PL1673365T3 - Sposób wytwarzania Z-flupentiksolu - Google Patents
Sposób wytwarzania Z-flupentiksoluInfo
- Publication number
- PL1673365T3 PL1673365T3 PL04769498T PL04769498T PL1673365T3 PL 1673365 T3 PL1673365 T3 PL 1673365T3 PL 04769498 T PL04769498 T PL 04769498T PL 04769498 T PL04769498 T PL 04769498T PL 1673365 T3 PL1673365 T3 PL 1673365T3
- Authority
- PL
- Poland
- Prior art keywords
- flupentixol
- preparation
- isomers
- separation
- relates
- Prior art date
Links
- NJMYODHXAKYRHW-DVZOWYKESA-N cis-flupenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C2/1 NJMYODHXAKYRHW-DVZOWYKESA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- -1 decanoate ester Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002024A ITMI20032024A1 (it) | 2003-10-17 | 2003-10-17 | Procedimento per la preparazione dello z-flupentixol |
| PCT/IB2004/003155 WO2005037820A1 (en) | 2003-10-17 | 2004-09-29 | Process for the preparation of z-flupentixol |
| EP04769498A EP1673365B1 (en) | 2003-10-17 | 2004-09-29 | Process for the preparation of z-flupentixol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1673365T3 true PL1673365T3 (pl) | 2008-08-29 |
Family
ID=34452249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04769498T PL1673365T3 (pl) | 2003-10-17 | 2004-09-29 | Sposób wytwarzania Z-flupentiksolu |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1673365B1 (pl) |
| CN (1) | CN1867558B (pl) |
| AT (1) | ATE388949T1 (pl) |
| CA (1) | CA2536667C (pl) |
| CY (1) | CY1108121T1 (pl) |
| DE (1) | DE602004012430T2 (pl) |
| DK (1) | DK1673365T3 (pl) |
| ES (1) | ES2302032T3 (pl) |
| IT (1) | ITMI20032024A1 (pl) |
| PL (1) | PL1673365T3 (pl) |
| PT (1) | PT1673365E (pl) |
| WO (1) | WO2005037820A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102002034B (zh) * | 2009-08-28 | 2012-11-28 | 江苏恩华药业股份有限公司 | 盐酸氟哌噻吨异构体的分离方法 |
| CN101912397B (zh) * | 2010-04-30 | 2013-03-27 | H.隆德贝克有限公司 | 氟哌噻吨组合物 |
| CN102786511B (zh) * | 2011-05-18 | 2014-10-15 | 重庆圣华曦药业股份有限公司 | 一种制备盐酸氟哌噻吨中间体的改进方法 |
| CN103450151B (zh) * | 2013-02-04 | 2014-07-30 | 四川海思科制药有限公司 | 一种氟哌噻吨化合物的制备方法 |
| CN105348256B (zh) * | 2015-11-16 | 2018-01-30 | 成都倍特药业有限公司 | 一种药用级盐酸氟哌噻吨的制备方法 |
| CN107382962B (zh) * | 2016-05-16 | 2020-11-03 | 江苏同禾药业有限公司 | 一种2-三氟甲基-9-烯丙基-9-噻吨醇的制备方法 |
| CN107987053B (zh) * | 2017-12-08 | 2023-04-14 | 植恩生物技术股份有限公司 | 一种高纯度z型盐酸氟哌噻吨的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1210890B (de) * | 1960-03-07 | 1966-02-17 | Smith & Kline & French Lab | Verfahren zur Herstellung von Trifluormethyl-xanthen- oder thioxanthenderivaten |
| US3282930A (en) * | 1962-08-17 | 1966-11-01 | Smith Kline French Lab | Hydroxyalkylenepiperazine derivatives and analogs thereof |
| US3681346A (en) * | 1969-06-20 | 1972-08-01 | Kefalas As | {60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions |
-
2003
- 2003-10-17 IT IT002024A patent/ITMI20032024A1/it unknown
-
2004
- 2004-09-29 CA CA2536667A patent/CA2536667C/en not_active Expired - Fee Related
- 2004-09-29 AT AT04769498T patent/ATE388949T1/de active
- 2004-09-29 PT PT04769498T patent/PT1673365E/pt unknown
- 2004-09-29 EP EP04769498A patent/EP1673365B1/en not_active Expired - Lifetime
