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PL2190978T3 - Sposób identyfikowania, namnażania i usuwania dorosłych komórek macierzystych i nowotworowych komórek macierzystych - Google Patents

Sposób identyfikowania, namnażania i usuwania dorosłych komórek macierzystych i nowotworowych komórek macierzystych

Info

Publication number
PL2190978T3
PL2190978T3 PL08793835T PL08793835T PL2190978T3 PL 2190978 T3 PL2190978 T3 PL 2190978T3 PL 08793835 T PL08793835 T PL 08793835T PL 08793835 T PL08793835 T PL 08793835T PL 2190978 T3 PL2190978 T3 PL 2190978T3
Authority
PL
Poland
Prior art keywords
stem cells
expanding
identifying
cancer stem
removing adult
Prior art date
Application number
PL08793835T
Other languages
English (en)
Inventor
Johannes Carolus Clevers
Nicholas Barker
Andrea Haegebarth
De Wetering Marcus Lambertus Van
Original Assignee
Koninklijke Nederlandse Akademie Van Wetenschappen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Nederlandse Akademie Van Wetenschappen filed Critical Koninklijke Nederlandse Akademie Van Wetenschappen
Publication of PL2190978T3 publication Critical patent/PL2190978T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0679Cells of the gastro-intestinal tract
    • C12N5/068Stem cells; Progenitors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL08793835T 2007-08-10 2008-08-08 Sposób identyfikowania, namnażania i usuwania dorosłych komórek macierzystych i nowotworowych komórek macierzystych PL2190978T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114192A EP2022848A1 (en) 2007-08-10 2007-08-10 A method for identifying, expanding, and removing adult stem cells and cancer stem cells
EP08793835.3A EP2190978B1 (en) 2007-08-10 2008-08-08 A method for identifying, expanding, and removing adult stem cells and cancer stem cells

Publications (1)

Publication Number Publication Date
PL2190978T3 true PL2190978T3 (pl) 2017-06-30

Family

ID=38611770

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08793835T PL2190978T3 (pl) 2007-08-10 2008-08-08 Sposób identyfikowania, namnażania i usuwania dorosłych komórek macierzystych i nowotworowych komórek macierzystych

Country Status (12)

