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PL2083811T3 - Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu - Google Patents

Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu

Info

Publication number
PL2083811T3
PL2083811T3 PL07862184T PL07862184T PL2083811T3 PL 2083811 T3 PL2083811 T3 PL 2083811T3 PL 07862184 T PL07862184 T PL 07862184T PL 07862184 T PL07862184 T PL 07862184T PL 2083811 T3 PL2083811 T3 PL 2083811T3
Authority
PL
Poland
Prior art keywords
syndrome
autism
fragile
methods
treating down
Prior art date
Application number
PL07862184T
Other languages
English (en)
Inventor
Randall L. Carpenter
Kathryn Roberts
Mark F. Bear
Original Assignee
Clinical Research Associates, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Research Associates, Llc filed Critical Clinical Research Associates, Llc
Publication of PL2083811T3 publication Critical patent/PL2083811T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Surgical Instruments (AREA)
PL07862184T 2006-11-22 2007-11-21 Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu PL2083811T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86073306P 2006-11-22 2006-11-22
US156707P 2007-11-02 2007-11-02
PCT/US2007/024311 WO2008066750A1 (en) 2006-11-22 2007-11-21 Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Publications (1)

Publication Number Publication Date
PL2083811T3 true PL2083811T3 (pl) 2017-05-31

Family

ID=39272866

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07862184T PL2083811T3 (pl) 2006-11-22 2007-11-21 Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu

Country Status (16)

Country Link
US (6) US8143311B2 (pl)
EP (3) EP2578216A1 (pl)
JP (1) JP2010510314A (pl)
AU (1) AU2007325836B2 (pl)
CA (1) CA2670116C (pl)
CY (1) CY1118406T1 (pl)
DK (1) DK2083811T3 (pl)
ES (1) ES2610508T3 (pl)
HR (1) HRP20170027T1 (pl)
HU (1) HUE032743T2 (pl)
LT (1) LT2083811T (pl)
PL (1) PL2083811T3 (pl)
PT (1) PT2083811T (pl)
RS (1) RS55585B1 (pl)
SI (1) SI2083811T1 (pl)
WO (1) WO2008066750A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2201950T1 (sl) 2008-12-08 2017-05-31 Biocodex Spojine in metode za zdravljenje motenj avtističnega spektra
US9463172B2 (en) 2009-02-12 2016-10-11 Indiana University Research & Technology Corporation Material and methods for treating developmental disorders including comorbid and idiopathic autism
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
WO2011053636A1 (en) * 2009-10-27 2011-05-05 Mount Sinai School Of Medicine Methods of treating psychiatric or neurological disorders with mglur antagonists
EP2544688B1 (en) * 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
US20120016021A1 (en) * 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
US8946206B2 (en) 2010-12-17 2015-02-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for improving cognitive function
US9622997B2 (en) 2012-06-01 2017-04-18 Lynn Health Science Institute, Inc. Methods for treating insomnia
EP2928300A4 (en) * 2012-11-28 2016-07-13 Neuren Pharmaceuticals Ltd TREATMENT OF AUTISTIC DISEASES WITH GLYCYL-L-2-METHYLPROLYL-L-GLUTAMINE ACID
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
WO2014128882A1 (ja) * 2013-02-21 2014-08-28 医療法人 和楽会 不安うつ病の治療薬
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
AU2014337504B2 (en) * 2013-10-14 2020-01-30 Indiana University Research And Technology Corporation Use of acamprosate to modulate ERK 1-2 activation in animal models for FXS and ASD and individuals diagnosed with FXS and ASD
US10350183B2 (en) 2015-01-15 2019-07-16 Allaysis, Llc Intravenous baclofen formulations and treatment methods
EP3258914A1 (en) 2015-02-20 2017-12-27 Osmotica Kereskedelmi ES Szolgaltato KFT Controlled release oral dosage form of gaba receptor agonist
US10300032B2 (en) 2015-02-20 2019-05-28 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
US10172800B2 (en) 2015-02-20 2019-01-08 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form with enhanced pharmacokinetics
US10987328B2 (en) 2015-02-20 2021-04-27 Osmotica Kereskedelmi Es Szolgaltato Kft Controlled release dosage form
AU2016295138B2 (en) * 2015-07-17 2021-11-04 Ovid Therapeutics Inc. Methods of treating developmental disorders with gaboxadol
US20180042903A1 (en) 2016-08-11 2018-02-15 Ovid Therapeutics Inc. Methods and compositions for treatment of epileptic disorders
US10535243B2 (en) * 2016-10-28 2020-01-14 HBH Development LLC Target behavior monitoring system
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
CA3071939A1 (en) 2017-08-04 2019-02-07 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
JP7212946B2 (ja) * 2018-01-18 2023-01-26 株式会社Cureapp 行動変容によって治療しうる疾患の治療のためのシステム、装置、方法及びプログラム
JP7422666B2 (ja) 2018-01-30 2024-01-26 アプニメッド，インコーポレイテッド（デラウェア） 睡眠時無呼吸を治療するための方法および組成物
WO2020061410A1 (en) 2018-09-20 2020-03-26 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering
US11186909B2 (en) * 2019-08-26 2021-11-30 Applied Materials, Inc. Methods of depositing low-K films
USD967184S1 (en) * 2021-02-26 2022-10-18 Oracle International Corporation Display screen or portion thereof with icon, or paper product with surface ornamentation
USD970544S1 (en) * 2021-02-26 2022-11-22 Oracle International Corporation Display screen or portion thereof with icon or paper product with surface ornamentation
USD1059370S1 (en) * 2021-09-15 2025-01-28 Capital Preferences NZ Limited Display screen or portion thereof with an animated graphical user interface for a sustainability simulator
US11523984B1 (en) 2021-11-12 2022-12-13 Amneal Pharmaceuticals Llc Compositions and methods of administering baclofen
WO2023178183A1 (en) * 2022-03-16 2023-09-21 University Of Florida Research Foundation, Incorporated Combinatorial activation of gaba(b) and alpha-2 adrenergic receptors for treatment of stress induced depression
US20240408042A1 (en) * 2023-06-08 2024-12-12 Clinical Research Associates LLC Orally disintegrating baclofen compositions and methods of making same
USD1103182S1 (en) * 2023-07-07 2025-11-25 Illumina, Inc. Display screen or portion thereof with graphical user interface

