[go: up one dir, main page]

PL2132221T3 - Przyłączone do matrycy peptydomimetyki - Google Patents

Przyłączone do matrycy peptydomimetyki

Info

Publication number
PL2132221T3
PL2132221T3 PL07701901T PL07701901T PL2132221T3 PL 2132221 T3 PL2132221 T3 PL 2132221T3 PL 07701901 T PL07701901 T PL 07701901T PL 07701901 T PL07701901 T PL 07701901T PL 2132221 T3 PL2132221 T3 PL 2132221T3
Authority
PL
Poland
Prior art keywords
tyr
template
dpro
cys
ala
Prior art date
Application number
PL07701901T
Other languages
English (en)
Inventor
Steven J Demarco
Reshmi Mukherjee
Kerstin Moehle
John Anthony Robinson
Heiko Henze
Barbara Romagnoli
Daniel Obrecht
Frank Gombert
Christian Ludin
Jan Wim Vrijbloed
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Publication of PL2132221T3 publication Critical patent/PL2132221T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Non-Reversible Transmitting Devices (AREA)
PL07701901T 2007-02-28 2007-02-28 Przyłączone do matrycy peptydomimetyki PL2132221T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CH2007/000101 WO2008104090A1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics
EP07701901A EP2132221B1 (en) 2007-02-28 2007-02-28 Template-fixed peptidomimetics

Publications (1)

Publication Number Publication Date
PL2132221T3 true PL2132221T3 (pl) 2011-04-29

Family

ID=37891752

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07701901T PL2132221T3 (pl) 2007-02-28 2007-02-28 Przyłączone do matrycy peptydomimetyki

Country Status (20)

