PL2199390T3 - Anti-epha2 antibody - Google Patents
Anti-epha2 antibodyInfo
- Publication number
- PL2199390T3 PL2199390T3 PL08828482T PL08828482T PL2199390T3 PL 2199390 T3 PL2199390 T3 PL 2199390T3 PL 08828482 T PL08828482 T PL 08828482T PL 08828482 T PL08828482 T PL 08828482T PL 2199390 T3 PL2199390 T3 PL 2199390T3
- Authority
- PL
- Poland
- Prior art keywords
- epha2 antibody
- epha2
- antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007224007 | 2007-08-30 | ||
| EP08828482.3A EP2199390B1 (en) | 2007-08-30 | 2008-08-29 | Anti-epha2 antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2199390T3 true PL2199390T3 (en) | 2017-06-30 |
Family
ID=40387351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08828482T PL2199390T3 (en) | 2007-08-30 | 2008-08-29 | Anti-epha2 antibody |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8449882B2 (en) |
| EP (1) | EP2199390B1 (en) |
| JP (2) | JP5312333B2 (en) |
| KR (4) | KR101561403B1 (en) |
| CN (1) | CN101848998B (en) |
| AU (1) | AU2008292352B2 (en) |
| BR (1) | BRPI0816094A2 (en) |
| CA (1) | CA2698146C (en) |
| CO (1) | CO6180469A2 (en) |
| CY (1) | CY1118763T1 (en) |
| DK (1) | DK2199390T3 (en) |
| ES (1) | ES2618316T3 (en) |
| HR (1) | HRP20170407T1 (en) |
| HU (1) | HUE032301T2 (en) |
| IL (1) | IL204211A (en) |
| LT (1) | LT2199390T (en) |
| MX (1) | MX2010002248A (en) |
| MY (1) | MY150621A (en) |
| NZ (1) | NZ583966A (en) |
| PL (1) | PL2199390T3 (en) |
| PT (1) | PT2199390T (en) |
| RU (1) | RU2525133C2 (en) |
| SI (1) | SI2199390T1 (en) |
| TW (1) | TWI443109B (en) |
| WO (1) | WO2009028639A1 (en) |
| ZA (1) | ZA201001340B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| WO2012008397A1 (en) * | 2010-07-12 | 2012-01-19 | 第一三共株式会社 | Anti-epha2 antibody and use thereof |
| US9220772B2 (en) | 2010-07-22 | 2015-12-29 | The Regents Of The University Of California | Anti-tumor antigen antibodies and methods of use |
| EP2446895A1 (en) * | 2010-10-01 | 2012-05-02 | Stemgen S.P.A. | EPH receptor expression in tumor stem cells |
| US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
| DK2686020T3 (en) | 2011-03-17 | 2017-05-01 | Univ Birmingham | REDIRECTED IMMUNTERY |
| JP5875054B2 (en) | 2013-02-13 | 2016-03-02 | 国立大学法人 東京大学 | Cancer testing method and testing kit |
| US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
| EP3442566A4 (en) * | 2016-04-14 | 2019-11-20 | Academia Sinica | INHIBITION OF SCUBE2, A NEW CO-RECEPTOR OF VEGFR2, REMOVING TUMOR ANGIOGENESIS |
| EP3468587A4 (en) * | 2016-06-09 | 2020-02-19 | University of Leicester | MONOCLONAL ANTIBODIES, COMPOSITIONS AND METHODS FOR DETECTION OF MUCIN-LIKE PROTEIN (MLP) AS A BIOMARKER FOR OVARIAN CANCER AND PANCREAS |
| CN110198956A (en) * | 2017-01-23 | 2019-09-03 | 学校法人东洋大学 | Anti-EPHA 2 antibody and the EPHA2 immune detection for using the anti-EPHA 2 antibody |
| EP3661552A4 (en) * | 2017-05-22 | 2021-08-25 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING MICA / B REJECTION |
| CN109879965B (en) * | 2017-12-06 | 2022-11-11 | 北京科立思维生物科技有限公司 | anti-EPHA 2 single-chain antibody, anti-CD 3E single-chain antibody, fusion protein and application thereof |
| US12448426B2 (en) | 2018-05-17 | 2025-10-21 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors with MYD88 and CD40 costimulatory domains |
| SMT202500141T1 (en) | 2018-09-06 | 2025-05-12 | Daiichi Sankyo Co Ltd | Antibody-drug conjugates of cyclic dinucleotide derivatives |
| US11702482B2 (en) | 2018-12-17 | 2023-07-18 | Revitope Limited | Twin immune cell engager |
| TW202241454A (en) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | Novel method for producing antibody-immunostimulator conjugate |
| EP4301785A4 (en) * | 2021-03-05 | 2025-04-23 | Atreca, Inc. | Epha2 antibodies |
| BR112023017365A2 (en) | 2021-03-12 | 2023-10-03 | Daiichi Sankyo Co Ltd | GLYCAN AND METHOD FOR PRODUCING MEDICINE CONTAINING GLYCAN |
