PL1727551T3 - Kompozycja farmaceutyczna zawierająca pochodną benzodiazepiny i inhibitor fuzji białek RSV - Google Patents
Kompozycja farmaceutyczna zawierająca pochodną benzodiazepiny i inhibitor fuzji białek RSVInfo
- Publication number
- PL1727551T3 PL1727551T3 PL05728747T PL05728747T PL1727551T3 PL 1727551 T3 PL1727551 T3 PL 1727551T3 PL 05728747 T PL05728747 T PL 05728747T PL 05728747 T PL05728747 T PL 05728747T PL 1727551 T3 PL1727551 T3 PL 1727551T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitor
- pharmaceutical composition
- fusion protein
- benzodiazepine derivative
- rsv fusion
- Prior art date
Links
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0406279.0A GB0406279D0 (en) | 2004-03-19 | 2004-03-19 | Therapeutic compounds |
| EP05728747A EP1727551B1 (en) | 2004-03-19 | 2005-03-18 | Pharmaceutical composition comprising a benzodiazepine derivative and a inhibitor of the rsv fusion protein |
| PCT/GB2005/001029 WO2005089771A1 (en) | 2004-03-19 | 2005-03-18 | Pharmaceutical composition comprising a benzodiazepine derivative and a inhibitor of the rsv fusion protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1727551T3 true PL1727551T3 (pl) | 2010-02-26 |
Family
ID=32118066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05728747T PL1727551T3 (pl) | 2004-03-19 | 2005-03-18 | Kompozycja farmaceutyczna zawierająca pochodną benzodiazepiny i inhibitor fuzji białek RSV |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070185096A1 (pl) |
| EP (1) | EP1727551B1 (pl) |
| JP (1) | JP2007529491A (pl) |
| KR (1) | KR20070009630A (pl) |
| CN (1) | CN100496499C (pl) |
| AT (1) | ATE442145T1 (pl) |
| AU (1) | AU2005224159B2 (pl) |
| BR (1) | BRPI0507652A (pl) |
| CA (1) | CA2557931A1 (pl) |
| DE (1) | DE602005016532D1 (pl) |
| DK (1) | DK1727551T3 (pl) |
| ES (1) | ES2331479T3 (pl) |
| GB (1) | GB0406279D0 (pl) |
| PL (1) | PL1727551T3 (pl) |
| PT (1) | PT1727551E (pl) |
| RU (1) | RU2006136881A (pl) |
| WO (1) | WO2005089771A1 (pl) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0406282D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
| CN101506203B (zh) * | 2006-08-24 | 2013-10-16 | 诺瓦提斯公司 | 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物 |
| JP5351025B2 (ja) | 2006-09-22 | 2013-11-27 | ノバルティス アーゲー | ヘテロ環式有機化合物 |
| JP2010513403A (ja) | 2006-12-20 | 2010-04-30 | ノバルティス アーゲー | Ｓｃｄ阻害剤としての２−置換５員ヘテロ環 |
| US20110118234A1 (en) * | 2008-05-05 | 2011-05-19 | Kaustav Biswas | Urea Compounds as Gamma Secretase Modulators |
| US9556236B1 (en) | 2012-11-29 | 2017-01-31 | University Of South Florida | Compositions and methods for treating respiratory syncytial virus infection |
| CN108200760B (zh) | 2015-07-22 | 2022-04-01 | 英安塔制药有限公司 | 作为rsv抑制剂的苯并二氮杂䓬衍生物 |
| EP3402799B1 (en) | 2016-01-15 | 2022-05-04 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| GB201613942D0 (en) * | 2016-08-15 | 2016-09-28 | Univ Of Durham The | An antimicrobial compound |
| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| EP3582784B1 (en) * | 2017-02-16 | 2022-06-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| US10752598B2 (en) | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
| WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019046364A1 (en) * | 2017-08-29 | 2019-03-07 | Emory University | INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF |
