PL1842920T3 - Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K - Google Patents
Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy KInfo
- Publication number
- PL1842920T3 PL1842920T3 PL07109353T PL07109353T PL1842920T3 PL 1842920 T3 PL1842920 T3 PL 1842920T3 PL 07109353 T PL07109353 T PL 07109353T PL 07109353 T PL07109353 T PL 07109353T PL 1842920 T3 PL1842920 T3 PL 1842920T3
- Authority
- PL
- Poland
- Prior art keywords
- vitamin
- dependent protein
- reductase
- productivity
- improve
- Prior art date
Links
- 108091005605 Vitamin K-dependent proteins Proteins 0.000 title 2
- 102000004960 NAD(P)H dehydrogenase (quinone) Human genes 0.000 title 1
- 108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 title 1
- 230000003247 decreasing effect Effects 0.000 abstract 3
- 230000035945 sensitivity Effects 0.000 abstract 3
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 3
- 229960005080 warfarin Drugs 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 101000621954 Synechococcus sp. (strain JA-2-3B'a(2-13)) Vitamin K epoxide reductase homolog Proteins 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50552703P | 2003-09-23 | 2003-09-23 | |
| EP07109353.8A EP1842920B2 (en) | 2003-09-23 | 2004-09-23 | Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein |
| EP04789039.7A EP1670947B1 (en) | 2003-09-23 | 2004-09-23 | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL1842920T3 true PL1842920T3 (pl) | 2010-06-30 |
| PL1842920T5 PL1842920T5 (pl) | 2018-04-30 |
Family
ID=34393028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07109353T PL1842920T5 (pl) | 2003-09-23 | 2004-09-23 | Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US7687233B2 (pl) |
| EP (4) | EP2336360A1 (pl) |
| JP (4) | JP2007506433A (pl) |
| AT (1) | ATE455174T1 (pl) |
| AU (2) | AU2004275828B2 (pl) |
| CA (1) | CA2539434C (pl) |
| DE (1) | DE602004025157D1 (pl) |
| DK (2) | DK2380985T3 (pl) |
| ES (2) | ES2453895T3 (pl) |
| PL (1) | PL1842920T5 (pl) |
| PT (1) | PT2380985E (pl) |
| WO (1) | WO2005030039A2 (pl) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2336360A1 (en) | 2003-09-23 | 2011-06-22 | University Of North Carolina At Chapel Hill | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage |
| EP2272951B1 (en) | 2003-10-14 | 2014-07-23 | Baxter International Inc. | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives |
| GB0324044D0 (en) | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| WO2006012902A2 (en) * | 2004-08-02 | 2006-02-09 | Novozymes A/S | Creation of diversity in polypeptides |
| US7445896B2 (en) | 2004-10-18 | 2008-11-04 | University Of Washington | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
| WO2006044686A2 (en) * | 2004-10-18 | 2006-04-27 | University Of Washington | Methods and compositions for predicting drug responses |
| PL1831402T3 (pl) * | 2004-12-21 | 2010-12-31 | Academia Sinica | Genetyczne warianty VKORC1 przewidujące wrażliwość na warfarynę |
| MX349285B (es) * | 2005-02-28 | 2017-07-20 | Baxalta Inc | Co-expresion recombinante de reductasa de epoxido de vitamina k subunidad 1 para mejorar la expresion de proteina dependiente de vitamina k. |
| US20090325226A1 (en) * | 2005-03-15 | 2009-12-31 | Stafford Darrel W | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins |
| MX2007012704A (es) * | 2005-04-13 | 2008-01-14 | Astrazeneca Ab | Celula huesped que comprende vector para la produccion de proteinas que requieren carboxilacion-gamma. |
| US8500720B2 (en) * | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
| PL1969127T5 (pl) * | 2005-12-21 | 2018-02-28 | Cnj Holdings, Inc | Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji |
| US20070298426A1 (en) * | 2006-06-02 | 2007-12-27 | Academia Sinica | Warfarin dosage prediction |
| US8206967B2 (en) | 2007-07-06 | 2012-06-26 | Medimmune Limited | Method for production of recombinant human thrombin |
| ES2466340T3 (es) | 2008-04-24 | 2014-06-10 | Cantab Biopharmaceuticals Patents Limited | Conjugados de Factor IX con semividas extendidas |
| WO2010045381A2 (en) * | 2008-10-15 | 2010-04-22 | President And Fellows Of Harvard College | Antimicrobial agents that target bacterial vkor |
| DK2451963T3 (da) | 2009-07-10 | 2014-08-04 | Csl Ltd | Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse |
| EP2655607A4 (en) | 2010-12-21 | 2014-05-14 | Univ North Carolina | METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS |
| JP2012139232A (ja) * | 2012-03-15 | 2012-07-26 | Univ Of North Carolina At Chapel Hill | 活性ビタミンk依存性タンパク質を生産するための方法及び組成物 |
| JP2014221048A (ja) * | 2014-06-16 | 2014-11-27 | ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 活性ビタミンk依存性タンパク質を生産するための方法及び組成物 |