| WO2022250431A1 (en) | 2021-05-25 | 2022-12-01 | 주식회사 박셀바이오 | Monobody-based chimeric antigen receptor and immune cell including same |
| CN115505041A (en) * | 2021-06-22 | 2022-12-23 | 北京免疫方舟医药科技有限公司 | anti-EphA 2 antibodies and uses thereof |
| AU2023229142A1 (en) | 2022-03-02 | 2024-10-03 | Daiichi Sankyo Company, Limited | METHOD FOR PRODUCING Fc-CONTAINING MOLECULE |
| WO2024053574A1 (en) | 2022-09-09 | 2024-03-14 | 第一三共株式会社 | Novel oligosaccharide, production intermediate for novel oligosaccharide, production method for novel oligosaccharide, and production method for production intermediate for novel oligosaccharide |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DK0585287T3 (en) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Process for producing specific binding pair elements |
| DE69229477T2 (en) | 1991-09-23 | 1999-12-09 | Cambridge Antibody Technology Ltd., Melbourn | Methods for the production of humanized antibodies |
| ATE463573T1 (en) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | PRODUCTION OF AUTOANTIBODIES ON PHAGE SURFACES BASED ON ANTIBODIES SEGMENT LIBRARIES |
| CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| AU690171B2 (en) | 1993-12-03 | 1998-04-23 | Medical Research Council | Recombinant binding proteins and peptides |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| JP4436457B2 (en) | 1995-08-18 | 2010-03-24 | モルフォシス アイピー ゲーエムベーハー | Protein / (poly) peptide library |
| US6972323B1 (en) | 1997-04-01 | 2005-12-06 | Sankyo Company, Limited | Anti-Fas antibodies |
| PT1144607E (en) | 1999-07-20 | 2009-04-22 | Morphosys Ag | Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds |
| EP2312316A1 (en) | 1999-08-17 | 2011-04-20 | Purdue Research Foundation | Anti-EPHA2 antibodies as a cancer diagnostic |
| ATE324877T1 (en) * | 1999-08-17 | 2006-06-15 | Purdue Research Foundation | TREATMENT OF METASTATIC DISEASE |
| AU2001256970C1 (en) | 2000-03-31 | 2008-07-03 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| US20020025536A1 (en) | 2000-06-26 | 2002-02-28 | Jeno Gyuris | Methods and reagents for isolating biologically active antibodies |
| US7101976B1 (en) * | 2000-09-12 | 2006-09-05 | Purdue Research Foundation | EphA2 monoclonal antibodies and methods of making and using same |
| ES2620359T3 (en) | 2000-10-06 | 2017-06-28 | Kyowa Hakko Kirin Co., Ltd. | Cells that produce antibody compositions |
| JP4799816B2 (en) * | 2001-06-05 | 2011-10-26 | ヴァレオ | Locking device with transmission gear |
| JP2005500034A (en) | 2001-06-20 | 2005-01-06 | プロション バイオテク リミテッド | Antibody that blocks activation of receptor protein tyrosine kinase, screening method thereof, and use thereof |
| US20040247592A1 (en) | 2001-07-03 | 2004-12-09 | Roifman Chaim M. | Ephrin and eph receptor mediated immune modulation |
| FR2838742B1 (en) * | 2002-04-23 | 2004-07-09 | Inst Nat Sante Rech Med | EPITOPES T OF THE EPHA2 ANTIGEN |
| US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
| EP1575509B1 (en) | 2002-05-10 | 2011-10-26 | Purdue Research Foundation | Epha2 agonistic monoclonal antibodies and methods of use thereof |
| AU2003243228B2 (en) * | 2002-05-10 | 2009-03-26 | Medimmune, Llc | EphA2 monoclonal antibodies and methods of use thereof |
| JP2006501153A (en) | 2002-05-23 | 2006-01-12 | パーデュー・リサーチ・ファウンデーション | Low molecular weight protein tyrosine phosphatase (LMW-PTP) as a diagnostic and therapeutic target |
| US7326552B1 (en) * | 2002-06-21 | 2008-02-05 | Takeda San Diego, Inc. | Wild-type kinase domain of human Ephrin receptor A2 (EPHA2) and crystallization thereof |
| EP1852441B1 (en) | 2002-09-24 | 2012-03-28 | The Burnham Institute | Agents that modulate EPH receptor activity |
| CA2499580A1 (en) | 2002-09-24 | 2004-04-08 | The Burnham Institute | Novel agents that modulate eph receptor activity |
| JP4589914B2 (en) | 2003-01-07 | 2010-12-01 | シムフォゲン・アクティーゼルスカブ | Method for producing recombinant polyclonal protein |
