PL2279175T3 - Sposób wytwarzania związków pośrednich naftalen-2-ylopirazol-3-onu użytecznych w syntezie inhibitorów receptorów sigma - Google Patents
Sposób wytwarzania związków pośrednich naftalen-2-ylopirazol-3-onu użytecznych w syntezie inhibitorów receptorów sigmaInfo
- Publication number
- PL2279175T3 PL2279175T3 PL09735117T PL09735117T PL2279175T3 PL 2279175 T3 PL2279175 T3 PL 2279175T3 PL 09735117 T PL09735117 T PL 09735117T PL 09735117 T PL09735117 T PL 09735117T PL 2279175 T3 PL2279175 T3 PL 2279175T3
- Authority
- PL
- Poland
- Prior art keywords
- naphthalen
- pyrazol
- synthesis
- preparation
- receptor inhibitors
- Prior art date
Links
- OPPJNMMXXKNRRY-UHFFFAOYSA-N 4-naphthalen-2-ylpyrazol-3-one Chemical compound O=C1N=NC=C1C1=CC=C(C=CC=C2)C2=C1 OPPJNMMXXKNRRY-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 108010085082 sigma receptors Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08384006A EP2112139A1 (en) | 2008-04-25 | 2008-04-25 | Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors |
| EP20090735117 EP2279175B1 (en) | 2008-04-25 | 2009-04-24 | Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors |
| PCT/EP2009/054981 WO2009130314A1 (en) | 2008-04-25 | 2009-04-24 | Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2279175T3 true PL2279175T3 (pl) | 2015-10-30 |
Family
ID=39717791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09735117T PL2279175T3 (pl) | 2008-04-25 | 2009-04-24 | Sposób wytwarzania związków pośrednich naftalen-2-ylopirazol-3-onu użytecznych w syntezie inhibitorów receptorów sigma |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8329880B2 (pl) |
| EP (2) | EP2112139A1 (pl) |
| JP (2) | JP5781923B2 (pl) |
| KR (1) | KR101641696B1 (pl) |
| CN (1) | CN102066332B (pl) |
| AU (1) | AU2009239889B2 (pl) |
| BR (1) | BRPI0910675A2 (pl) |
| CA (1) | CA2722250C (pl) |
| DK (1) | DK2279175T3 (pl) |
| ES (1) | ES2544759T3 (pl) |
| HU (1) | HUE026759T2 (pl) |
| MX (1) | MX2010011677A (pl) |
| PL (1) | PL2279175T3 (pl) |
| PT (1) | PT2279175E (pl) |
| RU (1) | RU2509763C2 (pl) |
| WO (1) | WO2009130314A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2418192A1 (en) | 2010-07-30 | 2012-02-15 | Esteve Química, S.A. | Intermediates for the preparation of 1-aryl-pyrazol-3-one compounds useful as sigma receptors inhibitors |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| KR101306958B1 (ko) * | 2010-11-08 | 2013-09-10 | 건국대학교 산학협력단 | 세포사멸 유도 활성을 갖는 트리메톡시페닐-4,5-디하이드로-1ｈ-피라졸-3-일-나프탈렌-2-올 유도체 |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2908677A (en) * | 1955-03-30 | 1959-10-13 | Eastman Kodak Co | Nickel and cobalt complexes of pyrazolone monoazo compounds |
| NL125658C (pl) * | 1964-02-03 | |||
| CH471199A (de) * | 1965-07-06 | 1969-04-15 | Sandoz Ag | Verfahren zur Herstellung metallhaltiger Azofarbstoffe |
| DE2313722C3 (de) * | 1973-03-20 | 1987-04-16 | Bayer Ag, 5090 Leverkusen | Chromischkomplex-Farbstoff und dessen Verwendung zum Färben und Bedrucken von stickstoffhaltigen Fasermaterialien |
| DE2347015C2 (de) * | 1973-09-14 | 1985-12-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue Pyrazolyloxyessigsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
| IT1005472B (it) * | 1974-02-15 | 1976-08-20 | Montedison Spa | Procedimento per la preparazione del 2,5, dimetil 3,2h, furanone |
| CA1121651A (en) | 1978-07-27 | 1982-04-13 | Chi-Kuen Shu | 2,5-dialkyl dihydrofuranones and 2,4,5-trialkyl dihydrofuranones, mixtures of same and organoleptic uses thereof |