| AU2018339068B2 (en) | 2017-09-29 | 2022-12-15 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| MX394621B (es) | 2017-11-13 | 2025-03-24 | Enanta Pharm Inc | Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| WO2019199908A1 (en) | 2018-04-11 | 2019-10-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| PH12021552201A1 (en) | 2019-03-18 | 2022-05-30 | Enanta Pharm Inc | Benzodiazepine derivatives as rsv inhibitors |
| US11179400B2 (en) | 2019-04-09 | 2021-11-23 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| GB201911944D0 (en) | 2019-08-20 | 2019-10-02 | Reviral Ltd | Pharmaceutical compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| MX2022003984A (es) | 2019-10-04 | 2022-07-27 | Enanta Pharm Inc | Compuestos heterociclicos antivirales. |
| GB201915273D0 (en) * | 2019-10-22 | 2019-12-04 | Reviral Ltd | Pharmaceutical compounds |
| GB201915932D0 (en) | 2019-11-01 | 2019-12-18 | Reviral Ltd | Pharmaceutical compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| US11945830B2 (en) | 2021-02-26 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| EP0491218A1 (en) * | 1990-12-17 | 1992-06-24 | F. Hoffmann-La Roche Ag | Benzodiazepinones |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| JP2005511714A (ja) * | 2001-12-10 | 2005-04-28 | ブリストル−マイヤーズ スクイブ カンパニー | Ｒｓｖ融合インヒビターのジ塩酸塩・モノ水和物 |
| US6919331B2 (en) * | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| EA012387B1 (ru) * | 2002-09-20 | 2009-10-30 | Эрроу Терапьютикс Лимитед | Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение |
| GB0406282D0 (en) * | 2004-03-19 | 2004-04-21 | Arrow Therapeutics Ltd | Therapeutic compounds |
-
2004
- 2004-03-19 GB GBGB0406279.0A patent/GB0406279D0/en not_active Ceased
-
2005
- 2005-03-18 CA CA002557931A patent/CA2557931A1/en not_active Abandoned
- 2005-03-18 JP JP2007503412A patent/JP2007529491A/ja not_active Withdrawn
- 2005-03-18 RU RU2006136881/15A patent/RU2006136881A/ru not_active Application Discontinuation
- 2005-03-18 AT AT05728747T patent/ATE442145T1/de not_active IP Right Cessation
- 2005-03-18 BR BRPI0507652-8A patent/BRPI0507652A/pt not_active IP Right Cessation
- 2005-03-18 US US10/593,382 patent/US20070185096A1/en not_active Abandoned
- 2005-03-18 WO PCT/GB2005/001029 patent/WO2005089771A1/en not_active Ceased
- 2005-03-18 PT PT05728747T patent/PT1727551E/pt unknown
- 2005-03-18 EP EP05728747A patent/EP1727551B1/en not_active Expired - Lifetime
- 2005-03-18 KR KR1020067021651A patent/KR20070009630A/ko not_active Withdrawn
- 2005-03-18 DK DK05728747T patent/DK1727551T3/da active
- 2005-03-18 CN CNB2005800089207A patent/CN100496499C/zh not_active Expired - Fee Related
- 2005-03-18 DE DE602005016532T patent/DE602005016532D1/de not_active Expired - Fee Related
- 2005-03-18 AU AU2005224159A patent/AU2005224159B2/en not_active Ceased
- 2005-03-18 ES ES05728747T patent/ES2331479T3/es not_active Expired - Lifetime
- 2005-03-18 PL PL05728747T patent/PL1727551T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1727551B1 (en) | 2009-09-09 |
| AU2005224159A1 (en) | 2005-09-29 |
| CA2557931A1 (en) | 2005-09-29 |
| RU2006136881A (ru) | 2008-04-27 |
| CN100496499C (zh) | 2009-06-10 |
| KR20070009630A (ko) | 2007-01-18 |
| AU2005224159B2 (en) | 2009-05-21 |
| ATE442145T1 (de) | 2009-09-15 |
| DK1727551T3 (da) | 2009-12-14 |
| GB0406279D0 (en) | 2004-04-21 |
| BRPI0507652A (pt) | 2007-07-10 |
| EP1727551A1 (en) | 2006-12-06 |
| DE602005016532D1 (de) | 2009-10-22 |
| JP2007529491A (ja) | 2007-10-25 |
| CN1933841A (zh) | 2007-03-21 |
| US20070185096A1 (en) | 2007-08-09 |
| PT1727551E (pt) | 2009-10-08 |
| WO2005089771A1 (en) | 2005-09-29 |
| ES2331479T3 (es) | 2010-01-05 |
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