Country Link
US (7) US8399611B2 (pl)
EP (1) EP2132221B1 (pl)
JP (1) JP5140686B2 (pl)
KR (1) KR101479148B1 (pl)
CN (1) CN101641372B (pl)
AT (1) ATE475667T1 (pl)
AU (1) AU2007348171B2 (pl)
BR (1) BRPI0721259C1 (pl)
CA (1) CA2679414C (pl)
DE (1) DE602007008150D1 (pl)
DK (1) DK2132221T3 (pl)
EA (1) EA017583B1 (pl)
ES (1) ES2349879T3 (pl)
IL (1) IL200312A (pl)
MX (1) MX2009008843A (pl)
NO (1) NO342598B1 (pl)
NZ (1) NZ579875A (pl)
PL (1) PL2132221T3 (pl)
PT (1) PT2132221E (pl)
WO (1) WO2008104090A1 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
ES2425575T3 (es) 2007-01-29 2013-10-16 Polyphor Ltd. Peptidomiméticos fijados a una matriz
ATE475667T1 (de) * 2007-02-28 2010-08-15 Polyphor Ltd Templat-fixierte peptidomimetika
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
WO2011066869A1 (en) * 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
RU2638802C2 (ru) 2011-05-16 2017-12-15 Джензим Корпорейшн Применение антагонистов cxcr4
MX343205B (es) * 2011-06-07 2016-10-28 Polyphor Ag Peptidomiméticos de horquilla beta como antagonistas de cxc4.
CN103842373B (zh) * 2011-10-07 2018-12-21 波利弗尔股份公司 模板-固定的肽模拟物作为fpr1的抑制物
ES2647076T3 (es) * 2012-06-06 2017-12-19 Polyphor Ag Peptidomiméticos de horquilla beta
RS56249B1 (sr) * 2012-08-08 2017-11-30 Polyphor Ag Kombinacije sa ciklizovanom okosnicom peptida
WO2019156137A1 (ja) 2018-02-08 2019-08-15 株式会社ステムリム 乾癬の治療薬
BR112021005982A2 (pt) * 2018-10-05 2021-06-29 StemRIM Inc. peptídeo possuindo atividade de mobilização de células-tronco mesenquimais
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
MX2023005829A (es) 2020-11-19 2023-08-21 Spexis Ag Combinaciones farmaceuticas para tratar el cancer.
WO2022184320A2 (en) 2021-03-03 2022-09-09 Spexis Ag Medical use of cyclic peptides
WO2023285677A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2023285681A1 (en) 2021-07-16 2023-01-19 Spexis Ag Pharmaceutical combinations for treating cancer
WO2025068346A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4, pd-1 and fak inhibitors for treating cancer
WO2025068348A1 (en) 2023-09-27 2025-04-03 Spexis Ag Pharmaceutical combination of cxcr4 and pd-1 inhibitors for treating cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2382931C (en) 1999-08-30 2011-01-25 Polyphor Ag Synthesis of template-fixed .beta.-hairpin loop mimetics
ES2527339T3 (es) * 2001-02-23 2015-01-23 Polyphor Ltd. Peptidomiméticos fijados a patrón con actividad antimicrobiana
CN101157924A (zh) 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
EP1483254A4 (en) * 2002-01-07 2005-06-08 Sequoia Pharmaceuticals INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
WO2004018503A1 (en) 2002-08-20 2004-03-04 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
US7838496B2 (en) 2003-05-02 2010-11-23 Polyphor Ag/Ltd. Template-fixed peptidomimetics as medicaments against HIV and cancer
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
US7681235B2 (en) 2003-05-19 2010-03-16 Radware Ltd. Dynamic network protection
JP5553954B2 (ja) 2003-11-15 2014-07-23 ポリファー リミテッド テンプレート固定β−ヘアピンループ模倣体とそのファージディスプレイにおける使用
EA013814B1 (ru) 2005-02-17 2010-08-30 Полифор Лтд. Связанные с матрицей бета-шпилечные пептидомиметики с ингибирующей активностью в отношении протеаз
EP1879911B1 (en) 2005-05-02 2011-08-17 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
ES2425575T3 (es) 2007-01-29 2013-10-16 Polyphor Ltd. Peptidomiméticos fijados a una matriz
ATE475667T1 (de) 2007-02-28 2010-08-15 Polyphor Ltd Templat-fixierte peptidomimetika
WO2010015287A2 (en) 2008-08-08 2010-02-11 Polyphor Ag Template-fixed peptidomimetics
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
SG177521A1 (en) 2009-08-05 2012-02-28 Polyphor Ag Conformationally constrained, fully synthetic macrocyclic compounds
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
WO2011066869A1 (en) 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
AU2010344997B2 (en) 2010-02-05 2015-09-10 Polyphor Ag Template - fixed peptidomimetics with CXCR7 modulating activity
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
MX343205B (es) 2011-06-07 2016-10-28 Polyphor Ag Peptidomiméticos de horquilla beta como antagonistas de cxc4.
CN103842373B (zh) 2011-10-07 2018-12-21 波利弗尔股份公司 模板-固定的肽模拟物作为fpr1的抑制物
WO2013139697A1 (en) 2012-03-17 2013-09-26 Polyphor Ag Conformationally constrained, fully synthetic macrocyclic compounds
ES2647076T3 (es) 2012-06-06 2017-12-19 Polyphor Ag Peptidomiméticos de horquilla beta
RS56249B1 (sr) 2012-08-08 2017-11-30 Polyphor Ag Kombinacije sa ciklizovanom okosnicom peptida
BR112015002726B1 (pt) 2012-08-08 2022-10-04 Polyphor Ag Combinação, composição farmacêutica, kit, e, usos de uma combinação, e de uma composição farmacêutica
CA2908385C (en) 2013-03-30 2021-05-18 Polyphor Ag Beta-hairpin peptidomimetics
BR112015024871A2 (pt) 2013-03-30 2017-07-18 Polyphor Ag composto, diastereoisômero ou epímero, composição farmacêutica, uso de um composto, e, método para tratamento de uma infecção
KR102214693B1 (ko) 2013-12-27 2021-02-10 폴리포 리미티드 선택적인 엘라스타제 저해제로서 β-헤어핀 펩타이드 모방체
HUE059846T2 (hu) 2013-12-27 2023-01-28 Spexis Ag Béta-hajtû peptidomimimetikumok, mint szelektív elasztáz inhibitorok

