PL2029561T3 - Związek trójpierścieniowy i jego farmaceutyczne zastosowanie - Google Patents

Związek trójpierścieniowy i jego farmaceutyczne zastosowanie

Info

Publication number: PL2029561T3
Authority: PL; Poland
Prior art keywords: pharmaceutical use; tricyclic compound; tricyclic; compound; pharmaceutical
Prior art date: 2006-06-19

Application number

PL07767453T

Other languages

English (en)

Inventor

Osamu Uchikawa

Tatsuki Koike

Yasutaka Hoashi

Takafumi Takai

Original Assignee

Takeda Pharmaceuticals Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-19

Filing date

2007-06-18

Publication date

2015-03-31

2007-06-18 Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co

2015-03-31 Publication of PL2029561T3 publication Critical patent/PL2029561T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL07767453T 2006-06-19 2007-06-18 Związek trójpierścieniowy i jego farmaceutyczne zastosowanie PL2029561T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2006168518		2006-06-19
EP07767453.9A EP2029561B1 (en)	2006-06-19	2007-06-18	Tricyclic compound and pharmaceutical use thereof
PCT/JP2007/062645 WO2007148808A1 (en)	2006-06-19	2007-06-18	Tricyclic compound and pharmaceutical use thereof

Publications (1)

Publication Number	Publication Date
PL2029561T3 true PL2029561T3 (pl)	2015-03-31

Family

ID=38519675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07767453T PL2029561T3 (pl)	2006-06-19	2007-06-18	Związek trójpierścieniowy i jego farmaceutyczne zastosowanie

Country Status (35)

Country	Link
US (5)	US8030337B2 (pl)
EP (1)	EP2029561B1 (pl)
JP (1)	JP5222737B2 (pl)
KR (1)	KR101442274B1 (pl)
CN (1)	CN101506181B (pl)
AR (1)	AR061478A1 (pl)
AU (1)	AU2007261953B2 (pl)
BR (1)	BRPI0713743C1 (pl)
CA (1)	CA2655753C (pl)
CL (1)	CL2007001779A1 (pl)
CO (1)	CO6150175A2 (pl)
CR (1)	CR10524A (pl)
CY (1)	CY1115729T1 (pl)
DK (1)	DK2029561T3 (pl)
ES (1)	ES2523410T3 (pl)
GE (1)	GEP20125392B (pl)
HR (1)	HRP20141046T1 (pl)
IL (1)	IL195639A0 (pl)
JO (1)	JO2999B1 (pl)
MA (1)	MA30523B1 (pl)
ME (2)	ME00582A (pl)
MX (1)	MX2008015842A (pl)
MY (1)	MY158069A (pl)
NO (1)	NO341739B1 (pl)
NZ (1)	NZ574037A (pl)
PE (1)	PE20080941A1 (pl)
PL (1)	PL2029561T3 (pl)
PT (1)	PT2029561E (pl)
RS (1)	RS53616B1 (pl)
RU (1)	RU2456278C2 (pl)
SI (1)	SI2029561T1 (pl)
TW (1)	TWI402261B (pl)
UA (1)	UA99104C2 (pl)
WO (1)	WO2007148808A1 (pl)
ZA (1)	ZA200900151B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI402261B (zh) *	2006-06-19	2013-07-21	Takeda Pharmaceutical	三環化合物及其醫藥組成物
EP2098513B1 (en) *	2006-12-28	2015-01-21	Takeda Pharmaceutical Company Limited	Tricyclic compound and pharmaceutical use thereof
CN103450111B (zh) *	2013-09-04	2015-07-08	温州大学	一种苯并噻唑杂环化合物的绿色合成方法
US20160253891A1 (en) *	2015-02-27	2016-09-01	Elwha Llc	Device that determines that a subject may contact a sensed object and that warns of the potential contact
ES2987503T3 (es) *	2016-01-08	2024-11-15	Takeda Pharmaceuticals Co	Compuestos que tienen afinidad por el receptor de melatonina como agente profiláctico o terapéutico para el delirio confusional
KR20180100646A (ko)	2016-01-08	2018-09-11	다케다 야쿠힌 고교 가부시키가이샤	자폐 스펙트럼 장애의 예방 또는 치료제
CN110072882A (zh)	2016-10-19	2019-07-30	孟山都技术公司	用于改变开花和植物株型以提高产量潜力的组合物和方法
WO2025155789A1 (en) *	2024-01-17	2025-07-24	Rivo Bio, Inc.	Indane-, indene-, azaindane-, and azaindene-amines as activators of serotonin receptors

