PH12019502122A1 - Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders - Google Patents
Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disordersInfo
- Publication number
- PH12019502122A1 PH12019502122A1 PH12019502122A PH12019502122A PH12019502122A1 PH 12019502122 A1 PH12019502122 A1 PH 12019502122A1 PH 12019502122 A PH12019502122 A PH 12019502122A PH 12019502122 A PH12019502122 A PH 12019502122A PH 12019502122 A1 PH12019502122 A1 PH 12019502122A1
- Authority
- PH
- Philippines
- Prior art keywords
- ire1
- pyridyloxy
- pyrimidinyl
- methods
- treating
- Prior art date
Links
- -1 Pyrimidinyl-pyridyloxy-naphthyl compounds Chemical class 0.000 title abstract 2
- 101100452784 Caenorhabditis elegans ire-1 gene Proteins 0.000 title 1
- 208000037765 diseases and disorders Diseases 0.000 title 1
- 102100030013 Endoribonuclease Human genes 0.000 abstract 3
- 108091006081 Inositol-requiring enzyme-1 Proteins 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula (I) or (I') structure : or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) or (I') compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017077059 | 2017-03-17 | ||
| CN2018050281 | 2018-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12019502122A1 true PH12019502122A1 (en) | 2020-07-06 |
Family
ID=71571944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12019502122A PH12019502122A1 (en) | 2017-03-17 | 2019-09-16 | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders |
Country Status (1)
| Country | Link |
|---|---|
| PH (1) | PH12019502122A1 (en) |
-
2019
- 2019-09-16 PH PH12019502122A patent/PH12019502122A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202108745B (en) | Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof | |
| ZA202500997B (en) | Benzoxazepin oxazolidinone compounds and methods of use | |
| CR20190433A (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders | |
| ZA202204929B (en) | Rimegepant for cgrp related disorders | |
| PH12020551578A1 (en) | Modulators of methyl modifying enzymes, compositions and uses thereof | |
| ZA202403923B (en) | Heterocyclic compounds as immunomodulators | |
| MX2021000887A (en) | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer. | |
| PH12021551256A1 (en) | Pantetheine derivatives and uses thereof | |
| PH12019500202A1 (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| PH12019500207A1 (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
| MX2020007731A (en) | ESTROGEN RECEPTOR MODULATOR COMPOUNDS. | |
| MY207469A (en) | Therapeutic compounds | |
| PH12021550671A1 (en) | Prodrugs of cgrp antagonists | |
| EP4494705A3 (en) | Non-peptide oxytocin receptor agonists | |
| PH12019502122A1 (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders | |
| PH12017501736B1 (en) | Indole derivatives | |
| JOP20200233A1 (en) | Triazacyclododecansulfonamide ("tcd")-based protein secretion inhibitors | |
| EA202192092A3 (en) | TETRAHYDRO-PYRIDO[3,4-B]INDOL MODULATORS OF ESTROGEN RECEPTORS AND THEIR APPLICATION | |
| NZ801355A (en) | Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors |