-27 |
| CN104496988B (zh) | 2017-04-12 |
| EP3034493A1 (en) | 2016-06-22 |
| KR20110067117A (ko) | 2011-06-21 |
| US20140031549A1 (en) | 2014-01-30 |
| JP5736313B2 (ja) | 2015-06-17 |
| EP2346823B1 (en) | 2015-08-19 |
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