Family Cites Families (21)

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CA1292226C (en) *	1986-01-16	1991-11-19	Terumi Hachiya	Indenothiazole derivative and process for preparing the same
FR2680366B1 (fr)	1991-08-13	1995-01-20	Adir	Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5654325A (en)	1993-11-18	1997-08-05	Eli Lilly And Company	Melatonin derivatives for use in treating sleep disorders
US6180657B1 (en) *	1993-11-18	2001-01-30	Eli Lilly And Company	Melatonin derivatives for use in treating desynchronization disorders
FR2725985B1 (fr)	1994-10-21	1996-11-15	Adir	Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19502895A1 (de)	1995-01-31	1996-08-01	Merck Patent Gmbh	4-Mercapto-benzoylguanidin-Derivate
US5596019A (en) *	1995-06-07	1997-01-21	Bristol-Myers Squibb Company	N-acyl-cycloalkylamine derivatives as melatonergics
CA2176854A1 (en)	1995-06-07	1996-12-08	Daniel J. Keavy	N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
US5753709A (en) *	1995-06-07	1998-05-19	Bristol-Myers Squibb Company	N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
FR2742153B1 (fr)	1995-12-12	1998-02-13	Innothera Lab Sa	Utilisation de derives tricycliques du 1,4-dihydro-1,4- dioxo-1h-naphtalene, nouveaux composes obtenus et leur application en therapeutique
US6034239A (en)	1996-03-08	2000-03-07	Takeda Chemical Industries, Ltd.	Tricyclic compounds, their production and use
KR100494214B1 (ko) *	1996-03-08	2005-11-25	다케다 야쿠힌 고교 가부시키가이샤	삼환화합물,그의제조방법및용도
SE9802360D0 (sv) *	1998-07-01	1998-07-01	Wikstroem Hakan Vilhelm	New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
ATE443526T1 (de) *	1999-08-20	2009-10-15	Takeda Pharmaceutical	Zusammensetzung für perkutane absorption mit einem melantoninrezeptor-agonistisch wirkendem wirkstoff
WO2002040054A1 (en) *	2000-11-17	2002-05-23	Takeda Chemical Industries, Ltd.	Pharmaceutical preparation containing copolyvidone
JP3633895B2 (ja)	2000-11-17	2005-03-30	武田薬品工業株式会社	コポリビドン含有製剤
US6569894B1 (en) *	2001-10-04	2003-05-27	Bristol-Myers Squibb Company	Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) *	2002-03-12	2004-05-18	Bristol-Myers Squibb Company	Benzoxazole derivatives as novel melatonergic agents
US20050197365A1 (en) *	2004-02-27	2005-09-08	Jeffrey Sterling	Diamino thiazoloindan derivatives and their use
US20060223877A1 (en)	2005-03-31	2006-10-05	Zemlan Frank P	Methods of treatment utilizing certain melatonin derivatives
TWI402261B (zh) *	2006-06-19	2013-07-21	Takeda Pharmaceutical	三環化合物及其醫藥組成物