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
GB1247067A (en) 1968-02-16 1971-09-22 Fujisawa Pharmaceutical Co Tricyclic enol ether compounds and the preparation thereof
FR2492258A1 (fr) 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4411901A (en) 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH0625181B2 (ja) 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
EP0385237B1 (en) 1989-03-03 1994-06-29 Dainippon Pharmaceutical Co., Ltd. 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same
GB8908085D0 (en) 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5238945A (en) 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
ES2076253T3 (es) 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US6107025A (en) 1991-05-24 2000-08-22 Baylor College Of Medicine Diagnosis of the fragile X syndrome
US6180337B1 (en) 1991-05-24 2001-01-30 Baylor College Of Medicine Diagnosis of the fragile X syndrome
DE4243287A1 (de) 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4339702A1 (de) 1993-11-22 1995-05-24 Bayer Ag Verfahren zur Herstellung von harten Polyurethanschaumstoffen
KR970701719A (ko) 1994-03-14 1997-04-12 안네 제케르 헤테로고리화합물과 그것의 제법 및 사용(heterocyclic compounds, their preparation and use)
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
AU1106195A (en) 1994-11-09 1996-06-06 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
US6011021A (en) 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
EP0842176A1 (en) 1995-07-31 1998-05-20 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
EP0843660A1 (en) 1995-07-31 1998-05-27 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
GB9609976D0 (en) 1996-05-13 1996-07-17 Lilly Industries Ltd Pharmaceutical compounds
US5795877A (en) 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5863536A (en) 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US5902817A (en) 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US5672592A (en) 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
WO1998006724A1 (en) 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
FR2759366B1 (fr) 1997-02-11 1999-04-16 Centre Nat Rech Scient Composes constituant notamment des effecteurs de recepteurs du systeme nerveux central sensibles aux amino acides neuroexcitateurs, leur preparation et leurs applications biologiques
ID23013A (id) 1997-04-07 1999-12-30 Lilly Co Eli Bahan-bahan farmakologi
WO1998053812A1 (en) 1997-05-27 1998-12-03 Guilford Pharmaceuticals Inc. Inhibitors of naaladase enzyme activity
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
CN1154489C (zh) 1997-08-14 2004-06-23 弗·哈夫曼-拉罗切有限公司 抗神经学疾病的杂环乙烯基醚
YU10500A (sh) * 1997-08-25 2002-10-18 Neurogen Corporation Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi
EP1037878A2 (en) 1997-11-21 2000-09-27 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists for treating central nervous system diseases
EP1059090A4 (en) 1998-03-03 2002-02-27 Yamanouchi Pharma Co Ltd DRUGS AGAINST BLEEDING OF THE BRAIN
WO1999054280A1 (en) 1998-04-17 1999-10-28 Kenneth Curry Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation
US20030216293A1 (en) 1998-07-07 2003-11-20 Tomas Eriksson Use of composition comprising at least one substance within the group GnRH-analogues for treatment of obsessive -compulsive disorder (OCD)
SE9802438L (sv) 1998-07-07 1999-07-19 Laekartjaenster I Vaestsverige Användning av komposition omfattande minst ett ämne inom gruppen GnRH-analoger för framställning av ett läkemedel för behandling av tvångstanke-tvångshandlingssjukdom
WO2000020001A1 (en) 1998-10-02 2000-04-13 Novartis Ag Mglur5 antagonists for the treatment of pain and anxiety
GB9823845D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
GB9823847D0 (en) 1998-11-02 1998-12-23 Lilly Co Eli Pharmaceutical compounds
TW593241B (en) 1999-04-20 2004-06-21 Hoffmann La Roche Carbamic acid derivatives
WO2000069816A1 (en) 1999-05-17 2000-11-23 Eli Lilly And Company Metabotropic glutamate receptor antagonists
CN1361768A (zh) 1999-06-02 2002-07-31 Nps药物有限公司 代谢移变的谷氨酸盐受体拮抗剂和它们治疗中枢神经系统疾病的用途
AU5667900A (en) 1999-06-30 2001-01-22 Prescient Neuropharma Inc. 2-aminoindane analogs
MXPA02000261A (es) 1999-07-02 2003-08-20 Prescient Nerupharma Inc Aminoindanos novedosos.
DE60002733T2 (de) 1999-07-06 2004-03-18 Eli Lilly And Co., Indianapolis Diester prodrugs von decahydroischinoline-3-carbonsäure
AU5959900A (en) 1999-07-15 2001-02-05 Mcgill University Oligonucleotides for metabotropic glutamate receptor type 1 (mglur1)
EP1205187A1 (en) 1999-08-02 2002-05-15 Yamanouchi Pharmaceutical Co. Ltd. Remedies for neurogenic pains
ATE254614T1 (de) 1999-08-06 2003-12-15 Hoffmann La Roche Tetrahydro-benzo(d)azepine und deren verwendung als metabotrope glutamatrezeptor-antagonisten
IL148052A0 (en) * 1999-08-10 2002-09-12 Uab Research Foundation Use of gaba antagonists for treatment of spastic disorders, convulsions, and epilepsy
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
AU1071301A (en) 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
GB0005700D0 (en) 2000-03-09 2000-05-03 Glaxo Group Ltd Therapy
US20030008897A1 (en) 2000-03-17 2003-01-09 Mendel Carl M. Method of controlling weight gain associated with therapeutic drugs
US6455553B1 (en) * 2000-10-03 2002-09-24 Albert Einstein College Of Medicine Of Yeshiva University Method for treating a demyelinating condition
US20020123490A1 (en) 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
AU2002307049A1 (en) 2001-04-02 2002-10-15 Brown University Research Foundation Use of mglur5 antagonists in the manufacture of a medicament in the treatment of autism, mental retardation, schizophrenia
US6916821B2 (en) 2001-04-02 2005-07-12 Brown University Methods of treating disorders with Group I mGluR antagonists
US6831077B2 (en) 2002-07-25 2004-12-14 Comprehensive Neuroscience, Inc. Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation
US6656172B1 (en) * 2002-09-27 2003-12-02 Medtronic, Inc. Method for treating severe tinnitus
CA2778126A1 (en) 2003-06-24 2005-01-13 University Of Connecticut Methods of inhibiting vascular permeability and apoptosis
WO2005019163A2 (en) * 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
WO2006012403A1 (en) * 2004-07-20 2006-02-02 Massachusetts Institute Of Technology Methods of treatment: cell signaling and glutamate release
US20060058271A1 (en) 2004-09-16 2006-03-16 Geier Mark R Methods for screening, studying, and treating dissorders with a component of mercurial toxicity
US20070254314A1 (en) 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
WO2006121919A2 (en) * 2005-05-05 2006-11-16 Massachusetts Institute Of Technology Methods of treating obsessive compulsive disorder
WO2007029063A2 (en) * 2005-07-29 2007-03-15 Ecole Polytechnique Federale De Lausanne (Epfl) Treatment and/or prevention of pervasive developmental disorders
WO2007050741A2 (en) * 2005-10-26 2007-05-03 Emory University Compositions for treating fragile x and other disorders methods of use thereof and screening for compounds for fragile x and other disorders
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070191440A1 (en) * 2006-01-25 2007-08-16 Solomon Michael E Methods of treating autism and fragile X syndrome
CA2780205A1 (en) 2009-11-05 2011-05-12 Brown University Methods of treating elevations in mtor signaling

Also Published As

Publication number Publication date
DK2083811T3 (en) 2017-01-30
US20130261186A1 (en) 2013-10-03
SI2083811T1 (sl) 2017-02-28
US8143311B2 (en) 2012-03-27
CA2670116A1 (en) 2008-06-05
AU2007325836B2 (en) 2011-07-21
US8278276B2 (en) 2012-10-02
AU2007325836A1 (en) 2008-06-05
US20130012586A1 (en) 2013-01-10
JP2010510314A (ja) 2010-04-02
US20120122986A1 (en) 2012-05-17
US9044443B2 (en) 2015-06-02
ES2610508T3 (es) 2017-04-27
US8273715B2 (en) 2012-09-25
EP2083811A1 (en) 2009-08-05
EP2578216A1 (en) 2013-04-10
WO2008066750A1 (en) 2008-06-05
CA2670116C (en) 2015-03-10
EP2567696A1 (en) 2013-03-13
US20130012587A1 (en) 2013-01-10
LT2083811T (lt) 2017-01-25
HRP20170027T1 (hr) 2017-03-10
US20100029770A1 (en) 2010-02-04
PT2083811T (pt) 2017-01-23
CY1118406T1 (el) 2017-06-28
HUE032743T2 (en) 2017-10-30
US20120129940A1 (en) 2012-05-24
EP2083811B1 (en) 2016-10-26
RS55585B1 (sr) 2017-06-30

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