[go: up one dir, main page]

PL2148880T3 - Inhibitory kinazy p70 S6 - Google Patents

Inhibitory kinazy p70 S6

Info

Publication number
PL2148880T3
PL2148880T3 PL08747285T PL08747285T PL2148880T3 PL 2148880 T3 PL2148880 T3 PL 2148880T3 PL 08747285 T PL08747285 T PL 08747285T PL 08747285 T PL08747285 T PL 08747285T PL 2148880 T3 PL2148880 T3 PL 2148880T3
Authority
PL
Poland
Prior art keywords
kinase inhibitors
kinase
inhibitors
Prior art date
Application number
PL08747285T
Other languages
English (en)
Inventor
Robert Dean Dally
Jianping Huang
Sajan Joseph
Timothy Alan Shepherd
Christian L Holst
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL2148880T3 publication Critical patent/PL2148880T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL08747285T 2007-05-11 2008-05-01 Inhibitory kinazy p70 S6 PL2148880T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11
EP08747285.8A EP2148880B1 (en) 2007-05-11 2008-05-01 P70 s6 kinase inhibitors
PCT/US2008/062143 WO2008140947A1 (en) 2007-05-11 2008-05-01 P70 s6 kinase inhibitors

Publications (1)

Publication Number Publication Date
PL2148880T3 true PL2148880T3 (pl) 2014-10-31

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08747285T PL2148880T3 (pl) 2007-05-11 2008-05-01 Inhibitory kinazy p70 S6

Country Status (33)

Country Link
US (2) US8093383B2 (pl)
EP (1) EP2148880B1 (pl)
JP (1) JP5503532B2 (pl)
KR (1) KR101088219B1 (pl)
CN (1) CN101679439B (pl)
AR (1) AR066344A1 (pl)
AU (1) AU2008251692B2 (pl)
BR (1) BRPI0811212A2 (pl)
CA (1) CA2687265C (pl)
CL (1) CL2008001230A1 (pl)
CO (1) CO6241109A2 (pl)
CR (1) CR11106A (pl)
DK (1) DK2148880T3 (pl)
DO (1) DOP2009000257A (pl)
EA (1) EA016445B1 (pl)
EC (1) ECSP099721A (pl)
ES (1) ES2483726T3 (pl)
GT (1) GT200900292A (pl)
HR (1) HRP20140611T1 (pl)
IL (1) IL201564A (pl)
MA (1) MA31433B1 (pl)
MX (1) MX2009012075A (pl)
MY (1) MY154898A (pl)
NZ (1) NZ580423A (pl)
PE (1) PE20090887A1 (pl)
PL (1) PL2148880T3 (pl)
PT (1) PT2148880E (pl)
RS (1) RS53451B (pl)
SI (1) SI2148880T1 (pl)
TN (1) TN2009000446A1 (pl)
TW (1) TWI423805B (pl)
UA (1) UA99284C2 (pl)
WO (1) WO2008140947A1 (pl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
US8252791B2 (en) * 2008-08-13 2012-08-28 Jenrin Discovery, Inc. Purine compounds as cannabinoid receptor blockers
WO2010056574A1 (en) * 2008-11-11 2010-05-20 Eli Lilly And Company P70 s6 kinase inhibitor and mtor inhibitor combination therapy
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
US8334293B2 (en) 2008-11-11 2012-12-18 Eli Lilly And Company P70 S6 kinase inhibitor and EGFR inhibitor combination therapy
CA2751886C (en) 2009-02-11 2017-08-29 Merck Patent Gmbh Novel amino azaheterocyclic carboxamides
WO2011017009A1 (en) 2009-08-07 2011-02-10 Merck Patent Gmbh Novel azaheterocyclic compounds
WO2011050016A1 (en) * 2009-10-23 2011-04-28 Eli Lilly And Company Akt inhibitors
MX2012009030A (es) 2010-02-03 2012-09-12 Signal Pharm Llc Identificacion de mutacion lkb1 como biomarcador predictivo para sensibilidad a inhibidores de tor cinasa.
EP2598497B1 (en) 2010-07-29 2019-03-06 Merck Patent GmbH Cyclic amine azaheterocyclic carboxamides
UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
EP2643313B9 (en) 2010-11-24 2017-02-22 Merck Patent GmbH Quinazoline carboxamide azetidines
CN106946796B (zh) 2011-09-12 2020-05-08 默克专利有限公司 用作激酶活性调节剂的氨基嘧啶衍生物
MX346095B (es) 2011-09-12 2017-03-07 Merck Patent Gmbh Nuevas imidazol-aminas como moduladores de la actividad de cinasas.
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
WO2014078634A1 (en) * 2012-11-16 2014-05-22 Merck Patent Gmbh Novel imidazol-piperidinyl derivatives as modulators of kinase activity
AR093512A1 (es) 2012-11-16 2015-06-10 Merck Patent Gmbh Derivados heterociclicos como moduladores de la actividad de cinasas
PE20151782A1 (es) 2012-11-29 2015-12-02 Merck Patent Gmbh Derivados de azaquinolin-carboxamida
SG10201900954SA (en) * 2013-03-11 2019-02-27 Merck Patent Gmbh Heterocycles as Modulators of Kinase Activity
MX374749B (es) 2013-04-17 2025-03-06 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tratar cancer.
NZ629230A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
NZ629332A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
CA2909579A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
EP2986322A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629469A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
HK1223286A1 (zh) 2013-05-29 2017-07-28 西格诺药品有限公司 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9980966B2 (en) 2014-04-03 2018-05-29 Merck Patent Gmbh Combinations of cancer therapeutics
EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
WO2016040078A1 (en) * 2014-09-10 2016-03-17 Eli Lilly And Company Substituted phenyl imidazolyl piperidyl compounds as p70s6k1 inhibitors
WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
WO2022101459A1 (en) 2020-11-16 2022-05-19 Merck Patent Gmbh Kinase inhibitor combinations for cancer treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP5213229B2 (ja) * 2004-04-23 2013-06-19 エグゼリクシス， インコーポレイテッド キナーゼ調節因子および使用方法
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
ATE543821T1 (de) 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
US20090325924A1 (en) 2005-06-30 2009-12-31 Stuart Edward GPCR Agonists
JP2009536620A (ja) 2006-04-25 2009-10-15 アステックス、セラピューティックス、リミテッド 医薬組み合わせ物
US8796293B2 (en) 2006-04-25 2014-08-05 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008012635A2 (en) 2006-07-26 2008-01-31 Pfizer Products Inc. Amine derivatives useful as anticancer agents
AR064416A1 (es) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Also Published As

