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PH12015501940B1 - Dihydropyridazine-3,5-dione derivative - Google Patents

Dihydropyridazine-3,5-dione derivative

Info

Publication number
PH12015501940B1
PH12015501940B1 PH12015501940A PH12015501940A PH12015501940B1 PH 12015501940 B1 PH12015501940 B1 PH 12015501940B1 PH 12015501940 A PH12015501940 A PH 12015501940A PH 12015501940 A PH12015501940 A PH 12015501940A PH 12015501940 B1 PH12015501940 B1 PH 12015501940B1
Authority
PH
Philippines
Prior art keywords
dihydropyridazine
dione derivative
prophylactic
salt
derivative
Prior art date
Application number
PH12015501940A
Other versions
PH12015501940A1 (en
Inventor
Yoshihito Ohtake
Naoki Okamoto
Yoshiyuki Ono
Hirotaka Kashiwagi
Atsushi Kimbara
Takeo Harada
Yoshihisa Murata
Kenichi Nomura
Kazutaka Tachibana
Shota Tanaka
Mitsuaki Ide
Eisaku Mizuguchi
Yasuhiro Ichida
Shuichi Ohtomo
Naoshi Horiba
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of PH12015501940B1 publication Critical patent/PH12015501940B1/en
Publication of PH12015501940A1 publication Critical patent/PH12015501940A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/504Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)

Abstract

According to the present invention, provided are a dihydropyridazine-3,5-dione derivative, a salt thereof, and solvates of the derivative and of the salt. Also provided are the following that contain any of said compounds as an active ingredient: a drug, a drug composition, a sodium-dependent phosphate transporter inhibitor, and a prophylactic and/or therapeutic agent as well as a prophylactic and/or therapeutic method for hyperphosphatemia, secondary hyperparathyroidism, and chronic renal failure.
PH12015501940A 2013-03-13 2015-09-03 Dihydropyridazine-3,5-dione derivative PH12015501940A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013051082 2013-03-13
JP2013132889 2013-06-25
PCT/JP2014/056778 WO2014142273A1 (en) 2013-03-13 2014-03-13 Dihydropyridazine-3,5-dione derivative

Publications (2)

Publication Number Publication Date
PH12015501940B1 true PH12015501940B1 (en) 2016-01-11
PH12015501940A1 PH12015501940A1 (en) 2016-01-11

Family

ID=51536921

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12015501940A PH12015501940A1 (en) 2013-03-13 2015-09-03 Dihydropyridazine-3,5-dione derivative

Country Status (29)

Country Link
EP (2) EP2975030B1 (en)
JP (2) JP5814488B2 (en)
KR (2) KR101664460B1 (en)
CN (1) CN105073715B (en)
AU (1) AU2014230552B2 (en)
BR (1) BR112015022092B1 (en)
CA (1) CA2901868C (en)
CL (1) CL2015002543A1 (en)
CR (1) CR20150505A (en)
DK (1) DK2975030T3 (en)
ES (1) ES2811126T3 (en)
HR (1) HRP20201211T1 (en)
HU (1) HUE050577T2 (en)
IL (1) IL240825B (en)
LT (1) LT2975030T (en)
MX (1) MX376532B (en)
MY (1) MY174269A (en)
NZ (1) NZ711182A (en)
PE (1) PE20151535A1 (en)
PH (1) PH12015501940A1 (en)
PL (1) PL2975030T3 (en)
PT (1) PT2975030T (en)
RS (1) RS60911B1 (en)
RU (1) RU2662832C2 (en)
SG (1) SG11201507345RA (en)
SI (1) SI2975030T1 (en)
TW (2) TWI596095B (en)
UA (1) UA118755C2 (en)
WO (1) WO2014142273A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2975030T1 (en) * 2013-03-13 2020-10-30 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative
WO2016039458A1 (en) * 2014-09-12 2016-03-17 中外製薬株式会社 Pharmaceutical containing sodium-dependent phosphate transporter inhibitor
WO2018019721A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
WO2018019755A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
CN110885290A (en) * 2019-12-16 2020-03-17 阿里生物新材料(常州)有限公司 Synthetic method of 3-fluoro-2-methyl-4-trifluoromethylaniline hydrochloride
AU2021296100A1 (en) * 2020-06-26 2023-02-16 Nihon Nohyaku Co., Ltd. Aryltetrahydropyridazine derivative or salt thereof, insecticidal agent containing the compound, and method of use thereof
WO2022221182A1 (en) * 2021-04-12 2022-10-20 Jnana Therapeutics Inc. Small molecule inhibitors of mammalian slc34a1 function
AR126060A1 (en) * 2021-06-08 2023-09-06 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING DIHYDROPYRIDAZIN-3,5-DIONE DERIVATIVE
BR112023023708A2 (en) * 2021-06-08 2024-01-30 Chugai Pharmaceutical Co Ltd FORMULATION CONTAINING DI-HYDROPYRANZINO-3,5-DIONE DERIVATIVE
AU2022427156B2 (en) 2021-12-28 2025-12-11 Nihon Nohyaku Co., Ltd. Aryltetrahydropyridazine derivative or salt thereof and insecticidal agent containing the compound and method for using same
US20250302833A1 (en) 2022-05-11 2025-10-02 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for treating or preventing cystic disease
CN116217862A (en) * 2023-03-21 2023-06-06 中国农业科学院农业环境与可持续发展研究所 A kind of preparation method of degradable biofilm aid

