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PH12016500743A1 - Treatment using bruton`s tyrosine kinase inhibitors and immunotherapy - Google Patents

Treatment using bruton`s tyrosine kinase inhibitors and immunotherapy

Info

Publication number
PH12016500743A1
PH12016500743A1 PH12016500743A PH12016500743A PH12016500743A1 PH 12016500743 A1 PH12016500743 A1 PH 12016500743A1 PH 12016500743 A PH12016500743 A PH 12016500743A PH 12016500743 A PH12016500743 A PH 12016500743A PH 12016500743 A1 PH12016500743 A1 PH 12016500743A1
Authority
PH
Philippines
Prior art keywords
bruton
tyrosine kinase
immunotherapy
treatment
kinase inhibitors
Prior art date
Application number
PH12016500743A
Inventor
Levy Ronald
Chang Betty
Ng Patrick
Sagiv-Barfi Idit
Kohrt Holbrook
Original Assignee
Pharmacyclics Llc
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/062278 external-priority patent/WO2015061752A1/en
Application filed by Pharmacyclics Llc, Univ Leland Stanford Junior filed Critical Pharmacyclics Llc
Publication of PH12016500743A1 publication Critical patent/PH12016500743A1/en

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Abstract

Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., l-((R)-3-(4-amino-3-(4- phenoxyphenyl)- 1 H-pyrazolo [3,4-d]pyrimidin- 1 -yl)piperidin- 1 -yl)prop-2-en- 1 -one, with immunotherapy are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1- ((R)-3-(4-amino-3-(4-phenoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidin-l-yl)prop-2- en-l-one, and an immune checkpoint inhibitor.
PH12016500743A 2013-10-25 2016-04-20 Treatment using bruton`s tyrosine kinase inhibitors and immunotherapy PH12016500743A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361895988P 2013-10-25 2013-10-25
US201361899764P 2013-11-04 2013-11-04
US201361911953P 2013-12-04 2013-12-04
US201461937392P 2014-02-07 2014-02-07
US201462023705P 2014-07-11 2014-07-11
US201462023742P 2014-07-11 2014-07-11
PCT/US2014/062278 WO2015061752A1 (en) 2013-10-25 2014-10-24 Treatment using bruton's tyrosine kinase inhibitors and immunotherapy

Publications (1)

Publication Number Publication Date
PH12016500743A1 true PH12016500743A1 (en) 2016-06-20

Family

ID=57908617

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12016500743A PH12016500743A1 (en) 2013-10-25 2016-04-20 Treatment using bruton`s tyrosine kinase inhibitors and immunotherapy

Country Status (1)

Country Link
PH (1) PH12016500743A1 (en)

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