Publication number Publication date
JP2010526814A (ja) 2010-08-05
PT2148880E (pt) 2014-08-28
TW200848053A (en) 2008-12-16
EP2148880B1 (en) 2014-05-28
AR066344A1 (es) 2009-08-12
PE20090887A1 (es) 2009-07-13
EA016445B1 (ru) 2012-05-30
CO6241109A2 (es) 2011-01-20
MY154898A (en) 2015-08-28
IL201564A (en) 2014-08-31
SI2148880T1 (sl) 2014-07-31
CA2687265C (en) 2012-12-04
HK1140767A1 (en) 2010-10-22
EP2148880A1 (en) 2010-02-03
RS53451B (sr) 2014-12-31
DOP2009000257A (es) 2010-03-31
WO2008140947A1 (en) 2008-11-20
CN101679439B (zh) 2013-09-11
MA31433B1 (fr) 2010-06-01
CR11106A (es) 2010-04-12
US20120071490A1 (en) 2012-03-22
CL2008001230A1 (es) 2009-05-22
TN2009000446A1 (en) 2011-03-31
CN101679439A (zh) 2010-03-24
CA2687265A1 (en) 2008-11-20
KR101088219B1 (ko) 2011-11-30
MX2009012075A (es) 2009-11-19
KR20100005710A (ko) 2010-01-15
AU2008251692B2 (en) 2012-10-11
BRPI0811212A2 (pt) 2014-10-29
AU2008251692A1 (en) 2008-11-20
US8093383B2 (en) 2012-01-10
TWI423805B (zh) 2014-01-21
HRP20140611T1 (hr) 2014-08-15
JP5503532B2 (ja) 2014-05-28
DK2148880T3 (da) 2014-06-16
US20090163714A1 (en) 2009-06-25
NZ580423A (en) 2012-02-24
IL201564A0 (en) 2010-05-31
ECSP099721A (es) 2009-12-28
GT200900292A (es) 2011-06-24
UA99284C2 (ru) 2012-08-10
EA200971051A1 (ru) 2010-06-30
ES2483726T3 (es) 2014-08-07

Similar Documents

Publication Publication Date Title
IL201564A0 (en) P70 s6 kinase inhibitors
IL284889A (en) Imidazotriazines and imidazopyrimidines as kinase inhibitors
ZA201004942B (en) Ptrrolopyrazine kinase inhibitors
ZA201002543B (en) Polo-like kinase inhibitors
ZA200901073B (en) Kinase inhibitor
ZA201004055B (en) 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
IL190078A0 (en) Kinase inhibitors
ZA201005166B (en) 2-benzylpyridazinone derivatives as met kinase inhibitors
EP2222166A4 (en) INHIBITORS OF HETEROCYCLIC KINASES
IL211940A0 (en) Akt and p70 s6 kinase inhibitors
SI1943243T1 (sl) Inhibotorji kinaz
ZA200908943B (en) Pyrazolopyrimidinone kinase inhibitor
IL197981A0 (en) Kinase inhibitors
GB0603522D0 (en) Kinase inhibition
GB0714941D0 (en) Inhibitors
GB0606238D0 (en) Kinase inhibition
GB0715470D0 (en) IKK- serine-threonine protein kinase inhibitors
GB0713152D0 (en) Phosphodlesterase inhibitors
IL189985A0 (en) Kinase inhibitors
ZA200803287B (en) Kinase inhibitors