| AU2003900541A0 (en) | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
| KR20110094361A (en) | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | Recombinant IL-1 antibodies and uses thereof |
| EP1618184A4 (en) | 2003-04-11 | 2006-06-21 | Medimmune Inc | Epha2, hypoproliferative cell disorders and epithelial and endothelial reconstitution |
| US20050059592A1 (en) | 2003-04-11 | 2005-03-17 | Kiener Peter A. | EphA2 and hyperproliferative cell disorders |
| US8012681B2 (en) | 2003-05-13 | 2011-09-06 | Novartis Vaccines And Diagnostics, Inc. | Methods of modulating metastasis and skeletal related events resulting from metastases |
| US20050147593A1 (en) | 2003-05-22 | 2005-07-07 | Medimmune, Inc. | EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders |
| CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| US20050009033A1 (en) | 2003-07-08 | 2005-01-13 | The Regents Of The University Of California | Breast cancer genes |
| WO2005016381A2 (en) | 2003-07-21 | 2005-02-24 | Medimmune, Inc. | Combination therapy for the treatment and prevention of cancer using epha2, pcdgf, and haah |
| EP1651671A2 (en) | 2003-07-30 | 2006-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Epha2 t-cell epitope agonists and uses therefor |
| JP4934426B2 (en) * | 2003-08-18 | 2012-05-16 | メディミューン,エルエルシー | Antibody humanization |
| JP2007528723A (en) | 2003-08-22 | 2007-10-18 | メディミューン,インコーポレーテッド | Antibody humanization |
| AU2004281834A1 (en) | 2003-10-15 | 2005-04-28 | Cerus Corporation | Listeria-based EphA2 vaccines |
| DE10354115A1 (en) * | 2003-11-19 | 2005-07-21 | Beiersdorf Ag | New use of surfactant systems to reduce damage to the skin's own enzymes |
| EP1689346A4 (en) * | 2003-11-20 | 2007-11-21 | Medimmune Inc | EPHA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USING SAME |
| WO2005056766A2 (en) | 2003-12-04 | 2005-06-23 | Medimmune, Inc. | TARGETED DRUG DELIVERY USING EphA2 OR Eph4 BINDING MOIETIES |
| WO2005067460A2 (en) | 2003-12-24 | 2005-07-28 | Medimmune, Inc. | Epha2 vaccines |
| AU2005245896A1 (en) | 2004-05-14 | 2005-12-01 | Receptor Biologix, Inc. | Cell surface receptor isoforms and methods of identifying and using the same |
| JP2008510007A (en) | 2004-08-16 | 2008-04-03 | メディミューン,インコーポレーテッド | Eph receptor Fc variants with enhanced antibody-dependent cellular cytotoxic activity |
| WO2006052409A2 (en) | 2004-10-23 | 2006-05-18 | Case Western Reserve University | Peptide and small molecule agonists of epha and their uses |
| JP2008518021A (en) | 2004-10-27 | 2008-05-29 | メディミューン,インコーポレーテッド | Use of EPHA2 and EPHRINA1 modulators for the treatment and prevention of infections |
| AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| JP2008518022A (en) | 2004-10-27 | 2008-05-29 | メディミューン,インコーポレーテッド | EphA2 and ephrinA1 modulators for treating fibrosis related diseases |
| US7569672B2 (en) * | 2005-02-04 | 2009-08-04 | Raven Biotechnologies, Inc. | Antibodies that bind to EphA2 and methods of use thereof |
| JP2008536815A (en) | 2005-03-14 | 2008-09-11 | メディミューン,エルエルシー | Macromolecules containing thioether bridges |
| EP1888106A4 (en) | 2005-05-20 | 2009-01-14 | Univ Illinois | COMPOSITIONS AND METHODS FOR TREATING EPHRIN SIGNALING WITH CUPREDOXINES |
| KR20080080482A (en) * | 2005-09-07 | 2008-09-04 | 메디뮨 엘엘씨 | EPH receptor receptor conjugated with toxin |
| WO2007035451A2 (en) | 2005-09-16 | 2007-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of modulating angiogenesis and screening compounds for activity in modulating angiogenesis |
| EP1968998A4 (en) * | 2005-12-21 | 2010-01-27 | Medimmune Llc | Affinity optimized epha2 agonistic antibodies and methods of use thereof |
| EP1981532A4 (en) | 2005-12-21 | 2010-06-30 | Medimmune Llc | Epha2 bite molecules and uses thereof |
| CA2641026A1 (en) | 2006-02-01 | 2007-08-09 | The Johns Hopkins University | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| US20080003210A1 (en) * | 2006-03-13 | 2008-01-03 | Medimmune, Inc. | Non-human primate receptor tyrosine kinases |