2007
- 2007-06-15 TW TW096121686A patent/TWI402261B/zh active
- 2007-06-15 AR ARP070102638A patent/AR061478A1/es not_active Application Discontinuation
- 2007-06-18 GE GEAP200711069A patent/GEP20125392B/en unknown
- 2007-06-18 CL CL2007001779A patent/CL2007001779A1/es unknown
- 2007-06-18 JP JP2008557541A patent/JP5222737B2/ja active Active
- 2007-06-18 RU RU2009101299/04A patent/RU2456278C2/ru not_active IP Right Cessation
- 2007-06-18 EP EP07767453.9A patent/EP2029561B1/en active Active
- 2007-06-18 WO PCT/JP2007/062645 patent/WO2007148808A1/en not_active Ceased
- 2007-06-18 US US12/305,560 patent/US8030337B2/en active Active
- 2007-06-18 ZA ZA200900151A patent/ZA200900151B/xx unknown
- 2007-06-18 MX MX2008015842A patent/MX2008015842A/es active IP Right Grant
- 2007-06-18 DK DK07767453.9T patent/DK2029561T3/da active
- 2007-06-18 AU AU2007261953A patent/AU2007261953B2/en active Active
- 2007-06-18 ES ES07767453.9T patent/ES2523410T3/es active Active
- 2007-06-18 ME MEP-16/09A patent/ME00582A/xx unknown
- 2007-06-18 UA UAA200900323A patent/UA99104C2/uk unknown
- 2007-06-18 PL PL07767453T patent/PL2029561T3/pl unknown
- 2007-06-18 PE PE2007000764A patent/PE20080941A1/es active IP Right Grant
- 2007-06-18 SI SI200731532T patent/SI2029561T1/sl unknown
- 2007-06-18 JO JOP/2007/0230A patent/JO2999B1/ar active
- 2007-06-18 CN CN2007800308773A patent/CN101506181B/zh active Active
- 2007-06-18 KR KR1020097000940A patent/KR101442274B1/ko active Active
- 2007-06-18 NZ NZ574037A patent/NZ574037A/en not_active IP Right Cessation
- 2007-06-18 BR BRPI0713743A patent/BRPI0713743C1/pt active IP Right Grant
- 2007-06-18 HR HRP20141046TT patent/HRP20141046T1/hr unknown
- 2007-06-18 RS RS20140609A patent/RS53616B1/sr unknown
- 2007-06-18 ME MEP-2014-143A patent/ME01998B/me unknown
- 2007-06-18 CA CA2655753A patent/CA2655753C/en active Active
- 2007-06-18 PT PT77674539T patent/PT2029561E/pt unknown
2008
- 2008-12-01 IL IL195639A patent/IL195639A0/en active IP Right Grant
- 2008-12-05 MY MYPI20084958A patent/MY158069A/en unknown
- 2008-12-18 CR CR10524A patent/CR10524A/es unknown
- 2008-12-19 MA MA31489A patent/MA30523B1/fr unknown
2009
- 2009-01-14 NO NO20090234A patent/NO341739B1/no not_active IP Right Cessation
- 2009-01-19 CO CO09003953A patent/CO6150175A2/es unknown
2011
- 2011-03-14 US US13/047,409 patent/US8236837B2/en not_active Expired - Fee Related
- 2011-03-14 US US13/047,363 patent/US8349879B2/en not_active Expired - Fee Related
2012
- 2012-10-23 US US13/657,956 patent/US8552037B2/en active Active
2013
- 2013-09-04 US US14/017,819 patent/US8895591B2/en active Active
2014
- 2014-11-07 CY CY20141100927T patent/CY1115729T1/el unknown