| US4207392A (en) * | 1978-10-30 | 1980-06-10 | Eastman Kodak Company | Heat developable and stabilizable photographic materials and process |
| US4234616A (en) | 1979-08-03 | 1980-11-18 | International Flavors & Fragrances Inc. | Flavoring with mixtures of 2,5-dialkyl dihydrofuranones and 2,4,5-trialkyl dihydrofuranones |
| EP0054002B1 (de) * | 1980-12-10 | 1985-08-21 | Ciba-Geigy Ag | Verfahren zur Herstellung von 3-Pyrazolidinonen und ihre Verwendung in photographischen Entwicklerlösungen |
| JPH1036259A (ja) | 1996-04-11 | 1998-02-10 | Kikkoman Corp | 白内障の予防または治療薬剤 |
| US7091257B2 (en) * | 1999-07-27 | 2006-08-15 | Alcatel | Radiation-curable composition with simultaneous color formation during cure |
| WO2001074950A2 (en) * | 2000-04-03 | 2001-10-11 | Sun Chemical Corporation | Mono- and bis-hydrazone pigments |
| PL1781618T3 (pl) * | 2004-08-27 | 2013-03-29 | Esteve Labor Dr | Inhibitory receptora sigma |
| MX2008011016A (es) | 2006-03-01 | 2008-09-08 | Esteve Labor Dr | Inhibidores de receptor sigma. |
-
2008
- 2008-04-25 EP EP08384006A patent/EP2112139A1/en not_active Withdrawn
-
2009
- 2009-04-24 PL PL09735117T patent/PL2279175T3/pl unknown
- 2009-04-24 DK DK09735117.5T patent/DK2279175T3/en active
- 2009-04-24 KR KR1020107026370A patent/KR101641696B1/ko not_active Expired - Fee Related
- 2009-04-24 MX MX2010011677A patent/MX2010011677A/es active IP Right Grant
- 2009-04-24 PT PT97351175T patent/PT2279175E/pt unknown
- 2009-04-24 AU AU2009239889A patent/AU2009239889B2/en not_active Ceased
- 2009-04-24 HU HUE09735117A patent/HUE026759T2/en unknown
- 2009-04-24 ES ES09735117.5T patent/ES2544759T3/es active Active
- 2009-04-24 JP JP2011505524A patent/JP5781923B2/ja not_active Expired - Fee Related
- 2009-04-24 US US12/988,922 patent/US8329880B2/en not_active Expired - Fee Related
- 2009-04-24 WO PCT/EP2009/054981 patent/WO2009130314A1/en not_active Ceased
- 2009-04-24 CA CA2722250A patent/CA2722250C/en not_active Expired - Fee Related
- 2009-04-24 CN CN200980122965.5A patent/CN102066332B/zh not_active Expired - Fee Related
- 2009-04-24 RU RU2010147938/04A patent/RU2509763C2/ru not_active IP Right Cessation
- 2009-04-24 EP EP20090735117 patent/EP2279175B1/en active Active
- 2009-04-24 BR BRPI0910675-8A patent/BRPI0910675A2/pt not_active IP Right Cessation
-
2014
- 2014-07-04 JP JP2014138953A patent/JP2014237654A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102066332A (zh) | 2011-05-18 |
| AU2009239889A1 (en) | 2009-10-29 |
| EP2279175B1 (en) | 2015-05-13 |
| KR101641696B1 (ko) | 2016-07-22 |
| JP5781923B2 (ja) | 2015-09-24 |
| CA2722250C (en) | 2016-07-26 |
| RU2010147938A (ru) | 2012-05-27 |
| AU2009239889B2 (en) | 2014-02-13 |
| US20110071282A1 (en) | 2011-03-24 |
| ES2544759T3 (es) | 2015-09-03 |
| HUE026759T2 (en) | 2016-07-28 |
| MX2010011677A (es) | 2010-11-25 |
| DK2279175T3 (en) | 2015-08-10 |
| JP2011518808A (ja) | 2011-06-30 |
| EP2279175A1 (en) | 2011-02-02 |
| WO2009130314A1 (en) | 2009-10-29 |
| US8329880B2 (en) | 2012-12-11 |
| RU2509763C2 (ru) | 2014-03-20 |
| JP2014237654A (ja) | 2014-12-18 |
| HK1155436A1 (en) | 2012-05-18 |
| CA2722250A1 (en) | 2009-10-29 |
| KR20110017367A (ko) | 2011-02-21 |
| EP2112139A1 (en) | 2009-10-28 |
| CN102066332B (zh) | 2016-10-26 |
| PT2279175E (pt) | 2015-08-28 |
| BRPI0910675A2 (pt) | 2015-08-11 |
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