- 2004-09-29 DK DK04769498T patent/DK1673365T3/da active
- 2004-09-29 WO PCT/IB2004/003155 patent/WO2005037820A1/en not_active Ceased
- 2004-09-29 CN CN2004800304514A patent/CN1867558B/zh not_active Expired - Lifetime
- 2004-09-29 DE DE602004012430T patent/DE602004012430T2/de not_active Expired - Lifetime
- 2004-09-29 ES ES04769498T patent/ES2302032T3/es not_active Expired - Lifetime
- 2004-09-29 PL PL04769498T patent/PL1673365T3/pl unknown
-
2008
- 2008-06-06 CY CY20081100599T patent/CY1108121T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536667C (en) | 2012-01-10 |
| ATE388949T1 (de) | 2008-03-15 |
| DE602004012430D1 (de) | 2008-04-24 |
| PT1673365E (pt) | 2008-05-20 |
| DK1673365T3 (da) | 2008-06-30 |
| EP1673365B1 (en) | 2008-03-12 |
| WO2005037820A1 (en) | 2005-04-28 |
| EP1673365A1 (en) | 2006-06-28 |
| CY1108121T1 (el) | 2014-02-12 |
| ITMI20032024A1 (it) | 2005-04-18 |
| DE602004012430T2 (de) | 2009-03-05 |
| CN1867558B (zh) | 2013-02-06 |
| CA2536667A1 (en) | 2005-04-28 |
| ES2302032T3 (es) | 2008-07-01 |
| CN1867558A (zh) | 2006-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1108121T1 (el) | Διαδικασια παρασκευης ζ-φλουπεντιξολης | |
| TW200508201A (en) | Novel process for the preparation of roflumilast | |
| IL185731A0 (en) | Purification of montelukast | |
| SI1633697T1 (sl) | Postopek za pripravo substituiranih 3-aril-butilaminskih spojin | |
| IL181002A0 (en) | Methods for the separation of modafinil | |
| ECSP095220A (es) | Derivados de n-fenil-2-pirimidin-amina | |
| AU2003239793A1 (en) | Alicyclic esters having a musky smell | |
| HRP20080057T3 (en) | 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof | |
| AU2003290269A1 (en) | Process for the production of synthetic magnesium silicate compositions | |
| YU101402A (sh) | Visoko prečišćeni preparati simvastatina | |
| SE0302029D0 (sv) | Novel process | |
| MY120750A (en) | Process for the production of methyl methacrylate | |
| TW200728310A (en) | Process for the preparation of ferri-succinylcasein | |
| AU2003292814A1 (en) | Process for the production of pentaerythritol diphosphonates | |
| TW200800986A (en) | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | |
| SG146645A1 (en) | Process for the synthesis of 6-amino-4-(3-chloro-4fluoro-phenylamino)-7- ethoxy-quinoline-3-carbonitrile | |
| WO2004065396A3 (de) | Phosphorsäureester von polyisobuten-substituierten aromatischen hydroxyverbindungen | |
| AU2003210379A1 (en) | Method for the production of cyclohexanol from benzole | |
| WO2005054175A3 (en) | New process for the preparation of nitrooxyderivatives of paracetamol | |
| AU2002351074A1 (en) | Process for the separation of racemic mixtures | |
| AU2003237494A1 (en) | A process for automating the attachment of a clip to a product | |
| AU2002358557A1 (en) | Improved method for the production of biphosphites | |
| TW200407314A (en) | Preparation of 4, 6-dichloro-5-fluoropyrimidine | |
| TW200621734A (en) | Process for preparing diarylcycloalkyl derivatives | |
| PL1687356T3 (pl) | Sposób ciągłego wytwarzania poliamidów o ulepszonych własnościach płynięcia |