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KR100663147B1 (en) * 2002-02-19 2007-02-28 오노 야꾸힝 고교 가부시키가이샤 Condensed Pyridazine Derivative Compounds and Pharmaceuticals Containing the Same as Active Ingredients
CN1662529A (en) * 2002-06-19 2005-08-31 默克专利有限公司 Thiazole derivatives as phosphodiesterase IV inhibitors
KR20080019236A (en) * 2005-05-18 2008-03-03 어레이 바이오파마 인크. Heterocyclic Inhibitor of MEV and Method of Use thereof
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
EA017900B1 (en) * 2006-11-03 2013-04-30 Басф Се Process for preparing difluoromethylpyrazolyl carboxylates
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
EP2334682B1 (en) * 2008-08-20 2017-10-04 Fibrogen, Inc. Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
WO2011048611A1 (en) * 2009-10-07 2011-04-28 Torrent Pharmaceuticals Limited Novel fused pyridazine derivatives
MX2012012421A (en) * 2010-04-28 2012-12-17 Astellas Pharma Inc Tetrahydrobenzothiophene compound.
EP2591354B1 (en) 2010-07-07 2016-09-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012006474A2 (en) * 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP2013107880A (en) 2011-10-27 2013-06-06 Astellas Pharma Inc N-thienyl benzamide derivative
SI2975030T1 (en) * 2013-03-13 2020-10-30 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative

Also Published As

Publication number Publication date
EP2975030A4 (en) 2016-08-03
KR102072268B1 (en) 2020-01-31
BR112015022092A2 (en) 2017-07-18
LT2975030T (en) 2020-09-25
EP2975030B1 (en) 2020-07-15
DK2975030T3 (en) 2020-08-31
ES2811126T3 (en) 2021-03-10
AU2014230552A1 (en) 2015-08-13
JP5814488B2 (en) 2015-11-17
KR101664460B1 (en) 2016-10-10
PE20151535A1 (en) 2015-10-28
EP3757093A1 (en) 2020-12-30
TWI683811B (en) 2020-02-01
UA118755C2 (en) 2019-03-11
RU2015143507A (en) 2017-04-19
IL240825B (en) 2020-07-30
TWI596095B (en) 2017-08-21
SG11201507345RA (en) 2015-10-29
JP6420738B2 (en) 2018-11-07
RS60911B1 (en) 2020-11-30
CN105073715A (en) 2015-11-18
MX2015012537A (en) 2016-02-10
BR112015022092A8 (en) 2018-01-23
CL2015002543A1 (en) 2016-02-26
CA2901868A1 (en) 2014-09-18
CA2901868C (en) 2022-05-03
BR112015022092B1 (en) 2023-04-11
HK1212700A1 (en) 2016-06-17
IL240825A0 (en) 2015-10-29
HUE050577T2 (en) 2020-12-28
TW201741304A (en) 2017-12-01
MY174269A (en) 2020-04-01
JPWO2014142273A1 (en) 2017-02-16
AU2014230552B2 (en) 2017-11-16
CR20150505A (en) 2015-10-26
MX376532B (en) 2025-03-07
CN105073715B (en) 2017-12-01
RU2662832C2 (en) 2018-07-31
KR20150127721A (en) 2015-11-17
WO2014142273A1 (en) 2014-09-18
SI2975030T1 (en) 2020-10-30
TW201446756A (en) 2014-12-16
PH12015501940A1 (en) 2016-01-11
EP2975030A1 (en) 2016-01-20
PL2975030T3 (en) 2021-01-11
HRP20201211T1 (en) 2020-11-13
JP2016040262A (en) 2016-03-24
PT2975030T (en) 2020-09-28
KR20160119282A (en) 2016-10-12
NZ711182A (en) 2020-05-29

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