Also Published As

Publication number Publication date
PT2132221E (pt) 2010-10-26
CA2679414C (en) 2014-10-28
EP2132221A1 (en) 2009-12-16
JP2010519331A (ja) 2010-06-03
AU2007348171A1 (en) 2008-09-04
NZ579875A (en) 2012-02-24
US10144765B2 (en) 2018-12-04
US8399611B2 (en) 2013-03-19
MX2009008843A (es) 2009-08-28
NO20093064L (no) 2009-09-28
US20180127467A1 (en) 2018-05-10
DK2132221T3 (da) 2010-11-22
ATE475667T1 (de) 2010-08-15
BRPI0721259A2 (pt) 2013-01-15
US20130150299A1 (en) 2013-06-13
DE602007008150D1 (de) 2010-09-09
EP2132221B1 (en) 2010-07-28
BRPI0721259C1 (pt) 2021-05-25
EA017583B1 (ru) 2013-01-30
US9556234B2 (en) 2017-01-31
BRPI0721259B1 (pt) 2020-04-07
US9879047B2 (en) 2018-01-30
US20190100558A1 (en) 2019-04-04
IL200312A0 (en) 2010-04-29
US8921325B2 (en) 2014-12-30
US10787486B2 (en) 2020-09-29
EA200901178A1 (ru) 2010-04-30
KR101479148B1 (ko) 2015-01-05
ES2349879T3 (es) 2011-01-12
BRPI0721259B8 (pt) 2020-09-15
IL200312A (en) 2014-11-30
US20150080317A1 (en) 2015-03-19
NO342598B1 (no) 2018-06-18
AU2007348171B2 (en) 2012-09-06
HK1138011A1 (en) 2010-08-13
US20200399317A1 (en) 2020-12-24
CN101641372B (zh) 2012-11-28
CN101641372A (zh) 2010-02-03
US11421001B2 (en) 2022-08-23
CA2679414A1 (en) 2008-09-04
US20100048463A1 (en) 2010-02-25
US20170096453A1 (en) 2017-04-06
WO2008104090A1 (en) 2008-09-04
JP5140686B2 (ja) 2013-02-06
KR20100014596A (ko) 2010-02-10

Similar Documents

Publication Publication Date Title
IL200312A0 (en) Template-fixed peptidomimetics
WO2009061853A3 (en) Mutant interleukin-2 (il-2) polypeptides
MY199965A (en) Bridged bicyclic inhibitors of menin-mll and methods of use
NZ611108A (en) Methods of treating fgf21-associated disorders
UA106318C2 (ru) Производный полипептид il-2 с агонистической активностью для лечения рака и хронических инфекций
WO2011133879A3 (en) Combination therapies with mitochondrial-targeted anti-tumor agents
TN2011000382A1 (en) Indole derivatives as crth2 receptor antagonists
WO2010009892A8 (en) Compositions for the treatment of pain and/or inflamation
HK1210422A1 (en) Compositions and methods for treating cutaneous scarring
MY163055A (en) Polycyclic antagonists of lysophosphatidic acid receptors
MX2009003129A (es) Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.
NZ603196A (en) Methods of use of soluble cd24 for therapy of rheumatoid arthritis
IL195256A0 (en) Compositions of r(+)and s(-)pramipexole and methods of using the same
MX2008011633A (es) Aminoquinolonas como inhibidores de gsk-3.
WO2018215525A8 (en) Mic-1 compounds and uses thereof
GEP20247585B (en) Furoindazole derivatives
EP3911355A4 (en) RECOMBINANT LUBRICINS AND COMPOSITIONS AND METHODS OF USE THEREOF
EP4545589A3 (en) Compositions comprising glucose and hemicellulose and their use
MX2024013184A (es) Metodos y composiciones para tratar apnea del sue?o
AU2011279845A8 (en) Novel pyrrolidine derived beta 3 adrenergic receptor agonists
WO2008049098A3 (en) ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR α1
NZ595271A (en) Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
TW200738232A (en) Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma
AU2019253577A1 (en) Oxytocin compositions and methods of use
EP2129359A4 (en) GPCR1 35 OR GPCR1 ANTAGONIST CHIMERIC PEPTIDE 42