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PL2084124T3 - Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates - Google Patents

Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates

Info

Publication number
PL2084124T3
PL2084124T3 PL06809471T PL06809471T PL2084124T3 PL 2084124 T3 PL2084124 T3 PL 2084124T3 PL 06809471 T PL06809471 T PL 06809471T PL 06809471 T PL06809471 T PL 06809471T PL 2084124 T3 PL2084124 T3 PL 2084124T3
Authority
PL
Poland
Prior art keywords
prostaglandins
positively charged
related compounds
skin penetration
charged water
Prior art date
Application number
PL06809471T
Other languages
Polish (pl)
Inventor
Chongxi Yu
Lina Xu
Original Assignee
Techfields Biochem Co Ltd
Chongxi Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techfields Biochem Co Ltd, Chongxi Yu filed Critical Techfields Biochem Co Ltd
Publication of PL2084124T3 publication Critical patent/PL2084124T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
PL06809471T 2006-10-02 2006-10-02 Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates PL2084124T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06809471.3A EP2084124B9 (en) 2006-10-02 2006-10-02 Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates
PCT/IB2006/053594 WO2008041054A1 (en) 2006-10-02 2006-10-02 Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates

Publications (1)

Publication Number Publication Date
PL2084124T3 true PL2084124T3 (en) 2014-08-29

Family

ID=39268128

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06809471T PL2084124T3 (en) 2006-10-02 2006-10-02 Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates

Country Status (10)

Country Link
US (2) US11555014B2 (en)
EP (2) EP2084124B9 (en)
JP (1) JP5378219B2 (en)
CN (1) CN101535240B (en)
AU (1) AU2006349143B2 (en)
CA (1) CA2665081C (en)
ES (1) ES2466346T3 (en)
HK (1) HK1202524A1 (en)
PL (1) PL2084124T3 (en)
WO (1) WO2008041054A1 (en)

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US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
WO2008149181A1 (en) 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
US7960378B2 (en) 2008-03-18 2011-06-14 Allergan, Inc. Therapeutic compounds
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
WO2009131977A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Therapeutic compounds
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WO2009137411A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
US8569349B2 (en) 2008-05-09 2013-10-29 Allergan, Inc. Therapeutic compounds
WO2010065936A1 (en) * 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
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JP6030168B2 (en) * 2015-03-09 2016-11-24 テックフィールズ バイオケム カンパニー リミテッド Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin permeability
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Also Published As

Publication number Publication date
US20230174476A1 (en) 2023-06-08
US11555014B2 (en) 2023-01-17
EP2084124A4 (en) 2011-11-09
JP5378219B2 (en) 2013-12-25
EP2781505A1 (en) 2014-09-24
EP2084124B9 (en) 2015-07-01
WO2008041054A1 (en) 2008-04-10
CN101535240A (en) 2009-09-16
JP2010505808A (en) 2010-02-25
AU2006349143B2 (en) 2013-07-18
EP2084124A1 (en) 2009-08-05
CA2665081C (en) 2015-12-01
AU2006349143A1 (en) 2008-04-10
ES2466346T3 (en) 2014-06-10
CA2665081A1 (en) 2008-04-10
EP2084124B1 (en) 2014-02-26
US20090252685A1 (en) 2009-10-08
HK1202524A1 (en) 2015-10-02
CN101535240B (en) 2015-07-22
HK1137411A1 (en) 2010-07-30

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