| BR102015012334A2 (pt) | 2015-05-27 | 2016-11-29 | Fundação Hemoct De Ribeirão Preto Fundherp | processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| AU2019383976B2 (en) | 2018-11-19 | 2025-07-03 | Bt Bidco, Inc. | Methods and devices for treating a disease with biotherapeutics |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
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| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
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| JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
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| US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
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| EP2336360A1 (en) | 2003-09-23 | 2011-06-22 | University Of North Carolina At Chapel Hill | Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage |
| EP2272951B1 (en) | 2003-10-14 | 2014-07-23 | Baxter International Inc. | Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives |
| GB0324044D0 (en) | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| US7445896B2 (en) * | 2004-10-18 | 2008-11-04 | University Of Washington | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
| WO2006044686A2 (en) | 2004-10-18 | 2006-04-27 | University Of Washington | Methods and compositions for predicting drug responses |
| PL1831402T3 (pl) * | 2004-12-21 | 2010-12-31 | Academia Sinica | Genetyczne warianty VKORC1 przewidujące wrażliwość na warfarynę |
| US20090100533A1 (en) | 2004-12-21 | 2009-04-16 | Novo Nordisk Health Care Ag | Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host sytems |
| MX349285B (es) | 2005-02-28 | 2017-07-20 | Baxalta Inc | Co-expresion recombinante de reductasa de epoxido de vitamina k subunidad 1 para mejorar la expresion de proteina dependiente de vitamina k. |
| US20090325226A1 (en) | 2005-03-15 | 2009-12-31 | Stafford Darrel W | Methods and Compositions for Producing Active Vitamin K-Dependent Proteins |
| MX2007012704A (es) | 2005-04-13 | 2008-01-14 | Astrazeneca Ab | Celula huesped que comprende vector para la produccion de proteinas que requieren carboxilacion-gamma. |
| EP1963506B1 (en) | 2005-12-02 | 2010-10-27 | Wake Forest University Health Sciences | Compositions and methods for increasing production of recombinant gamma-carboxylated proteins |
| PL1969127T5 (pl) | 2005-12-21 | 2018-02-28 | Cnj Holdings, Inc | Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji |
| US20070298426A1 (en) | 2006-06-02 | 2007-12-27 | Academia Sinica | Warfarin dosage prediction |
| JP2009005240A (ja) * | 2007-06-25 | 2009-01-08 | Nec Tokin Corp | 無線ネットワークシステムおよび無線ネットワーク通信方法 |
-
2004
- 2004-09-23 EP EP10178665A patent/EP2336360A1/en not_active Withdrawn
- 2004-09-23 ES ES11156979.4T patent/ES2453895T3/es not_active Expired - Lifetime
- 2004-09-23 US US10/573,131 patent/US7687233B2/en not_active Expired - Fee Related
- 2004-09-23 AU AU2004275828A patent/AU2004275828B2/en not_active Expired
- 2004-09-23 WO PCT/US2004/031481 patent/WO2005030039A2/en not_active Ceased
- 2004-09-23 AT AT07109353T patent/ATE455174T1/de not_active IP Right Cessation
- 2004-09-23 EP EP07109353.8A patent/EP1842920B2/en not_active Expired - Lifetime
- 2004-09-23 ES ES07109353.8T patent/ES2339710T5/es not_active Expired - Lifetime
- 2004-09-23 DK DK11156979.4T patent/DK2380985T3/en active
- 2004-09-23 EP EP04789039.7A patent/EP1670947B1/en not_active Expired - Lifetime
- 2004-09-23 DK DK07109353.8T patent/DK1842920T4/da active
- 2004-09-23 PL PL07109353T patent/PL1842920T5/pl unknown
- 2004-09-23 PT PT111569794T patent/PT2380985E/pt unknown
- 2004-09-23 CA CA2539434A patent/CA2539434C/en not_active Expired - Lifetime
- 2004-09-23 JP JP2006528251A patent/JP2007506433A/ja not_active Withdrawn
- 2004-09-23 DE DE602004025157T patent/DE602004025157D1/de not_active Expired - Lifetime
- 2004-09-23 EP EP11156979.4A patent/EP2380985B1/en not_active Expired - Lifetime
-
2006
- 2006-09-06 US US11/516,229 patent/US7524665B2/en not_active Expired - Lifetime
-
2007
- 2007-01-30 US US11/699,930 patent/US7482141B2/en not_active Expired - Lifetime
- 2007-10-26 US US11/924,707 patent/US8097410B2/en not_active Expired - Fee Related
-
2009
- 2009-01-28 US US12/361,053 patent/US7858318B2/en not_active Expired - Fee Related
-
2010
- 2010-07-02 JP JP2010151738A patent/JP5094920B2/ja not_active Expired - Fee Related
- 2010-07-26 AU AU2010203318A patent/AU2010203318B2/en not_active Ceased
- 2010-12-17 US US12/971,574 patent/US8426128B2/en not_active Expired - Fee Related
-
2012
- 2012-03-12 JP JP2012054537A patent/JP5840539B2/ja not_active Expired - Lifetime
-
2015
- 2015-05-07 JP JP2015094928A patent/JP2015180205A/ja active Pending
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