| WO2007146968A2 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
| CN101622276B (en) | 2006-07-18 | 2015-04-22 | 赛诺菲-安万特 | Antagonistic antibodies against EPHA2 for the treatment of cancer |
| WO2008066498A1 (en) | 2006-12-01 | 2008-06-05 | Agency For Science, Technology And Research | Cancer-related protein kinases |
| WO2008070042A2 (en) | 2006-12-04 | 2008-06-12 | Medimmune, Inc. | High potency recombinant antibodies, methods for producing them and use in cancer therapy |
| US20100093626A1 (en) | 2006-12-15 | 2010-04-15 | Bingcheng Wang | Peptide and small molecule agonists of epha and their uses in disease |
| US20080199426A1 (en) * | 2007-01-11 | 2008-08-21 | Sukhatme Vikas P | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders |
| JP2010523139A (en) | 2007-04-13 | 2010-07-15 | 株式会社サイトパスファインダー | Compound profiling method |
| AU2008265928A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Synergistic treatment of cells that express EphA2 and ErbB2 |
| US20120039870A9 (en) | 2007-09-07 | 2012-02-16 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
| WO2009052830A1 (en) | 2007-10-22 | 2009-04-30 | Genmab A/S | Novel antibody therapies |
-
2008
- 2008-08-29 PL PL08828482T patent/PL2199390T3/en unknown
- 2008-08-29 LT LTEP08828482.3T patent/LT2199390T/en unknown
- 2008-08-29 WO PCT/JP2008/065486 patent/WO2009028639A1/en not_active Ceased
- 2008-08-29 HR HRP20170407TT patent/HRP20170407T1/en unknown
- 2008-08-29 ES ES08828482.3T patent/ES2618316T3/en active Active
- 2008-08-29 KR KR1020147036821A patent/KR101561403B1/en not_active Expired - Fee Related
- 2008-08-29 BR BRPI0816094 patent/BRPI0816094A2/en not_active Application Discontinuation
- 2008-08-29 NZ NZ583966A patent/NZ583966A/en not_active IP Right Cessation
- 2008-08-29 RU RU2010111896/10A patent/RU2525133C2/en not_active IP Right Cessation
- 2008-08-29 EP EP08828482.3A patent/EP2199390B1/en not_active Not-in-force
- 2008-08-29 CN CN200880114621.5A patent/CN101848998B/en not_active Expired - Fee Related
- 2008-08-29 KR KR1020157008278A patent/KR101561417B1/en not_active Expired - Fee Related
- 2008-08-29 KR KR1020157008277A patent/KR101561416B1/en not_active Expired - Fee Related
- 2008-08-29 CA CA2698146A patent/CA2698146C/en not_active Expired - Fee Related
- 2008-08-29 MY MYPI20100815 patent/MY150621A/en unknown
- 2008-08-29 MX MX2010002248A patent/MX2010002248A/en active IP Right Grant
- 2008-08-29 PT PT88284823T patent/PT2199390T/en unknown
- 2008-08-29 KR KR1020107004260A patent/KR101521668B1/en not_active Expired - Fee Related
- 2008-08-29 HU HUE08828482A patent/HUE032301T2/en unknown
- 2008-08-29 DK DK08828482.3T patent/DK2199390T3/en active
- 2008-08-29 JP JP2009530190A patent/JP5312333B2/en not_active Expired - Fee Related
- 2008-08-29 AU AU2008292352A patent/AU2008292352B2/en not_active Ceased
- 2008-08-29 SI SI200831748A patent/SI2199390T1/en unknown
- 2008-08-29 TW TW97133095A patent/TWI443109B/en not_active IP Right Cessation
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2010
- 2010-02-24 ZA ZA2010/01340A patent/ZA201001340B/en unknown
- 2010-02-25 US US12/713,041 patent/US8449882B2/en not_active Expired - Fee Related
- 2010-02-28 IL IL204211A patent/IL204211A/en not_active IP Right Cessation
- 2010-03-11 CO CO10028981A patent/CO6180469A2/en active IP Right Grant
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2013
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- 2013-06-05 JP JP2013118547A patent/JP5688433B2/en not_active Expired - Fee Related
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2015
- 2015-10-05 US US14/875,360 patent/US20160031987A1/en not_active Abandoned
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2017
- 2017-03-16 CY CY20171100336T patent/CY1118763T1/en unknown
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