Country Link
US (4) US8906631B2 (pl)
EP (3) EP2022848A1 (pl)
CN (2) CN104483485B (pl)
AU (1) AU2008287605B2 (pl)
CA (1) CA2696047C (pl)
DK (1) DK2190978T3 (pl)
ES (1) ES2617304T3 (pl)
HR (1) HRP20170326T1 (pl)
HU (1) HUE032118T2 (pl)
PL (1) PL2190978T3 (pl)
PT (1) PT2190978T (pl)
WO (1) WO2009022907A2 (pl)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
CA2705509A1 (en) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-gpr49 antibody
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP3061808B1 (en) 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
EP4190149A1 (en) 2009-12-25 2023-06-07 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having nog established cancer cell line transplanted therein
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2404500A1 (en) 2010-07-07 2012-01-11 Universite Pierre Et Marie Curie - Paris 6 A transgenic animal as a model for identifying adult stem cells, and uses thereof
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
WO2012019061A2 (en) 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
CN103476429B (zh) 2010-09-03 2016-08-24 施特姆森特克斯股份有限公司 新型调节剂及使用方法
US11124773B2 (en) * 2010-10-06 2021-09-21 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
US20140302034A1 (en) 2010-12-08 2014-10-09 Stem Centrx, Inc. Novel modulators and methods of use
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
GB201106395D0 (en) * 2011-04-14 2011-06-01 Hubrecht Inst Compounds
EP2533045A1 (en) 2011-06-08 2012-12-12 Université Pierre et Marie Curie Paris 6 Methods for identifying adult stem cells
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
EP2749641B1 (en) 2011-09-07 2021-06-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
EP2772268B8 (en) 2011-10-28 2020-01-08 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
MX347853B (es) 2011-12-19 2017-05-16 Umc Utrecht Holding Bv Ensayo cuantitativo rapido para medir la funcion del regulador de conductancia de transmembrana de fibrosis quistica (cftr) en un molde de cultivo intestinal primario.
RU2014138047A (ru) 2012-02-23 2016-04-10 Орегон Стейт Боард Оф Хайе Эдьюкейшн Он Бехалф Оф Портланд Стейт Юниверсити Селективное выявление тиолов
ES2812849T3 (es) 2012-02-24 2021-03-18 Abbvie Stemcentrx Llc Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos
ES2741936T3 (es) 2012-02-24 2020-02-12 Abbvie Stemcentrx Llc Anticuerpos anti-SEZ6 y procedimientos de uso
JPWO2014007369A1 (ja) * 2012-07-05 2016-06-02 国立研究開発法人国立がん研究センター Fgfr2融合遺伝子
CN104822827B (zh) 2012-12-06 2020-01-21 干细胞生物科技公司 Lgr5+体干细胞
WO2014130879A2 (en) 2013-02-22 2014-08-28 Stem Centrx, Inc. Novel antibody conjugates and uses thereof
AU2014251110A1 (en) * 2013-04-08 2015-11-26 Regentys Corporation Method and composition for treating inflammatory bowel disease without colectomy
EP2818544A1 (en) * 2013-06-24 2014-12-31 Stembios Technologies, Inc. Method for counting number of stem cells in human or animal samples
EP3338793A1 (en) 2013-08-28 2018-06-27 AbbVie Stemcentrx LLC Novel sez6 modulators and methods of use
PE20160674A1 (es) 2013-08-28 2016-07-21 Stemcentrx Inc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
KR102298172B1 (ko) 2013-09-06 2021-09-06 아카데미아 시니카 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화
JP2016537399A (ja) 2013-09-17 2016-12-01 ジェネンテック, インコーポレイテッド 抗lgr5抗体を使用する方法
RU2016122041A (ru) 2013-11-06 2017-12-11 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые анти-клаудин антитела и способы их применения
JP2017500028A (ja) 2013-12-12 2017-01-05 アッヴィ・ステムセントルクス・エル・エル・シー 新規の抗dpep3抗体および使用方法
EA201691683A1 (ru) 2014-02-21 2017-04-28 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Антитела против dll3 и конъюгаты антитело-лекарственное средство для применения при меланоме
EP3119448B1 (en) 2014-03-21 2020-04-22 University of Pittsburgh- Of the Commonwealth System of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
AU2015267052A1 (en) 2014-05-27 2016-12-15 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR20240096599A (ko) 2014-05-27 2024-06-26 아카데미아 시니카 항-cd20 글리코항체 및 이의 용도
US10005847B2 (en) 2014-05-27 2018-06-26 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP7063538B2 (ja) 2014-05-28 2022-05-09 アカデミア シニカ 抗TNFα糖操作抗体群およびその使用
ES2791199T3 (es) 2014-06-25 2020-11-03 Tel Hashomer Medical Res Infrastructure & Services Ltd Identificación de marcadores de células madre cancerosas y uso de los mismos para diagnóstico y tratamiento
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法
JP2018501189A (ja) * 2014-11-19 2018-01-18 ステムバイオス テクノロジーズ,インコーポレイテッド 骨欠損を治療するための体性幹細胞
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
CN104360070B (zh) * 2014-11-28 2017-02-22 山东新创生物科技有限公司 肽基精氨酸脱亚胺酶2在制备肿瘤临床血液诊断试剂中的应用
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
CN107430127B (zh) * 2015-01-24 2020-08-28 中央研究院 癌症标记及其使用方法
SG10201902872YA (en) 2015-04-03 2019-04-29 Propagenix Inc Ex vivo proliferation of epithelial cells
US10100285B2 (en) 2015-04-03 2018-10-16 Propagenix Inc. Ex vivo proliferation of epithelial cells