Also Published As

Publication number	Publication date
BRPI0713743B1 (pt)	2020-03-17
RU2009101299A (ru)	2010-07-27
UA99104C2 (uk)	2012-07-25
AR061478A1 (es)	2008-08-27
US8030337B2 (en)	2011-10-04
EP2029561B1 (en)	2014-08-13
DK2029561T3 (da)	2014-11-10
MA30523B1 (fr)	2009-06-01
PT2029561E (pt)	2014-11-12
US8895591B2 (en)	2014-11-25
US8552037B2 (en)	2013-10-08
GEP20125392B (en)	2012-02-10
US20110190361A1 (en)	2011-08-04
KR101442274B1 (ko)	2014-09-22
MY158069A (en)	2016-08-30
ES2523410T3 (es)	2014-11-25
NO20090234L (no)	2009-02-12
CY1115729T1 (el)	2017-01-25
CL2007001779A1 (es)	2008-01-04
ME00582A (en)	2011-12-20
CN101506181B (zh)	2011-12-07
JP5222737B2 (ja)	2013-06-26
NZ574037A (en)	2011-10-28
US20140011849A1 (en)	2014-01-09
CR10524A (es)	2009-01-27
US20130079374A1 (en)	2013-03-28
AU2007261953A1 (en)	2007-12-27
PE20080941A1 (es)	2008-09-04
HK1130049A1 (en)	2009-12-18
SI2029561T1 (sl)	2014-11-28
CA2655753C (en)	2015-08-04
BRPI0713743B8 (pt)	2020-05-19
US8236837B2 (en)	2012-08-07
RU2456278C2 (ru)	2012-07-20
BRPI0713743C1 (pt)	2021-05-25
RS53616B1 (sr)	2015-04-30
US8349879B2 (en)	2013-01-08
CN101506181A (zh)	2009-08-12
US20090182023A1 (en)	2009-07-16
BRPI0713743A2 (pt)	2012-11-06
ME01998B (me)	2015-05-20
CO6150175A2 (es)	2010-04-20
CA2655753A1 (en)	2007-12-27
TW200815376A (en)	2008-04-01
ZA200900151B (en)	2010-03-31
JP2009541202A (ja)	2009-11-26
JO2999B1 (ar)	2016-09-05
NO341739B1 (no)	2018-01-15
IL195639A0 (en)	2009-09-01
EP2029561A1 (en)	2009-03-04
AU2007261953B2 (en)	2012-11-08
US20110196003A1 (en)	2011-08-11
TWI402261B (zh)	2013-07-21
WO2007148808A1 (en)	2007-12-27
HRP20141046T1 (hr)	2014-12-19
MX2008015842A (es)	2009-01-09
KR20090023701A (ko)	2009-03-05

Publication	Publication Date	Title
IL193240A0 (en)	2009-08-03	Dihydrodiazepine derivatives and pharmaceutical compositions containing the same
GB0625659D0 (en)	2007-01-31	Therapeutic compounds and their use
IL194751A0 (en)	2009-08-03	Drugs and uses
SI2001556T1 (sl)	2014-12-31	Tioninijeve spojine in njihova uporaba
IL194899A0 (en)	2009-08-03	Amino-ethyl-amino-aryl (aeaa) compounds and their use
IL195639A0 (en)	2009-09-01	Tricyclic compound and pharmaceutical use thereof
EP2070919A4 (en)	2010-05-05	SPIROCHINONE COMPOUND AND PHARMACEUTICAL COMPOSITION
EP2124908A4 (en)	2011-04-27	CONNECTIONS AND ITS USE
GB0611115D0 (en)	2006-07-19	Compounds and their use
EP2120563A4 (en)	2011-04-27	CONNECTIONS AND ITS USES
EP2099459A4 (en)	2011-04-27	COMPOUNDS AND USES THEREOF
GB0614365D0 (en)	2006-08-30	Pharmaceutical compositions and their use
EP2114404A4 (en)	2010-03-03	COMPOUND AND PHARMACEUTICAL COMPOSITION
IL192820A0 (en)	2009-02-11	Novel compounds and use thereof
AP2734A (en)	2013-09-30	Pharmaceutical carrier composition and pharmaceutical composition
GB0619611D0 (en)	2006-11-15	Compounds and their use
GB0701295D0 (en)	2007-02-28	Z-stilbenes derivatives and the pharmaceutical composition thereof
EP2120957A4 (en)	2011-05-04	COMPOUNDS AND USES THEREOF
HUP0600122A3 (en)	2008-12-29	New compounds and their use
GB0614538D0 (en)	2006-08-30	Therapeutic Compounds And Their Use
GB0608846D0 (en)	2006-06-14	Compounds and their use
GB0603376D0 (en)	2006-03-29	Compounds and their use
GB0610888D0 (en)	2006-08-09	Compounds and their use
GB0603378D0 (en)	2006-03-29	Compounds and their use
GB0619610D0 (en)	2006-11-15	Compounds and their use