PL2049529T3 - Podstawione związki diazepanowe - antagoniści receptora oreksyny - Google Patents
Podstawione związki diazepanowe - antagoniści receptora oreksynyInfo
- Publication number
- PL2049529T3 PL2049529T3 PL07796852T PL07796852T PL2049529T3 PL 2049529 T3 PL2049529 T3 PL 2049529T3 PL 07796852 T PL07796852 T PL 07796852T PL 07796852 T PL07796852 T PL 07796852T PL 2049529 T3 PL2049529 T3 PL 2049529T3
- Authority
- PL
- Poland
- Prior art keywords
- receptor antagonists
- orexin receptor
- substituted diazepan
- substituted
- compounds
- Prior art date
Links
- 229940123730 Orexin receptor antagonist Drugs 0.000 title 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical class N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 title 1
- 108050000742 Orexin Receptor Proteins 0.000 abstract 3
- 102000008834 Orexin receptor Human genes 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical class C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83098306P | 2006-07-14 | 2006-07-14 | |
| PCT/US2007/016038 WO2008008518A1 (en) | 2006-07-14 | 2007-07-13 | Substituted diazepan orexin receptor antagonists |
| EP07796852A EP2049529B1 (en) | 2006-07-14 | 2007-07-13 | Substituted diazepan orexin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2049529T3 true PL2049529T3 (pl) | 2011-01-31 |
Family
ID=38654759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07796852T PL2049529T3 (pl) | 2006-07-14 | 2007-07-13 | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090192143A1 (pl) |
| EP (1) | EP2049529B1 (pl) |
| JP (1) | JP5479893B2 (pl) |
| AT (1) | ATE477252T1 (pl) |
| AU (1) | AU2007272855B2 (pl) |
| CA (1) | CA2657552A1 (pl) |
| CY (1) | CY1110882T1 (pl) |
| DE (1) | DE602007008434D1 (pl) |
| DK (1) | DK2049529T3 (pl) |
| ES (1) | ES2348685T3 (pl) |
| PL (1) | PL2049529T3 (pl) |
| PT (1) | PT2049529E (pl) |
| SI (1) | SI2049529T1 (pl) |
| WO (1) | WO2008008518A1 (pl) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008008517A2 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Bridged diazepan orexin receptor antagonists |
| PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| WO2008143856A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| AU2008257411B2 (en) | 2007-05-23 | 2012-04-26 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8362009B2 (en) | 2007-10-29 | 2013-01-29 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
| US8623863B2 (en) * | 2008-10-21 | 2014-01-07 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| US8178666B2 (en) | 2008-10-23 | 2012-05-15 | Albany Molecular Research, Inc. | 2-aminobenzoxazole process |
| US8853202B2 (en) | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
| MX2011004490A (es) | 2008-11-04 | 2011-07-20 | Chemocentryx Inc | Moduladores de cxcr7. |
| US9062044B2 (en) | 2009-10-23 | 2015-06-23 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| US8653263B2 (en) | 2009-10-23 | 2014-02-18 | Janssen Pharmaceutica | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| US8680275B2 (en) | 2009-10-23 | 2014-03-25 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| TW201204732A (en) | 2010-07-09 | 2012-02-01 | Leo Pharma As | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
| WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| ES2672732T3 (es) | 2012-02-07 | 2018-06-15 | Eolas Therapeutics Inc. | Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina |
| BR112015012366A8 (pt) | 2012-11-29 | 2019-10-01 | Chemocentryx Inc | antagonistas de cxcr7, uso dos mesmos, composição farmacêutica, bem como métodos para detectar níveis elevados de cxcr7 em uma amostra e para imagear um tumor, órgão, ou tecido |
| US9732077B2 (en) | 2013-12-18 | 2017-08-15 | Merck Sharp & Dohme Corp. | Diazepane orexin receptor antagonists |
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| UY36272A (es) | 2014-08-13 | 2016-02-29 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores de los receptores de orexinas |
| CN105461699B (zh) * | 2014-09-25 | 2019-07-09 | 广东东阳光药业有限公司 | 取代的杂环化合物及其使用方法和用途 |
| US10000499B2 (en) | 2014-11-26 | 2018-06-19 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
| JP6698633B2 (ja) | 2015-04-24 | 2020-05-27 | 武田薬品工業株式会社 | 複素環化合物 |
| AU2016295693B2 (en) * | 2015-07-17 | 2020-05-21 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| CN106749269B (zh) | 2015-11-23 | 2019-01-04 | 广东东阳光药业有限公司 | 八氢吡咯并[3,4-c]吡咯衍生物及其用途 |
| CN107021964A (zh) * | 2016-02-01 | 2017-08-08 | 广东东阳光药业有限公司 | 萘啶衍生物及其用途 |
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| BR112018067906A2 (pt) | 2016-03-10 | 2019-01-29 | Janssen Pharmaceutica Nv | métodos de tratamento de depressão usando antagonistas do receptor de orexina-2 |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
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|---|---|---|---|---|
| US5021421A (en) * | 1989-03-03 | 1991-06-04 | Dainippon Pharmaceutical Co., Ltd. | 2-(1-Piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same |
| JPH0747574B2 (ja) * | 1989-03-03 | 1995-05-24 | 大日本製薬株式会社 | ピリジン誘導体及びそれを有効成分とする向精神剤 |
| GB0127145D0 (en) * | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
| PE20081229A1 (es) * | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| US8362009B2 (en) * | 2007-10-29 | 2013-01-29 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
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- 2007-07-13 PT PT07796852T patent/PT2049529E/pt unknown
- 2007-07-13 WO PCT/US2007/016038 patent/WO2008008518A1/en not_active Ceased
- 2007-07-13 CA CA002657552A patent/CA2657552A1/en not_active Abandoned
- 2007-07-13 US US12/309,239 patent/US20090192143A1/en not_active Abandoned
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| WO2008008518A1 (en) | 2008-01-17 |
| AU2007272855A1 (en) | 2008-01-17 |
| AU2007272855B2 (en) | 2013-08-01 |
| CA2657552A1 (en) | 2008-01-17 |
| JP5479893B2 (ja) | 2014-04-23 |
| PT2049529E (pt) | 2010-10-13 |
| DK2049529T3 (da) | 2010-11-29 |
| EP2049529A1 (en) | 2009-04-22 |
| US20090192143A1 (en) | 2009-07-30 |
| SI2049529T1 (sl) | 2010-11-30 |
| CY1110882T1 (el) | 2015-06-10 |
| ES2348685T3 (es) | 2010-12-10 |
| EP2049529B1 (en) | 2010-08-11 |
| JP2009543786A (ja) | 2009-12-10 |
| DE602007008434D1 (de) | 2010-09-23 |
| ATE477252T1 (de) | 2010-08-15 |
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