CN104862272B (zh) * 2015-05-29 2018-08-10 吉林大学 Y-27632抑制剂在cd44阳性肠干细胞分选中的应用
EP3347450B1 (en) 2015-09-11 2021-03-17 Propagenix Inc. Ex vivo proliferation of epithelial cells
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
CA3017747A1 (en) 2016-03-14 2017-09-21 Regentys Corporation Method and composition for treating inflammatory bowel disease
JP2019522960A (ja) 2016-04-21 2019-08-22 アッヴィ・ステムセントルクス・エル・エル・シー 新規の抗bmpr1b抗体及び使用方法
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
AU2017316663B2 (en) 2016-08-22 2024-02-22 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3604522B1 (en) * 2017-03-28 2022-07-13 Keio University Human tissue stem cell and use thereof
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
WO2019178267A2 (en) * 2018-03-13 2019-09-19 University Of Iowa Research Foundation Inductive regeneration of the airway by transcriptional factor modulation of glandular myoepithelial stem cells
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US20220095597A1 (en) * 2019-01-24 2022-03-31 North Carolina State University Transgenic models for stem cell therapies
GB201903573D0 (en) 2019-03-15 2019-05-01 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for head and neck organoids
GB201906978D0 (en) 2019-05-17 2019-07-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method using integrin agonist
CN114555101B (zh) * 2019-08-27 2024-08-20 河北医科大学第三医院 多潜能关节祖细胞、其组合物及制备方法
EP3789049A1 (en) 2019-09-06 2021-03-10 QGel SA Method for obtaining healthy intestinal organoids
US12451250B2 (en) 2019-10-22 2025-10-21 Tempus Ai, Inc. Systems and methods for predicting therapeutic sensitivity
US11629385B2 (en) 2019-11-22 2023-04-18 Tempus Labs, Inc. Tumor organoid culture compositions, systems, and methods
JP7744340B2 (ja) 2019-12-05 2025-09-25 テンパス・エーアイ・インコーポレイテッド ハイスループット薬物スクリーニングのためのシステムおよび方法
EP4121111A4 (en) * 2020-03-20 2024-05-15 University of Houston System METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND FIBROTIC PULMONARY DISORDERS
US11561178B2 (en) 2020-04-20 2023-01-24 Tempus Labs, Inc. Artificial fluorescent image systems and methods
WO2022261183A2 (en) * 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
CN113637634A (zh) * 2021-08-01 2021-11-12 杭州憶盛医疗科技有限公司 一种基于结合化合物的间充质干细胞分离的方法
CN114045336B (zh) * 2021-09-28 2024-01-02 中国人民解放军空军军医大学 Cga基因作为靶点在制备用于诊断和治疗耐药实体瘤药物的应用
GB202204266D0 (en) 2022-03-25 2022-05-11 Stichting Hubrecht Organoid Tech Methods for co-culturing genotoxic bacteria and organoids
CN115453114A (zh) * 2022-07-29 2022-12-09 成都锦欣生殖医学与遗传学研究所 一种用于观察胎儿脱落细胞状态的试剂盒及其制备方法和应用
CN115792227A (zh) * 2022-12-07 2023-03-14 西北农林科技大学 一种绒山羊毛囊干细胞的鉴定、分离和培养方法
EP4495227A1 (en) 2023-07-18 2025-01-22 HUB Organoids IP B.V. Co-cultures of organoids and stromal cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
AU2002303437A1 (en) * 2001-04-20 2002-11-05 Children's Hospital Of Orange County Isolation of neural stem cells using gangliosides and other surface markers
US20040058392A1 (en) 2002-09-17 2004-03-25 Kylix B.V. Use of novel stem cell markers for isolation of intestinal stem cells, and use of the intestinal stem cells thus obtained for the preparation of a therapeutical composition
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
DE602004015064D1 (de) 2003-01-06 2008-08-28 Wyeth Corp Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs
DE10339820A1 (de) * 2003-08-22 2005-03-17 Hinzmann, Bernd, Dr. Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
AU2004315399B2 (en) 2004-01-29 2009-08-06 Cellzome Ag Treatment of neurodegenerative diseases by the use of ATP7A-modulators
DK1713501T3 (da) * 2004-01-29 2008-05-26 Cellzome Ag Behandling af neurodegenerative sygdomme ved anvendelse af GPR49
CN1940062B (zh) * 2005-09-28 2010-04-28 上海市肿瘤研究所 一种肝癌干细胞及其分离方法和用途
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
EP3061808B1 (en) 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
MX347853B (es) 2011-12-19 2017-05-16 Umc Utrecht Holding Bv Ensayo cuantitativo rapido para medir la funcion del regulador de conductancia de transmembrana de fibrosis quistica (cftr) en un molde de cultivo intestinal primario.

Also Published As

Publication number Publication date
US9833496B2 (en) 2017-12-05
EP3190180A3 (en) 2017-08-09
CN101868534A (zh) 2010-10-20
WO2009022907A3 (en) 2009-06-25
EP2190978B1 (en) 2016-11-30
EP2190978A2 (en) 2010-06-02
HRP20170326T1 (hr) 2017-04-21
US20150231201A1 (en) 2015-08-20
US20170151308A9 (en) 2017-06-01
PT2190978T (pt) 2017-01-31
AU2008287605B2 (en) 2014-07-03
US20210228682A1 (en) 2021-07-29
CA2696047A1 (en) 2009-02-19
CN101868534B (zh) 2014-12-10
CA2696047C (en) 2023-10-03
US20180221441A1 (en) 2018-08-09
AU2008287605A1 (en) 2009-02-19
EP2022848A1 (en) 2009-02-11
DK2190978T3 (en) 2017-02-06
EP3190180A2 (en) 2017-07-12
HUE032118T2 (en) 2017-08-28
ES2617304T3 (es) 2017-06-16
CN104483485B (zh) 2017-12-12
US10940180B2 (en) 2021-03-09
US8906631B2 (en) 2014-12-09
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